Compile Data Set for Download or QSAR

Found 22 hits of ic50 data for polymerid = 2621   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24541 (4-{2-[(3Z)-5-(benzylsulfamoyl)-2-oxo-2,3-dihydro-1...) Show SMILES OC(=O)c1ccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccccc2)cc1 |w:8.7| Show InChI InChI=1S/C22H18N4O5S/c27-21-20(26-25-16-8-6-15(7-9-16)22(28)29)18-12-17(10-11-19(18)24-21)32(30,31)23-13-14-4-2-1-3-5-14/h1-12,23,25H,13H2,(H,28,29)(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24549 (4-{2-[(3Z)-5-{[(4-fluorophenyl)methyl]sulfamoyl}-2...) Show SMILES OC(=O)c1ccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(F)cc2)cc1 |w:8.7| Show InChI InChI=1S/C22H17FN4O5S/c23-15-5-1-13(2-6-15)12-24-33(31,32)17-9-10-19-18(11-17)20(21(28)25-19)27-26-16-7-3-14(4-8-16)22(29)30/h1-11,24,26H,12H2,(H,29,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24533 ((3Z)-3-[2-(2-carboxyphenyl)hydrazin-1-ylidene]-2-o...) Show SMILES OC(=O)c1ccc2NC(=O)C(=NNc3ccccc3C(O)=O)c2c1 |w:11.11| Show InChI InChI=1S/C16H11N3O5/c20-14-13(10-7-8(15(21)22)5-6-11(10)17-14)19-18-12-4-2-1-3-9(12)16(23)24/h1-7,18H,(H,21,22)(H,23,24)(H,17,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.54E+4	n/a	n/a	n/a	n/a	7.0	22
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24536 (3-{2-[(3Z)-2-oxo-5-(propan-2-ylsulfamoyl)-2,3-dihy...) Show SMILES CC(C)NS(=O)(=O)c1ccc2NC(=O)C(=NNc3cccc(c3)C(O)=O)c2c1 |w:15.15| Show InChI InChI=1S/C18H18N4O5S/c1-10(2)22-28(26,27)13-6-7-15-14(9-13)16(17(23)19-15)21-20-12-5-3-4-11(8-12)18(24)25/h3-10,20,22H,1-2H3,(H,24,25)(H,19,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.57E+4	n/a	n/a	n/a	n/a	7.0	22
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24546 (3-{2-[(3Z)-5-{[(2-chlorophenyl)methyl]sulfamoyl}-2...) Show SMILES OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccccc2Cl)c1 |w:9.8| Show InChI InChI=1S/C22H17ClN4O5S/c23-18-7-2-1-4-14(18)12-24-33(31,32)16-8-9-19-17(11-16)20(21(28)25-19)27-26-15-6-3-5-13(10-15)22(29)30/h1-11,24,26H,12H2,(H,29,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24543 (3-{2-[(3Z)-5-{[(4-chlorophenyl)methyl]sulfamoyl}-2...) Show SMILES OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(Cl)cc2)c1 |w:9.8| Show InChI InChI=1S/C22H17ClN4O5S/c23-15-6-4-13(5-7-15)12-24-33(31,32)17-8-9-19-18(11-17)20(21(28)25-19)27-26-16-3-1-2-14(10-16)22(29)30/h1-11,24,26H,12H2,(H,29,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24544 (4-{2-[(3Z)-5-{[(4-chlorophenyl)methyl]sulfamoyl}-2...) Show SMILES OC(=O)c1ccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(Cl)cc2)cc1 |w:8.7| Show InChI InChI=1S/C22H17ClN4O5S/c23-15-5-1-13(2-6-15)12-24-33(31,32)17-9-10-19-18(11-17)20(21(28)25-19)27-26-16-7-3-14(4-8-16)22(29)30/h1-11,24,26H,12H2,(H,29,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.81E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24548 (3-{2-[(3Z)-5-{[(4-fluorophenyl)methyl]sulfamoyl}-2...) Show SMILES OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(F)cc2)c1 |w:9.8| Show