BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1682 hits of ic50 for UniProtKB: Q08345   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1b (unknown origin) assessed as reduction in collagen-induced DDR1b activation

J Med Chem 58: 3287-301 (2015)


Article DOI: 10.1021/jm5012319
BindingDB Entry DOI: 10.7270/Q2DV1MMV
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50509520
PNG
(CHEMBL4539920)
Show SMILES Cn1ccc(n1)-c1cncc(CNc2cc(ccc2F)C(=O)Nc2cccc(OC(F)(F)F)c2)c1
Show InChI InChI=1S/C24H19F4N5O2/c1-33-8-7-21(32-33)17-9-15(12-29-14-17)13-30-22-10-16(5-6-20(22)25)23(34)31-18-3-2-4-19(11-18)35-24(26,27)28/h2-12,14,30H,13H2,1H3,(H,31,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.708n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged DDR1 in human HEK293 cells assessed as reduction in collagen-1-induced DDR1 phosphorylation incubated for 18 hrs by ELISA

ACS Med Chem Lett 11: 29-33 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00382
BindingDB Entry DOI: 10.7270/Q2NP27QG
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM185584
PNG
(US9156852, 1 | USRE47451, Example 1)
Show SMILES Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-2-7-16-15(8-9-26-22(16)29-14-5-3-13(24)4-6-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
As such, the compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profili...

PubChem Bioassay (2006)


BindingDB Entry DOI: 10.7270/Q2XW4N61
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM185584
PNG
(US9156852, 1 | USRE47451, Example 1)
Show SMILES Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-2-7-16-15(8-9-26-22(16)29-14-5-3-13(24)4-6-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/an/an/a



HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...

US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human DDR1 using KKSRGDYMTMQIG as substrate by [gamma-33P]-ATP assay

Citation and Details

Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223090
PNG
(2-Morpholinoethyl 4-(6-((5-((2-chloro-6-methylphen...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CC1)C(=O)OCCN1CCOCC1
Show InChI InChI=1S/C27H33ClN8O4S/c1-18-4-3-5-20(28)24(18)33-25(37)21-17-29-26(41-21)32-22-16-23(31-19(2)30-22)35-6-8-36(9-7-35)27(38)40-15-12-34-10-13-39-14-11-34/h3-5,16-17H,6-15H2,1-2H3,(H,33,37)(H,29,30,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.26n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50430865
PNG
(CHEMBL2336037)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C22H15ClN4O/c1-15-5-7-18(22(28)26-20-4-2-3-19(23)12-20)11-17(15)8-6-16-13-24-21-9-10-25-27(21)14-16/h2-5,7,9-14H,1H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...

J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50368552
PNG
(CHEMBL4161036)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cnccn34)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-3-4-23(15-22(20)5-6-26-17-34-27-18-33-7-8-38(26)27)28(39)35-25-14-21(13-24(16-25)29(30,31)32)19-37-11-9-36(2)10-12-37/h3-4,7-8,13-18H,9-12,19H2,1-2H3,(H,35,39)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay

J Med Chem 61: 7977-7990 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223091
PNG
(2-(Dimethylamino)ethyl 4-(6-((5-((2-chloro-6-methy...)
Show SMILES CN(C)CCOC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C25H31ClN8O3S/c1-16-6-5-7-18(26)22(16)31-23(35)19-15-27-24(38-19)30-20-14-21(29-17(2)28-20)33-8-10-34(11-9-33)25(36)37-13-12-32(3)4/h5-7,14-15H,8-13H2,1-4H3,(H,31,35)(H,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.56n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50507707
PNG
(CHEMBL4466555)
Show SMILES Cc1ccc(cc1NC(=O)C1(CC1)c1ncnc2[nH]cnc12)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H18ClF3N6O2/c1-12-2-3-13(21(35)33-14-4-5-16(25)15(9-14)24(26,27)28)8-17(12)34-22(36)23(6-7-23)19-18-20(31-10-29-18)32-11-30-19/h2-5,8-11H,6-7H2,1H3,(H,33,35)(H,34,36)(H,29,30,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human DDR1 using KKSRGDYMTMQIG as substrate by [gamma-33P]-ATP assay

Eur J Med Chem 163: 243-255 (2019)


Article DOI: 10.1016/j.ejmech.2018.11.033
BindingDB Entry DOI: 10.7270/Q24B34M5
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223082
PNG
(Ethyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl...)
Show SMILES CCOC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C23H26ClN7O3S/c1-4-34-23(33)31-10-8-30(9-11-31)19-12-18(26-15(3)27-19)28-22-25-13-17(35-22)21(32)29-20-14(2)6-5-7-16(20)24/h5-7,12-13H,4,8-11H2,1-3H3,(H,29,32)(H,25,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.15n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50368455
PNG
(CHEMBL4175086)
Show SMILES CCc1ccc(cc1C#Cc1cnc2cnccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O/c1-3-22-4-5-24(16-23(22)6-7-27-18-35-28-19-34-8-9-39(27)28)29(40)36-26-15-21(14-25(17-26)30(31,32)33)20-38-12-10-37(2)11-13-38/h4-5,8-9,14-19H,3,10-13,20H2,1-2H3,(H,36,40)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.20n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay

J Med Chem 61: 7977-7990 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223085
PNG
(Butyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl...)
Show SMILES CCCCOC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C25H30ClN7O3S/c1-4-5-13-36-25(35)33-11-9-32(10-12-33)21-14-20(28-17(3)29-21)30-24-27-15-19(37-24)23(34)31-22-16(2)7-6-8-18(22)26/h6-8,14-15H,4-5,9-13H2,1-3H3,(H,31,34)(H,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.20n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 3.70n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of autophosphorylation of DDR1 expressed in HEK293 cells by ELISA

Bioorg Med Chem 18: 6977-86 (2010)


Article DOI: 10.1016/j.bmc.2010.08.026
BindingDB Entry DOI: 10.7270/Q2930TC9
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50368547
PNG
(CHEMBL4164448)
Show SMILES CCc1ccc(cc1C#Cc1cnc2cccnn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O/c1-3-22-6-7-24(17-23(22)8-9-27-19-34-28-5-4-10-35-39(27)28)29(40)36-26-16-21(15-25(18-26)30(31,32)33)20-38-13-11-37(2)12-14-38/h4-7,10,15-19H,3,11-14,20H2,1-2H3,(H,36,40)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.90n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay

J Med Chem 61: 7977-7990 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50368600
PNG
(CHEMBL4164030)
Show SMILES CCc1ccc(cc1C#Cc1cnc(N)nc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H29F3N6O/c1-3-21-6-7-23(14-22(21)5-4-19-16-33-27(32)34-17-19)26(38)35-25-13-20(12-24(15-25)28(29,30)31)18-37-10-8-36(2)9-11-37/h6-7,12-17H,3,8-11,18H2,1-2H3,(H,35,38)(H2,32,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.90n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay

J Med Chem 61: 7977-7990 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50430862
PNG
(CHEMBL2336040)
Show SMILES COc1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C23H18N4O2/c1-16-6-8-19(23(28)26-20-4-3-5-21(13-20)29-2)12-18(16)9-7-17-14-24-22-10-11-25-27(22)15-17/h3-6,8,10-15H,1-2H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...

J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM378887
PNG
(US10266537, Compound 31)
Show SMILES CN1CCC(CC1)n1nc(C#Cc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)c2c(N)ncnc12
Show InChI InChI=1S/C28H26F3N7O/c1-17-6-8-21(35-27(39)19-4-3-5-20(14-19)28(29,30)31)15-18(17)7-9-23-24-25(32)33-16-34-26(24)38(36-23)22-10-12-37(2)13-11-22/h3-6,8,14-16,22H,10-13H2,1-2H3,(H,35,39)(H2,32,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Kalypsys, Inc.



Assay Description
The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...

Bioorg Med Chem Lett 17: 3562-9 (2007)


BindingDB Entry DOI: 10.7270/Q21C2065
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50509521
PNG
(CHEMBL4439970)
Show SMILES Cc1ccc(cc1NCc1cncc(c1)C(N)=O)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H19F3N4O2/c1-13-5-6-15(21(31)29-18-4-2-3-17(9-18)22(23,24)25)8-19(13)28-11-14-7-16(20(26)30)12-27-10-14/h2-10,12,28H,11H2,1H3,(H2,26,30)(H,29,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer 178 binding to recombinant human His-tagged DDR1 expressed in baculovirus infected Sf9 cells incubated for 1 hr by TR-FRE...

ACS Med Chem Lett 11: 29-33 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00382
BindingDB Entry DOI: 10.7270/Q2NP27QG
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223089
PNG
(2-Chloroethyl 4-(6-((5-((2-chloro-6-methylphenyl)c...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CC1)C(=O)OCCCl
Show InChI InChI=1S/C23H25Cl2N7O3S/c1-14-4-3-5-16(25)20(14)30-21(33)17-13-26-22(36-17)29-18-12-19(28-15(2)27-18)31-7-9-32(10-8-31)23(34)35-11-6-24/h3-5,12-13H,6-11H2,1-2H3,(H,30,33)(H,26,27,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.21n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223093
PNG
((E)-2-((6-(4-(but-2-enoyl)piperazin-1-yl)-2-methyl...)
Show SMILES C\C=C\C(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C24H26ClN7O2S/c1-4-6-21(33)32-11-9-31(10-12-32)20-13-19(27-16(3)28-20)29-24-26-14-18(35-24)23(34)30-22-15(2)7-5-8-17(22)25/h4-8,13-14H,9-12H2,1-3H3,(H,30,34)(H,26,27,28,29)/b6-4+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.25n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 4.30n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human DDR1 using KKSRGDYMTMQIG as substrate by [gamma-33P]-ATP assay

Eur J Med Chem 161: 456-467 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.052
BindingDB Entry DOI: 10.7270/Q2W380MT
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223081
PNG
(Methyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoy...)
Show SMILES COC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C22H24ClN7O3S/c1-13-5-4-6-15(23)19(13)28-20(31)16-12-24-21(34-16)27-17-11-18(26-14(2)25-17)29-7-9-30(10-8-29)22(32)33-3/h4-6,11-12H,7-10H2,1-3H3,(H,28,31)(H,24,25,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.32n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50577169
PNG
(CHEMBL4846921)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc3scc(-c4cccc(NS(C)(=O)=O)c4)c3n2)cc1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of DDR1 (unknown origin)

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00459
BindingDB Entry DOI: 10.7270/Q2TT4VSH
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223092
PNG
(2-((6-(4-Acryloylpiperazin-1-yl)-2-methylpyrimidin...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C23H24ClN7O2S/c1-4-20(32)31-10-8-30(9-11-31)19-12-18(26-15(3)27-19)28-23-25-13-17(34-23)22(33)29-21-14(2)6-5-7-16(21)24/h4-7,12-13H,1,8-11H2,2-3H3,(H,29,33)(H,25,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.54n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM88314
PNG
(US9695118, 202)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@@H](CNC)C2)c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-3-36(34,35)22-5-4-18(25)8-17(22)12-31-23(33)16-9-20(24(27,28)29)19(21(26)10-16)14-32-7-6-15(13-32)11-30-2/h4-5,8-10,15,30H,3,6-7,11-14H2,1-2H3,(H,31,33)/t15-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4.60n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...

US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50509520
PNG
(CHEMBL4539920)
Show SMILES Cn1ccc(n1)-c1cncc(CNc2cc(ccc2F)C(=O)Nc2cccc(OC(F)(F)F)c2)c1
Show InChI InChI=1S/C24H19F4N5O2/c1-33-8-7-21(32-33)17-9-15(12-29-14-17)13-30-22-10-16(5-6-20(22)25)23(34)31-18-3-2-4-19(11-18)35-24(26,27)28/h2-12,14,30H,13H2,1H3,(H,31,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.70n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer 178 binding to recombinant human His-tagged DDR1 expressed in baculovirus infected Sf9 cells incubated for 1 hr by TR-FRE...

ACS Med Chem Lett 11: 29-33 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00382
BindingDB Entry DOI: 10.7270/Q2NP27QG
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
Article
PubMed
n/an/a 4.80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...

J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50297825
PNG
(5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)...)
Show SMILES Cc1ccc(cc1Nc1cncc(c1)C(N)=O)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N4O2/c1-12-5-6-13(8-18(12)27-17-7-14(19(25)29)10-26-11-17)20(30)28-16-4-2-3-15(9-16)21(22,23)24/h2-11,27H,1H3,(H2,25,29)(H,28,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Similars
Article
PubMed
n/an/a 4.80n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged DDR1 in human HEK293 cells assessed as reduction in collagen-1-induced DDR1 phosphorylation incubated for 18 hrs by ELISA

ACS Med Chem Lett 11: 29-33 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00382
BindingDB Entry DOI: 10.7270/Q2NP27QG
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50368573
PNG
(CHEMBL4174682)
Show SMILES CCc1ccc(cc1C#Cc1cnc(NC)nc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H31F3N6O/c1-4-22-7-8-24(15-23(22)6-5-20-17-34-28(33-2)35-18-20)27(39)36-26-14-21(13-25(16-26)29(30,31)32)19-38-11-9-37(3)10-12-38/h7-8,13-18H,4,9-12,19H2,1-3H3,(H,36,39)(H,33,34,35)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay

J Med Chem 61: 7977-7990 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM185589
PNG
(US9156852, 83 | USRE47451, Example 83)
Show SMILES CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C25H20N6O2S/c1-13-3-8-18-17(9-10-27-24(18)30-16-6-4-15(5-7-16)14(2)32)20(13)31-25(33)19-11-34-22-21(19)28-12-29-23(22)26/h3-12H,1-2H3,(H,27,30)(H,31,33)(H2,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/an/an/a



HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...

US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM185589
PNG
(US9156852, 83 | USRE47451, Example 83)
Show SMILES CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C25H20N6O2S/c1-13-3-8-18-17(9-10-27-24(18)30-16-6-4-15(5-7-16)14(2)32)20(13)31-25(33)19-11-34-22-21(19)28-12-29-23(22)26/h3-12H,1-2H3,(H,27,30)(H,31,33)(H2,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
As such, the compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profili...

PubChem Bioassay (2006)


BindingDB Entry DOI: 10.7270/Q2XW4N61
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50555129
PNG
(CHEMBL4794765)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4ccnn4c3)cc2C(F)(F)F)CC1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-poly GAT as substrate measured after 1 hr by LANCE ULTRA kinase assay

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115876
BindingDB Entry DOI: 10.7270/Q2WW7NBN
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223094
PNG
(Methyl 3-(6-((5-((2-chloro-6-methylphenyl)carbamoy...)
Show SMILES COC(=O)N1CCC(C1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C22H23ClN6O3S/c1-12-5-4-6-15(23)19(12)28-20(30)17-10-24-21(33-17)27-18-9-16(25-13(2)26-18)14-7-8-29(11-14)22(31)32-3/h4-6,9-10,14H,7-8,11H2,1-3H3,(H,28,30)(H,24,25,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.23n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528533
PNG
(CHEMBL4558430)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 5.60n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50509522
PNG
(CHEMBL4467377)
Show SMILES COc1cncc(CNc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N3O2/c1-14-6-7-16(9-20(14)27-12-15-8-19(30-2)13-26-11-15)21(29)28-18-5-3-4-17(10-18)22(23,24)25/h3-11,13,27H,12H2,1-2H3,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.90n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of kinase tracer 178 binding to recombinant human His-tagged DDR1 expressed in baculovirus infected Sf9 cells incubated for 1 hr by TR-FRE...

ACS Med Chem Lett 11: 29-33 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00382
BindingDB Entry DOI: 10.7270/Q2NP27QG
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223083
PNG
(Isopropyl 4-(6-((5-((2-chloro-6-methylphenyl)carba...)
Show SMILES CC(C)OC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C24H28ClN7O3S/c1-14(2)35-24(34)32-10-8-31(9-11-32)20-12-19(27-16(4)28-20)29-23-26-13-18(36-23)22(33)30-21-15(3)6-5-7-17(21)25/h5-7,12-14H,8-11H2,1-4H3,(H,30,33)(H,26,27,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.99n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50430868
PNG
(CHEMBL2331602)
Show SMILES Cc1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C23H18N4O/c1-16-4-3-5-21(12-16)26-23(28)20-8-6-17(2)19(13-20)9-7-18-14-24-22-10-11-25-27(22)15-18/h3-6,8,10-15H,1-2H3,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...

J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50112618
PNG
(CHEMBL3608787)
Show SMILES C[C@H](NC(=O)Nc1ccccc1)c1ccc(C)c(NC(=O)c2cnc3ccccn23)c1 |r|
Show InChI InChI=1S/C24H23N5O2/c1-16-11-12-18(17(2)26-24(31)27-19-8-4-3-5-9-19)14-20(16)28-23(30)21-15-25-22-10-6-7-13-29(21)22/h3-15,17H,1-2H3,(H,28,30)(H2,26,27,31)/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Astex Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) after 1 hr by time resolved fluorescence method

ACS Med Chem Lett 6: 798-803 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00143
BindingDB Entry DOI: 10.7270/Q2SQ925G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50430857
PNG
(CHEMBL2336021)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H15F3N4O/c1-15-5-7-18(22(31)29-20-4-2-3-19(12-20)23(24,25)26)11-17(15)8-6-16-13-27-21-9-10-28-30(21)14-16/h2-5,7,9-14H,1H3,(H,29,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...

J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50368541
PNG
(CHEMBL4171640)
Show SMILES CCc1ccc(cc1C#Cc1cnc2ccccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C31H30F3N5O/c1-3-23-7-8-25(18-24(23)9-10-28-20-35-29-6-4-5-11-39(28)29)30(40)36-27-17-22(16-26(19-27)31(32,33)34)21-38-14-12-37(2)13-15-38/h4-8,11,16-20H,3,12-15,21H2,1-2H3,(H,36,40)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.20n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay

J Med Chem 61: 7977-7990 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50430850
PNG
(CHEMBL2336006)
Show SMILES Cc1cc(C)cc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C24H20N4O/c1-16-10-17(2)12-22(11-16)27-24(29)21-6-4-18(3)20(13-21)7-5-19-14-25-23-8-9-26-28(23)15-19/h4,6,8-15H,1-3H3,(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...

J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM77638
PNG
(US9695118, 161)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCC[C@H](N)C2)c(OC(F)(F)F)c1 |r|
Show InChI InChI=1S/C23H27ClF3N3O4S/c1-2-35(32,33)21-8-7-18(24)10-17(21)12-29-22(31)15-5-6-16(20(11-15)34-23(25,26)27)13-30-9-3-4-19(28)14-30/h5-8,10-11,19H,2-4,9,12-14,28H2,1H3,(H,29,31)/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6.5n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...

US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50260041
PNG
(CHEMBL4097012)
Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1 |r|
Show InChI InChI=1S/C29H33F3N6O/c1-20-16-38(26-14-33-19-34-15-26)18-23-12-22(4-5-27(20)23)28(39)35-25-11-21(10-24(13-25)29(30,31)32)17-37-7-3-6-36(2)8-9-37/h4-5,10-15,19-20H,3,6-9,16-18H2,1-2H3,(H,35,39)/t20-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.60n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged DDR1 catalytic domain expressed in baculovirus expression system using Fluorescein-Poly GAT as substrate m...

ACS Med Chem Lett 8: 327-332 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00497
BindingDB Entry DOI: 10.7270/Q2N0190M
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223084
PNG
(Allyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CC1)C(=O)OCC=C
Show InChI InChI=1S/C24H26ClN7O3S/c1-4-12-35-24(34)32-10-8-31(9-11-32)20-13-19(27-16(3)28-20)29-23-26-14-18(36-23)22(33)30-21-15(2)6-5-7-17(21)25/h4-7,13-14H,1,8-12H2,2-3H3,(H,30,33)(H,26,27,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.69n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50430847
PNG
(CHEMBL2336009)
Show SMILES CN1CCN(Cc2cc(C)cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4ccnn4c3)c2)CC1
Show InChI InChI=1S/C29H30N6O/c1-21-14-24(19-34-12-10-33(3)11-13-34)16-27(15-21)32-29(36)26-6-4-22(2)25(17-26)7-5-23-18-30-28-8-9-31-35(28)20-23/h4,6,8-9,14-18,20H,10-13,19H2,1-3H3,(H,32,36)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.70n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...

J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM88312
PNG
(US9695118, 200)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-3-36(34,35)22-7-6-17(25)9-16(22)12-31-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-4-5-18(13-32)30-2/h6-7,9-11,18,30H,3-5,8,12-14H2,1-2H3,(H,31,33)/t18-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6.70n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...

US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM223086
PNG
(Isobutyl 4-(6-((5-((2-chloro-6-methylphenyl)carbam...)
Show SMILES CC(C)COC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C25H30ClN7O3S/c1-15(2)14-36-25(35)33-10-8-32(9-11-33)21-12-20(28-17(4)29-21)30-24-27-13-19(37-24)23(34)31-22-16(3)6-5-7-18(22)26/h5-7,12-13,15H,8-11,14H2,1-4H3,(H,31,34)(H,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.75n/an/an/an/a7.525



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...

Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50430839
PNG
(CHEMBL2336015)
Show SMILES CCc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O/c1-3-23-6-7-25(16-24(23)5-4-21-18-34-28-8-9-35-39(28)20-21)29(40)36-27-15-22(14-26(17-27)30(31,32)33)19-38-12-10-37(2)11-13-38/h6-9,14-18,20H,3,10-13,19H2,1-2H3,(H,36,40)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.80n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged DDR1 catalytic domain (440 to 876 residues) expressed in baculovirus expression system using Fluorescein-p...

ACS Med Chem Lett 11: 379-384 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00495
BindingDB Entry DOI: 10.7270/Q29P350H
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50430839
PNG
(CHEMBL2336015)
Show SMILES CCc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O/c1-3-23-6-7-25(16-24(23)5-4-21-18-34-28-8-9-35-39(28)20-21)29(40)36-27-15-22(14-26(17-27)30(31,32)33)19-38-12-10-37(2)11-13-38/h6-9,14-18,20H,3,10-13,19H2,1-2H3,(H,36,40)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...

J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1682 total )  |  Next  |  Last  >>
Jump to: