Found 133 hits of ki data for polymerid = 3971,50000237 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
MMDB
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| MMDB
Article
PubMed
| 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description
Agonistic activity of the compound towards retinoic acid receptor-gamma |
J Med Chem 40: 4222-34 (1998)
Article DOI: 10.1021/jm9704309
BindingDB Entry DOI: 10.7270/Q21J98VC |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
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| MMDB
Article
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-RA to binding Retinoic acid receptor RAR gamma |
Bioorg Med Chem Lett 4: 2117-2122 (1994)
Article DOI: 10.1016/S0960-894X(01)80113-X
BindingDB Entry DOI: 10.7270/Q2V40V4W |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
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| MMDB
Article
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards human Retinoic acid receptor gamma |
Bioorg Med Chem Lett 7: 2313-2318 (1997)
Article DOI: 10.1016/S0960-894X(97)00420-4
BindingDB Entry DOI: 10.7270/Q2Z89CDD |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
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| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description
Binding affinity against Retinoic acid receptor gamma |
Bioorg Med Chem Lett 11: 1583-6 (2001)
BindingDB Entry DOI: 10.7270/Q20R9NQW |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31892
(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+ | PDB
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| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description
Agonistic activity of the compound towards retinoic acid receptor-gamma |
J Med Chem 40: 4222-34 (1998)
Article DOI: 10.1021/jm9704309
BindingDB Entry DOI: 10.7270/Q21J98VC |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Retinoic acid receptor gamma [183-417]
(Homo sapiens (Human)) | BDBM31889
(BMS 961 | BMS270394 | BMS961)Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)[C@@H](O)C(=O)Nc1ccc(cc1F)C(O)=O Show InChI InChI=1S/C23H26FNO4/c1-22(2)9-10-23(3,4)16-11-13(5-7-15(16)22)19(26)20(27)25-18-8-6-14(21(28)29)12-17(18)24/h5-8,11-12,19,26H,9-10H2,1-4H3,(H,25,27)(H,28,29)/t19-/m1/s1 | PDB
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| 1.5 | -11.2 | n/a | n/a | n/a | n/a | n/a | 8.0 | 4 |
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)
| Assay Description
Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)... |
Chem Biol 6: 519-29 (1999)
Article DOI: 10.1016/S1074-5521(99)80084-2
BindingDB Entry DOI: 10.7270/Q2CV4G39 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048296
(4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-anthrace...)Show SMILES CC1(C)CCC(C)(C)c2cc3cc(ccc3cc12)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C25H26O2/c1-24(2)11-12-25(3,4)22-15-20-13-18(9-10-19(20)14-21(22)24)16-5-7-17(8-6-16)23(26)27/h5-10,13-15H,11-12H2,1-4H3,(H,26,27) | PDB
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50032219
((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ | PDB
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048295
(4-[(E)-2-(3-tert-Butyl-4-methoxy-phenyl)-propenyl]...)Show SMILES COc1ccc(cc1C(C)(C)C)C(\C)=C\c1ccc(cc1)C(O)=O Show InChI InChI=1S/C21H24O3/c1-14(12-15-6-8-16(9-7-15)20(22)23)17-10-11-19(24-5)18(13-17)21(2,3)4/h6-13H,1-5H3,(H,22,23)/b14-12+ | PDB
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB
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| MMDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma |
J Med Chem 39: 2659-63 (1996)
Article DOI: 10.1021/jm960285j
BindingDB Entry DOI: 10.7270/Q2988631 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50290081
(3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...)Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C1=Cc2ccc(cc2OC1)C(O)=O |t:16| Show InChI InChI=1S/C24H26O3/c1-23(2)9-10-24(3,4)20-12-15(7-8-19(20)23)18-11-16-5-6-17(22(25)26)13-21(16)27-14-18/h5-8,11-13H,9-10,14H2,1-4H3,(H,25,26) | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards Retinoic acid receptor gamma |
Bioorg Med Chem Lett 7: 2289-2294 (1997)
Article DOI: 10.1016/S0960-894X(97)00405-8
BindingDB Entry DOI: 10.7270/Q2HD7W4M |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048278
(4-[(E)-2-(3-Adamantan-1-yl-4-hydroxy-phenyl)-vinyl...)Show SMILES OC(=O)c1ccc(\C=C\c2ccc(O)c(c2)C23CC4CC(CC(C4)C2)C3)cc1 |TLB:23:22:25:17.18.19,23:18:25:24.22.21,THB:21:20:17:24.22.23,21:22:17:25.20.19| Show InChI InChI=1S/C25H26O3/c26-23-8-5-17(2-1-16-3-6-21(7-4-16)24(27)28)12-22(23)25-13-18-9-19(14-25)11-20(10-18)15-25/h1-8,12,18-20,26H,9-11,13-15H2,(H,27,28)/b2-1+ | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31892
(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+ | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma |
J Med Chem 39: 2659-63 (1996)
Article DOI: 10.1021/jm960285j
BindingDB Entry DOI: 10.7270/Q2988631 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048293
(4-{(E)-2-[4-Hydroxy-3-(1-methyl-cyclohexyl)-phenyl...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc(O)c(c1)C1(C)CCCCC1 Show InChI InChI=1S/C23H26O3/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-21(24)20(15-19)23(2)12-4-3-5-13-23/h6-11,14-15,24H,3-5,12-13H2,1-2H3,(H,25,26)/b16-14+ | PDB
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048285
(4-{(E)-2-[4-Methoxy-3-(1-methyl-cyclohexyl)-phenyl...)Show SMILES COc1ccc(cc1C1(C)CCCCC1)C(\C)=C\c1ccc(cc1)C(O)=O Show InChI InChI=1S/C24H28O3/c1-17(15-18-7-9-19(10-8-18)23(25)26)20-11-12-22(27-3)21(16-20)24(2)13-5-4-6-14-24/h7-12,15-16H,4-6,13-14H2,1-3H3,(H,25,26)/b17-15+ | PDB
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50290137
((2E,4E)-3-Methyl-5-{2-[(E)-2-(3,3,6,6-tetramethyl-...)Show SMILES C\C(\C=C\C1CC1\C=C\C1=CC(C)(C)CCC1(C)C)=C/C(O)=O |t:10| Show InChI InChI=1S/C21H30O2/c1-15(12-19(22)23)6-7-16-13-17(16)8-9-18-14-20(2,3)10-11-21(18,4)5/h6-9,12,14,16-17H,10-11,13H2,1-5H3,(H,22,23)/b7-6+,9-8+,15-12+ | PDB
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards human Retinoic acid receptor gamma |
Bioorg Med Chem Lett 7: 2313-2318 (1997)
Article DOI: 10.1016/S0960-894X(97)00420-4
BindingDB Entry DOI: 10.7270/Q2Z89CDD |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048289
(6-[3-Adamantan-1-yl-4-(2,3-dihydroxy-propyl)-pheny...)Show SMILES OCC(O)Cc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O |TLB:14:15:19:12.13.18,THB:14:13:19:20.15.16,16:15:12:19.17.18,16:17:12:20.15.14| Show InChI InChI=1S/C30H32O4/c31-17-27(32)12-25-5-3-24(22-1-2-23-11-26(29(33)34)6-4-21(23)10-22)13-28(25)30-14-18-7-19(15-30)9-20(8-18)16-30/h1-6,10-11,13,18-20,27,31-32H,7-9,12,14-17H2,(H,33,34) | PDB
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| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048281
(5',5',8',8'-Tetramethyl-5',6',7',8'-tetrahydro-[2,...)Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)-c1ccc2cc(ccc2c1)C(O)=O Show InChI InChI=1S/C25H26O2/c1-24(2)11-12-25(3,4)22-15-19(9-10-21(22)24)17-5-6-18-14-20(23(26)27)8-7-16(18)13-17/h5-10,13-15H,11-12H2,1-4H3,(H,26,27) | PDB
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| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048281
(5',5',8',8'-Tetramethyl-5',6',7',8'-tetrahydro-[2,...)Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)-c1ccc2cc(ccc2c1)C(O)=O Show InChI InChI=1S/C25H26O2/c1-24(2)11-12-25(3,4)22-15-19(9-10-21(22)24)17-5-6-18-14-20(23(26)27)8-7-16(18)13-17/h5-10,13-15H,11-12H2,1-4H3,(H,26,27) | PDB
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| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards Retinoic acid receptor gamma |
Bioorg Med Chem Lett 7: 2289-2294 (1997)
Article DOI: 10.1016/S0960-894X(97)00405-8
BindingDB Entry DOI: 10.7270/Q2HD7W4M |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048276
(4-[(E)-2-(3-Adamantan-1-yl-4-hydroxy-phenyl)-prope...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2 |TLB:26:25:28:20.21.22,26:21:28:27.25.24,THB:24:25:20:28.23.22,24:23:20:27.25.26| Show InChI InChI=1S/C26H28O3/c1-16(8-17-2-4-21(5-3-17)25(28)29)22-6-7-24(27)23(12-22)26-13-18-9-19(14-26)11-20(10-18)15-26/h2-8,12,18-20,27H,9-11,13-15H2,1H3,(H,28,29)/b16-8+ | PDB
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| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048284
(6-[3-Adamantan-1-yl-4-(3-hydroxy-propyl)-phenyl]-n...)Show SMILES OCCCc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O |TLB:13:14:18:11.12.17,17:16:19:11.12.13,17:12:19:18.16.15,THB:13:12:18:19.14.15| Show InChI InChI=1S/C30H32O3/c31-9-1-2-22-3-4-26(24-5-6-25-14-27(29(32)33)8-7-23(25)13-24)15-28(22)30-16-19-10-20(17-30)12-21(11-19)18-30/h3-8,13-15,19-21,31H,1-2,9-12,16-18H2,(H,32,33) | PDB
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| 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048291
(6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-...)Show SMILES OC(=O)c1ccc2cc(ccc2c1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2 |TLB:18:20:23:27.26.25,THB:21:22:25:29.20.28,21:20:23.22.27:25,28:20:23:27.26.25,28:26:23:29.21.20| Show InChI InChI=1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30) | PDB
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| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048290
(4-[(E)-2-(3-tert-Butyl-4-hydroxy-phenyl)-propenyl]...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc(O)c(c1)C(C)(C)C Show InChI InChI=1S/C20H22O3/c1-13(11-14-5-7-15(8-6-14)19(22)23)16-9-10-18(21)17(12-16)20(2,3)4/h5-12,21H,1-4H3,(H,22,23)/b13-11+ | PDB
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| 85 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048277
(4-[(E)-2-(3-Adamantan-1-yl-4-methoxy-phenyl)-prope...)Show SMILES COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)C(\C)=C\c1ccc(cc1)C(O)=O |TLB:15:14:17:9.10.11,15:10:17:16.14.13,THB:13:14:9:17.12.11,13:12:9:16.14.15| Show InChI InChI=1S/C27H30O3/c1-17(9-18-3-5-22(6-4-18)26(28)29)23-7-8-25(30-2)24(13-23)27-14-19-10-20(15-27)12-21(11-19)16-27/h3-9,13,19-21H,10-12,14-16H2,1-2H3,(H,28,29)/b17-9+ | PDB
MMDB
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| 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048287
(6-[4-Hydroxy-3-(1-methyl-cyclohexyl)-phenyl]-napht...)Show SMILES CC1(CCCCC1)c1cc(ccc1O)-c1ccc2cc(ccc2c1)C(O)=O Show InChI InChI=1S/C24H24O3/c1-24(11-3-2-4-12-24)21-15-19(9-10-22(21)25)17-5-6-18-14-20(23(26)27)8-7-16(18)13-17/h5-10,13-15,25H,2-4,11-12H2,1H3,(H,26,27) | PDB
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| 121 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50052033
((2E,4E,6E)-7-(3,5-Di-tert-butyl-phenyl)-3-methyl-o...)Show SMILES C\C(\C=C\C=C(/C)c1cc(cc(c1)C(C)(C)C)C(C)(C)C)=C/C(O)=O Show InChI InChI=1S/C23H32O2/c1-16(12-21(24)25)10-9-11-17(2)18-13-19(22(3,4)5)15-20(14-18)23(6,7)8/h9-15H,1-8H3,(H,24,25)/b10-9+,16-12+,17-11+ | PDB
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| 124 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma |
J Med Chem 39: 2659-63 (1996)
Article DOI: 10.1021/jm960285j
BindingDB Entry DOI: 10.7270/Q2988631 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50052033
((2E,4E,6E)-7-(3,5-Di-tert-butyl-phenyl)-3-methyl-o...)Show SMILES C\C(\C=C\C=C(/C)c1cc(cc(c1)C(C)(C)C)C(C)(C)C)=C/C(O)=O Show InChI InChI=1S/C23H32O2/c1-16(12-21(24)25)10-9-11-17(2)18-13-19(22(3,4)5)15-20(14-18)23(6,7)8/h9-15H,1-8H3,(H,24,25)/b10-9+,16-12+,17-11+ | PDB
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| 124 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma |
J Med Chem 39: 2659-63 (1996)
Article DOI: 10.1021/jm960285j
BindingDB Entry DOI: 10.7270/Q2988631 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048280
(6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic ac...)Show SMILES COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O |TLB:7:8:11:15.14.13,THB:9:10:13:17.8.16,9:8:11.10.15:13,16:8:11:15.14.13,16:14:11:17.9.8| Show InChI InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30) | PDB
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| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards Retinoic acid receptor gamma |
Bioorg Med Chem Lett 7: 2289-2294 (1997)
Article DOI: 10.1016/S0960-894X(97)00405-8
BindingDB Entry DOI: 10.7270/Q2HD7W4M |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50032675
(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26) | PDB
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| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description
Selective activity of the compound towards retinoic acid receptor-gamma |
J Med Chem 40: 4222-34 (1998)
Article DOI: 10.1021/jm9704309
BindingDB Entry DOI: 10.7270/Q21J98VC |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048280
(6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic ac...)Show SMILES COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O |TLB:7:8:11:15.14.13,THB:9:10:13:17.8.16,9:8:11.10.15:13,16:8:11:15.14.13,16:14:11:17.9.8| Show InChI InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30) | PDB
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| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50290078
(3-(3-Adamantan-1-yl-4-hydroxy-phenyl)-2H-chromene-...)Show SMILES OC(=O)c1ccc2C=C(COc2c1)c1ccc(O)c(c1)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |c:7,TLB:27:22:29:28.26.25,27:26:29:21.22.23| Show InChI InChI=1S/C26H26O4/c27-23-4-3-18(21-8-19-1-2-20(25(28)29)10-24(19)30-14-21)9-22(23)26-11-15-5-16(12-26)7-17(6-15)13-26/h1-4,8-10,15-17,27H,5-7,11-14H2,(H,28,29)/t15-,16+,17-,26? | PDB
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| 148 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards Retinoic acid receptor gamma |
Bioorg Med Chem Lett 7: 2289-2294 (1997)
Article DOI: 10.1016/S0960-894X(97)00405-8
BindingDB Entry DOI: 10.7270/Q2HD7W4M |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048297
(6-[3-Adamantan-1-yl-4-(2,3-dihydroxy-propoxy)-phen...)Show SMILES OCC(O)COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O |TLB:15:16:20:13.14.19,THB:15:14:20:21.16.17,17:16:13:20.18.19,17:18:13:21.16.15| Show InChI InChI=1S/C30H32O5/c31-16-26(32)17-35-28-6-5-24(22-1-2-23-11-25(29(33)34)4-3-21(23)10-22)12-27(28)30-13-18-7-19(14-30)9-20(8-18)15-30/h1-6,10-12,18-20,26,31-32H,7-9,13-17H2,(H,33,34) | PDB
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| 151 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048282
(6-[3-Adamantan-1-yl-4-(1,2-dihydroxy-ethyl)-phenyl...)Show SMILES OCC(O)c1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O |TLB:13:14:18:11.12.17,17:12:19:18.16.15,17:16:19:11.12.13,THB:13:12:18:19.14.15| Show InChI InChI=1S/C29H30O4/c30-16-27(31)25-6-5-23(21-1-2-22-11-24(28(32)33)4-3-20(22)10-21)12-26(25)29-13-17-7-18(14-29)9-19(8-17)15-29/h1-6,10-12,17-19,27,30-31H,7-9,13-16H2,(H,32,33) | PDB
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| 153 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048292
(6-[4-Methoxy-3-(1-methyl-cyclohexyl)-phenyl]-napht...)Show SMILES COc1ccc(cc1C1(C)CCCCC1)-c1ccc2cc(ccc2c1)C(O)=O Show InChI InChI=1S/C25H26O3/c1-25(12-4-3-5-13-25)22-16-20(10-11-23(22)28-2)18-6-7-19-15-21(24(26)27)9-8-17(19)14-18/h6-11,14-16H,3-5,12-13H2,1-2H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50290082
(3-(3-Adamantan-1-yl-4-methoxy-phenyl)-2H-chromene-...)Show SMILES COc1ccc(cc1C12C[C@H]3C[C@H](C[C@H](C3)C1)C2)C1=Cc2ccc(cc2OC1)C(O)=O |t:22,TLB:15:10:17:16.14.13,15:14:17:9.10.11| Show InChI InChI=1S/C27H28O4/c1-30-24-5-4-19(22-9-20-2-3-21(26(28)29)11-25(20)31-15-22)10-23(24)27-12-16-6-17(13-27)8-18(7-16)14-27/h2-5,9-11,16-18H,6-8,12-15H2,1H3,(H,28,29)/t16-,17+,18-,27? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 174 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards Retinoic acid receptor gamma |
Bioorg Med Chem Lett 7: 2289-2294 (1997)
Article DOI: 10.1016/S0960-894X(97)00405-8
BindingDB Entry DOI: 10.7270/Q2HD7W4M |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048294
(6-(3-tert-Butyl-4-hydroxy-phenyl)-naphthalene-2-ca...)Show InChI InChI=1S/C21H20O3/c1-21(2,3)18-12-16(8-9-19(18)22)14-4-5-15-11-17(20(23)24)7-6-13(15)10-14/h4-12,22H,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048294
(6-(3-tert-Butyl-4-hydroxy-phenyl)-naphthalene-2-ca...)Show InChI InChI=1S/C21H20O3/c1-21(2,3)18-12-16(8-9-19(18)22)14-4-5-15-11-17(20(23)24)7-6-13(15)10-14/h4-12,22H,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards Retinoic acid receptor gamma |
Bioorg Med Chem Lett 7: 2289-2294 (1997)
Article DOI: 10.1016/S0960-894X(97)00405-8
BindingDB Entry DOI: 10.7270/Q2HD7W4M |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50283073
(6-[(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-c...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)NC1OC(C(O)C(O)C1O)C(O)=O |c:4| Show InChI InChI=1S/C26H37NO7/c1-15(11-12-18-17(3)10-7-13-26(18,4)5)8-6-9-16(2)14-19(28)27-24-22(31)20(29)21(30)23(34-24)25(32)33/h6,8-9,11-12,14,20-24,29-31H,7,10,13H2,1-5H3,(H,27,28)(H,32,33)/b9-6+,12-11+,15-8+,16-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-RA binding to Retinoic acid receptor RAR gamma |
Bioorg Med Chem Lett 4: 2117-2122 (1994)
Article DOI: 10.1016/S0960-894X(01)80113-X
BindingDB Entry DOI: 10.7270/Q2V40V4W |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048283
(6-(3-Adamantan-1-yl-4-hydroxymethyl-phenyl)-naphth...)Show SMILES OCc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O |TLB:11:12:16:9.10.15,15:14:17:9.10.11,15:10:17:16.14.13,THB:11:10:16:17.12.13| Show InChI InChI=1S/C28H28O3/c29-16-25-6-4-23(21-1-2-22-11-24(27(30)31)5-3-20(22)10-21)12-26(25)28-13-17-7-18(14-28)9-19(8-17)15-28/h1-6,10-12,17-19,29H,7-9,13-16H2,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 386 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50092055
((2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cycl...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)Nc1ccc(O)cc1 |c:4| Show InChI InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| >400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description
Binding affinity against Retinoic acid receptor gamma |
Bioorg Med Chem Lett 11: 1583-6 (2001)
BindingDB Entry DOI: 10.7270/Q20R9NQW |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048279
(6-(3-tert-Butyl-4-methoxy-phenyl)-naphthalene-2-ca...)Show SMILES COc1ccc(cc1C(C)(C)C)-c1ccc2cc(ccc2c1)C(O)=O Show InChI InChI=1S/C22H22O3/c1-22(2,3)19-13-17(9-10-20(19)25-4)15-5-6-16-12-18(21(23)24)8-7-14(16)11-15/h5-13H,1-4H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 426 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50052588
((2E,4E,6Z)-7-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,...)Show SMILES COc1cc2c(cc1\C(C)=C/C=C/C(/C)=C/C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H32O3/c1-16(13-22(25)26)9-8-10-17(2)18-14-19-20(15-21(18)27-7)24(5,6)12-11-23(19,3)4/h8-10,13-15H,11-12H2,1-7H3,(H,25,26)/b9-8+,16-13+,17-10- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 437 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma |
J Med Chem 39: 3229-34 (1996)
Article DOI: 10.1021/jm960311d
BindingDB Entry DOI: 10.7270/Q2ZW1K14 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50061615
(4-(10,10,13,13,15-Pentamethyl-11,12,13,15-tetrahyd...)Show SMILES CN1c2cc3c(cc2N=C(c2ccc(cc2)C(O)=O)c2ccc4ccccc4c12)C(C)(C)CCC3(C)C |t:9| Show InChI InChI=1S/C33H32N2O2/c1-32(2)16-17-33(3,4)26-19-28-27(18-25(26)32)34-29(21-10-12-22(13-11-21)31(36)37)24-15-14-20-8-6-7-9-23(20)30(24)35(28)5/h6-15,18-19H,16-17H2,1-5H3,(H,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
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| CHEMBL
PC cid
PC sid
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| Article
PubMed
| 490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description
Antagonistic activity of the compound towards retinoic acid receptor-gamma |
J Med Chem 40: 4222-34 (1998)
Article DOI: 10.1021/jm9704309
BindingDB Entry DOI: 10.7270/Q21J98VC |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50290083
(3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2H-chromene...)Show SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)C1=Cc2ccc(cc2OC1)C(O)=O |t:16| Show InChI InChI=1S/C24H28O4/c1-23(2,3)18-10-16(11-19(21(18)25)24(4,5)6)17-9-14-7-8-15(22(26)27)12-20(14)28-13-17/h7-12,25H,13H2,1-6H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 531 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards Retinoic acid receptor gamma |
Bioorg Med Chem Lett 7: 2289-2294 (1997)
Article DOI: 10.1016/S0960-894X(97)00405-8
BindingDB Entry DOI: 10.7270/Q2HD7W4M |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50283072
((2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cycl...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)NC1OC(CO)C(O)C(O)C1O |c:4| Show InChI InChI=1S/C26H39NO6/c1-16(11-12-19-18(3)10-7-13-26(19,4)5)8-6-9-17(2)14-21(29)27-25-24(32)23(31)22(30)20(15-28)33-25/h6,8-9,11-12,14,20,22-25,28,30-32H,7,10,13,15H2,1-5H3,(H,27,29)/b9-6+,12-11+,16-8+,17-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| 710 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-RA to binding Retinoic acid receptor RAR gamma |
Bioorg Med Chem Lett 4: 2117-2122 (1994)
Article DOI: 10.1016/S0960-894X(01)80113-X
BindingDB Entry DOI: 10.7270/Q2V40V4W |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50048298
(6-(4,4-Dimethyl-chroman-6-yl)-naphthalene-2-carbox...)Show SMILES CC1(C)CCOc2ccc(cc12)-c1ccc2cc(ccc2c1)C(O)=O Show InChI InChI=1S/C22H20O3/c1-22(2)9-10-25-20-8-7-17(13-19(20)22)15-3-4-16-12-18(21(23)24)6-5-14(16)11-15/h3-8,11-13H,9-10H2,1-2H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 860 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA
Curated by ChEMBL
| Assay Description
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand |
J Med Chem 38: 4993-5006 (1996)
BindingDB Entry DOI: 10.7270/Q20G3J8S |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50033079
(4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-napht...)Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)C(=C)c1ccc(cc1)C(O)=O Show InChI InChI=1S/C23H26O2/c1-15(16-6-8-17(9-7-16)21(24)25)18-10-11-19-20(14-18)23(4,5)13-12-22(19,2)3/h6-11,14H,1,12-13H2,2-5H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| 887 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-ATRA bindng to RAR gamma receptor |
Bioorg Med Chem Lett 7: 2747-2752 (1997)
Article DOI: 10.1016/S0960-894X(97)10079-8
BindingDB Entry DOI: 10.7270/Q2JW8DW6 |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50290192
(3-Methyl-5-[5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahy...)Show SMILES C\C(\C=C\[C@]12CC1(CCC2)c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O Show InChI InChI=1S/C26H34O2/c1-18(15-22(27)28)9-12-25-10-6-11-26(25,17-25)19-7-8-20-21(16-19)24(4,5)14-13-23(20,2)3/h7-9,12,15-16H,6,10-11,13-14,17H2,1-5H3,(H,27,28)/b12-9+,18-15+/t25-,26?/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR beta |
Bioorg Med Chem Lett 7: 2393-2398 (1997)
Article DOI: 10.1016/S0960-894X(97)00437-X
BindingDB Entry DOI: 10.7270/Q2FB52XX |
More data for this
Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50290186
((2E,4E)-3-Methyl-5-[(1R,2R)-1-methyl-2-(5,5,8,8-te...)Show SMILES C\C(\C=C\[C@@]1(C)CCC[C@@H]1c1ccc2c(c1)C(C)(C)CCC2(C)C)=C/C(O)=O Show InChI InChI=1S/C26H36O2/c1-18(16-23(27)28)11-13-26(6)12-7-8-20(26)19-9-10-21-22(17-19)25(4,5)15-14-24(21,2)3/h9-11,13,16-17,20H,7-8,12,14-15H2,1-6H3,(H,27,28)/b13-11+,18-16+/t20-,26-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma |
Bioorg Med Chem Lett 7: 2393-2398 (1997)
Article DOI: 10.1016/S0960-894X(97)00437-X
BindingDB Entry DOI: 10.7270/Q2FB52XX |
More data for this
Ligand-Target Pair | |
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