Compile Data Set for Download or QSAR

Found 42 hits of ec50 for UniProtKB: P04629   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446394 (CHEMBL3109646 | US9181261, 1) Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C19H19F3N4OS/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.5	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of TrkA (unknown origin) using fluorescently labeled peptide substrate after 3 hrs				ACS Med Chem Lett 5: 8-9 (2014) Article DOI: 10.1021/ml4005073 BindingDB Entry DOI: 10.7270/Q2B56M6V
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446394 (CHEMBL3109646 | US9181261, 1) Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C19H19F3N4OS/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	6.5	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446392 (CHEMBL3109645 | US9181261, 2) Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C19H19F3N4O2/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of TrkA (unknown origin) using fluorescently labeled peptide substrate after 3 hrs				ACS Med Chem Lett 5: 8-9 (2014) Article DOI: 10.1021/ml4005073 BindingDB Entry DOI: 10.7270/Q2B56M6V
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446392 (CHEMBL3109645 | US9181261, 2) Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C19H19F3N4O2/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11.3	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191135 (US9181261, 5) Show SMILES CC1(C)CCN(C(=O)N1Cc1c[nH]c2ncccc12)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C21H21F3N4OS/c1-20(2)9-11-27(15-5-7-16(8-6-15)30-21(22,23)24)19(29)28(20)13-14-12-26-18-17(14)4-3-10-25-18/h3-8,10,12H,9,11,13H2,1-2H3,(H,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	19.7	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191136 (US9181261, 6) Show SMILES CC(C)N(Cc1n[nH]c2ncccc12)C(=O)Nc1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H18F3N5OS/c1-11(2)26(10-15-14-4-3-9-22-16(14)25-24-15)17(27)23-12-5-7-13(8-6-12)28-18(19,20)21/h3-9,11H,10H2,1-2H3,(H,23,27)(H,22,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	24.9	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50565738 (CHEMBL4794404) Show SMILES CN1CCN(CC(=O)Nc2nc(C)c(s2)-c2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TEL fused wild type TRKA (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y490 residue afte...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112744 BindingDB Entry DOI: 10.7270/Q20V8HJN
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50565738 (CHEMBL4794404) Show SMILES CN1CCN(CC(=O)Nc2nc(C)c(s2)-c2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<30	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TRKA in human KM-12-LUC cells assessed as reduction in AKT phosphorylation at T308 residue after 2 hrs by Western blot analysis				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112744 BindingDB Entry DOI: 10.7270/Q20V8HJN
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50565738 (CHEMBL4794404) Show SMILES CN1CCN(CC(=O)Nc2nc(C)c(s2)-c2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<30	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TRKA in human KM-12-LUC cells assessed as reduction in ERK1/2 phosphorylation at T202/Y204 residues after 2 hrs by Western blot analysi...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112744 BindingDB Entry DOI: 10.7270/Q20V8HJN
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50565738 (CHEMBL4794404) Show SMILES CN1CCN(CC(=O)Nc2nc(C)c(s2)-c2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<30	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TRKA in human KM-12-LUC cells assessed as reduction in AKT phosphorylation at S473 residue after 2 hrs by Western blot analysis				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112744 BindingDB Entry DOI: 10.7270/Q20V8HJN