InChI InChI=1S/C22H17FN4O5S/c23-15-6-4-13(5-7-15)12-24-33(31,32)17-8-9-19-18(11-17)20(21(28)25-19)27-26-16-3-1-2-14(10-16)22(29)30/h1-11,24,26H,12H2,(H,29,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.83E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24535 (3-{2-[(3Z)-5-{[(4-chlorophenyl)methyl]carbamoyl}-2...) Show SMILES OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)C(=O)NCc2ccc(Cl)cc2)c1 |w:9.8| Show InChI InChI=1S/C23H17ClN4O4/c24-16-7-4-13(5-8-16)12-25-21(29)14-6-9-19-18(11-14)20(22(30)26-19)28-27-17-3-1-2-15(10-17)23(31)32/h1-11,27H,12H2,(H,25,29)(H,31,32)(H,26,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.94E+4	n/a	n/a	n/a	n/a	7.0	22
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24537 (4-{2-[(3Z)-2-oxo-5-(propan-2-ylsulfamoyl)-2,3-dihy...) Show SMILES CC(C)NS(=O)(=O)c1ccc2NC(=O)C(=NNc3ccc(cc3)C(O)=O)c2c1 |w:15.15| Show InChI InChI=1S/C18H18N4O5S/c1-10(2)22-28(26,27)13-7-8-15-14(9-13)16(17(23)19-15)21-20-12-5-3-11(4-6-12)18(24)25/h3-10,20,22H,1-2H3,(H,24,25)(H,19,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.77E+4	n/a	n/a	n/a	n/a	7.0	22
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24547 (2-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl...) Show SMILES OC(=O)c1ccccc1NN=C1C(=O)Nc2ccc(cc12)S(=O)(=O)NCc1ccc(Cl)c(c1)C(F)(F)F |w:10.10| Show InChI InChI=1S/C23H16ClF3N4O5S/c24-17-7-5-12(9-16(17)23(25,26)27)11-28-37(35,36)13-6-8-18-15(10-13)20(21(32)29-18)31-30-19-4-2-1-3-14(19)22(33)34/h1-10,28,30H,11H2,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24540 (3-{2-[(3Z)-5-{[(4-methylphenyl)methyl]sulfamoyl}-2...) Show SMILES Cc1ccc(CNS(=O)(=O)c2ccc3NC(=O)C(=NNc4cccc(c4)C(O)=O)c3c2)cc1 |w:18.18| Show InChI InChI=1S/C23H20N4O5S/c1-14-5-7-15(8-6-14)13-24-33(31,32)18-9-10-20-19(12-18)21(22(28)25-20)27-26-17-4-2-3-16(11-17)23(29)30/h2-12,24,26H,13H2,1H3,(H,29,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24539 ((3Z)-N-[(4-chlorophenyl)methyl]-3-[2-(2-nitropheny...) Show SMILES [O-][N+](=O)c1ccccc1NN=C1C(=O)Nc2ccc(cc12)S(=O)(=O)NCc1ccc(Cl)cc1 |w:10.10| Show InChI InChI=1S/C21H16ClN5O5S/c22-14-7-5-13(6-8-14)12-23-33(31,32)15-9-10-17-16(11-15)20(21(28)24-17)26-25-18-3-1-2-4-19(18)27(29)30/h1-11,23,25H,12H2,(H,24,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.09E+4	n/a	n/a	n/a	n/a	7.0	22
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24542 (3-{2-[(3Z)-5-{[(3-chlorophenyl)methyl]sulfamoyl}-2...) Show SMILES OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2cccc(Cl)c2)c1 |w:9.8| Show InChI InChI=1S/C22H17ClN4O5S/c23-15-5-1-3-13(9-15)12-24-33(31,32)17-7-8-19-18(11-17)20(21(28)25-19)27-26-16-6-2-4-14(10-16)22(29)30/h1-11,24,26H,12H2,(H,29,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24552 (4-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl...) Show SMILES OC(=O)c1ccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(Cl)c(c2)C(F)(F)F)cc1 |w:8.7| Show InChI InChI=1S/C23H16ClF3N4O5S/c24-18-7-1-12(9-17(18)23(25,26)27)11-28-37(35,36)15-6-8-19-16(10-15)20(21(32)29-19)31-30-14-4-2-13(3-5-14)22(33)34/h1-10,28,30H,11H2,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24545 (4-{2-[(3Z)-5-{[(2-chlorophenyl)methyl]sulfamoyl}-2...) Show SMILES OC(=O)c1ccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccccc2Cl)cc1 |w:8.7| Show InChI InChI=1S/C22H17ClN4O5S/c23-18-4-2-1-3-14(18)12-24-33(31,32)16-9-10-19-17(11-16)20(21(28)25-19)27-26-15-7-5-13(6-8-15)22(29)30/h1-11,24,26H,12H2,(H,29,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24531 ((3Z)-3-[2-(2-nitrophenyl)hydrazin-1-ylidene]-2-oxo...) Show SMILES OS([O-])(=O)=c1ccc2[nH+]c(=O)\c(=N/Nc3ccccc3[N+]([O-])=O)c2c1 Show InChI InChI=1S/C14H10N4O6S/c19-14-13(17-16-11-3-1-2-4-12(11)18(20)21)9-7-8(25(22,23)24)5-6-10(9)15-14/h1-7,16H,(H2,22,23,24)/b17-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.80E+4	n/a	n/a	n/a	n/a	7.0	22
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24534 ((3Z)-3-[2-(3-carboxyphenyl)hydrazin-1-ylidene]-2-o...) Show SMILES OC(=O)c1ccc2NC(=O)C(=NNc3cccc(c3)C(O)=O)c2c1 |w:11.11| Show InChI InChI=1S/C16H11N3O5/c20-14-13(11-7-9(16(23)24)4-5-12(11)17-14)19-18-10-3-1-2-8(6-10)15(21)22/h1-7,18H,(H,21,22)(H,23,24)(H,17,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.25E+4	n/a	n/a	n/a	n/a	7.0	22
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24551 (3-{2-[(3Z)-5-{[2-(2,4-dichlorophenyl)ethyl]sulfamo...) Show SMILES OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCCc2ccc(Cl)cc2Cl)c1 |w:9.8| Show InChI InChI=1S/C23H18Cl2N4O5S/c24-15-5-4-13(19(25)11-15)8-9-26-35(33,34)17-6-7-20-18(12-17)21(22(30)27-20)29-28-16-3-1-2-14(10-16)23(31)32/h1-7,10-12,26,28H,8-9H2,(H,31,32)(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.34E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24553 (3-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl...) Show SMILES OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(Cl)c(c2)C(F)(F)F)c1 |w:9.8| Show InChI InChI=1S/C23H16ClF3N4O5S/c24-18-6-4-12(8-17(18)23(25,26)27)11-28-37(35,36)15-5-7-19-16(10-15)20(21(32)29-19)31-30-14-3-1-2-13(9-14)22(33)34/h1-10,28,30H,11H2,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24538 ((3Z)-3-[2-(2-nitrophenyl)hydrazin-1-ylidene]-2-oxo...) Show SMILES NS(=O)(=O)c1ccc2NC(=O)C(=NNc3ccccc3[N+]([O-])=O)c2c1 |w:12.12| Show InChI InChI=1S/C14H11N5O5S/c15-25(23,24)8-5-6-10-9(7-8)13(14(20)16-10)18-17-11-3-1-2-4-12(11)19(21)22/h1-7,17H,(H2,15,23,24)(H,16,18,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.04E+5	n/a	n/a	n/a	n/a	7.0	22
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 [205-595] (Homo sapiens (Human))	BDBM24550 (3-{2-[(3Z)-5-{[(3-chloro-4-fluorophenyl)methyl]sul...) Show SMILES OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(F)c(Cl)c2)c1 |w:9.8| Show InChI InChI=1S/C22H16ClFN4O5S/c23-17-8-12(4-6-18(17)24)11-25-34(32,33)15-5-7-19-16(10-15)20(21(29)26-19)28-27-14-3-1-2-13(9-14)22(30)31/h1-10,25,27H,11H2,(H,30,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.23E+5	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair