Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gag-Pol polyprotein [588-1027] (Human immunodeficiency virus type 1 group M subtyp...) | BDBM2483 ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 30 | -10.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Siena | Assay Description The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th... | J Med Chem 52: 1224-8 (2009) Article DOI: 10.1021/jm801395v BindingDB Entry DOI: 10.7270/Q237772D | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gag-Pol polyprotein [588-1027] (Human immunodeficiency virus type 1 group M subtyp...) | BDBM27580 (8-[4-(3-chlorophenoxymethyl)phenyl]-8-ethyl-9-oxa-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 100 | -9.93 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Siena | Assay Description The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th... | J Med Chem 52: 1224-8 (2009) Article DOI: 10.1021/jm801395v BindingDB Entry DOI: 10.7270/Q237772D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein [588-1027] (Human immunodeficiency virus type 1 group M subtyp...) | BDBM27582 (8-[4-(3-chlorophenoxymethyl)phenyl]-8-ethyl-9-oxa-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 110 | -9.87 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Siena | Assay Description The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th... | J Med Chem 52: 1224-8 (2009) Article DOI: 10.1021/jm801395v BindingDB Entry DOI: 10.7270/Q237772D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein [588-1027] (Human immunodeficiency virus type 1 group M subtyp...) | BDBM27581 (8-ethyl-8-[4-(phenoxymethyl)phenyl]-9-oxa-2,14-dia...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 250 | -9.36 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Siena | Assay Description The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th... | J Med Chem 52: 1224-8 (2009) Article DOI: 10.1021/jm801395v BindingDB Entry DOI: 10.7270/Q237772D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein [588-1027] (Human immunodeficiency virus type 1 group M subtyp...) | BDBM1434 (11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 400 | -9.07 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Universita di Siena | Assay Description The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th... | J Med Chem 52: 1224-8 (2009) Article DOI: 10.1021/jm801395v BindingDB Entry DOI: 10.7270/Q237772D | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |