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Compile Data Set for Download or QSAR

Found 123 hits of ic50 for UniProtKB: P00371   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM406238
PNG
(US10336724, Compound Table 1.18)
Show SMILES O=C(Oc1cc(CCc2cccc3ccccc23)n[nH]c1=O)c1cc(CCc2ccccc2)n[nH]1
Show InChI InChI=1S/C28H24N4O3/c33-27-26(35-28(34)25-17-22(29-31-25)15-13-19-7-2-1-3-8-19)18-23(30-32-27)16-14-21-11-6-10-20-9-4-5-12-24(20)21/h1-12,17-18H,13-16H2,(H,29,31)(H,32,33)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...

US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM406232
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES O=C(Oc1cc(Cc2cccc3ccccc23)n[nH]c1=O)c1cc(CCc2ccccc2)n[nH]1
Show InChI InChI=1S/C27H22N4O3/c32-26-25(17-22(29-31-26)15-20-11-6-10-19-9-4-5-12-23(19)20)34-27(33)24-16-21(28-30-24)14-13-18-7-2-1-3-8-18/h1-12,16-17H,13-15H2,(H,28,30)(H,31,32)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...

US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM406234
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES Fc1ccc(CCc2cc([nH]n2)C(=O)Oc2cc(Cc3cccc4ccccc34)n[nH]c2=O)cc1
Show InChI InChI=1S/C27H21FN4O3/c28-20-11-8-17(9-12-20)10-13-21-15-24(31-29-21)27(34)35-25-16-22(30-32-26(25)33)14-19-6-3-5-18-4-1-2-7-23(18)19/h1-9,11-12,15-16H,10,13-14H2,(H,29,31)(H,32,33)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...

US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM406239
PNG
(US10336724, Compound Table 1.19)
Show SMILES O=C(Oc1cc(Cc2ccc3ccccc3c2)n[nH]c1=O)c1cc(CCc2ccccc2)n[nH]1
Show InChI InChI=1S/C27H22N4O3/c32-26-25(17-23(29-31-26)15-19-10-12-20-8-4-5-9-21(20)14-19)34-27(33)24-16-22(28-30-24)13-11-18-6-2-1-3-7-18/h1-10,12,14,16-17H,11,13,15H2,(H,28,30)(H,31,32)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...

US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM406237
PNG
(US10336724, Compound Table 1.17)
Show SMILES Clc1ccc(CCc2cc([nH]n2)C(=O)Oc2cc(CCc3cccc4ccccc34)n[nH]c2=O)cc1
Show InChI InChI=1S/C28H23ClN4O3/c29-21-12-8-18(9-13-21)10-14-22-16-25(32-30-22)28(35)36-26-17-23(31-33-27(26)34)15-11-20-6-3-5-19-4-1-2-7-24(19)20/h1-9,12-13,16-17H,10-11,14-15H2,(H,30,32)(H,33,34)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...

US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM406233
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES Clc1cccc(CCc2cc([nH]n2)C(=O)Oc2cc(Cc3cccc4ccccc34)n[nH]c2=O)c1
Show InChI InChI=1S/C27H21ClN4O3/c28-20-9-3-5-17(13-20)11-12-21-15-24(31-29-21)27(34)35-25-16-22(30-32-26(25)33)14-19-8-4-7-18-6-1-2-10-23(18)19/h1-10,13,15-16H,11-12,14H2,(H,29,31)(H,32,33)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...

US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM406236
PNG
(US10336724, Compound Table 1.16)
Show SMILES Clc1ccccc1CCc1cc([nH]n1)C(=O)Oc1cc(Cc2cccc3ccccc23)n[nH]c1=O
Show InChI InChI=1S/C27H21ClN4O3/c28-23-11-4-2-7-18(23)12-13-20-15-24(31-29-20)27(34)35-25-16-21(30-32-26(25)33)14-19-9-5-8-17-6-1-3-10-22(17)19/h1-11,15-16H,12-14H2,(H,29,31)(H,32,33)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...

US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM406235
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES O=C(Oc1cc(Cc2cccc3ccccc23)n[nH]c1=O)c1cc(Cc2ccccc2)n[nH]1
Show InChI InChI=1S/C26H20N4O3/c31-25-24(33-26(32)23-15-20(27-29-23)13-17-7-2-1-3-8-17)16-21(28-30-25)14-19-11-6-10-18-9-4-5-12-22(18)19/h1-12,15-16H,13-14H2,(H,27,29)(H,30,31)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...

US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM31148
PNG
(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Show SMILES Oc1cc2ccccc2[nH]c1=O
Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)10-9(8)12/h1-5,11H,(H,10,12)
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n/an/a 100n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170227
PNG
(CHEMBL3805642)
Show SMILES Cc1c(F)cnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C8H6FN3O2/c1-3-4(9)2-10-6-5(3)11-7(13)8(14)12-6/h2H,1H3,(H,11,13)(H,10,12,14)
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n/an/a 150n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170229
PNG
(CHEMBL3804851)
Show SMILES Clc1ccnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C7H4ClN3O2/c8-3-1-2-9-5-4(3)10-6(12)7(13)11-5/h1-2H,(H,10,12)(H,9,11,13)
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n/an/a 180n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM23174
PNG
(6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]iso...)
Show SMILES Clc1ccc2c(c1)o[nH]c2=O
Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)
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n/an/a 188n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...

J Med Chem 51: 3357-9 (2008)


Article DOI: 10.1021/jm800200u
BindingDB Entry DOI: 10.7270/Q21G0JJJ
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50393043
PNG
(CHEMBL2152732)
Show SMILES On1c2ccc3CCOc3c2[nH]c1=O
Show InChI InChI=1S/C9H8N2O3/c12-9-10-7-6(11(9)13)2-1-5-3-4-14-8(5)7/h1-2,13H,3-4H2,(H,10,12)
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay

ACS Med Chem Lett 3: 839-843 (2012)


Article DOI: 10.1021/ml300212a
BindingDB Entry DOI: 10.7270/Q2WM1FGX
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170230
PNG
(CHEMBL445990)
Show SMILES Oc1noc2cc(Cl)ccc12
Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)
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n/an/a 210n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170228
PNG
(CHEMBL3804953)
Show SMILES Brc1ccnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C7H4BrN3O2/c8-3-1-2-9-5-4(3)10-6(12)7(13)11-5/h1-2H,(H,10,12)(H,9,11,13)
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n/an/a 220n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170225
PNG
(CHEMBL3805223)
Show SMILES Clc1cnc2[nH]c(=O)c(=O)[nH]c2c1Br
Show InChI InChI=1S/C7H3BrClN3O2/c8-3-2(9)1-10-5-4(3)11-6(13)7(14)12-5/h1H,(H,11,13)(H,10,12,14)
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n/an/a 240n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170226
PNG
(CHEMBL92084)
Show SMILES Cc1c(Cl)cnc2nc(O)c(O)nc12
Show InChI InChI=1S/C8H6ClN3O2/c1-3-4(9)2-10-6-5(3)11-7(13)8(14)12-6/h2H,1H3,(H,11,13)(H,10,12,14)
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n/an/a 260n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM23175
PNG
(6-methyl-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-...)
Show SMILES Cc1ccc2c(c1)o[nH]c2=O
Show InChI InChI=1S/C8H7NO2/c1-5-2-3-6-7(4-5)11-9-8(6)10/h2-4H,1H3,(H,9,10)
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n/an/a 269n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...

J Med Chem 51: 3357-9 (2008)


Article DOI: 10.1021/jm800200u
BindingDB Entry DOI: 10.7270/Q21G0JJJ
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM258351
PNG
(US9505753, 10t)
Show SMILES CCOc1ccc(CCn2nc(O)c(=O)[nH]c2=O)cc1
Show InChI InChI=1S/C13H15N3O4/c1-2-20-10-5-3-9(4-6-10)7-8-16-13(19)14-11(17)12(18)15-16/h3-6H,2,7-8H2,1H3,(H,15,18)(H,14,17,19)
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n/an/a 300n/an/an/an/a8.525



THE JOHNS HOPKINS UNIVERSITY

US Patent


Assay Description
A reliable 96-well plate D-amino acid oxidase (DAAO) assay was developed based on previously published reports (J. Biol. Chem. 277: 27782 (2002)). Br...

US Patent US9505753 (2016)


BindingDB Entry DOI: 10.7270/Q21J98QK
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM406228
PNG
(5-chloro-2-oxo-1,2-dihydroquinolin-3-yl 3-(4-chlor...)
Show SMILES Clc1ccc(CCc2cc([nH]n2)C(=O)Oc2cc3c(Cl)cccc3[nH]c2=O)cc1
Show InChI InChI=1S/C21H15Cl2N3O3/c22-13-7-4-12(5-8-13)6-9-14-10-18(26-25-14)21(28)29-19-11-15-16(23)2-1-3-17(15)24-20(19)27/h1-5,7-8,10-11H,6,9H2,(H,24,27)(H,25,26)
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n/an/a 300n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...

US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170234
PNG
(CHEMBL329680)
Show SMILES Cc1c(Br)cnc2nc(O)c(O)nc12
Show InChI InChI=1S/C8H6BrN3O2/c1-3-4(9)2-10-6-5(3)11-7(13)8(14)12-6/h2H,1H3,(H,11,13)(H,10,12,14)
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n/an/a 400n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50393045
PNG
(CHEMBL2152734)
Show SMILES On1c2cc(F)cc(F)c2[nH]c1=O
Show InChI InChI=1S/C7H4F2N2O2/c8-3-1-4(9)6-5(2-3)11(13)7(12)10-6/h1-2,13H,(H,10,12)
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n/an/a 400n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay

ACS Med Chem Lett 3: 839-843 (2012)


Article DOI: 10.1021/ml300212a
BindingDB Entry DOI: 10.7270/Q2WM1FGX
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50393063
PNG
(CHEMBL2152724)
Show SMILES COc1cccc2n(O)c(=O)[nH]c12
Show InChI InChI=1S/C8H8N2O3/c1-13-6-4-2-3-5-7(6)9-8(11)10(5)12/h2-4,12H,1H3,(H,9,11)
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n/an/a 400n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay

ACS Med Chem Lett 3: 839-843 (2012)


Article DOI: 10.1021/ml300212a
BindingDB Entry DOI: 10.7270/Q2WM1FGX
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50393061
PNG
(CHEMBL2152722)
Show SMILES Cc1cccc2n(O)c(=O)[nH]c12
Show InChI InChI=1S/C8H8N2O2/c1-5-3-2-4-6-7(5)9-8(11)10(6)12/h2-4,12H,1H3,(H,9,11)
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n/an/a 400n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay

ACS Med Chem Lett 3: 839-843 (2012)


Article DOI: 10.1021/ml300212a
BindingDB Entry DOI: 10.7270/Q2WM1FGX
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM23173
PNG
(6-fluoro-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-...)
Show SMILES Fc1ccc2c(c1)o[nH]c2=O
Show InChI InChI=1S/C7H4FNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)
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n/an/a 444n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...

J Med Chem 51: 3357-9 (2008)


Article DOI: 10.1021/jm800200u
BindingDB Entry DOI: 10.7270/Q21G0JJJ
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170246
PNG
(CHEMBL3806244)
Show SMILES Fc1cnc2[nH]c(=O)c(=O)[nH]c2c1
Show InChI InChI=1S/C7H4FN3O2/c8-3-1-4-5(9-2-3)11-7(13)6(12)10-4/h1-2H,(H,10,12)(H,9,11,13)
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n/an/a 460n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170232
PNG
(CHEMBL3805370)
Show SMILES Clc1c(Br)cnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C7H3BrClN3O2/c8-2-1-10-5-4(3(2)9)11-6(13)7(14)12-5/h1H,(H,11,13)(H,10,12,14)
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n/an/a 480n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50393060
PNG
(CHEMBL2152721)
Show SMILES On1c2cccc(F)c2[nH]c1=O
Show InChI InChI=1S/C7H5FN2O2/c8-4-2-1-3-5-6(4)9-7(11)10(5)12/h1-3,12H,(H,9,11)
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay

ACS Med Chem Lett 3: 839-843 (2012)


Article DOI: 10.1021/ml300212a
BindingDB Entry DOI: 10.7270/Q2WM1FGX
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170274
PNG
(CHEMBL3804949)
Show SMILES FC(F)(F)c1ccnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C8H4F3N3O2/c9-8(10,11)3-1-2-12-5-4(3)13-6(15)7(16)14-5/h1-2H,(H,13,15)(H,12,14,16)
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n/an/a 520n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170231
PNG
(CHEMBL3806101)
Show SMILES Brc1cnc2[nH]c(=O)c(=O)[nH]c2c1Br
Show InChI InChI=1S/C7H3Br2N3O2/c8-2-1-10-5-4(3(2)9)11-6(13)7(14)12-5/h1H,(H,11,13)(H,10,12,14)
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n/an/a 530n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM406224
PNG
(5-chloro-2-oxo-1,2-dihydroquinolin-3-yl 3-phenethy...)
Show SMILES Clc1cccc2[nH]c(=O)c(OC(=O)c3cc(CCc4ccccc4)n[nH]3)cc12
Show InChI InChI=1S/C21H16ClN3O3/c22-16-7-4-8-17-15(16)12-19(20(26)23-17)28-21(27)18-11-14(24-25-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H,23,26)(H,24,25)
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US Patent
n/an/a 550n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...

US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM406229
PNG
(5-(((3,4-dichlorophenyl) thio) methyl)-2-oxo-1,2-d...)
Show SMILES Clc1ccc(SCc2c[nH]c(=O)c(OC(=O)c3cc(CCc4ccccc4)n[nH]3)c2)cc1Cl
Show InChI InChI=1S/C24H19Cl2N3O3S/c25-19-9-8-18(12-20(19)26)33-14-16-10-22(23(30)27-13-16)32-24(31)21-11-17(28-29-21)7-6-15-4-2-1-3-5-15/h1-5,8-13H,6-7,14H2,(H,27,30)(H,28,29)
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n/an/a 550n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...

US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM23170
PNG
(5-bromo-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-o...)
Show SMILES Brc1ccc2o[nH]c(=O)c2c1
Show InChI InChI=1S/C7H4BrNO2/c8-4-1-2-6-5(3-4)7(10)9-11-6/h1-3H,(H,9,10)
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n/an/a 599n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...

J Med Chem 51: 3357-9 (2008)


Article DOI: 10.1021/jm800200u
BindingDB Entry DOI: 10.7270/Q21G0JJJ
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50393051
PNG
(CHEMBL2152740)
Show SMILES On1c2cc(F)ccc2[nH]c1=O
Show InChI InChI=1S/C7H5FN2O2/c8-4-1-2-5-6(3-4)10(12)7(11)9-5/h1-3,12H,(H,9,11)
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n/an/a 600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay

ACS Med Chem Lett 3: 839-843 (2012)


Article DOI: 10.1021/ml300212a
BindingDB Entry DOI: 10.7270/Q2WM1FGX
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM258352
PNG
(US9505753, 10u)
Show SMILES Cc1ccc2ccccc2c1Cn1nc(O)c(=O)[nH]c1=O
Show InChI InChI=1S/C15H13N3O3/c1-9-6-7-10-4-2-3-5-11(10)12(9)8-18-15(21)16-13(19)14(20)17-18/h2-7H,8H2,1H3,(H,17,20)(H,16,19,21)
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US Patent
n/an/a 600n/an/an/an/a8.525



THE JOHNS HOPKINS UNIVERSITY

US Patent


Assay Description
A reliable 96-well plate D-amino acid oxidase (DAAO) assay was developed based on previously published reports (J. Biol. Chem. 277: 27782 (2002)). Br...

US Patent US9505753 (2016)


BindingDB Entry DOI: 10.7270/Q21J98QK
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170277
PNG
(CHEMBL3805717)
Show SMILES Cc1ccnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C8H7N3O2/c1-4-2-3-9-6-5(4)10-7(12)8(13)11-6/h2-3H,1H3,(H,10,12)(H,9,11,13)
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n/an/a 630n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50170233
PNG
(CHEMBL3805789)
Show SMILES Clc1cnc2[nH]c(=O)c(=O)[nH]c2c1Cl
Show InChI InChI=1S/C7H3Cl2N3O2/c8-2-1-10-5-4(3(2)9)11-6(13)7(14)12-5/h1H,(H,11,13)(H,10,12,14)
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n/an/a 650n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...

Eur J Med Chem 117: 19-32 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.017
BindingDB Entry DOI: 10.7270/Q2V989ZS
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50393070
PNG
(CHEMBL2152731)
Show SMILES Cc1c(F)ccc2n(O)c(=O)[nH]c12
Show InChI InChI=1S/C8H7FN2O2/c1-4-5(9)2-3-6-7(4)10-8(12)11(6)13/h2-3,13H,1H3,(H,10,12)
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n/an/a 700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay

ACS Med Chem Lett 3: 839-843 (2012)


Article DOI: 10.1021/ml300212a
BindingDB Entry DOI: 10.7270/Q2WM1FGX
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM23178
PNG
(6-nitro-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-o...)
Show SMILES [O-][N+](=O)c1ccc2c(c1)o[nH]c2=O
Show InChI InChI=1S/C7H4N2O4/c10-7-5-2-1-4(9(11)12)3-6(5)13-8-7/h1-3H,(H,8,10)
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n/an/a 722n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...

J Med Chem 51: 3357-9 (2008)


Article DOI: 10.1021/jm800200u
BindingDB Entry DOI: 10.7270/Q21G0JJJ
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50211362
PNG
(5-methyl-1H-pyrazole-3-carboxylic acid | 5-methyl-...)
Show SMILES Cc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C5H6N2O2/c1-3-2-4(5(8)9)7-6-3/h2H,1H3,(H,6,7)(H,8,9)
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n/an/a 933n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.129038
BindingDB Entry DOI: 10.7270/Q2RB78PT
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50211362
PNG
(5-methyl-1H-pyrazole-3-carboxylic acid | 5-methyl-...)
Show SMILES Cc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C5H6N2O2/c1-3-2-4(5(8)9)7-6-3/h2H,1H3,(H,6,7)(H,8,9)
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n/an/a 933n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmc.2022.117030
BindingDB Entry DOI: 10.7270/Q241724G
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50393059
PNG
(CHEMBL2152720)
Show SMILES On1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C7H6N2O2/c10-7-8-5-3-1-2-4-6(5)9(7)11/h1-4,11H,(H,8,10)
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay

ACS Med Chem Lett 3: 839-843 (2012)


Article DOI: 10.1021/ml300212a
BindingDB Entry DOI: 10.7270/Q2WM1FGX
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50393069
PNG
(CHEMBL2152730)
Show SMILES Cc1ccc2n(O)c(=O)[nH]c2c1C
Show InChI InChI=1S/C9H10N2O2/c1-5-3-4-7-8(6(5)2)10-9(12)11(7)13/h3-4,13H,1-2H3,(H,10,12)
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay

ACS Med Chem Lett 3: 839-843 (2012)


Article DOI: 10.1021/ml300212a
BindingDB Entry DOI: 10.7270/Q2WM1FGX
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50393046
PNG
(CHEMBL2152735)
Show SMILES On1c2ccc(F)cc2[nH]c1=O
Show InChI InChI=1S/C7H5FN2O2/c8-4-1-2-6-5(3-4)9-7(11)10(6)12/h1-3,12H,(H,9,11)
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay

ACS Med Chem Lett 3: 839-843 (2012)


Article DOI: 10.1021/ml300212a
BindingDB Entry DOI: 10.7270/Q2WM1FGX
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50393049
PNG
(CHEMBL2152738)
Show SMILES Cc1cc2[nH]c(=O)n(O)c2cc1F
Show InChI InChI=1S/C8H7FN2O2/c1-4-2-6-7(3-5(4)9)11(13)8(12)10-6/h2-3,13H,1H3,(H,10,12)
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay

ACS Med Chem Lett 3: 839-843 (2012)


Article DOI: 10.1021/ml300212a
BindingDB Entry DOI: 10.7270/Q2WM1FGX
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM258362
PNG
(US9505753, 32)
Show SMILES Oc1nn(CCc2ccc(cc2)N2CCOCC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C15H18N4O4/c20-13-14(21)17-19(15(22)16-13)6-5-11-1-3-12(4-2-11)18-7-9-23-10-8-18/h1-4H,5-10H2,(H,17,21)(H,16,20,22)
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US Patent
n/an/a 1.00E+3n/an/an/an/a8.525



THE JOHNS HOPKINS UNIVERSITY

US Patent


Assay Description
A reliable 96-well plate D-amino acid oxidase (DAAO) assay was developed based on previously published reports (J. Biol. Chem. 277: 27782 (2002)). Br...

US Patent US9505753 (2016)


BindingDB Entry DOI: 10.7270/Q21J98QK
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50140172
PNG
(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Show SMILES COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
Show InChI InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
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n/an/a 1.07E+3n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmc.2022.117030
BindingDB Entry DOI: 10.7270/Q241724G
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM50140172
PNG
(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Show SMILES COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
Show InChI InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
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n/an/a 1.07E+3n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.129038
BindingDB Entry DOI: 10.7270/Q2RB78PT
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM23171
PNG
(5-iodo-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-ol...)
Show SMILES Ic1ccc2o[nH]c(=O)c2c1
Show InChI InChI=1S/C7H4INO2/c8-4-1-2-6-5(3-4)7(10)9-11-6/h1-3H,(H,9,10)
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n/an/a 1.51E+3n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...

J Med Chem 51: 3357-9 (2008)


Article DOI: 10.1021/jm800200u
BindingDB Entry DOI: 10.7270/Q21G0JJJ
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Sus scrofa (pig))		BDBM23166
PNG
(1,2-benzoxazol-3-ol | benzo[d]isoxazol-3-ol)
Show SMILES O=c1[nH]oc2ccccc12
Show InChI InChI=1S/C7H5NO2/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9)
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n/an/a 1.88E+3n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...

J Med Chem 51: 3357-9 (2008)


Article DOI: 10.1021/jm800200u
BindingDB Entry DOI: 10.7270/Q21G0JJJ
More data for this
Ligand-Target Pair
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