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Compile Data Set for Download or QSAR

Found 139 hits of kd data for polymerid = 2298,2980,49000664   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406532
PNG
(CHEMBL298859)
Show SMILES CC(C)CNC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C14H18N4/c1-11(2)7-15-9-17-13-5-3-12(4-6-13)14-8-16-10-18-14/h3-6,8-11H,7H2,1-2H3,(H,15,17)(H,16,18)
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n/an/an/a 5.25n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406533
PNG
(CHEMBL299537)
Show SMILES CCC(C)(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C15H20N4/c1-4-15(2,3)19-11-17-13-7-5-12(6-8-13)14-9-16-10-18-14/h5-11H,4H2,1-3H3,(H,16,18)(H,17,19)
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n/an/an/a 7.59n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50404029
PNG
(CHEMBL45728)
Show SMILES [O-][N+](=O)c1ccc(NCCCCCCCC[N-]C(NCCCOc2cccc(CN3CCCCC3)c2)=[NH+]C#N)c2[n-][o+]nc12
Show InChI InChI=1S/C31H42N9O4/c32-24-36-31(35-18-11-21-43-26-13-10-12-25(22-26)23-39-19-8-5-9-20-39)34-17-7-4-2-1-3-6-16-33-27-14-15-28(40(41)42)30-29(27)37-44-38-30/h10,12-15,22,33H,1-9,11,16-21,23H2,(H-,34,35,36)/q-1/p+1
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n/an/an/a 11.0n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonistic activity on the isolated spontaneously beating guinea pig right atrium


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406530
PNG
(CHEMBL51541)
Show SMILES CC(C)(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C14H18N4/c1-14(2,3)18-10-16-12-6-4-11(5-7-12)13-8-15-9-17-13/h4-10H,1-3H3,(H,15,17)(H,16,18)
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n/an/an/a 11.2n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406528
PNG
(CHEMBL362059)
Show SMILES CCCCNC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C14H18N4/c1-2-3-8-15-10-17-13-6-4-12(5-7-13)14-9-16-11-18-14/h4-7,9-11H,2-3,8H2,1H3,(H,15,17)(H,16,18)
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n/an/an/a 11.2n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22892
PNG
(DA 4577 | DA-4577 | Mifentidine | N-[4-(1H-imidazo...)
Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)
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n/an/an/a 12n/an/an/a7.8n/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.8


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406529
PNG
(CHEMBL51540)
Show SMILES CCC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C14H18N4/c1-3-11(2)16-10-17-13-6-4-12(5-7-13)14-8-15-9-18-14/h4-11H,3H2,1-2H3,(H,15,18)(H,16,17)
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n/an/an/a 14.1n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22892
PNG
(DA 4577 | DA-4577 | Mifentidine | N-[4-(1H-imidazo...)
Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)
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n/an/an/a 17n/an/an/a7.4n/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.4


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50036754
PNG
((1Z)-N'-(aminosulfonyl)-3-[({2-[(diaminomethylene)...)
Show SMILES NC(N)=Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
Show InChI InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
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n/an/an/a 18.2n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonistic activity on the isolated spontaneously beating guinea pig right atrium


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50404824
PNG
(CHEMBL302907)
Show SMILES NC(N)=Nc1nc(CSCCNc2ns(=O)nc2N)cs1
Show InChI InChI=1S/C9H14N8OS3/c10-6-7(17-21(18)16-6)13-1-2-19-3-5-4-20-9(14-5)15-8(11)12/h4H,1-3H2,(H2,10,16)(H,13,17)(H4,11,12,14,15)
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n/an/an/a 25.1n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive antagonism of Histamine H2 receptor in the isolated guinea pig atrium


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50404041
PNG
(CHEMBL45725)
Show SMILES [O-][N+](=O)c1ccc(NCCCCCC(=O)NCC[N-]C(NCCCOc2cccc(CN3CCCCC3)c2)=[NH+]C#N)c2[n-][o+]nc12
Show InChI InChI=1S/C31H42N10O5/c32-23-37-31(35-15-8-20-45-25-10-7-9-24(21-25)22-40-18-5-2-6-19-40)36-17-16-34-28(42)11-3-1-4-14-33-26-12-13-27(41(43)44)30-29(26)38-46-39-30/h7,9-10,12-13,21,33H,1-6,8,11,14-20,22H2,(H3,34,35,36,37,42)
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n/an/an/a 25.7n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonistic activity on the isolated spontaneously beating guinea pig right atrium


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406535
PNG
(CHEMBL50020)
Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)
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n/an/an/a 28.2n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406527
PNG
(CHEMBL423660)
Show SMILES CCC(CC)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C15H20N4/c1-3-13(4-2)17-11-18-14-7-5-12(6-8-14)15-9-16-10-19-15/h5-11,13H,3-4H2,1-2H3,(H,16,19)(H,17,18)
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n/an/an/a 31.6n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50404033
PNG
(CHEMBL46043)
Show SMILES [O-][N+](=O)c1ccc(NCCCCCC[N-]C(NCCCOc2cccc(CN3CCCCC3)c2)=[NH+]C#N)c2[n-][o+]nc12
Show InChI InChI=1S/C29H38N9O4/c30-22-34-29(33-16-9-19-41-24-11-8-10-23(20-24)21-37-17-6-3-7-18-37)32-15-5-2-1-4-14-31-25-12-13-26(38(39)40)28-27(25)35-42-36-28/h8,10-13,20,31H,1-7,9,14-19,21H2,(H-,32,33,34)/q-1/p+1
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n/an/an/a 32.4n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonistic activity on the isolated spontaneously beating guinea pig right atrium


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50404035
PNG
(CHEMBL295682)
Show SMILES [O-][N+](=O)c1ccc(NCCC[N-]C(NCCCOc2cccc(CN3CCCCC3)c2)=[NH+]C#N)c2[n-][o+]nc12
Show InChI InChI=1S/C26H32N9O4/c27-19-31-26(29-12-5-11-28-22-9-10-23(35(36)37)25-24(22)32-39-33-25)30-13-6-16-38-21-8-4-7-20(17-21)18-34-14-2-1-3-15-34/h4,7-10,17,28H,1-3,5-6,11-16,18H2,(H-,29,30,31)/q-1/p+1
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n/an/an/a 37.1n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonistic activity on the isolated spontaneously beating guinea pig right atrium


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50404032
PNG
(ROXATIDINE ACETATE)
Show SMILES CC(=O)OCC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C19H28N2O4/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23)
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n/an/an/a 38.9n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonistic activity on the isolated spontaneously beating guinea pig right atrium


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406670
PNG
(DALCOTIDINE)
Show SMILES CCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C18H29N3O2/c1-2-19-18(22)20-10-7-13-23-17-9-6-8-16(14-17)15-21-11-4-3-5-12-21/h6,8-9,14H,2-5,7,10-13,15H2,1H3,(H2,19,20,22)
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n/an/an/a 40.7n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406531
PNG
(CHEMBL296826)
Show SMILES CCNC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C12H14N4/c1-2-13-8-15-11-5-3-10(4-6-11)12-7-14-9-16-12/h3-9H,2H2,1H3,(H,13,15)(H,14,16)
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n/an/an/a 42.7n/an/an/an/an/a



Research Laboratories of Istituto De Angeli

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonism on the right atrium of the guinea pig


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406648
PNG
(CHEMBL82654)
Show SMILES CC(C)NC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C19H31N3O2/c1-16(2)21-19(23)20-10-7-13-24-18-9-6-8-17(14-18)15-22-11-4-3-5-12-22/h6,8-9,14,16H,3-5,7,10-13,15H2,1-2H3,(H2,20,21,23)
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n/an/an/a 43.6n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406660
PNG
(CHEMBL81545)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)NC1CCCCC1
Show InChI InChI=1S/C22H35N3O2/c26-22(24-20-10-3-1-4-11-20)23-13-8-16-27-21-12-7-9-19(17-21)18-25-14-5-2-6-15-25/h7,9,12,17,20H,1-6,8,10-11,13-16,18H2,(H2,23,24,26)
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n/an/an/a 43.6n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22892
PNG
(DA 4577 | DA-4577 | Mifentidine | N-[4-(1H-imidazo...)
Show SMILES CC(C)NC=Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)
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n/an/an/a 45.7n/an/an/a7.0n/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.0