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191137 (US9181261, 10) Show SMILES CC(C#C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C22H18F3N3O2S/c1-3-15(2)28(14-16-5-4-6-17(13-16)20-26-11-12-31-20)21(29)27-18-7-9-19(10-8-18)30-22(23,24)25/h1,4-13,15H,14H2,2H3,(H,27,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50578295 (CHEMBL4861572) Show SMILES COCc1ccc(OC(F)(F)F)c(CNC(=O)Nc2c(nc3c(C)nccn23)-c2ccccc2)c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	61	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human full length TRKA at inactive state expressed in rat PC-12 cells assessed as induction of kinase conformational change at 40...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00483 BindingDB Entry DOI: 10.7270/Q2G73JJ9
					More data for this Ligand-Target Pair				3D Structure (crystal)
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50565738 (CHEMBL4794404) Show SMILES CN1CCN(CC(=O)Nc2nc(C)c(s2)-c2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	67	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LMNA fused TRKA G667C mutant (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y490 residue ...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112744 BindingDB Entry DOI: 10.7270/Q20V8HJN
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50073587 (CHEMBL3408947 | US10358436, Example A185 | US20230...) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	84	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of TRKA (unknown origin)				Eur J Med Chem 95: 35-40 (2015) Article DOI: 10.1016/j.ejmech.2015.03.020 BindingDB Entry DOI: 10.7270/Q2NG4SBV
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50073587 (CHEMBL3408947 | US10358436, Example A185 | US20230...) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	84	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TRKA (unknown origin) by cell-based assay				J Med Chem 58: 147-69 (2015) Article DOI: 10.1021/jm5005336 BindingDB Entry DOI: 10.7270/Q2M0475V
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191138 (US9181261, 15) Show SMILES CC(C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1cnc(nc1)C(C)(C)C Show InChI InChI=1S/C22H27N5OS/c1-15(2)27(14-16-7-6-8-17(11-16)19-23-9-10-29-19)21(28)26-18-12-24-20(25-13-18)22(3,4)5/h6-13,15H,14H2,1-5H3,(H,26,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	102	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50022677 (CHEMBL3298270 | US9181261, 17) Show SMILES CC(C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C21H20F3N3O2S/c1-14(2)27(13-15-4-3-5-16(12-15)19-25-10-11-30-19)20(28)26-17-6-8-18(9-7-17)29-21(22,23)24/h3-12,14H,13H2,1-2H3,(H,26,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	119	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50565738 (CHEMBL4794404) Show SMILES CN1CCN(CC(=O)Nc2nc(C)c(s2)-c2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LMNA fused TRKA G595R mutant (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y490 residue ...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112744 BindingDB Entry DOI: 10.7270/Q20V8HJN
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191139 (US9181261, 20) Show SMILES CC(C)N(Cc1n[nH]c2ncccc12)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C18H18F3N5O2/c1-11(2)26(10-15-14-4-3-9-22-16(14)25-24-15)17(27)23-12-5-7-13(8-6-12)28-18(19,20)21/h3-9,11H,10H2,1-2H3,(H,23,27)(H,22,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	141	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505017 (CHEMBL4462161) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2cccc(C)c2)c1=O Show InChI InChI=1S/C25H23N3O6/c1-17-7-6-8-18(15-17)27-23(29)26-24(30)28(25(27)31)19-11-12-21(22(16-19)33-14-13-32-2)34-20-9-4-3-5-10-20/h3-12,15-16H,13-14H2,1-2H3,(H,26,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505015 (CHEMBL4538772) Show SMILES Brc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C21H14BrN3O4/c22-17-13-15(11-12-18(17)29-16-9-5-2-6-10-16)25-20(27)23-19(26)24(21(25)28)14-7-3-1-4-8-14/h1-13H,(H,23,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505010 (CHEMBL4455143) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C24H20ClN3O6/c1-32-12-13-33-21-15-18(10-11-20(21)34-19-8-3-2-4-9-19)28-23(30)26-22(29)27(24(28)31)17-7-5-6-16(25)14-17/h2-11,14-15H,12-13H2,1H3,(H,26,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505006 (CHEMBL4483402) Show SMILES COc1cc(Oc2ccccc2)ccc1-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O |(72.02,-7.51,;73.36,-8.28,;73.36,-9.82,;72.02,-10.6,;72.03,-12.14,;70.69,-12.91,;69.36,-12.15,;69.36,-10.61,;68.02,-9.84,;66.69,-10.61,;66.7,-12.16,;68.03,-12.92,;73.37,-12.91,;74.7,-12.13,;74.69,-10.6,;76.02,-9.82,;77.36,-10.59,;77.36,-12.13,;78.69,-9.82,;78.69,-8.28,;80.02,-7.52,;77.36,-7.5,;77.36,-5.96,;78.69,-5.19,;78.69,-3.65,;77.36,-2.88,;76.02,-3.66,;76.03,-5.2,;76.02,-8.28,;74.69,-7.52,)| Show InChI InChI=1S/C22H17N3O5/c1-29-19-14-17(30-16-10-6-3-7-11-16)12-13-18(19)25-21(27)23-20(26)24(22(25)28)15-8-4-2-5-9-15/h2-14H,1H3,(H,23,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505011 (CHEMBL4529332) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccc(C)cc2)c1=O Show InChI InChI=1S/C25H23N3O6/c1-17-8-10-18(11-9-17)27-23(29)26-24(30)28(25(27)31)19-12-13-21(22(16-19)33-15-14-32-2)34-20-6-4-3-5-7-20/h3-13,16H,14-15H2,1-2H3,(H,26,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505018 (CHEMBL4464173) Show SMILES COc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C22H17N3O5/c1-29-19-14-16(12-13-18(19)30-17-10-6-3-7-11-17)25-21(27)23-20(26)24(22(25)28)15-8-4-2-5-9-15/h2-14H,1H3,(H,23,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505007 (CHEMBL4464037) Show SMILES Cc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C22H17N3O4/c1-15-14-17(12-13-19(15)29-18-10-6-3-7-11-18)25-21(27)23-20(26)24(22(25)28)16-8-4-2-5-9-16/h2-14H,1H3,(H,23,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	340	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505012 (CHEMBL4472787) Show SMILES CC(C)Oc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C24H21N3O5/c1-16(2)31-21-15-18(13-14-20(21)32-19-11-7-4-8-12-19)27-23(29)25-22(28)26(24(27)30)17-9-5-3-6-10-17/h3-16H,1-2H3,(H,25,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	360	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505016 (CHEMBL4527488) Show SMILES CCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C23H19N3O5/c1-2-30-20-15-17(13-14-19(20)31-18-11-7-4-8-12-18)26-22(28)24-21(27)25(23(26)29)16-9-5-3-6-10-16/h3-15H,2H2,1H3,(H,24,27,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	390	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505005 (CHEMBL4455810) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccc(Cl)cc2)c1=O Show InChI InChI=1S/C24H20ClN3O6/c1-32-13-14-33-21-15-18(11-12-20(21)34-19-5-3-2-4-6-19)28-23(30)26-22(29)27(24(28)31)17-9-7-16(25)8-10-17/h2-12,15H,13-14H2,1H3,(H,26,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	480	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505013 (CHEMBL4574315) Show SMILES Cn1c(=O)[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OCC3COC3)c2)c1=O Show InChI InChI=1S/C20H19N3O6/c1-22-18(24)21-19(25)23(20(22)26)14-7-8-16(29-15-5-3-2-4-6-15)17(9-14)28-12-13-10-27-11-13/h2-9,13H,10-12H2,1H3,(H,21,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505019 (CHEMBL4465865) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OCC3COC3)c2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C25H21N3O6/c29-23-26-24(30)28(25(31)27(23)18-7-3-1-4-8-18)19-11-12-21(34-20-9-5-2-6-10-20)22(13-19)33-16-17-14-32-15-17/h1-13,17H,14-16H2,(H,26,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50508282 (CHEMBL4471556) Show SMILES COc1ccc(cc1)-c1cc2cccc(O)c2c(=O)o1 Show InChI InChI=1S/C16H12O4/c1-19-12-7-5-10(6-8-12)14-9-11-3-2-4-13(17)15(11)16(18)20-14/h2-9,17H,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	667	n/a	n/a	n/a	n/a
Indian Institute of Technology Madras Curated by ChEMBL					Assay Description Agonist activity at RFP-fused TrkA receptor (unknown origin) expressed in HEK293T cells after 6 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 29: 585-590 (2019) Article DOI: 10.1016/j.bmcl.2018.12.057 BindingDB Entry DOI: 10.7270/Q2542RVM
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High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505014 (CHEMBL4467829) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OC3CCOC3)c2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C25H21N3O6/c29-23-26-24(30)28(25(31)27(23)17-7-3-1-4-8-17)18-11-12-21(33-19-9-5-2-6-10-19)22(15-18)34-20-13-14-32-16-20/h1-12,15,20H,13-14,16H2,(H,26,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	780	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505008 (CHEMBL4518577) Show SMILES COc1cccc(c1)-n1c(=O)[nH]c(=O)n(-c2ccc(Oc3ccccc3)cc2)c1=O Show InChI InChI=1S/C22H17N3O5/c1-29-19-9-5-6-16(14-19)25-21(27)23-20(26)24(22(25)28)15-10-12-18(13-11-15)30-17-7-3-2-4-8-17/h2-14H,1H3,(H,23,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	830	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446393 (CHEMBL3109644 | US9181261, 74) Show SMILES CC1(C)CN(C(=O)N1Cc1cccc(c1)-c1nccs1)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C22H20F3N3O2S/c1-21(2)14-27(17-6-8-18(9-7-17)30-22(23,24)25)20(29)28(21)13-15-4-3-5-16(12-15)19-26-10-11-31-19/h3-12H,13-14H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.01E+3	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of TrkA (unknown origin) using fluorescently labeled peptide substrate after 3 hrs				ACS Med Chem Lett 5: 8-9 (2014) Article DOI: 10.1021/ml4005073 BindingDB Entry DOI: 10.7270/Q2B56M6V
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446393 (CHEMBL3109644 | US9181261, 74) Show SMILES CC1(C)CN(C(=O)N1Cc1cccc(c1)-c1nccs1)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C22H20F3N3O2S/c1-21(2)14-27(17-6-8-18(9-7-17)30-22(23,24)25)20(29)28(21)13-15-4-3-5-16(12-15)19-26-10-11-31-19/h3-12H,13-14H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	1.01E+3	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505009 (CHEMBL4542212) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)cc2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C21H15N3O4/c25-19-22-20(26)24(21(27)23(19)15-7-3-1-4-8-15)16-11-13-18(14-12-16)28-17-9-5-2-6-10-17/h1-14H,(H,22,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50242740 (CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...) Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of NTRK1				Proc Natl Acad Sci USA 104: 19936-41 (2007) Article DOI: 10.1073/pnas.0707498104 BindingDB Entry DOI: 10.7270/Q24X58QS
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50551644 (CHEMBL4745937) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc3oc(cc3c2)C(=O)c2cc3cc(O)ccc3[nH]2)no1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.86E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human NTRK1 incubated for 30 mins by Kinobead based assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112232 BindingDB Entry DOI: 10.7270/Q25H7KWP
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191140 (US9181261, 152) Show SMILES CC(C)N(Cc1cc(ccn1)-c1nccs1)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C20H19F3N4O2S/c1-13(2)27(12-16-11-14(7-8-24-16)18-25-9-10-30-18)19(28)26-15-3-5-17(6-4-15)29-20(21,22)23/h3-11,13H,12H2,1-2H3,(H,26,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8.08E+3	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50578295 (CHEMBL4861572) Show SMILES COCc1ccc(OC(F)(F)F)c(CNC(=O)Nc2c(nc3c(C)nccn23)-c2ccccc2)c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human full length TRKA at active state expressed in rat PC-12 cells assessed as induction of kinase conformational change at 52 d...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00483 BindingDB Entry DOI: 10.7270/Q2G73JJ9
					More data for this Ligand-Target Pair				3D Structure (crystal)
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50020712 (10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...) Show SMILES [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 Show InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	8.60E+4	n/a	n/a	n/a	n/a
Southmead Hospital Curated by ChEMBL					Assay Description Antagonist activity at full length glycosylated human TrkA expressed in HEKN3S cells cells assessed as reduction in NGF-induced ERK 42/44 phosphoryla...				J Med Chem 58: 767-77 (2015) Article DOI: 10.1021/jm501307e BindingDB Entry DOI: 10.7270/Q25B045H
					More data for this Ligand-Target Pair