Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ubiquitin carboxyl-terminal hydrolase 15 (Homo sapiens (Human)) | BDBM50538571 (CHEMBL4635160) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
RAPT Therapeutics, Inc. Curated by ChEMBL | Assay Description Inhibition of human USP15 isoform 2 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine11... | J Med Chem 63: 5398-5420 (2020) Article DOI: 10.1021/acs.jmedchem.0c00245 BindingDB Entry DOI: 10.7270/Q2XK8K2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin carboxyl-terminal hydrolase 15 (Homo sapiens (Human)) | BDBM50442907 (Acetyl Isogambogic Acid | CHEMBL3039433) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.11E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delaware | Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff... | ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin carboxyl-terminal hydrolase 15 (Homo sapiens (Human)) | BDBM205457 ((2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 3.28E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delaware | Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff... | ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin carboxyl-terminal hydrolase 15 (Homo sapiens (Human)) | BDBM200235 (Rifampicin | cid_5381226) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.61E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delaware | Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff... | ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin carboxyl-terminal hydrolase 15 (Homo sapiens (Human)) | BDBM50242207 (CHEMBL455364 | Mangiferin) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.66E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delaware | Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff... | ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ubiquitin carboxyl-terminal hydrolase 15 (Homo sapiens (Human)) | BDBM65524 ((-)-Aricine | Heterophylline (VAN) | Quinovatine) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.14E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delaware | Assay Description Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff... | ACS Chem Biol 12: 2399-2407 (2017) Article DOI: 10.1021/acschembio.7b00543 BindingDB Entry DOI: 10.7270/Q21J97WD | |||||||||||
More data for this Ligand-Target Pair |