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Compile Data Set for Download or QSAR

Found 677 hits of ec50 for UniProtKB: P29275   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50368543
PNG
(CHEMBL605668)
Show SMILES Cc1ccc(CCOc2nc(N)c3ncn(C4O[C@@H](CO)[C@H](O)[C@@H]4O)c3n2)cc1 |r|
Show InChI InChI=1S/C19H23N5O5/c1-10-2-4-11(5-3-10)6-7-28-19-22-16(20)13-17(23-19)24(9-21-13)18-15(27)14(26)12(8-25)29-18/h2-5,9,12,14-15,18,25-27H,6-8H2,1H3,(H2,20,22,23)/t12-,14-,15-,18?/m0/s1
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n/an/an/an/a 0.191n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50230152
PNG
(Binodenoson | Corvue | MRE0470 | WRC-0470)
Show SMILES Nc1nc(N\N=C\C2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C17H25N7O4/c18-14-11-15(22-17(21-14)23-20-6-9-4-2-1-3-5-9)24(8-19-11)16-13(27)12(26)10(7-25)28-16/h6,8-10,12-13,16,25-27H,1-5,7H2,(H3,18,21,22,23)/b20-6+/t10-,12-,13-,16-/m1/s1
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n/an/an/an/a 0.257n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421975
PNG
(CHEMBL611607)
Show SMILES Nc1nc(N=NCC2CCC=CC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O |r,w:5.5,c:10|
Show InChI InChI=1S/C17H23N7O4/c18-14-11-15(22-17(21-14)23-20-6-9-4-2-1-3-5-9)24(8-19-11)16-13(27)12(26)10(7-25)28-16/h1-2,8-10,12-13,16,25-27H,3-7H2,(H2,18,21,22)/t9?,10-,12-,13-,16?/m1/s1
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n/an/an/an/a 0.324n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM50594320
PNG
(CHEMBL5177040)
Show SMILES Nc1sc(c(c1C(=O)c1ccccc1)-c1cccc(c1)C(F)(F)F)-c1ccc(cc1)-c1cn(CCCCCCNc2ncnc3n(cnc23)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)nn1 |r|
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n/an/an/an/a 0.324n/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00320
BindingDB Entry DOI: 10.7270/Q2JQ151Q
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM50594320
PNG
(CHEMBL5177040)
Show SMILES Nc1sc(c(c1C(=O)c1ccccc1)-c1cccc(c1)C(F)(F)F)-c1ccc(cc1)-c1cn(CCCCCCNc2ncnc3n(cnc23)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)nn1 |r|
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n/an/an/an/a 0.380n/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00320
BindingDB Entry DOI: 10.7270/Q2JQ151Q
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421890
PNG
(CHEMBL2311197)
Show SMILES Nc1nc(OCCc2ccc(Cl)cc2)nc2n(cnc12)[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C18H20ClN5O5/c19-10-3-1-9(2-4-10)5-6-28-18-22-15(20)12-16(23-18)24(8-21-12)17-14(27)13(26)11(7-25)29-17/h1-4,8,11,13-14,17,25-27H,5-7H2,(H2,20,22,23)/t11-,13-,14-,17-/m0/s1
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n/an/an/an/a 0.389n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421980
PNG