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406655
PNG
(CHEMBL432167)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)NC1CC1
Show InChI InChI=1S/C19H29N3O2/c23-19(21-17-8-9-17)20-10-5-13-24-18-7-4-6-16(14-18)15-22-11-2-1-3-12-22/h4,6-7,14,17H,1-3,5,8-13,15H2,(H2,20,21,23)
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n/an/an/a 47.9n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22893
PNG
(CHEMBL512 | Ranitidine | ZANTAC | dimethyl[(5-{[(2...)
Show SMILES CN\C([CH-][N+]([O-])=O)=[NH+]/CCSCc1ccc(CN(C)C)o1
Show InChI InChI=1S/C13H21N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9H,6-8,10H2,1-3H3,(H,14,15)/q-1/p+1
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n/an/an/a 64.6n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro inhibitory activity against histamine H2 receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406673
PNG
(CHEMBL78519)
Show SMILES CCCCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H33N3O2/c1-2-3-11-21-20(24)22-12-8-15-25-19-10-7-9-18(16-19)17-23-13-5-4-6-14-23/h7,9-10,16H,2-6,8,11-15,17H2,1H3,(H2,21,22,24)
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n/an/an/a 81.3n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406659
PNG
(CHEMBL78339)
Show SMILES FCCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C18H28FN3O2/c19-8-10-21-18(23)20-9-5-13-24-17-7-4-6-16(14-17)15-22-11-2-1-3-12-22/h4,6-7,14H,1-3,5,8-13,15H2,(H2,20,21,23)
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n/an/an/a 85.1n/an/an/an/an/a



Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406658
PNG
(CHEMBL81750)
Show SMILES CCC(C)NC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H33N3O2/c1-3-17(2)22-20(24)21-11-8-14-25-19-10-7-9-18(15-19)16-23-12-5-4-6-13-23/h7,9-10,15,17H,3-6,8,11-14,16H2,1-2H3,(H2,21,22,24)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406674
PNG
(CHEMBL82599)
Show SMILES CCCNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C19H31N3O2/c1-2-10-20-19(23)21-11-7-14-24-18-9-6-8-17(15-18)16-22-12-4-3-5-13-22/h6,8-9,15H,2-5,7,10-14,16H2,1H3,(H2,20,21,23)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50036754
PNG
((1Z)-N'-(aminosulfonyl)-3-[({2-[(diaminomethylene)...)
Show SMILES NC(N)=Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
Show InChI InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406666
PNG
(CHEMBL80046)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)Nc1ccccc1
Show InChI InChI=1S/C22H29N3O2/c26-22(24-20-10-3-1-4-11-20)23-13-8-16-27-21-12-7-9-19(17-21)18-25-14-5-2-6-15-25/h1,3-4,7,9-12,17H,2,5-6,8,13-16,18H2,(H2,23,24,26)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406647
PNG
(CHEMBL81506)
Show SMILES CNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C17H27N3O2/c1-18-17(21)19-9-6-12-22-16-8-5-7-15(13-16)14-20-10-3-2-4-11-20/h5,7-8,13H,2-4,6,9-12,14H2,1H3,(H2,18,19,21)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406657
PNG
(CHEMBL309401)
Show SMILES Nc1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C22H30N4O2/c23-19-8-5-9-20(16-19)25-22(27)24-11-6-14-28-21-10-4-7-18(15-21)17-26-12-2-1-3-13-26/h4-5,7-10,15-16H,1-3,6,11-14,17,23H2,(H2,24,25,27)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro inhibitory activity against histamine H2 receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406656
PNG
(CHEMBL81039)
Show SMILES COc1ccc(OC)c(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C24H33N3O4/c1-29-20-10-11-23(30-2)22(17-20)26-24(28)25-12-7-15-31-21-9-6-8-19(16-21)18-27-13-4-3-5-14-27/h6,8-11,16-17H,3-5,7,12-15,18H2,1-2H3,(H2,25,26,28)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM22893
PNG
(CHEMBL512 | Ranitidine | ZANTAC | dimethyl[(5-{[(2...)
Show SMILES CN\C([CH-][N+]([O-])=O)=[NH+]/CCSCc1ccc(CN(C)C)o1
Show InChI InChI=1S/C13H21N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9H,6-8,10H2,1-3H3,(H,14,15)/q-1/p+1
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Peking University

