Compile Data Set for Download or QSAR

Found 1481 hits of ic50 for UniProtKB: P09960   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM326921 (4-(1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- yl...) Show SMILES OC(=O)CCCC1CCN(Cc2ccc(cc2)[C@H]2COc3ccccc3O2)CC1 |r| Show InChI InChI=1S/C24H29NO4/c26-24(27)7-3-4-18-12-14-25(15-13-18)16-19-8-10-20(11-9-19)23-17-28-21-5-1-2-6-22(21)29-23/h1-2,5-6,8-11,18,23H,3-4,7,12-17H2,(H,26,27)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0420	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM326945 (1-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...) Show SMILES NC(=O)NC1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C20H24N4O3/c21-20(25)23-16-7-10-24(11-8-16)12-14-3-5-15(6-4-14)18-13-26-17-2-1-9-22-19(17)27-18/h1-6,9,16,18H,7-8,10-13H2,(H3,21,23,25)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327137 (4-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...) Show SMILES OC(=O)c1ccc(cc1)C1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C26H26N2O4/c29-26(30)22-9-7-19(8-10-22)20-11-14-28(15-12-20)16-18-3-5-21(6-4-18)24-17-31-23-2-1-13-27-25(23)32-24/h1-10,13,20,24H,11-12,14-17H2,(H,29,30)/t24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327016 ((3S)-3-{4-[(1s,4s)-7- azabicyclo[2.2.1]hept-7- y...) Show SMILES C(N1[C@H]2CC[C@@H]1CC2)c1ccc(cc1)[C@H]1COc2cccnc2O1 |r,TLB:0:1:6.7:3.4| Show InChI InChI=1S/C20H22N2O2/c1-2-18-20(21-11-1)24-19(13-23-18)15-5-3-14(4-6-15)12-22-16-7-8-17(22)10-9-16/h1-6,11,16-17,19H,7-10,12-13H2/t16-,17+,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327189 (5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b]pyridin...) Show SMILES NC(=O)N1CC2CN(Cc3ccc(cc3)[C@H]3COc4cccnc4O3)CC2C1 |r| Show InChI InChI=1S/C21H24N4O3/c22-21(26)25-11-16-9-24(10-17(16)12-25)8-14-3-5-15(6-4-14)19-13-27-18-2-1-7-23-20(18)28-19/h1-7,16-17,19H,8-13H2,(H2,22,26)/t16?,17?,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327181 (1-{(1S,4S)-5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,...) Show SMILES CC(=O)N1C[C@@H]2CC[C@H]1CN2Cc1ccc(cc1)[C@H]1COc2cccnc2O1 |r| Show InChI InChI=1S/C22H25N3O3/c1-15(26)25-13-18-8-9-19(25)12-24(18)11-16-4-6-17(7-5-16)21-14-27-20-3-2-10-23-22(20)28-21/h2-7,10,18-19,21H,8-9,11-14H2,1H3/t18-,19-,21+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM326957 (N-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...) Show SMILES CS(=O)(=O)NC1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C20H25N3O4S/c1-28(24,25)22-17-8-11-23(12-9-17)13-15-4-6-16(7-5-15)19-14-26-18-3-2-10-21-20(18)27-19/h2-7,10,17,19,22H,8-9,11-14H2,1H3/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327040 (4-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...) Show SMILES OC(=O)CCCC1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C23H28N2O4/c26-22(27)5-1-3-17-10-13-25(14-11-17)15-18-6-8-19(9-7-18)21-16-28-20-4-2-12-24-23(20)29-21/h2,4,6-9,12,17,21H,1,3,5,10-11,13-16H2,(H,26,27)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327151 (7-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benz...) Show SMILES NC(=O)N1CCCC11CCN(Cc2ccc(cc2)[C@H]2COc3ccccc3O2)C1 |r| Show InChI InChI=1S/C23H27N3O3/c24-22(27)26-12-3-10-23(26)11-13-25(16-23)14-17-6-8-18(9-7-17)21-15-28-19-4-1-2-5-20(19)29-21/h1-2,4-9,21H,3,10-16H2,(H2,24,27)/t21-,23?