(CHEMBL2113592)
Show SMILES CC(C)CCN=Nc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r,w:5.4|
Show InChI InChI=1S/C15H23N7O4/c1-7(2)3-4-18-21-15-19-12(16)9-13(20-15)22(6-17-9)14-11(25)10(24)8(5-23)26-14/h6-8,10-11,14,23-25H,3-5H2,1-2H3,(H2,16,19,20)/t8-,10-,11-,14-/m1/s1
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n/an/an/an/a 0.468n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406504
PNG
(CHEMBL605878)
Show SMILES Nc1nc(OCCc2ccc3ccccc3c2)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C22H23N5O5/c23-19-16-20(27(11-24-16)21-18(30)17(29)15(10-28)32-21)26-22(25-19)31-8-7-12-5-6-13-3-1-2-4-14(13)9-12/h1-6,9,11,15,17-18,21,28-30H,7-8,10H2,(H2,23,25,26)/t15-,17-,18-,21?/m0/s1
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n/an/an/an/a 0.501n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421982
PNG
(CHEMBL608663)
Show SMILES Nc1nc(N=NCCC2CCCCC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O |r,w:5.5|
Show InChI InChI=1S/C18H27N7O4/c19-15-12-16(25(9-20-12)17-14(28)13(27)11(8-26)29-17)23-18(22-15)24-21-7-6-10-4-2-1-3-5-10/h9-11,13-14,17,26-28H,1-8H2,(H2,19,22,23)/t11-,13-,14-,17?/m1/s1
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n/an/an/an/a 0.692n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406519
PNG
(CHEMBL606080)
Show SMILES Nc1nc(OCCc2ccc(F)cc2)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C18H20FN5O5/c19-10-3-1-9(2-4-10)5-6-28-18-22-15(20)12-16(23-18)24(8-21-12)17-14(27)13(26)11(7-25)29-17/h1-4,8,11,13-14,17,25-27H,5-7H2,(H2,20,22,23)/t11-,13-,14-,17?/m0/s1
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n/an/an/an/a 0.871n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421985
PNG
(CHEMBL611916)
Show SMILES CCCCCN=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r,w:5.4|
Show InChI InChI=1S/C15H23N7O4/c1-2-3-4-5-18-21-15-19-12(16)9-13(20-15)22(7-17-9)14-11(25)10(24)8(6-23)26-14/h7-8,10-11,14,23-25H,2-6H2,1H3,(H2,16,19,20)/t8-,10-,11-,14?/m1/s1
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n/an/an/an/a 1n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406499
PNG
(CHEMBL605463)
Show SMILES COc1ccc(CCOc2nc(N)c3ncn(C4O[C@@H](CO)[C@H](O)[C@@H]4O)c3n2)cc1 |r|
Show InChI InChI=1S/C19H23N5O6/c1-28-11-4-2-10(3-5-11)6-7-29-19-22-16(20)13-17(23-19)24(9-21-13)18-15(27)14(26)12(8-25)30-18/h2-5,9,12,14-15,18,25-27H,6-8H2,1H3,(H2,20,22,23)/t12-,14-,15-,18?/m0/s1
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n/an/an/an/a 1.40n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406511
PNG
(CHEMBL604836)
Show SMILES Cc1cccc(CCOc2nc(N)c3ncn(C4O[C@@H](CO)[C@H](O)[C@@H]4O)c3n2)c1 |r|
Show InChI InChI=1S/C19H23N5O5/c1-10-3-2-4-11(7-10)5-6-28-19-22-16(20)13-17(23-19)24(9-21-13)18-15(27)14(26)12(8-25)29-18/h2-4,7,9,12,14-15,18,25-27H,5-6,8H2,1H3,(H2,20,22,23)/t12-,14-,15-,18?/m0/s1