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonistic activity on the isolated spontaneously beating guinea pig right atrium


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406661
PNG
(CHEMBL79974)
Show SMILES CC(C)CNC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Show InChI InChI=1S/C20H33N3O2/c1-17(2)15-22-20(24)21-10-7-13-25-19-9-6-8-18(14-19)16-23-11-4-3-5-12-23/h6,8-9,14,17H,3-5,7,10-13,15-16H2,1-2H3,(H2,21,22,24)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406664
PNG
(CHEMBL81859)
Show SMILES [O-][N+](=O)c1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C22H28N4O4/c27-22(24-19-8-10-20(11-9-19)26(28)29)23-12-5-15-30-21-7-4-6-18(16-21)17-25-13-2-1-3-14-25/h4,6-11,16H,1-3,5,12-15,17H2,(H2,23,24,27)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro inhibitory activity against histamine H2 receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50404038
PNG
(CHEMBL47917)
Show SMILES O=C(NCCNC(NCCCOc1cccc(CN2CCCCC2)c1)=NC#N)c1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C33H37N7O2/c34-24-38-33(36-16-9-21-42-26-11-8-10-25(22-26)23-40-19-6-1-7-20-40)37-18-17-35-32(41)31-27-12-2-4-14-29(27)39-30-15-5-3-13-28(30)31/h2-5,8,10-15,22H,1,6-7,9,16-21,23H2,(H,35,41)(H2,36,37,38)
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Peking University

Curated by ChEMBL


Assay Description
Histamine H2 receptor antagonistic activity on the isolated spontaneously beating guinea pig right atrium


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406669
PNG
(CHEMBL80084)
Show SMILES COc1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C23H31N3O3/c1-28-21-10-6-9-20(17-21)25-23(27)24-12-7-15-29-22-11-5-8-19(16-22)18-26-13-3-2-4-14-26/h5-6,8-11,16-17H,2-4,7,12-15,18H2,1H3,(H2,24,25,27)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50405173
PNG
(CHEMBL545393)
Show SMILES Cc1nc[nH]c1CSCCNC(=N)NCCSCc1[nH]cnc1C
Show InChI InChI=1S/C15H25N7S2/c1-11-13(21-9-19-11)7-23-5-3-17-15(16)18-4-6-24-8-14-12(2)20-10-22-14/h9-10H,3-8H2,1-2H3,(H,19,21)(H,20,22)(H3,16,17,18)
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n/an/an/a 214n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against H2 receptor in guinea pig.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50403559
PNG
(Brumetadina | CIMETIDINE)
Show SMILES CNC(NCCSCc1[nH]cnc1C)=NC#N
Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406652
PNG
(CHEMBL311978)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C22H28N4O4/c27-22(24-19-8-5-9-20(16-19)26(28)29)23-11-6-14-30-21-10-4-7-18(15-21)17-25-12-2-1-3-13-25/h4-5,7-10,15-16H,1-3,6,11-14,17H2,(H2,23,24,27)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406649
PNG
(CHEMBL81758)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)Nc1ccc2OCOc2c1
Show InChI InChI=1S/C23H29N3O4/c27-23(25-19-8-9-21-22(15-19)30-17-29-21)24-10-5-13-28-20-7-4-6-18(14-20)16-26-11-2-1-3-12-26/h4,6-9,14-15H,1-3,5,10-13,16-17H2,(H2,24,25,27)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50405160
PNG
(CHEMBL1744352)
Show SMILES Cc1nc[nH]c1CSCCNC(=N)NCCCc1nccs1
Show InChI InChI=1S/C14H22N6S2/c1-11-12(20-10-19-11)9-21-7-5-18-14(15)17-4-2-3-13-16-6-8-22-13/h6,8,10H,2-5,7,9H2,1H3,(H,19,20)(H3,15,17,18)
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TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against H2 receptor in guinea pig.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406672
PNG
(CHEMBL309659)
Show SMILES Clc1cccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)c1
Show InChI InChI=1S/C22H28ClN3O2/c23-19-8-5-9-20(16-19)25-22(27)24-11-6-14-28-21-10-4-7-18(15-21)17-26-12-2-1-3-13-26/h4-5,7-10,15-16H,1-3,6,11-14,17H2,(H2,24,25,27)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406667
PNG
(CHEMBL80105)
Show SMILES O=C(NCCCOc1cccc(CN2CCCCC2)c1)NCc1ccccc1
Show InChI InChI=1S/C23H31N3O2/c27-23(25-18-20-9-3-1-4-10-20)24-13-8-16-28-22-12-7-11-21(17-22)19-26-14-5-2-6-15-26/h1,3-4,7,9-12,17H,2,5-6,8,13-16,18-19H2,(H2,24,25,27)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50403559
PNG
(Brumetadina | CIMETIDINE)
Show SMILES CNC(NCCSCc1[nH]cnc1C)=NC#N
Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
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n/an/an/a 372n/an/an/a7.8n/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against Histamine H2 receptor expressed as the charge of receptor sensitivity was determined at pH 7.8


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50403559
PNG
(Brumetadina | CIMETIDINE)
Show SMILES CNC(NCCSCc1[nH]cnc1C)=NC#N
Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
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n/an/an/a 398n/an/an/a7.4n/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against Histamine H2 receptor expressed as the charge of receptor sensitivity was determined at pH 7.4


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406650
PNG
(CHEMBL82430)
Show SMILES CCOc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C24H33N3O3/c1-2-29-22-12-10-21(11-13-22)26-24(28)25-14-7-17-30-23-9-6-8-20(18-23)19-27-15-4-3-5-16-27/h6,8-13,18H,2-5,7,14-17,19H2,1H3,(H2,25,26,28)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50405174
PNG
(CHEMBL30761)
Show SMILES Cc1nc[nH]c1CSCCNC(NCCCc1cnc[nH]1)=NC#N
Show InChI InChI=1S/C15H22N8S/c1-12-14(23-11-21-12)8-24-6-5-19-15(20-9-16)18-4-2-3-13-7-17-10-22-13/h7,10-11H,2-6,8H2,1H3,(H,17,22)(H,21,23)(H2,18,19,20)
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TBA

Curated by ChEMBL


Assay Description
Antagonistic activity against H2 receptor in guinea pig.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406646
PNG
(CHEMBL311272)
Show SMILES Cc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C23H31N3O2/c1-19-9-11-21(12-10-19)25-23(27)24-13-6-16-28-22-8-5-7-20(17-22)18-26-14-3-2-4-15-26/h5,7-12,17H,2-4,6,13-16,18H2,1H3,(H2,24,25,27)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50406668
PNG
(CHEMBL81520)
Show SMILES Clc1ccc(NC(=O)NCCCOc2cccc(CN3CCCCC3)c2)cc1
Show InChI InChI=1S/C22H28ClN3O2/c23-19-8-10-20(11-9-19)25-22(27)24-12-5-15-28-21-7-4-6-18(16-21)17-26-13-2-1-3-14-26/h4,6-11,16H,1-3,5,12-15,17H2,(H2,24,25,27)
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Kyorin Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against histamine H2-receptor in isolated Guinea pig right atria.


Citation and Details
More data for this
Ligand-Target Pair
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