Compile Data Set for Download or QSAR

Found 4 hits of ec50 for UniProtKB: Q08345   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM104010 (DDR1-IN-2) Show SMILES CCN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(NCc3cnc4[nH]ccc4c3OC)c2)CC1 Show InChI InChI=1S/C31H35F3N6O2/c1-4-39-11-13-40(14-12-39)19-22-7-6-21(15-26(22)31(32,33)34)30(41)38-24-8-5-20(2)27(16-24)36-17-23-18-37-29-25(9-10-35-29)28(23)42-3/h5-10,15-16,18,36H,4,11-14,17,19H2,1-3H3,(H,35,37)(H,38,41)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Massachusetts General Hospital and Harvard Medical School					Assay Description The enzyme kinase assay was carried out using the Lanthascreen technology.				ACS Chem Biol 8: 2145-50 (2013) Article DOI: 10.1021/cb400430t BindingDB Entry DOI: 10.7270/Q2WS8RWD
					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50582161 (CHEMBL5076889) Show SMILES CC(=O)Nc1ccc(cc1)-n1nc2c(c1-c1oc3cc(ccc3c1C)C(=O)Nc1cccc(c1)C(F)(F)F)c(N)n[nH]c2=O |(21.52,-24.11,;22.28,-22.79,;23.81,-22.79,;21.52,-21.47,;20,-21.46,;19.22,-20.12,;17.69,-20.12,;16.92,-21.45,;17.68,-22.79,;19.22,-22.8,;15.38,-21.44,;14.48,-22.67,;13.03,-22.2,;13.04,-20.67,;14.49,-20.21,;14.97,-18.74,;14.07,-17.49,;14.98,-16.25,;14.66,-14.76,;15.8,-13.73,;17.26,-14.21,;17.58,-15.71,;16.43,-16.73,;16.43,-18.27,;17.68,-19.18,;15.48,-12.23,;14.02,-11.75,;16.63,-11.2,;16.31,-9.69,;17.46,-8.66,;17.14,-7.16,;15.67,-6.68,;14.53,-7.72,;14.85,-9.22,;13.06,-7.24,;11.92,-8.28,;11.56,-6.84,;12.73,-5.74,;11.71,-19.89,;11.72,-18.35,;10.36,-20.65,;10.36,-22.19,;11.69,-22.97,;11.68,-24.51,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of DDR1 in human THP-1 cells assessed as reduction in collagen induced DDR1 autophosphorylation by Western blot analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01205 BindingDB Entry DOI: 10.7270/Q28K7DZ4
					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM104009 (DDR1-IN-1) Show SMILES CCN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(Oc3ccc4NC(=O)Cc4c3)c2)CC1 Show InChI InChI=1S/C30H31F3N4O3/c1-3-36-10-12-37(13-11-36)18-21-6-5-20(15-25(21)30(31,32)33)29(39)34-23-7-4-19(2)27(17-23)40-24-8-9-26-22(14-24)16-28(38)35-26/h4-9,14-15,17H,3,10-13,16,18H2,1-2H3,(H,34,39)(H,35,38)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	86	n/a	n/a	n/a	n/a
Massachusetts General Hospital and Harvard Medical School					Assay Description The enzyme kinase assay was carried out using the Lanthascreen technology.				ACS Chem Biol 8: 2145-50 (2013) Article DOI: 10.1021/cb400430t BindingDB Entry DOI: 10.7270/Q2WS8RWD
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50582160 (CHEMBL5072982) Show SMILES CCN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(Oc3ccc4CC(=O)Nc4c3)c2)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	115	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of DDR1 in human THP-1 cells assessed as reduction in collagen induced DDR1 autophosphorylation by Western blot analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01205 BindingDB Entry DOI: 10.7270/Q28K7DZ4
					More data for this Ligand-Target Pair