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM326992 ((3S)-3-[4-(azepan-1- ylmethyl)phenyl]-2,3- dihyd...) Show SMILES C(N1CCCCCC1)c1ccc(cc1)[C@H]1COc2cccnc2O1 |r| Show InChI InChI=1S/C20H24N2O2/c1-2-4-13-22(12-3-1)14-16-7-9-17(10-8-16)19-15-23-18-6-5-11-21-20(18)24-19/h5-11,19H,1-4,12-15H2/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM326947 (1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benz...) Show SMILES CC1CCCCN1Cc1ccc(cc1)[C@H]1COc2ccccc2O1 |r| Show InChI InChI=1S/C21H25NO2/c1-16-6-4-5-13-22(16)14-17-9-11-18(12-10-17)21-15-23-19-7-2-3-8-20(19)24-21/h2-3,7-12,16,21H,4-6,13-15H2,1H3/t16?,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327185 ((1S,4S)-5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b...) Show SMILES NC(=O)N1C[C@@H]2C[C@H]1CN2Cc1ccc(cc1)[C@H]1COc2cccnc2O1 |r| Show InChI InChI=1S/C20H22N4O3/c21-20(25)24-11-15-8-16(24)10-23(15)9-13-3-5-14(6-4-13)18-12-26-17-2-1-7-22-19(17)27-18/h1-7,15-16,18H,8-12H2,(H2,21,25)/t15-,16-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM326933 (US9662339, 184 | [(3R)-1-{4-[(2S)-2,3-dihydro-1,4-...) Show SMILES OC(=O)C[C@H]1CCN(Cc2ccc(cc2)[C@H]2COc3ccccc3O2)C1 |r| Show InChI InChI=1S/C21H23NO4/c23-21(24)11-16-9-10-22(13-16)12-15-5-7-17(8-6-15)20-14-25-18-3-1-2-4-19(18)26-20/h1-8,16,20H,9-14H2,(H,23,24)/t16-,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM326997 (1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- yl]be...) Show SMILES OC(=O)C1CCN(Cc2ccc(cc2)[C@H]2COc3ccccc3O2)CC1 |r| Show InChI InChI=1S/C21H23NO4/c23-21(24)17-9-11-22(12-10-17)13-15-5-7-16(8-6-15)20-14-25-18-3-1-2-4-19(18)26-20/h1-8,17,20H,9-14H2,(H,23,24)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327156 ((1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- yl]b...) Show SMILES O=C(C1CCN(Cc2ccc(cc2)[C@H]2COc3ccccc3O2)CC1)N1CCOCC1 |r| Show InChI InChI=1S/C25H30N2O4/c28-25(27-13-15-29-16-14-27)21-9-11-26(12-10-21)17-19-5-7-20(8-6-19)24-18-30-22-3-1-2-4-23(22)31-24/h1-8,21,24H,9-18H2/t24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM326944 (7-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]pyrid...) Show SMILES O=C1CCC2(CCN(Cc3ccc(cc3)[C@H]3COc4cccnc4O3)C2)N1 |r| Show InChI InChI=1S/C21H23N3O3/c25-19-7-8-21(23-19)9-11-24(14-21)12-15-3-5-16(6-4-15)18-13-26-17-2-1-10-22-20(17)27-18/h1-6,10,18H,7-9,11-14H2,(H,23,25)/t18-,21?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM50575488 (CHEMBL4852381) Show SMILES N[C@@H](CC(O)=O)Cn1nnc(n1)-c1ccc(Oc2ncc(Cl)cc2F)cc1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01955 BindingDB Entry DOI: 10.7270/Q2B85CZG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327007 (N-(1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- yl...) Show SMILES CN(C1CCN(Cc2ccc(cc2)[C@H]2COc3ccccc3O2)C1)C(C)=O |r| Show InChI InChI=1S/C22H26N2O3/c1-16(25)23(2)19-11-12-24(14-19)13-17-7-9-18(10-8-17)22-15-26-20-5-3-4-6-21(20)27-22/h3-10,19,22H,11-15H2,1-2H3/t19?