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n/an/an/an/a 1.60n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421983
PNG
(CHEMBL608966)
Show SMILES Nc1nc(N=NCCCC2CCCCC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O |r,w:5.5|
Show InChI InChI=1S/C19H29N7O4/c20-16-13-17(26(10-21-13)18-15(29)14(28)12(9-27)30-18)24-19(23-16)25-22-8-4-7-11-5-2-1-3-6-11/h10-12,14-15,18,27-29H,1-9H2,(H2,20,23,24)/t12-,14-,15-,18?/m1/s1
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n/an/an/an/a 1.80n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50009509
PNG
((CGS 22,492) 2-[6-Amino-2-(2-cyclohexyl-ethylamino...)
Show SMILES Nc1nc(NCCC2CCCCC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H28N6O4/c19-15-12-16(23-18(22-15)20-7-6-10-4-2-1-3-5-10)24(9-21-12)17-14(27)13(26)11(8-25)28-17/h9-11,13-14,17,25-27H,1-8H2,(H3,19,20,22,23)/t11-,13-,14-,17?/m1/s1
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n/an/an/an/a 1.90n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406503
PNG
(CHEMBL606081)
Show SMILES Nc1nc(OCCc2cccc(F)c2)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C18H20FN5O5/c19-10-3-1-2-9(6-10)4-5-28-18-22-15(20)12-16(23-18)24(8-21-12)17-14(27)13(26)11(7-25)29-17/h1-3,6,8,11,13-14,17,25-27H,4-5,7H2,(H2,20,22,23)/t11-,13-,14-,17?/m0/s1
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n/an/an/an/a 1.90n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421972
PNG
(CHEMBL611921)
Show SMILES CCCC(C)N=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r,w:5.4|
Show InChI InChI=1S/C15H23N7O4/c1-3-4-7(2)20-21-15-18-12(16)9-13(19-15)22(6-17-9)14-11(25)10(24)8(5-23)26-14/h6-8,10-11,14,23-25H,3-5H2,1-2H3,(H2,16,18,19)/t7?,8-,10-,11-,14?/m1/s1
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n/an/an/an/a 2n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50009535
PNG
((CGS 22,989) 2-[6-Amino-2-(2-cyclohex-1-enyl-ethyl...)
Show SMILES Nc1nc(NCCC2=CCCCC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O |t:7|
Show InChI InChI=1S/C18H26N6O4/c19-15-12-16(23-18(22-15)20-7-6-10-4-2-1-3-5-10)24(9-21-12)17-14(27)13(26)11(8-25)28-17/h4,9,11,13-14,17,25-27H,1-3,5-8H2,(H3,19,20,22,23)/t11-,13-,14-,17?/m1/s1
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n/an/an/an/a 2.20n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM50385957
PNG
(CHEMBL2042297)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(F)nc12 |r|
Show InChI InChI=1S/C12H15FN6O4/c1-2-15-10(22)7-5(20)6(21)11(23-7)19-3-16-4-8(14)17-12(13)18-9(4)19/h3,5-7,11,20-21H,2H2,1H3,(H,15,22)(H2,14,17,18)/t5-,6+,7-,11+/m0/s1
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n/an/an/an/a 2.30n/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins

J Med Chem 55: 3521-34 (2012)


Article DOI: 10.1021/jm300206u
BindingDB Entry DOI: 10.7270/Q2FT8N35
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406510
PNG
(CHEMBL605876)
Show SMILES Nc1nc(OCCc2ccccc2F)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C18H20FN5O5/c19-10-4-2-1-3-9(10)5-6-28-18-22-15(20)12-16(23-18)24(8-21-12)17-14(27)13(26)11(7-25)29-17/h1-4,8,11,13-14,17,25-27H,5-7H2,(H2,20,22,23)/t11-,13-,14-,17?/m0/s1
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n/an/an/an/a 2.60n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406518
PNG
(CHEMBL604422)
Show SMILES COc1cccc(CCOc2nc(N)c3ncn(C4O[C@@H](CO)[C@H](O)[C@@H]4O)c3n2)c1 |r|
Show InChI InChI=1S/C19H23N5O6/c1-28-11-4-2-3-10(7-11)5-6-29-19-22-16(20)13-17(23-19)24(9-21-13)18-15(27)14(26)12(8-25)30-18/h2-4,7,9,12,14-15,18,25-27H,5-6,8H2,1H3,(H2,20,22,23)/t12-,14-,15-,18?/m0/s1
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n/an/an/an/a 2.60n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406501
PNG
(CHEMBL606092)
Show SMILES Nc1nc(OCCc2ccccc2)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C18H21N5O5/c19-15-12-16(22-18(21-15)27-7-6-10-4-2-1-3-5-10)23(9-20-12)17-14(26)13(25)11(8-24)28-17/h1-5,9,11,13-14,17,24-26H,6-8H2,(H2,19,21,22)/t11-,13-,14-,17?/m0/s1
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n/an/an/an/a 2.80n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421979
PNG
(CHEMBL607585)
Show SMILES CCCCN=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r,w:4.3|
Show InChI InChI=1S/C14H21N7O4/c1-2-3-4-17-20-14-18-11(15)8-12(19-14)21(6-16-8)13-10(24)9(23)7(5-22)25-13/h6-7,9-10,13,22-24H,2-5H2,1H3,(H2,15,18,19)/t7-,9-,10-,13?/m1/s1
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n/an/an/an/a 2.90n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406514
PNG
(CHEMBL605873)
Show SMILES Nc1nc(OCCc2cccc(Cl)c2)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C18H20ClN5O5/c19-10-3-1-2-9(6-10)4-5-28-18-22-15(20)12-16(23-18)24(8-21-12)17-14(27)13(26)11(7-25)29-17/h1-3,6,8,11,13-14,17,25-27H,4-5,7H2,(H2,20,22,23)/t11-,13-,14-,17?/m0/s1
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n/an/an/an/a 3n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421986
PNG
(CHEMBL610443)
Show SMILES Nc1nc(N=NCC2=CC3CCC2C3)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O |r,w:5.5,t:7,TLB:6:7:13:11.10|
Show InChI InChI=1S/C18H23N7O4/c19-15-12-16(25(7-20-12)17-14(28)13(27)11(6-26)29-17)23-18(22-15)24-21-5-10-4-8-1-2-9(10)3-8/h4,7-9,11,13-14,17,26-28H,1-3,5-6H2,(H2,19,22,23)/t8?,9?,11-,13-,14-,17?/m1/s1
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n/an/an/an/a 3.30n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406521
PNG
(CHEMBL605461)
Show SMILES Nc1nc(OCCc2ccsc2)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C16H19N5O5S/c17-13-10-14(20-16(19-13)25-3-1-8-2-4-27-6-8)21(7-18-10)15-12(24)11(23)9(5-22)26-15/h2,4,6-7,9,11-12,15,22-24H,1,3,5H2,(H2,17,19,20)/t9-,11-,12-,15?/m0/s1
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n/an/an/an/a 3.40n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421976
PNG
(CHEMBL607796)
Show SMILES Nc1nc(N=NCC2=CCCCC2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O |r,w:5.5,t:7|
Show InChI InChI=1S/C17H23N7O4/c18-14-11-15(22-17(21-14)23-20-6-9-4-2-1-3-5-9)24(8-19-11)16-13(27)12(26)10(7-25)28-16/h4,8,10,12-13,16,25-27H,1-3,5-7H2,(H2,18,21,22)/t10-,12-,13-,16?/m1/s1
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n/an/an/an/a 3.5n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406509
PNG
(CHEMBL605667)
Show SMILES Nc1nc(OCCc2cccs2)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C16H19N5O5S/c17-13-10-14(20-16(19-13)25-4-3-8-2-1-5-27-8)21(7-18-10)15-12(24)11(23)9(6-22)26-15/h1-2,5,7,9,11-12,15,22-24H,3-4,6H2,(H2,17,19,20)/t9-,11-,12-,15?/m0/s1
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n/an/an/an/a 3.70n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406506
PNG
(CHEMBL606305)
Show SMILES Cc1ccccc1CCOc1nc(N)c2ncn(C3O[C@@H](CO)[C@H](O)[C@@H]3O)c2n1 |r|
Show InChI InChI=1S/C19H23N5O5/c1-10-4-2-3-5-11(10)6-7-28-19-22-16(20)13-17(23-19)24(9-21-13)18-15(27)14(26)12(8-25)29-18/h2-5,9,12,14-15,18,25-27H,6-8H2,1H3,(H2,20,22,23)/t12-,14-,15-,18?/m0/s1
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n/an/an/an/a 3.80n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM191805
PNG
(US9187428, 33)
Show SMILES NC(=O)c1cccc(CSc2nc(N)c(C#N)c(-c3ccccc3)c2C#N)c1
Show InChI InChI=1S/C21H15N5OS/c22-10-16-18(14-6-2-1-3-7-14)17(11-23)21(26-19(16)24)28-12-13-5-4-8-15(9-13)20(25)27/h1-9H,12H2,(H2,24,26)(H2,25,27)
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n/an/an/an/a 3.90n/an/a7.437



Bayer Intellectual Property GmbH

US Patent


Assay Description
The following test protocol is used for pharmacologically characterizing cells and for the robot-assisted substance screening:The stock cultures ar...

US Patent US9187428 (2015)


BindingDB Entry DOI: 10.7270/Q29Z93Q4
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM50263201
PNG
(CHEMBL4104819)
Show SMILES Nc1sc(c(c1C(=O)c1ccccc1)-c1cccc(c1)C(F)(F)F)-c1ccc(cc1)C(=O)NCCCCCCNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C41H40F3N7O6S/c42-41(43,44)27-12-8-11-26(19-27)29-30(32(53)23-9-4-3-5-10-23)36(45)58-35(29)24-13-15-25(16-14-24)39(56)47-18-7-2-1-6-17-46-37-31-38(49-21-48-37)51(22-50-31)40-34(55)33(54)28(20-52)57-40/h3-5,8-16,19,21-22,28,33-34,40,52,54-55H,1-2,6-7,17-18,20,45H2,(H,47,56)(H,46,48,49)/t28-,33-,34-,40-/m1/s1
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n/an/an/an/a 4.60n/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00320
BindingDB Entry DOI: 10.7270/Q2JQ151Q
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM21220
PNG
((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
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n/an/an/an/a 4.80n/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00320
BindingDB Entry DOI: 10.7270/Q2JQ151Q
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406508
PNG
(CHEMBL605465)
Show SMILES COc1ccc(CCOc2nc(N)c3ncn(C4O[C@@H](CO)[C@H](O)[C@@H]4O)c3n2)cc1OC |r|
Show InChI InChI=1S/C20H25N5O7/c1-29-11-4-3-10(7-12(11)30-2)5-6-31-20-23-17(21)14-18(24-20)25(9-22-14)19-16(28)15(27)13(8-26)32-19/h3-4,7,9,13,15-16,19,26-28H,5-6,8H2,1-2H3,(H2,21,23,24)/t13-,15-,16-,19?/m0/s1
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n/an/an/an/a 4.90n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the Adenosine A2 receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406507
PNG
(CHEMBL604837)
Show SMILES Nc1nc(OCCc2cccc3ccccc23)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C22H23N5O5/c23-19-16-20(27(11-24-16)21-18(30)17(29)15(10-28)32-21)26-22(25-19)31-9-8-13-6-3-5-12-4-1-2-7-14(12)13/h1-7,11,15,17-18,21,28-30H,8-10H2,(H2,23,25,26)/t15-,17-,18-,21?/m0/s1
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n/an/an/an/a 5n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406512
PNG
(CHEMBL603587)
Show SMILES Nc1nc(OCCc2ccccc2Cl)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C18H20ClN5O5/c19-10-4-2-1-3-9(10)5-6-28-18-22-15(20)12-16(23-18)24(8-21-12)17-14(27)13(26)11(7-25)29-17/h1-4,8,11,13-14,17,25-27H,5-7H2,(H2,20,22,23)/t11-,13-,14-,17?/m0/s1
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n/an/an/an/a 5.5n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421978
PNG
(CHEMBL611314)
Show SMILES CCC(CC)CN=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r,w:6.5|
Show InChI InChI=1S/C16H25N7O4/c1-3-8(4-2)5-19-22-16-20-13(17)10-14(21-16)23(7-18-10)15-12(26)11(25)9(6-24)27-15/h7-9,11-12,15,24-26H,3-6H2,1-2H3,(H2,17,20,21)/t9-,11-,12-,15?/m1/s1
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n/an/an/an/a 5.80n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406502
PNG
(CHEMBL604212)
Show SMILES Nc1nc(OCCCCCc2ccccc2)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C21H27N5O5/c22-18-15-19(26(12-23-15)20-17(29)16(28)14(11-27)31-20)25-21(24-18)30-10-6-2-5-9-13-7-3-1-4-8-13/h1,3-4,7-8,12,14,16-17,20,27-29H,2,5-6,9-11H2,(H2,22,24,25)/t14-,16-,17-,20?/m0/s1
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n/an/an/an/a 6.30n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM50594312
PNG
(CHEMBL5203917)
Show SMILES Nc1sc(c(c1C(=O)c1ccccc1)-c1cccc(c1)C(F)(F)F)-c1ccc(cc1)C(=O)NCCCc1ccc(Nc2ncnc3n(cnc23)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1 |r|
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n/an/an/an/a 6.30n/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00320
BindingDB Entry DOI: 10.7270/Q2JQ151Q
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM50205591
PNG
((2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-(6-(4-(2-oxo...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(Nc3ccc(OCC(=O)Nc4ccccc4)cc3)ncnc12
Show InChI InChI=1S/C26H27N7O6/c1-2-27-25(37)22-20(35)21(36)26(39-22)33-14-30-19-23(28-13-29-24(19)33)32-16-8-10-17(11-9-16)38-12-18(34)31-15-6-4-3-5-7-15/h3-11,13-14,20-22,26,35-36H,2,12H2,1H3,(H,27,37)(H,31,34)(H,28,29,32)/t20-,21+,22-,26+/m0/s1
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n/an/an/an/a 7.30n/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production

Bioorg Med Chem 15: 2514-27 (2007)


Article DOI: 10.1016/j.bmc.2007.01.055
BindingDB Entry DOI: 10.7270/Q2R78G14
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421984
PNG
(CHEMBL607599)
Show SMILES CC(C)CN=Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r,w:4.3|
Show InChI InChI=1S/C14H21N7O4/c1-6(2)3-17-20-14-18-11(15)8-12(19-14)21(5-16-8)13-10(24)9(23)7(4-22)25-13/h5-7,9-10,13,22-24H,3-4H2,1-2H3,(H2,15,18,19)/t7-,9-,10-,13?/m1/s1
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n/an/an/an/a 7.40n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50421971
PNG
(CHEMBL611917)
Show SMILES CC1(C)C2CC1C(CN=Nc1nc(N)c3ncn(C4O[C@H](CO)[C@@H](O)[C@H]4O)c3n1)=CC2 |r,w:8.8,c:32|
Show InChI InChI=1S/C20H27N7O4/c1-20(2)10-4-3-9(11(20)5-10)6-23-26-19-24-16(21)13-17(25-19)27(8-22-13)18-15(30)14(29)12(7-28)31-18/h3,8,10-12,14-15,18,28-30H,4-7H2,1-2H3,(H2,21,24,25)/t10?,11?,12-,14-,15-,18?/m1/s1
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n/an/an/an/a 7.40n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
In vitro effect on coronary vasodilation in guinea pig heart.

J Med Chem 35: 4557-61 (1993)


BindingDB Entry DOI: 10.7270/Q21Z43BT
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM50150076
PNG
(2-((1H-imidazol-2-yl)methylthio)-6-amino-4-(4-meth...)
Show SMILES COc1ccc(cc1)-c1c(C#N)c(N)nc(SCc2ncc[nH]2)c1C#N
Show InChI InChI=1S/C18H14N6OS/c1-25-12-4-2-11(3-5-12)16-13(8-19)17(21)24-18(14(16)9-20)26-10-15-22-6-7-23-15/h2-7H,10H2,1H3,(H2,21,24)(H,22,23)
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n/an/an/an/a 9n/an/an/an/a



University of Leiden

Curated by ChEMBL


Assay Description
Agonistic activity against human adenosine A2B receptor expressed in CHO cells

J Med Chem 47: 3707-9 (2004)


Article DOI: 10.1021/jm049947s
BindingDB Entry DOI: 10.7270/Q2833SS3
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM50458354
PNG
(CHEMBL4216880)
Show SMILES Nc1nc(SCc2ncc[nH]2)c(C#N)c(-c2ccc(OCC3CC3)cc2)c1C#N
Show InChI InChI=1S/C21H18N6OS/c22-9-16-19(14-3-5-15(6-4-14)28-11-13-1-2-13)17(10-23)21(27-20(16)24)29-12-18-25-7-8-26-18/h3-8,13H,1-2,11-12H2,(H2,24,27)(H,25,26)
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n/an/an/an/a 9.5n/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay

Eur J Med Chem 150: 127-139 (2018)


Article DOI: 10.1016/j.ejmech.2018.02.081
BindingDB Entry DOI: 10.7270/Q2NS0XHB
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406505
PNG
(CHEMBL605257)
Show SMILES Nc1nc(OCCCCc2ccccc2)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C20H25N5O5/c21-17-14-18(25(11-22-14)19-16(28)15(27)13(10-26)30-19)24-20(23-17)29-9-5-4-8-12-6-2-1-3-7-12/h1-3,6-7,11,13,15-16,19,26-28H,4-5,8-10H2,(H2,21,23,24)/t13-,15-,16-,19?/m0/s1
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n/an/an/an/a 9.5n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2a/A2b


(Homo sapiens (Human))		BDBM50406520
PNG
(CHEMBL605256)
Show SMILES Nc1nc(OCCc2c[nH]c3ccccc23)nc2n(cnc12)C1O[C@@H](CO)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C20H22N6O5/c21-17-14-18(26(9-23-14)19-16(29)15(28)13(8-27)31-19)25-20(24-17)30-6-5-10-7-22-12-4-2-1-3-11(10)12/h1-4,7,9,13,15-16,19,22,27-29H,5-6,8H2,(H2,21,24,25)/t13-,15-,16-,19?/m0/s1
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n/an/an/an/a 9.80n/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation

J Med Chem 34: 1340-4 (1991)


BindingDB Entry DOI: 10.7270/Q24T6KJM
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM561409
PNG
(3-(4-amino-2-((6-methylpyridin-2-yl)methyl)-7-(pyr...)
Show SMILES Cc1cccc(Cn2nc3c(N)nc(-c4cccc(c4)C#N)c(-c4ccncn4)c3n2)n1
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n/an/an/an/a<10n/an/an/an/a


TBA

Assay Description
Stably transfected HEK-293 cells expressing the human adenosine A2B receptor (Perkin Elmer) were maintained in MEM culture medium with 10% FBS and 10...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2MK6H4B
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM561410
PNG
(3-(4-amino-2-((6-methylpyridin-2-yl)methyl)-7-(pyr...)
Show SMILES Cc1cccc(Cn2nc3c(N)nc(-c4cccc(c4)C#N)c(-c4ccncc4)c3n2)n1
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n/an/an/an/a<10n/an/an/an/a


TBA

Assay Description
Stably transfected HEK-293 cells expressing the human adenosine A2B receptor (Perkin Elmer) were maintained in MEM culture medium with 10% FBS and 10...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2MK6H4B
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM561411
PNG
(3-(4-amino-2-((6-methylpyridin-2-yl)methyl)-7-(3-m...)
Show SMILES Cc1cccc(Cn2nc3c(N)nc(-c4cccc(c4)C#N)c(-c4ccncc4C)c3n2)n1 |(8.93,1.13,;7.39,1.13,;6.62,2.46,;5.08,2.46,;4.31,1.13,;5.08,-.21,;4.31,-1.54,;2.77,-1.54,;1.87,-2.79,;.4,-2.31,;-.93,-3.08,;-.93,-4.62,;-2.26,-2.31,;-2.26,-.77,;-3.6,,;-3.6,1.54,;-4.93,2.31,;-6.27,1.54,;-6.27,,;-4.93,-.77,;-7.6,-.77,;-8.93,-1.54,;-.93,,;-.93,1.54,;-2.26,2.31,;-2.26,3.85,;-.93,4.62,;.4,3.85,;.4,2.31,;1.74,1.54,;.4,-.77,;1.87,-.29,;6.62,-.21,)|
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n/an/an/an/a<10n/an/an/an/a


TBA

Assay Description
Stably transfected HEK-293 cells expressing the human adenosine A2B receptor (Perkin Elmer) were maintained in MEM culture medium with 10% FBS and 10...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2MK6H4B
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM561413
PNG
(3-(4-amino-7-(1-ethyl-1H-pyrazol-5-yl)-2-((6-methy...)
Show SMILES CCn1nccc1-c1c(nc(N)c2nn(Cc3cccc(C)n3)nc12)-c1cccc(c1)C#N |(2.87,3.41,;1.78,2.32,;.32,2.8,;-.16,4.26,;-1.7,4.26,;-2.18,2.8,;-.93,1.9,;-.93,.36,;-2.26,-.41,;-2.26,-1.95,;-.93,-2.72,;-.93,-4.26,;.4,-1.95,;1.87,-2.43,;2.77,-1.18,;4.31,-1.18,;5.08,.15,;4.31,1.48,;5.08,2.82,;6.62,2.82,;7.39,1.48,;8.93,1.48,;6.62,.15,;1.87,.06,;.4,-.41,;-3.6,.36,;-3.6,1.9,;-4.93,2.67,;-6.27,1.9,;-6.27,.36,;-4.93,-.41,;-7.6,-.41,;-8.93,-1.18,)|
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n/an/an/an/a<10n/an/an/an/a


TBA

Assay Description
Stably transfected HEK-293 cells expressing the human adenosine A2B receptor (Perkin Elmer) were maintained in MEM culture medium with 10% FBS and 10...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2MK6H4B
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))		BDBM561414
PNG
(3-(4-amino-7-(4-methyloxazol-5-yl)-2-((6-methylpyr...)
Show SMILES Cc1ncoc1-c1c(nc(N)c2nn(Cc3cccc(C)n3)nc12)-c1cccc(c1)C#N |(1.78,2.32,;.32,2.8,;-.16,4.26,;-1.7,4.26,;-2.18,2.8,;-.93,1.9,;-.93,.36,;-2.26,-.41,;-2.26,-1.95,;-.93,-2.72,;-.93,-4.26,;.4,-1.95,;1.87,-2.43,;2.77,-1.18,;4.31,-1.18,;5.08,.15,;4.31,1.48,;5.08,2.82,;6.62,2.82,;7.39,1.48,;8.93,1.48,;6.62,.15,;1.87,.06,;.4,-.41,;-3.6,.36,;-3.6,1.9,;-4.93,2.67,;-6.27,1.9,;-6.27,.36,;-4.93,-.41,;-7.6,-.41,;-8.93,-1.18,)|
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n/an/an/an/a<10n/an/an/an/a


TBA

Assay Description
Stably transfected HEK-293 cells expressing the human adenosine A2B receptor (Perkin Elmer) were maintained in MEM culture medium with 10% FBS and 10...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2MK6H4B
More data for this
Ligand-Target Pair
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