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Compile Data Set for Download or QSAR

Found 2115 hits of ic50 data for polymerid = 336   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasma kallikrein


(Homo sapiens (Human))
BDBM306676
PNG
((+-)-N-[(6-amino-2,4-dimethyl- pyridin-3-yl)methyl...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c2c1)c1cc2c(O)nnc(O)c2cc31
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n/an/a 0n/an/an/an/an/an/a



Tsukuba Research Laboratories





Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM212110
PNG
(US9290485, 142)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1cnn(Cc2ccc(Cn3ccccc3=O)cc2)c1
Show InChI InChI=1S/C25H26N6O2/c1-17-11-23(26)29-18(2)22(17)13-27-25(33)21-12-28-31(16-21)15-20-8-6-19(7-9-20)14-30-10-4-3-5-24(30)32/h3-12,16H,13-15H2,1-2H3,(H2,26,29)(H,27,33)
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n/an/a 0.0224n/an/an/an/a7.825



NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM212116
PNG
(US9290485, 148)
Show SMILES Cc1cc(C)n(Cc2ccc(Cn3cc(nn3)C(=O)NCc3c(C)cc(N)nc3C)cc2)n1
Show InChI InChI=1S/C24H28N8O/c1-15-9-23(25)27-18(4)21(15)11-26-24(33)22-14-31(30-28-22)12-19-5-7-20(8-6-19)13-32-17(3)10-16(2)29-32/h5-10,14H,11-13H2,1-4H3,(H2,25,27)(H,26,33)
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n/an/a 0.0300n/an/an/an/a7.825



NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM212114
PNG
(US9290485, 146)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(cn3)C(=O)NCc3c(C)cc(N)nc3C)cc2)c1
Show InChI InChI=1S/C24H27N7O/c1-16-9-27-30(12-16)13-19-4-6-20(7-5-19)14-31-15-21(10-28-31)24(32)26-11-22-17(2)8-23(25)29-18(22)3/h4-10,12,15H,11,13-14H2,1-3H3,(H2,25,29)(H,26,32)
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n/an/a 0.0400n/an/an/an/a7.825



NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM211977
PNG
(US9290485, 9)
Show SMILES COc1cc(Cn2cc(cn2)C(=O)NCc2c(C)cc(N)nc2C)ccc1Cn1cccn1
Show InChI InChI=1S/C24H27N7O2/c1-16-9-23(25)29-17(2)21(16)12-26-24(32)20-11-28-31(15-20)13-18-5-6-19(22(10-18)33-3)14-30-8-4-7-27-30/h4-11,15H,12-14H2,1-3H3,(H2,25,29)(H,26,32)
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n/an/a 0.0912n/an/an/an/a7.825



NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM212136
PNG
(US9290485, 168)
Show SMILES Cc1cc2cc(Cn3cc(cn3)C(=O)NCc3c(C)cc(N)nc3C)ccc2n1C
Show InChI InChI=1S/C23H26N6O/c1-14-7-22(24)27-16(3)20(14)11-25-23(30)19-10-26-29(13-19)12-17-5-6-21-18(9-17)8-15(2)28(21)4/h5-10,13H,11-12H2,1-4H3,(H2,24,27)(H,25,30)
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NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM212115
PNG
(US9290485, 147)
Show SMILES Cc1ccnn1Cc1ccc(Cn2cc(nn2)C(=O)NCc2c(C)cc(N)nc2C)cc1
Show InChI InChI=1S/C23H26N8O/c1-15-10-22(24)27-17(3)20(15)11-25-23(32)21-14-30(29-28-21)12-18-4-6-19(7-5-18)13-31-16(2)8-9-26-31/h4-10,14H,11-13H2,1-3H3,(H2,24,27)(H,25,32)
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n/an/a 0.100n/an/an/an/a7.825



NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM212004
PNG
(US9290485, 36)
Show SMILES Cc1cc(C)n(Cc2ccc(Cn3cc(cn3)C(=O)NCc3c(C)cc(N)nc3C)cc2)n1
Show InChI InChI=1S/C25H29N7O/c1-16-9-24(26)29-19(4)23(16)12-27-25(33)22-11-28-31(15-22)13-20-5-7-21(8-6-20)14-32-18(3)10-17(2)30-32/h5-11,15H,12-14H2,1-4H3,(H2,26,29)(H,27,33)
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n/an/a 0.134n/an/an/an/a7.825



NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM212113
PNG
(US9290485, 145)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1cnn(Cc2ccc(Cn3cccn3)cc2)c1
Show InChI InChI=1S/C23H25N7O/c1-16-10-22(24)28-17(2)21(16)12-25-23(31)20-11-27-30(15-20)14-19-6-4-18(5-7-19)13-29-9-3-8-26-29/h3-11,15H,12-14H2,1-2H3,(H2,24,28)(H,25,31)
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NOVARTIS AG

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Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM211974
PNG
(US9290485, 6)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1cn(Cc2ccc(Cn3cccn3)cc2)cn1
Show InChI InChI=1S/C23H25N7O/c1-16-10-22(24)28-17(2)20(16)11-25-23(31)21-14-29(15-26-21)12-18-4-6-19(7-5-18)13-30-9-3-8-27-30/h3-10,14-15H,11-13H2,1-2H3,(H2,24,28)(H,25,31)
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NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM212134
PNG
(US9290485, 166)
Show SMILES Cc1c(C)c2cc(Cn3cc(nn3)C(=O)NCc3c(C)cc(N)nc3C)ccc2n1C
Show InChI InChI=1S/C23H27N7O/c1-13-8-22(24)26-15(3)19(13)10-25-23(31)20-12-30(28-27-20)11-17-6-7-21-18(9-17)14(2)16(4)29(21)5/h6-9,12H,10-11H2,1-5H3,(H2,24,26)(H,25,31)
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NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM212135
PNG
(US9290485, 167)
Show SMILES Cc1nc(N)cc(Cl)c1CNC(=O)c1cnn(Cc2ccc(Cn3ccccc3=O)cc2)c1
Show InChI InChI=1S/C24H23ClN6O2/c1-16-20(21(25)10-22(26)29-16)12-27-24(33)19-11-28-31(15-19)14-18-7-5-17(6-8-18)13-30-9-3-2-4-23(30)32/h2-11,15H,12-14H2,1H3,(H2,26,29)(H,27,33)
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NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM263238
PNG
(5-amino-1-(4-pyrazol-1-ylmethyl-benzyl)-1h-pyrazol...)
Show SMILES Nc1nn(Cc2ccc(Cn3cccn3)cc2)cc1C(=O)NCc1ccc2c(N)nccc2c1
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n/an/a 0.330n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM212141
PNG
(US9290485, 173)
Show SMILES Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1CNC(=O)c1cnn(Cc2ccc3ncc(Cl)cc3c2)c1
Show InChI InChI=1S/C27H29ClN6O3/c1-16-8-24(33-26(36)37-27(3,4)5)32-17(2)22(16)13-30-25(35)20-11-31-34(15-20)14-18-6-7-23-19(9-18)10-21(28)12-29-23/h6-12,15H,13-14H2,1-5H3,(H,30,35)(H,32,33,36)
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n/an/a 0.400n/an/an/an/a7.825



NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM276779
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COc1cn(C(Cc2ccn(C)n2)C(=O)Nc2ccc(s2)C(N)=O)c(=O)cc1-c1cc(Cl)ccc1C#N
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n/an/a 0.490n/an/an/an/a7.425



