Compile Data Set for Download or QSAR

Found 55 hits of ic50 data for polymerid = 374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM205429 ( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...) Show SMILES Cc1nnc2[C@@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14| Show InChI InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TT4V40
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM50092323 (CHEMBL3581656 | US9675697, Cpd. No. 21) Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)n[nH]c3C)c21 |(5.34,2.95,;5.34,1.67,;3.96,.87,;2.62,1.63,;1.3,.87,;1.3,-.64,;2.62,-1.4,;3.96,-.64,;5.34,-1.44,;5.49,-3.01,;4.53,-3.86,;7.04,-3.34,;7.84,-1.97,;6.77,-.78,;7.03,.46,;,-1.4,;-1.3,-.64,;-2.64,-1.4,;-3.92,-.64,;-3.92,.87,;-2.64,1.63,;-2.66,3.22,;-1.38,4.15,;-.17,3.76,;-1.89,5.66,;-3.48,5.64,;-3.96,4.12,;-5.16,3.71,;-1.3,.87,)| Show InChI InChI=1S/C22H21N5O2/c1-10-19(11(2)26-25-10)22-21-14-9-18(28-5)15(20-12(3)27-29-13(20)4)8-17(14)24-16(21)6-7-23-22/h6-9,24H,1-5H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	<10	<-10.9	93	n/a	n/a	n/a	n/a	7.5	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...				US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313803 (US10167292, Example 47) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C#N Show InChI InChI=1S/C18H14ClN5/c1-12-18-16-7-2-13(11-20)10-17(16)23(8-9-24(18)22-21-12)15-5-3-14(19)4-6-15/h2-7,10H,8-9H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313802 (US10167292, Example 46) Show SMILES CONC(=O)c1ccc2-c3c(C)nnn3CCN(c3ccc(Cl)cc3)c2c1 Show InChI InChI=1S/C19H18ClN5O2/c1-12-18-16-8-3-13(19(26)22-27-2)11-17(16)24(9-10-25(18)23-21-12)15-6-4-14(20)5-7-15/h3-8,11H,9-10H2,1-2H3,(H,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313798 (US10167292, Example 42) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(N)=O Show InChI InChI=1S/C18H16ClN5O/c1-11-17-15-7-2-12(18(20)25)10-16(15)23(8-9-24(17)22-21-11)14-5-3-13(19)4-6-14/h2-7,10H,8-9H2,1H3,(H2,20,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313805 (US10167292, Example 49) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1noc(=O)[nH]1 Show InChI InChI=1S/C19H15ClN6O2/c1-11-17-15-7-2-12(18-21-19(27)28-23-18)10-16(15)25(8-9-26(17)24-22-11)14-5-3-13(20)4-6-14/h2-7,10H,8-9H2,1H3,(H,21,23,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313804 (US10167292, Example 48) Show SMILES CON(C)C(=O)c1ccc2-c3c(C)nnn3CCN(c3ccc(Cl)cc3)c2c1 Show InChI InChI=1S/C20H20ClN5O2/c1-13-19-17-9-4-14(20(27)24(2)28-3)12-18(17)25(10-11-26(19)23-22-13)16-7-5-15(21)6-8-16/h4-9,12H,10-11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313771 (US10167292, Example 5) Show SMILES Cc1nnn2CCN(c3ccccc3)c3ccccc3-c12 Show InChI InChI=1S/C17H16N4/c1-13-17-15-9-5-6-10-16(15)20(11-12-21(17)19-18-13)14-7-3-2-4-8-14/h2-10H,11-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313807 (US10167292, Example 51B) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1nn[nH]n1 Show InChI InChI=1S/C18H15ClN8/c1-11-17-15-7-2-12(18-21-23-24-22-18)10-16(15)26(8-9-27(17)25-20-11)14-5-3-13(19)4-6-14/h2-7,10H,8-9H2,1H3,(H,21,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313773 (US10167292, Example 7) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1ccc(C)nc1 Show InChI InChI=1S/C23H20ClN5/c1-15-3-4-18(14-25-15)17-5-10-21-22(13-17)28(20-8-6-19(24)7-9-20)11-12-29-23(21)16(2)26-27-29/h3-10,13-14H,11-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313774 (US10167292, Example 8) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1ccc(N)nc1 Show InChI InChI=1S/C22H19ClN6/c1-14-22-19-8-2-15(16-3-9-21(24)25-13-16)12-20(19)28(10-11-29(22)27-26-14)18-6-4-17(23)5-7-18/h2-9,12-13H,10-11H2,1H3,(H2,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313775 (US10167292, Example 10) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1cc[nH]n1 Show InChI InChI=1S/C20H17ClN6/c1-13-20-17-7-2-14(18-8-9-22-24-18)12-19(17)26(10-11-27(20)25-23-13)16-5-3-15(21)4-6-16/h2-9,12H,10-11H2,1H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313776 (US10167292, Example 11) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3ccccc3-c12 Show InChI InChI=1S/C17H15ClN4/c1-12-17-15-4-2-3-5-16(15)21(10-11-22(17)20-19-12)14-8-6-13(18)7-9-14/h2-9H,10-11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313777 (US10167292, Example 12) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1cnc(N)nc1 Show InChI InChI=1S/C21H18ClN7/c1-13-20-18-7-2-14(15-11-24-21(23)25-12-15)10-19(18)28(8-9-29(20)27-26-13)17-5-3-16(22)4-6-17/h2-7,10-12H,8-9H2,1H3,(H2,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313778 (US10167292, Example 13) Show SMILES C[C@H]1CN(c2ccc(Cl)cc2)c2ccccc2-c2c(C)nnn12 |r| Show InChI InChI=1S/C18H17ClN4/c1-12-11-22(15-9-7-14(19)8-10-15)17-6-4-3-5-16(17)18-13(2)20-21-23(12)18/h3-10,12H,11H2,1-2H3/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313779 (US10167292, Example 16) Show SMILES C[C@@H]1CN(c2ccc(Cl)cc2)c2ccccc2-c2c(C)nnn12 |r| Show InChI InChI=1S/C18H17ClN4/c1-12-11-22(15-9-7-14(19)8-10-15)17-6-4-3-5-16(17)18-13(2)20-21-23(12)18/h3-10,12H,11H2,1-2H3/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313801 (US10167292, Example 45) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(=O)NOCCO Show InChI InChI=1S/C20H20ClN5O3/c1-13-19-17-7-2-14(20(28)23-29-11-10-27)12-18(17)25(8-9-26(19)24-22-13)16-5-3-15(21)4-6-16/h2-7,12,27H,8-11H2,1H3,(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313781 (US10167292, Example 21) Show SMILES Cc1nnn2C(CCO)CN(c3ccc(Cl)cc3)c3ccccc3-c12 Show InChI InChI=1S/C19H19ClN4O/c1-13-19-17-4-2-3-5-18(17)23(15-8-6-14(20)7-9-15)12-16(10-11-25)24(19)22-21-13/h2-9,16,25H,10-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313782 (US10167292, Example 22) Show SMILES Cc1nnn2CCN(c3cccc(Br)c3)c3ccccc3-c12 Show InChI InChI=1S/C17H15BrN4/c1-12-17-15-7-2-3-8-16(15)21(9-10-22(17)20-19-12)14-6-4-5-13(18)11-14/h2-8,11H,9-10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313783 (US10167292, Example 23) Show SMILES Cc1nnn2CCN(c3cccc(C=C)c3)c3ccccc3-c12 Show InChI InChI=1S/C19H18N4/c1-3-15-7-6-8-16(13-15)22-11-12-23-19(14(2)20-21-23)17-9-4-5-10-18(17)22/h3-10,13H,1,11-12H2,2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313784 (US10167292, Example 24) Show SMILES Cc1nnn2CCN(c3cccc(c3)C(O)CO)c3ccccc3-c12 Show InChI InChI=1S/C19H20N4O2/c1-13-19-16-7-2-3-8-17(16)22(9-10-23(19)21-20-13)15-6-4-5-14(11-15)18(25)12-24/h2-8,11,18,24-25H,9-10,12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313800 (US10167292, Example 44) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(=O)NO Show InChI InChI=1S/C18H16ClN5O2/c1-11-17-15-7-2-12(18(25)21-26)10-16(15)23(8-9-24(17)22-20-11)14-5-3-13(19)4-6-14/h2-7,10,26H,8-9H2,1H3,(H,21,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313799 (US10167292, Example 43) Show SMILES C[C@H](NC(=O)c1ccc2-c3c(C)nnn3CCN(c3ccccc3)c2c1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H24FN5O/c1-17(19-8-11-21(27)12-9-19)28-26(33)20-10-13-23-24(16-20)31(22-6-4-3-5-7-22)14-15-32-25(23)18(2)29-30-32/h3-13,16-17H,14-15H2,1-2H3,(H,28,33)/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313787 (US10167292, Example 31) Show SMILES COC(=O)c1ccc2-c3c(C)nnn3CCN(c3ccc(Cl)cc3)c2c1 Show InChI InChI=1S/C19H17ClN4O2/c1-12-18-16-8-3-13(19(25)26-2)11-17(16)23(9-10-24(18)22-21-12)15-6-4-14(20)5-7-15/h3-8,11H,9-10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313788 (US10167292, Example 32) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(O)=O Show InChI InChI=1S/C18H15ClN4O2/c1-11-17-15-7-2-12(18(24)25)10-16(15)22(8-9-23(17)21-20-11)14-5-3-13(19)4-6-14/h2-7,10H,8-9H2,1H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313789 (US10167292, Example 33) Show SMILES C[C@H](NC(=O)c1ccc2-c3c(C)nnn3CCN(c3ccc(Cl)cc3)c2c1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H23ClFN5O/c1-16(18-3-8-21(28)9-4-18)29-26(34)19-5-12-23-24(15-19)32(22-10-6-20(27)7-11-22)13-14-33-25(23)17(2)30-31-33/h3-12,15-16H,13-14H2,1-2H3,(H,29,34)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313790 (US10167292, Example 34) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(CO)ccc3-c12 Show InChI InChI=1S/C18H17ClN4O/c1-12-18-16-7-2-13(11-24)10-17(16)22(8-9-23(18)21-20-12)15-5-3-14(19)4-6-15/h2-7,10,24H,8-9,11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313791 (US10167292, Example 35) Show SMILES C[C@H](NC(=O)c1ccc2-c3c(C)nnn3CCN(c3ccc(Cl)cc3)c2c1)c1ccccc1 |r| Show InChI InChI=1S/C26H24ClN5O/c1-17(19-6-4-3-5-7-19)28-26(33)20-8-13-23-24(16-20)31(22-11-9-21(27)10-12-22)14-15-32-25(23)18(2)29-30-32/h3-13,16-17H,14-15H2,1-2H3,(H,28,33)/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313792 (US10167292, Example 36) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(=O)Nc1ccccc1 Show InChI InChI=1S/C24H20ClN5O/c1-16-23-21-12-7-17(24(31)26-19-5-3-2-4-6-19)15-22(21)29(13-14-30(23)28-27-16)20-10-8-18(25)9-11-20/h2-12,15H,13-14H2,1H3,(H,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313793 (US10167292, Example 37) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(=O)NCc1ccccc1 Show InChI InChI=1S/C25H22ClN5O/c1-17-24-22-12-7-19(25(32)27-16-18-5-3-2-4-6-18)15-23(22)30(13-14-31(24)29-28-17)21-10-8-20(26)9-11-21/h2-12,15H,13-14,16H2,1H3,(H,27,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313794 (US10167292, Example 38) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(=O)NC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C31H26ClN5O/c1-21-30-27-17-12-24(31(38)33-29(22-8-4-2-5-9-22)23-10-6-3-7-11-23)20-28(27)36(18-19-37(30)35-34-21)26-15-13-25(32)14-16-26/h2-17,20,29H,18-19H2,1H3,(H,33,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313795 (US10167292, Example 39) Show SMILES C[C@@H](NC(=O)c1ccc2-c3c(C)nnn3CCN(c3ccc(Cl)cc3)c2c1)c1ccccc1 |r| Show InChI InChI=1S/C26H24ClN5O/c1-17(19-6-4-3-5-7-19)28-26(33)20-8-13-23-24(16-20)31(22-11-9-21(27)10-12-22)14-15-32-25(23)18(2)29-30-32/h3-13,16-17H,14-15H2,1-2H3,(H,28,33)/t17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313796 (US10167292, Example 40) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(=O)NS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C24H20ClN5O3S/c1-16-23-21-12-7-17(24(31)27-34(32,33)20-5-3-2-4-6-20)15-22(21)29(13-14-30(23)28-26-16)19-10-8-18(25)9-11-19/h2-12,15H,13-14H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313797 (US10167292, Example 41) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C19H18ClN5O3S/c1-12-18-16-8-3-13(19(26)22-29(2,27)28)11-17(16)24(9-10-25(18)23-21-12)15-6-4-14(20)5-7-15/h3-8,11H,9-10H2,1-2H3,(H,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM179460 (US9675697, Cpd. No. 17) Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c[nH]c4ccccc34)c21 |(-1.88,2.57,;-2.65,1.24,;-1.88,-.09,;-.34,-.09,;.43,-1.43,;-.34,-2.76,;-1.88,-2.76,;-2.65,-1.43,;-4.19,-1.43,;-5.1,-2.67,;-4.7,-4.16,;-6.56,-2.2,;-6.56,-.66,;-5.1,-.18,;-4.7,1.31,;.69,-3.9,;2.09,-3.28,;3.5,-3.9,;4.75,-3,;4.59,-1.47,;3.18,-.84,;2.78,.65,;1.53,1.55,;2.01,3.02,;3.55,3.02,;4.58,4.16,;6.09,3.84,;6.56,2.38,;5.53,1.23,;4.03,1.55,;1.93,-1.75,)| Show InChI InChI=1S/C25H20N4O2/c1-13-23(14(2)31-29-13)17-10-21-16(11-22(17)30-3)24-20(28-21)8-9-26-25(24)18-12-27-19-7-5-4-6-15(18)19/h4-12,27-28H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	<-10.9	142	n/a	n/a	n/a	n/a	7.5	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...				US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM50103503 (CHEMBL2393130 | US11117865, Compound RVX-208) Show SMILES COc1cc(OC)c2c(c1)nc([nH]c2=O)-c1cc(C)c(OCCO)c(C)c1 Show InChI InChI=1S/C20H22N2O5/c1-11-7-13(8-12(2)18(11)27-6-5-23)19-21-15-9-14(25-3)10-16(26-4)17(15)20(24)22-19/h7-10,23H,5-6H2,1-4H3,(H,21,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TT4V40
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM179457 (US9675697, Cpd. No. 3) Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3ccccc3)c21 |(-1.12,2.92,;-1.75,1.51,;-.98,.18,;.56,.18,;1.33,-1.16,;.56,-2.49,;-.98,-2.49,;-1.75,-1.16,;-3.29,-1.16,;-4.19,-2.4,;-3.79,-3.89,;-5.65,-1.93,;-5.65,-.39,;-4.19,.09,;-3.79,1.58,;1.6,-3.64,;3,-3.01,;4.41,-3.64,;5.65,-2.73,;5.49,-1.2,;4.09,-.57,;3.69,.92,;4.78,2,;4.38,3.49,;2.89,3.89,;1.8,2.8,;2.2,1.31,;2.84,-1.48,)| Show InChI InChI=1S/C23H19N3O2/c1-13-21(14(2)28-26-13)17-11-19-16(12-20(17)27-3)22-18(25-19)9-10-24-23(22)15-7-5-4-6-8-15/h4-12,25H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	35	-10.2	255	n/a	n/a	n/a	n/a	7.5	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...				US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM50092318 (CHEMBL3581657 | US9675697, Cpd. No. 2) Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3cn[nH]c3)c21 |(5.34,2.95,;5.34,1.67,;3.96,.87,;2.62,1.63,;1.3,.87,;1.3,-.64,;2.62,-1.4,;3.96,-.64,;5.34,-1.44,;5.49,-3.01,;4.53,-3.86,;7.04,-3.34,;7.84,-1.97,;6.77,-.78,;7.03,.46,;,-1.4,;-1.3,-.64,;-2.64,-1.4,;-3.92,-.64,;-3.92,.87,;-2.64,1.63,;-2.66,3.22,;-1.38,4.15,;-1.89,5.66,;-3.48,5.64,;-3.96,4.12,;-1.3,.87,)| Show InChI InChI=1S/C20H17N5O2/c1-10-18(11(2)27-25-10)14-6-16-13(7-17(14)26-3)19-15(24-16)4-5-21-20(19)12-8-22-23-9-12/h4-9,24H,1-3H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	42.3	-10.1	286	n/a	n/a	n/a	n/a	7.5	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...				US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM179458 (US9675697, Cpd. No. 4) Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3cccnc3)c21 |(-1.12,2.92,;-1.75,1.51,;-.98,.18,;.56,.18,;1.33,-1.16,;.56,-2.49,;-.98,-2.49,;-1.75,-1.16,;-3.29,-1.16,;-4.19,-2.4,;-3.79,-3.89,;-5.65,-1.93,;-5.65,-.39,;-4.19,.09,;-3.79,1.58,;1.6,-3.64,;3,-3.01,;4.41,-3.64,;5.65,-2.73,;5.49,-1.2,;4.09,-.57,;3.69,.92,;4.78,2,;4.38,3.49,;2.89,3.89,;1.8,2.8,;2.2,1.31,;2.84,-1.48,)| Show InChI InChI=1S/C22H18N4O2/c1-12-20(13(2)28-26-12)16-9-18-15(10-19(16)27-3)21-17(25-18)6-8-24-22(21)14-5-4-7-23-11-14/h4-11,25H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	57	-9.88	349	n/a	n/a	n/a	n/a	7.5	25
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent					Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...				US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313785 (US10167292, Example 29) Show SMILES FC(F)c1nnn2CCN(c3ccc(Cl)cc3)c3ccccc3-c12 Show InChI InChI=1S/C17H13ClF2N4/c18-11-5-7-12(8-6-11)23-9-10-24-16(15(17(19)20)21-22-24)13-3-1-2-4-14(13)23/h1-8,17H,9-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313780 (US10167292, Example 20) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(Cn4cccn4)ccc3-c12 Show InChI InChI=1S/C21H19ClN6/c1-15-21-19-8-3-16(14-26-10-2-9-23-26)13-20(19)27(11-12-28(21)25-24-15)18-6-4-17(22)5-7-18/h2-10,13H,11-12,14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313806 (US10167292, Example 50) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(O)C(F)(F)F Show InChI InChI=1S/C19H16ClF3N4O/c1-11-17-15-7-2-12(18(28)19(21,22)23)10-16(15)26(8-9-27(17)25-24-11)14-5-3-13(20)4-6-14/h2-7,10,18,28H,8-9H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313786 (US10167292, Example 30) Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(CCN4CCOCC4)ccc3-c12 Show InChI InChI=1S/C23H26ClN5O/c1-17-23-21-7-2-18(8-9-27-12-14-30-15-13-27)16-22(21)28(10-11-29(23)26-25-17)20-5-3-19(24)4-6-20/h2-7,16H,8-15H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM50527819 (CHEMBL4557050 | US11117865, Compound ZL0516) Show SMILES COc1cc(OC)c2c(c1)oc(cc2=O)-c1cc(C)c(OC[C@H](O)CN2CCN(C)CC2)c(C)c1 |r| Show InChI InChI=1S/C27H34N2O6/c1-17-10-19(23-14-22(31)26-24(33-5)12-21(32-4)13-25(26)35-23)11-18(2)27(17)34-16-20(30)15-29-8-6-28(3)7-9-29/h10-14,20,30H,6-9,15-16H2,1-5H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	914	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TT4V40
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM50527819 (CHEMBL4557050 | US11117865, Compound ZL0516) Show SMILES COc1cc(OC)c2c(c1)oc(cc2=O)-c1cc(C)c(OC[C@H](O)CN2CCN(C)CC2)c(C)c1 |r| Show InChI InChI=1S/C27H34N2O6/c1-17-10-19(23-14-22(31)26-24(33-5)12-21(32-4)13-25(26)35-23)11-18(2)27(17)34-16-20(30)15-29-8-6-28(3)7-9-29/h10-14,20,30H,6-9,15-16H2,1-5H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	914	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TT4V40
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM313772 (US10167292, Example 6) Show SMILES Cc1nnn2CCN(Cc3ccccc3)c3ccccc3-c12 Show InChI InChI=1S/C18H18N4/c1-14-18-16-9-5-6-10-17(16)21(11-12-22(18)20-19-14)13-15-7-3-2-4-8-15/h2-10H,11-13H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Catalyst Therapeutics Pty Ltd. US Patent					Assay Description BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...				US Patent US10167292 (2019) BindingDB Entry DOI: 10.7270/Q2765HFS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM518731 (US11117865, Compound ZL0590) Show SMILES FC(F)(F)c1ccc(NC(=O)Nc2ccc(cc2)S(=O)(=O)N2CCC[C@@H]2CN2CCOCC2)cc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TT4V40
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM518731 (US11117865, Compound ZL0590) Show SMILES FC(F)(F)c1ccc(NC(=O)Nc2ccc(cc2)S(=O)(=O)N2CCC[C@@H]2CN2CCOCC2)cc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TT4V40
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM518799 (US11117865, Compound ZL0591) Show SMILES OC1CCN(C[C@@H]2CCCN2S(=O)(=O)c2ccc(NC(=O)Nc3ccc(cc3)C(F)(F)F)cc2)CC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TT4V40
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 [364-436] (Homo sapiens (Human))	BDBM518799 (US11117865, Compound ZL0591) Show SMILES OC1CCN(C[C@@H]2CCCN2S(=O)(=O)c2ccc(NC(=O)Nc3ccc(cc3)C(F)(F)F)cc2)CC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TT4V40
					More data for this Ligand-Target Pair

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