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327061 (1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benz...) Show SMILES C(N1CCC(CC1)c1nnn[nH]1)c1ccc(cc1)[C@H]1COc2ccccc2O1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327096 (8-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]pyridin...) Show SMILES O=C1NC(=O)C2(CCN(Cc3ccc(cc3)[C@H]3COc4cccnc4O3)CC2)N1 |r| Show InChI InChI=1S/C21H22N4O4/c26-19-21(24-20(27)23-19)7-10-25(11-8-21)12-14-3-5-15(6-4-14)17-13-28-16-2-1-9-22-18(16)29-17/h1-6,9,17H,7-8,10-13H2,(H2,23,24,26,27)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327093 (1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benz...) Show SMILES O=S1(=O)CCCN1C1CCN(Cc2ccc(cc2)[C@H]2COc3ccccc3O2)CC1 |r| Show InChI InChI=1S/C23H28N2O4S/c26-30(27)15-3-12-25(30)20-10-13-24(14-11-20)16-18-6-8-19(9-7-18)23-17-28-21-4-1-2-5-22(21)29-23/h1-2,4-9,20,23H,3,10-17H2/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327068 ((3S)-3-{4-[(3-methoxypiperidin- 1-yl)methyl]phenyl...) Show SMILES COC1CCCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)C1 |r| Show InChI InChI=1S/C20H24N2O3/c1-23-17-4-3-11-22(13-17)12-15-6-8-16(9-7-15)19-14-24-18-5-2-10-21-20(18)25-19/h2,5-10,17,19H,3-4,11-14H2,1H3/t17?,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327012 ((3R)-1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]...) Show SMILES O[C@@H]1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)C1 |r| Show InChI InChI=1S/C18H20N2O3/c21-15-7-9-20(11-15)10-13-3-5-14(6-4-13)17-12-22-16-2-1-8-19-18(16)23-17/h1-6,8,15,17,21H,7,9-12H2/t15-,17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327133 (4-[(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]p...) Show SMILES OC(=O)c1ccc(CC2CCN(Cc3ccc(cc3)[C@H]3COc4cccnc4O3)CC2)cc1 |r| Show InChI InChI=1S/C27H28N2O4/c30-27(31)23-9-3-19(4-10-23)16-20-11-14-29(15-12-20)17-21-5-7-22(8-6-21)25-18-32-24-2-1-13-28-26(24)33-25/h1-10,13,20,25H,11-12,14-18H2,(H,30,31)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327085 (N-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...) Show SMILES OCC(=O)NC1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C21H25N3O4/c25-13-20(26)23-17-7-10-24(11-8-17)12-15-3-5-16(6-4-15)19-14-27-18-2-1-9-22-21(18)28-19/h1-6,9,17,19,25H,7-8,10-14H2,(H,23,26)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327084 ((1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]pyridi...) Show SMILES O=C(C1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1)N1CCOCC1 |r| Show InChI InChI=1S/C24H29N3O4/c28-24(27-12-14-29-15-13-27)20-7-10-26(11-8-20)16-18-3-5-19(6-4-18)22-17-30-21-2-1-9-25-23(21)31-22/h1-6,9,20,22H,7-8,10-17H2/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327187 (1-{5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b]pyri...) Show SMILES CC(=O)N1CC2CN(Cc3ccc(cc3)[C@H]3COc4cccnc4O3)CC2C1 |r| Show InChI InChI=1S/C22H25N3O3/c1-15(26)25-12-18-10-24(11-19(18)13-25)9-16-4-6-17(7-5-16)21-14-27-20-3-2-8-23-22(20)28-21/h2-8,18-19,21H,9-14H2,1H3/t18?,19?,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327013 ((3S)-3-[4-(morpholin-4- ylmethyl)phenyl]-2,3- di...) Show SMILES C(N1CCOCC1)c1ccc(cc1)[C@H]1COc2cccnc2O1 |r| Show InChI InChI=1S/C18H20N2O3/c1-2-16-18(19-7-1)23-17(13-22-16)15-5-3-14(4-6-15)12-20-8-10-21-11-9-20/h1-7,17H,8-13H2/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM326973 (8-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benz...) Show SMILES O=C1NCCC11CCN(Cc2ccc(cc2)[C@H]2COc3ccccc3O2)CC1 |r| Show InChI InChI=1S/C23H26N2O3/c26-22-23(9-12-24-22)10-13-25(14-11-23)15-17-5-7-18(8-6-17)21-16-27-19-3-1-2-4-20(19)28-21/h1-8,21H,9-16H2,(H,24,26)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327191 (2-{1-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b]pyri...) Show SMILES NC(=O)COC1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C21H25N3O4/c22-20(25)14-26-17-7-10-24(11-8-17)12-15-3-5-16(6-4-15)19-13-27-18-2-1-9-23-21(18)28-19/h1-6,9,17,19H,7-8,10-14H2,(H2,22,25)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327169 (N-{1-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b]pyri...) Show SMILES COCC(=O)NC1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C22H27N3O4/c1-27-15-21(26)24-18-8-11-25(12-9-18)13-16-4-6-17(7-5-16)20-14-28-19-3-2-10-23-22(19)29-20/h2-7,10,18,20H,8-9,11-15H2,1H3,(H,24,26)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327153 (3-[(4-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- y...) Show SMILES OC(=O)c1cccc(CN2CCN(Cc3ccc(cc3)[C@H]3COc4ccccc4O3)CC2)c1 |r| Show InChI InChI=1S/C27H28N2O4/c30-27(31)23-5-3-4-21(16-23)18-29-14-12-28(13-15-29)17-20-8-10-22(11-9-20)26-19-32-24-6-1-2-7-25(24)33-26/h1-11,16,26H,12-15,17-19H2,(H,30,31)/t26-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327209 (1-{(1S,4S)-5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3...) Show SMILES CC(=O)N1C[C@@H]2C[C@H]1CN2Cc1ccc(cc1)[C@H]1COc2cccnc2O1 |r| Show InChI InChI=1S/C21H23N3O3/c1-14(25)24-12-17-9-18(24)11-23(17)10-15-4-6-16(7-5-15)20-13-26-19-3-2-8-22-21(19)27-20/h2-8,17-18,20H,9-13H2,1H3/t17-,18-,20+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM326936 (8-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]pyrid...) Show SMILES O=C1NCCC11CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C22H25N3O3/c26-21-22(7-11-24-21)8-12-25(13-9-22)14-16-3-5-17(6-4-16)19-15-27-18-2-1-10-23-20(18)28-19/h1-6,10,19H,7-9,11-15H2,(H,24,26)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM326953 (1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]pyrid...) Show SMILES OC(=O)C1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C20H22N2O4/c23-20(24)16-7-10-22(11-8-16)12-14-3-5-15(6-4-14)18-13-25-17-2-1-9-21-19(17)26-18/h1-6,9,16,18H,7-8,10-13H2,(H,23,24)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327152 (1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benz...) Show SMILES CNC(=O)C1CCN(Cc2ccc(cc2)[C@H]2COc3ccccc3O2)CC1 |r| Show InChI InChI=1S/C22H26N2O3/c1-23-22(25)18-10-12-24(13-11-18)14-16-6-8-17(9-7-16)21-15-26-19-4-2-3-5-20(19)27-21/h2-9,18,21H,10-15H2,1H3,(H,23,25)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327168 (US9662339, 251 | [(1alpha,5alpha,6alpha)-3-[(S)-4-...) Show SMILES CC(C)(O)CNC(=O)[C@@H]1[C@H]2CN(Cc3ccc(cc3)[C@H]3COc4cccnc4O3)C[C@@H]12 |r| Show InChI InChI=1S/C24H29N3O4/c1-24(2,29)14-26-22(28)21-17-11-27(12-18(17)21)10-15-5-7-16(8-6-15)20-13-30-19-4-3-9-25-23(19)31-20/h3-9,17-18,20-21,29H,10-14H2,1-2H3,(H,26,28)/t17-,18+,20-,21+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327106 (N-{l-[4-(2,3-dihydro-1,4- benzodioxin-2- yl)benz...) Show SMILES CS(=O)(=O)NC1CCN(Cc2ccc(cc2)C2COc3ccccc3O2)CC1 Show InChI InChI=1S/C21H26N2O4S/c1-28(24,25)22-18-10-12-23(13-11-18)14-16-6-8-17(9-7-16)21-15-26-19-4-2-3-5-20(19)27-21/h2-9,18,21-22H,10-15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327190 (US9662339, 273 | {(exo)-8-[(S)-4-(2,3-Dihydro- [1...) Show SMILES NC(=O)N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc(cc1)[C@H]1COc2cccnc2O1 |r,THB:12:11:10.4.5:8.7| Show InChI InChI=1S/C22H26N4O3/c23-22(27)25-16-10-17-7-8-18(11-16)26(17)12-14-3-5-15(6-4-14)20-13-28-19-2-1-9-24-21(19)29-20/h1-6,9,16-18,20H,7-8,10-13H2,(H3,23,25,27)/t16-,17-,18+,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327072 (1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]pyridin...) Show SMILES N#CC1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C20H21N3O2/c21-12-15-7-10-23(11-8-15)13-16-3-5-17(6-4-16)19-14-24-18-2-1-9-22-20(18)25-19/h1-6,9,15,19H,7-8,10-11,13-14H2/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327081 (N-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...) Show SMILES CC(C)(O)C(=O)NC1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C23H29N3O4/c1-23(2,28)22(27)25-18-9-12-26(13-10-18)14-16-5-7-17(8-6-16)20-15-29-19-4-3-11-24-21(19)30-20/h3-8,11,18,20,28H,9-10,12-15H2,1-2H3,(H,25,27)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327089 (N-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...) Show SMILES OC1(CC1)C(=O)NC1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C23H27N3O4/c27-22(23(28)9-10-23)25-18-7-12-26(13-8-18)14-16-3-5-17(6-4-16)20-15-29-19-2-1-11-24-21(19)30-20/h1-6,11,18,20,28H,7-10,12-15H2,(H,25,27)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327182 (4-{1-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b]pyri...) Show SMILES OC(=O)C1CCC(CC1)C1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r,wU:20.21,(10.67,-1.15,;9.34,-1.93,;9.34,-3.47,;8,-1.15,;6.67,-1.93,;5.33,-1.15,;5.33,.38,;6.67,1.15,;8,.38,;4,1.15,;2.67,.38,;1.33,1.15,;1.33,2.69,;,3.47,;-1.33,2.69,;-1.33,1.15,;-2.67,.38,;-4,1.15,;-4,2.69,;-2.67,3.46,;-5.33,.38,;-5.33,-1.16,;-6.67,-1.93,;-8,-1.16,;-9.34,-1.93,;-10.67,-1.16,;-10.67,.38,;-9.34,1.15,;-8,.38,;-6.67,1.15,;2.67,3.47,;4,2.69,)| Show InChI InChI=1S/C26H32N2O4/c29-26(30)22-9-7-19(8-10-22)20-11-14-28(15-12-20)16-18-3-5-21(6-4-18)24-17-31-23-2-1-13-27-25(23)32-24/h1-6,13,19-20,22,24H,7-12,14-17H2,(H,29,30)/t19?,22?,24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327004 (N-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]pyrid...) Show SMILES CN(Cc1ccc(cc1)[C@H]1COc2cccnc2O1)C1CCCC1 |r| Show InChI InChI=1S/C20H24N2O2/c1-22(17-5-2-3-6-17)13-15-8-10-16(11-9-15)19-14-23-18-7-4-12-21-20(18)24-19/h4,7-12,17,19H,2-3,5-6,13-14H2,1H3/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327044 (1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]pyrid...) Show SMILES CNC(=O)C1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r| Show InChI InChI=1S/C21H25N3O3/c1-22-20(25)17-8-11-24(12-9-17)13-15-4-6-16(7-5-15)19-14-26-18-3-2-10-23-21(18)27-19/h2-7,10,17,19H,8-9,11-14H2,1H3,(H,22,25)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327198 (1-{(1S,4S)-5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,...) Show SMILES OCC(=O)N1C[C@@H]2CC[C@H]1CN2Cc1ccc(cc1)[C@H]1COc2cccnc2O1 |r| Show InChI InChI=1S/C22H25N3O4/c26-13-21(27)25-12-17-7-8-18(25)11-24(17)10-15-3-5-16(6-4-15)20-14-28-19-2-1-9-23-22(19)29-20/h1-6,9,17-18,20,26H,7-8,10-14H2/t17-,18-,20+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327199 (US9662339, 282 | {1-[(S)-4-(2,3-dihydro- [1,4]dio...) Show SMILES NC(=O)N1CC2(CCN(Cc3ccc(cc3)[C@H]3COc4cccnc4O3)CC2)c2ccccc12 |r| Show InChI InChI=1S/C27H28N4O3/c28-26(32)31-18-27(21-4-1-2-5-22(21)31)11-14-30(15-12-27)16-19-7-9-20(10-8-19)24-17-33-23-6-3-13-29-25(23)34-24/h1-10,13,24H,11-12,14-18H2,(H2,28,32)/t24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327088 (1-[(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]pyr...) Show SMILES O=C1CCCN1CC1CCCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)C1 |r| Show InChI InChI=1S/C24H29N3O3/c28-23-6-3-13-27(23)16-19-4-2-12-26(15-19)14-18-7-9-20(10-8-18)22-17-29-21-5-1-11-25-24(21)30-22/h1,5,7-11,19,22H,2-4,6,12-17H2/t19?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327164 (US9662339, 247 | [(1alpha,5alpha,6alpha)-3-[(S)-4-...) Show SMILES C[C@H](O)CNC(=O)[C@@H]1[C@H]2CN(Cc3ccc(cc3)[C@H]3COc4cccnc4O3)C[C@@H]12 |r| Show InChI InChI=1S/C23H27N3O4/c1-14(27)9-25-22(28)21-17-11-26(12-18(17)21)10-15-4-6-16(7-5-15)20-13-29-19-3-2-8-24-23(19)30-20/h2-8,14,17-18,20-21,27H,9-13H2,1H3,(H,25,28)/t14-,17-,18+,20+,21+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM327165 (US9662339, 248 | [(1alpha,5alpha,6alpha)-3-[(S)-4-...) Show SMILES C[C@@H](CO)NC(=O)[C@@H]1[C@H]2CN(Cc3ccc(cc3)[C@H]3COc4cccnc4O3)C[C@@H]12 |r| Show InChI InChI=1S/C23H27N3O4/c1-14(12-27)25-22(28)21-17-10-26(11-18(17)21)9-15-4-6-16(7-5-15)20-13-29-19-3-2-8-24-23(19)30-20/h2-8,14,17-18,20-21,27H,9-13H2,1H3,(H,25,28)/t14-,17-,18+,20+,21+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9662339 (2017) BindingDB Entry DOI: 10.7270/Q2GT5Q8D
					More data for this Ligand-Target Pair

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