Pfizer





J Med Chem 44: 1915-26 (2001)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM187100
PNG
(US9670157, 114 3-Methyl-1-[4-(4-methyl-pyrazol-1-y...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(C)cc(CN)cc4C)c(C)n3)cc2)c1
Show InChI InChI=1S/C27H32N6O/c1-18-12-30-32(14-18)15-22-5-7-23(8-6-22)16-33-17-26(21(4)31-33)27(34)29-13-25-19(2)9-24(11-28)10-20(25)3/h5-10,12,14,17H,11,13,15-16,28H2,1-4H3,(H,29,34)
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n/an/a 0.600n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM263258
PNG
(3-amino-1-[4-(4-methyl-pyrazol-1-ylmethyl)-benzyl]...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc5c(N)nccc5c4)c(N)n3)cc2)c1
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n/an/a 0.670n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM263231
PNG
(3-cyano-1-[4-(4-methyl-pyrazol-1-ylmethyl)-benzyl]...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc5c(N)nccc5c4)c(n3)C#N)cc2)c1
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n/an/a 0.740n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306556
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2,6-dimethyl-phenyl)m...)
Show SMILES Cc1cc(cc(C)c1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-c1ccc(F)cc1F)C(N)=N |r|
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n/an/a 0.741n/an/an/an/an/an/a



Tsukuba Research Laboratories





Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306637
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)m...)
Show SMILES NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)C4CC4)c3c2)c(F)c1 |r|
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n/an/a 0.759n/an/an/an/an/an/a



Tsukuba Research Laboratories





Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306613
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)m...)
Show SMILES NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2F)c(F)c1 |r|
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Tsukuba Research Laboratories





Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM285517
PNG
(5-({2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxop...)
Show SMILES COCCC(C(=O)Nc1ccn2ncc(C(N)=O)c2c1)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
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n/an/a 0.800n/an/an/an/a7.425



BioCryst Pharmaceuticals, Inc.





J Med Chem 47: 1919-29 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM263235
PNG
(3-(3,5-dimethyl-isoxazol-4-yl)-1-[4-(4-methyl-pyra...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc5c(N)nccc5c4)c(n3)-c3c(C)noc3C)cc2)c1
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n/an/a 0.890n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM212124
PNG
(US9290485, 156)
Show SMILES Cc1ccc2cc(Cn3cc(nn3)C(=O)NCc3c(C)cc(N)nc3C)cnc2c1
Show InChI InChI=1S/C22H23N7O/c1-13-4-5-17-8-16(9-24-19(17)6-13)11-29-12-20(27-28-29)22(30)25-10-18-14(2)7-21(23)26-15(18)3/h4-9,12H,10-11H2,1-3H3,(H2,23,26)(H,25,30)
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n/an/a 0.920n/an/an/an/a7.825



NOVARTIS AG

US Patent


Assay Description
Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM263298
PNG
(1-(4-pyrazol-1-ylmethyl-benzyl)-3-trifluoromethyl-...)
Show SMILES Nc1nccc2cc(CNC(=O)c3cn(Cc4ccc(Cn5cccn5)cc4)nc3C(F)(F)F)ccc12
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Kalvista Pharmaceuticals Limited

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM276767
PNG
(US10071995, Example 1 | US10071995, Example 8)
Show SMILES COCCC(C(=O)Nc1ccc(s1)C(N)=O)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1C#N
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Pfizer





J Med Chem 44: 1915-26 (2001)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306642
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)m...)
Show SMILES CC(=C)c1ccc2[C@@H]3O[C@H](c2c1)c1cc(ccc31)C(=O)NCc1c(F)cc(cc1F)C(N)=N |r|
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n/an/a 1n/an/an/an/an/an/a



Tsukuba Research Laboratories





Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306647
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2-fluorophenyl)-methy...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccccc2F)c(F)c1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM187104
PNG
(US9670157, 118 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(C)cc(CN)cc4C)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C27H29F3N6O/c1-17-11-33-35(13-17)14-20-4-6-21(7-5-20)15-36-16-24(25(34-36)27(28,29)30)26(37)32-12-23-18(2)8-22(10-31)9-19(23)3/h4-9,11,13,16H,10,12,14-15,31H2,1-3H3,(H,32,37)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM187097
PNG
(US9670157, 111 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(cn3)C(=O)NCc3c(C)cc(CN)cc3C)cc2)c1
Show InChI InChI=1S/C26H30N6O/c1-18-11-29-31(14-18)15-21-4-6-22(7-5-21)16-32-17-24(12-30-32)26(33)28-13-25-19(2)8-23(10-27)9-20(25)3/h4-9,11-12,14,17H,10,13,15-16,27H2,1-3H3,(H,28,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...


Citation and Details
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306620
PNG
((1S,8R)-N-[(4-carbamimidoyl- phenyl)methyl]-12-[(3...)
Show SMILES CN(c1ccc2[C@@H]3O[C@H](c2c1)c1cc(ccc31)C(=O)NCc1ccc(cc1)C(N)=N)c1cccc(Cl)c1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306581
PNG
((1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)meth...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@H](c4cc(Cn5ccccc5=O)ccc34)c2c1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306565
PNG
((1R,8S)-N-{[6-amino-2-methyl- 4-(propan-2-yl)-pyri...)
Show SMILES CC(C)c1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-c1ccc(F)cc1F |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306559
PNG
((1R,8S)-N-[(4- carbamimidoylphenyl) methyl]-12-(2,...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2F)cc1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306558
PNG
((1R,8S)-N-[(4- carbamimidoylphenyl) methyl]-12-(4-...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2)cc1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306538
PNG
((1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)meht...)
Show SMILES Cc1cnn(Cc2ccc3[C@@H]4O[C@H](c3c2)c2cc(ccc42)C(=O)NCc2c(C)cc(N)nc2C)c1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306536
PNG
((1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)meth...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@H](c4cc(Cn5cc(Cl)cn5)ccc34)c2c1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306535
PNG
((1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)meth...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@H](c4cc(Cn5cc(F)cn5)ccc34)c2c1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306648
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2-fluorophenyl)-methy...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2F)c(F)c1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306652
PNG
((1R,8S)-N-((4-carbamimidoyl- 2,6-difluorophenyl)me...)
Show SMILES NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(CCC(F)(F)F)ccc45)c3c2)c(F)c1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306658
PNG
((1R,8S)-N-[(4-carbamimidoyl-2- fluorophenyl)-methy...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)C4CC4)c3c2)c(F)c1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306662
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2-methylpheny])-methy...)
Show SMILES Cc1cc(ccc1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-c1ccc(F)cc1F)C(N)=N |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306663
PNG
((1S,8R)-N-[(4-carbamimidoyl- phenyl)methyl]-12-(3,...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)N4CC(F)(F)C4)c3c2)cc1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306668
PNG
((1S,8R)-N-[(4-carbamimidoyl-2- methylphenyl)-methy...)
Show SMILES Cc1cc(ccc1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-n1cccn1)C(N)=N |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306685
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2-fluorophenyl)-methy...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2)c(F)c1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306686
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2,6-dimethyl-phenyl)m...)
Show SMILES Cc1cc(cc(C)c1CNC(=O)c1ccc2[C@H]3O[C@H](c4cc(ccc34)C3CC3)c2c1)C(N)=N |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306703
PNG
((1S,8R)-N-[(4- carbamimidoylphenyl) methyl]-11,12-...)
Show SMILES CCc1cc2[C@@H]3O[C@H](c2cc1CC)c1cc(ccc31)C(=O)NCc1ccc(cc1)C(N)=N |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306708
PNG
((1S,8R)-N-[(4-carbamimidoyl- phenyl)methyl]-11,12-...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(C3CC3)c(cc42)C2CC2)cc1 |r|
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM306528
PNG
((+-)-N-[(4-carbamimidoylphenyl) methyl]-12-(2,4- d...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3C4OC(c3c2)c2cc(ccc42)-c2ccc(F)cc2F)cc1
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Bioorg Med Chem Lett 14: 3907-11 (2004)

More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM263229
PNG
(3-hydroxymethyl-1-[4-(4-methyl-pyrazol-1-ylmethyl)...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc5c(N)nccc5c4)c(CO)n3)cc2)c1
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Kalvista Pharmaceuticals Limited

US Patent




Citation and Details
More data for this
Ligand-Target Pair
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