Compile Data Set for Download or QSAR

Found 109 hits of ic50 data for polymerid = 4386,50007083   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50244721 (CHEMBL4100398) Show SMILES CN1c2ccc(cc2OC[C@H](N2CCc3c(Cl)n(Cc4ccccc4)nc3C2=O)C1=O)C#N |r| Show InChI InChI=1S/C24H20ClN5O3/c1-28-18-8-7-16(12-26)11-20(18)33-14-19(23(28)31)29-10-9-17-21(24(29)32)27-30(22(17)25)13-15-5-3-2-4-6-15/h2-8,11,19H,9-10,13-14H2,1H3/t19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929 cells assessed as decrease in TNFalpha/zVAD-FMK-induced MLKL phosphorylation at S358 residue preincubated for 30 mi...				J Med Chem 61: 2384-2409 (2018) Article DOI: 10.1021/acs.jmedchem.7b01647 BindingDB Entry DOI: 10.7270/Q2V98BGX
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50512997 (CHEMBL4545939) Show SMILES Cc1nnc(o1)N1CCC(CC1)C(=O)N1N=CC[C@H]1c1cc(F)cc(F)c1 |r,c:17| Show InChI InChI=1S/C18H19F2N5O2/c1-11-22-23-18(27-11)24-6-3-12(4-7-24)17(26)25-16(2-5-21-25)13-8-14(19)10-15(20)9-13/h5,8-10,12,16H,2-4,6-7H2,1H3/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of RIP1 in mouse L929 cells assessed as reduction in TNF/zVAD.fmk-induced necrotic death measured after 24 hrs by cell titer-glo luminesce...				J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318 BindingDB Entry DOI: 10.7270/Q24J0JFT
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50507336 (CHEMBL4514271) Show SMILES Fc1cc(F)cc(c1)[C@@H]1CC=NN1C(=O)C1CCN(CC1)c1cc(ncn1)C#N |r,c:11| Show InChI InChI=1S/C20H18F2N6O/c21-15-7-14(8-16(22)9-15)18-1-4-26-28(18)20(29)13-2-5-27(6-3-13)19-10-17(11-23)24-12-25-19/h4,7-10,12-13,18H,1-3,5-6H2/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of RIP1 in mouse L929 cells assessed as reduction in TNF/zVAD.fmk-induced necrotic death measured after 24 hrs by cell titer-glo luminesce...				J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318 BindingDB Entry DOI: 10.7270/Q24J0JFT
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50446278 (CHEMBL3109202) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cccc3c(N)nccc23)no1 Show InChI InChI=1S/C23H23N5O2/c1-23(2,3)19-13-20(28-30-19)27-22(29)26-15-9-7-14(8-10-15)16-5-4-6-18-17(16)11-12-25-21(18)24/h4-13H,1-3H3,(H2,24,25)(H2,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to mouse RIP1 (1 to 378 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assay				J Med Chem 59: 2163-78 (2016) Article DOI: 10.1021/acs.jmedchem.5b01898 BindingDB Entry DOI: 10.7270/Q26H4K97
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50446278 (CHEMBL3109202) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cccc3c(N)nccc23)no1 Show InChI InChI=1S/C23H23N5O2/c1-23(2,3)19-13-20(28-30-19)27-22(29)26-15-9-7-14(8-10-15)16-5-4-6-18-17(16)11-12-25-21(18)24/h4-13H,1-3H3,(H2,24,25)(H2,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of mouse WT RIP1 transfected in HEK293T cells assessed as reduction in S166 phosphorylation by ELISA				J Med Chem 59: 2163-78 (2016) Article DOI: 10.1021/acs.jmedchem.5b01898 BindingDB Entry DOI: 10.7270/Q26H4K97
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM423400 (US10501473, Example 39) Show SMILES Fc1ccc(cc1)-c1cccc2sc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C19H16FNO2S/c20-14-6-4-13(5-7-14)15-2-1-3-17-16(15)12-18(24-17)19(22)21-8-10-23-11-9-21/h1-7,12H,8-11H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse RGC-5 cells incubated for 30 mins in presence of [gamma32-ATP] by SDS-PAGE based radiometric assay				J Med Chem 63: 1490-1510 (2020) Article DOI: 10.1021/acs.jmedchem.9b01317 BindingDB Entry DOI: 10.7270/Q20K2CZB
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM423400 (US10501473, Example 39) Show SMILES Fc1ccc(cc1)-c1cccc2sc(cc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C19H16FNO2S/c20-14-6-4-13(5-7-14)15-2-1-3-17-16(15)12-18(24-17)19(22)21-8-10-23-11-9-21/h1-7,12H,8-11H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01518 BindingDB Entry DOI: 10.7270/Q2QC07MW
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263072 (CHEMBL4080426) Show SMILES Cc1cc(Nc2cc(nc(Sc3ccc(NC(=O)C4CCCCC4)cc3)n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C25H31N7O2S/c1-17-15-22(31-30-17)27-21-16-23(32-11-13-34-14-12-32)29-25(28-21)35-20-9-7-19(8-10-20)26-24(33)18-5-3-2-4-6-18/h7-10,15-16,18H,2-6,11-14H2,1H3,(H,26,33)(H2,27,28,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263072 (CHEMBL4080426) Show SMILES Cc1cc(Nc2cc(nc(Sc3ccc(NC(=O)C4CCCCC4)cc3)n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C25H31N7O2S/c1-17-15-22(31-30-17)27-21-16-23(32-11-13-34-14-12-32)29-25(28-21)35-20-9-7-19(8-10-20)26-24(33)18-5-3-2-4-6-18/h7-10,15-16,18H,2-6,11-14H2,1H3,(H,26,33)(H2,27,28,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263078 (CHEMBL4069988) Show SMILES Cc1cc(Nc2cc(nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C22H25N7O2S/c1-14-12-19(28-27-14)24-18-13-20(29-8-10-31-11-9-29)26-22(25-18)32-17-6-4-16(5-7-17)23-21(30)15-2-3-15/h4-7,12-13,15H,2-3,8-11H2,1H3,(H,23,30)(H2,24,25,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263058 (CHEMBL4090723) Show SMILES Cc1cc(Nc2cc(nc(Nc3ccc(NC(=O)C4CC4)cc3)n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C22H26N8O2/c1-14-12-19(29-28-14)25-18-13-20(30-8-10-32-11-9-30)27-22(26-18)24-17-6-4-16(5-7-17)23-21(31)15-2-3-15/h4-7,12-13,15H,2-3,8-11H2,1H3,(H,23,31)(H3,24,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263058 (CHEMBL4090723) Show SMILES Cc1cc(Nc2cc(nc(Nc3ccc(NC(=O)C4CC4)cc3)n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C22H26N8O2/c1-14-12-19(29-28-14)25-18-13-20(30-8-10-32-11-9-30)27-22(26-18)24-17-6-4-16(5-7-17)23-21(31)15-2-3-15/h4-7,12-13,15H,2-3,8-11H2,1H3,(H,23,31)(H3,24,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263046 (CHEMBL4069729) Show SMILES Cc1cc(Nc2cc(nc(Nc3ccc(NC(=O)C4CC4)cc3)n2)N2CCCCC2)n[nH]1 Show InChI InChI=1S/C23H28N8O/c1-15-13-20(30-29-15)26-19-14-21(31-11-3-2-4-12-31)28-23(27-19)25-18-9-7-17(8-10-18)24-22(32)16-5-6-16/h7-10,13-14,16H,2-6,11-12H2,1H3,(H,24,32)(H3,25,26,27,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50513004 (CHEMBL4521353) Show SMILES CC(C)(C)C(=O)N1N=CC[C@H]1c1ccccc1 |r,c:7| Show InChI InChI=1S/C14H18N2O/c1-14(2,3)13(17)16-12(9-10-15-16)11-7-5-4-6-8-11/h4-8,10,12H,9H2,1-3H3/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16...				J Med Chem 62: 5096-5110 (2019) Article DOI: 10.1021/acs.jmedchem.9b00318 BindingDB Entry DOI: 10.7270/Q24J0JFT
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263163 (CHEMBL4099814) Show SMILES Cc1cc(Nc2cc(nc(Nc3ccc(NC(=O)C4CCCCC4)cc3)n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C25H32N8O2/c1-17-15-22(32-31-17)28-21-16-23(33-11-13-35-14-12-33)30-25(29-21)27-20-9-7-19(8-10-20)26-24(34)18-5-3-2-4-6-18/h7-10,15-16,18H,2-6,11-14H2,1H3,(H,26,34)(H3,27,28,29,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263059 (CHEMBL4105556) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Nc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H29N9O/c1-15-13-20(30-29-15)26-19-14-21(32-11-9-31(2)10-12-32)28-23(27-19)25-18-7-5-17(6-8-18)24-22(33)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,33)(H3,25,26,27,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263046 (CHEMBL4069729) Show SMILES Cc1cc(Nc2cc(nc(Nc3ccc(NC(=O)C4CC4)cc3)n2)N2CCCCC2)n[nH]1 Show InChI InChI=1S/C23H28N8O/c1-15-13-20(30-29-15)26-19-14-21(31-11-3-2-4-12-31)28-23(27-19)25-18-9-7-17(8-10-18)24-22(32)16-5-6-16/h7-10,13-14,16H,2-6,11-12H2,1H3,(H,24,32)(H3,25,26,27,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263089 (CHEMBL4077434) Show SMILES Cc1cc(Nc2nc(Sc3ccc(NC(=O)C4CC4)cc3)nc(n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C21H24N8O2S/c1-13-12-17(28-27-13)23-19-24-20(29-8-10-31-11-9-29)26-21(25-19)32-16-6-4-15(5-7-16)22-18(30)14-2-3-14/h4-7,12,14H,2-3,8-11H2,1H3,(H,22,30)(H2,23,24,25,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263078 (CHEMBL4069988) Show SMILES Cc1cc(Nc2cc(nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C22H25N7O2S/c1-14-12-19(28-27-14)24-18-13-20(29-8-10-31-11-9-29)26-22(25-18)32-17-6-4-16(5-7-17)23-21(30)15-2-3-15/h4-7,12-13,15H,2-3,8-11H2,1H3,(H,23,30)(H2,24,25,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263085 (CHEMBL4102307) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Nc2ccc(NC(=O)C3CCCCC3)cc2)n1 Show InChI InChI=1S/C26H35N9O/c1-18-16-23(33-32-18)29-22-17-24(35-14-12-34(2)13-15-35)31-26(30-22)28-21-10-8-20(9-11-21)27-25(36)19-6-4-3-5-7-19/h8-11,16-17,19H,3-7,12-15H2,1-2H3,(H,27,36)(H3,28,29,30,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50004205 (MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50159508 (CHEMBL3786078) Show SMILES CN1c2ccccc2NC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O |r| Show InChI InChI=1S/C21H20N4O3/c1-25-19-10-6-5-9-16(19)22-13-18(21(25)27)23-20(26)17-12-15(28-24-17)11-14-7-3-2-4-8-14/h2-10,12,18,22H,11,13H2,1H3,(H,23,26)/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to mouse RIP1 (1 to 378 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assay				J Med Chem 59: 2163-78 (2016) Article DOI: 10.1021/acs.jmedchem.5b01898 BindingDB Entry DOI: 10.7270/Q26H4K97
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50004205 (MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263059 (CHEMBL4105556) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Nc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H29N9O/c1-15-13-20(30-29-15)26-19-14-21(32-11-9-31(2)10-12-32)28-23(27-19)25-18-7-5-17(6-8-18)24-22(33)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,33)(H3,25,26,27,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263159 (CHEMBL4065014) Show SMILES Cc1cc(Nc2nc(Nc3ccc(NC(=O)C4CC4)cc3)nc(n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C21H25N9O2/c1-13-12-17(29-28-13)24-20-25-19(26-21(27-20)30-8-10-32-11-9-30)23-16-6-4-15(5-7-16)22-18(31)14-2-3-14/h4-7,12,14H,2-3,8-11H2,1H3,(H,22,31)(H3,23,24,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263164 (CHEMBL4086975) Show SMILES CN1CCN(CC1)c1nc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C22H27N9OS/c1-14-13-18(29-28-14)24-20-25-21(31-11-9-30(2)10-12-31)27-22(26-20)33-17-7-5-16(6-8-17)23-19(32)15-3-4-15/h5-8,13,15H,3-4,9-12H2,1-2H3,(H,23,32)(H2,24,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50502339 (CHEMBL4452233) Show SMILES Fc1cc(F)c2NC(=O)[C@H](CCc2c1)NC(=O)c1n[nH]c(Cc2ccccc2)n1 |r| Show InChI InChI=1S/C20H17F2N5O2/c21-13-9-12-6-7-15(19(28)25-17(12)14(22)10-13)23-20(29)18-24-16(26-27-18)8-11-4-2-1-3-5-11/h1-5,9-10,15H,6-8H2,(H,23,29)(H,25,28)(H,24,26,27)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of RIP1 in mouse L929 cells assessed as reduction in necroptosis incubated for 24 hrs by cell titer-glo luminescent cell viability assay				ACS Med Chem Lett 10: 857-862 (2019) Article DOI: 10.1021/acsmedchemlett.9b00108 BindingDB Entry DOI: 10.7270/Q2VT1WB8
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50233225 (CHEMBL4071864) Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O |r| Show InChI InChI=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23-24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Queen Mary University of London Curated by ChEMBL					Assay Description Inhibition of RIP1 in mouse L929 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...				J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263089 (CHEMBL4077434) Show SMILES Cc1cc(Nc2nc(Sc3ccc(NC(=O)C4CC4)cc3)nc(n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C21H24N8O2S/c1-13-12-17(28-27-13)23-19-24-20(29-8-10-31-11-9-29)26-21(25-19)32-16-6-4-15(5-7-16)22-18(30)14-2-3-14/h4-7,12,14H,2-3,8-11H2,1H3,(H,22,30)(H2,23,24,25,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263163 (CHEMBL4099814) Show SMILES Cc1cc(Nc2cc(nc(Nc3ccc(NC(=O)C4CCCCC4)cc3)n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C25H32N8O2/c1-17-15-22(32-31-17)28-21-16-23(33-11-13-35-14-12-33)30-25(29-21)27-20-9-7-19(8-10-20)26-24(34)18-5-3-2-4-6-18/h7-10,15-16,18H,2-6,11-14H2,1H3,(H,26,34)(H3,27,28,29,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263099 (CHEMBL4084466) Show SMILES Cc1cc(Nc2nc(Sc3ccc(NC(=O)C4CCCCC4)cc3)nc(n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C24H30N8O2S/c1-16-15-20(31-30-16)26-22-27-23(32-11-13-34-14-12-32)29-24(28-22)35-19-9-7-18(8-10-19)25-21(33)17-5-3-2-4-6-17/h7-10,15,17H,2-6,11-14H2,1H3,(H,25,33)(H2,26,27,28,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263079 (CHEMBL4089624) Show SMILES Cc1cc(Nc2cc(nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)N2CCCCC2)n[nH]1 Show InChI InChI=1S/C23H27N7OS/c1-15-13-20(29-28-15)25-19-14-21(30-11-3-2-4-12-30)27-23(26-19)32-18-9-7-17(8-10-18)24-22(31)16-5-6-16/h7-10,13-14,16H,2-6,11-12H2,1H3,(H,24,31)(H2,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263079 (CHEMBL4089624) Show SMILES Cc1cc(Nc2cc(nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)N2CCCCC2)n[nH]1 Show InChI InChI=1S/C23H27N7OS/c1-15-13-20(29-28-15)25-19-14-21(30-11-3-2-4-12-30)27-23(26-19)32-18-9-7-17(8-10-18)24-22(31)16-5-6-16/h7-10,13-14,16H,2-6,11-12H2,1H3,(H,24,31)(H2,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263085 (CHEMBL4102307) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Nc2ccc(NC(=O)C3CCCCC3)cc2)n1 Show InChI InChI=1S/C26H35N9O/c1-18-16-23(33-32-18)29-22-17-24(35-14-12-34(2)13-15-35)31-26(30-22)28-21-10-8-20(9-11-21)27-25(36)19-6-4-3-5-7-19/h8-11,16-17,19H,3-7,12-15H2,1-2H3,(H,27,36)(H3,28,29,30,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263161 (CHEMBL4064167) Show SMILES Cc1cc(Nc2cc(nc(Sc3ccc(NC(=O)C4CCCCC4)cc3)n2)N2CCCCC2)n[nH]1 Show InChI InChI=1S/C26H33N7OS/c1-18-16-23(32-31-18)28-22-17-24(33-14-6-3-7-15-33)30-26(29-22)35-21-12-10-20(11-13-21)27-25(34)19-8-4-2-5-9-19/h10-13,16-17,19H,2-9,14-15H2,1H3,(H,27,34)(H2,28,29,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263084 (CHEMBL4081804) Show SMILES Cc1cc(Nc2cc(nc(Nc3ccc(NC(=O)C4CCCCC4)cc3)n2)N2CCCCC2)n[nH]1 Show InChI InChI=1S/C26H34N8O/c1-18-16-23(33-32-18)29-22-17-24(34-14-6-3-7-15-34)31-26(30-22)28-21-12-10-20(11-13-21)27-25(35)19-8-4-2-5-9-19/h10-13,16-17,19H,2-9,14-15H2,1H3,(H,27,35)(H3,28,29,30,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50233225 (CHEMBL4071864) Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O |r| Show InChI InChI=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23-24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Queen Mary University of London Curated by ChEMBL					Assay Description Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)-amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)...				J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263159 (CHEMBL4065014) Show SMILES Cc1cc(Nc2nc(Nc3ccc(NC(=O)C4CC4)cc3)nc(n2)N2CCOCC2)n[nH]1 Show InChI InChI=1S/C21H25N9O2/c1-13-12-17(29-28-13)24-20-25-19(26-21(27-20)30-8-10-32-11-9-30)23-16-6-4-15(5-7-16)22-18(31)14-2-3-14/h4-7,12,14H,2-3,8-11H2,1H3,(H,22,31)(H3,23,24,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263111 (CHEMBL4092699) Show SMILES Cc1cc(Nc2nc(Nc3ccc(NC(=O)C4CC4)cc3)nc(n2)N2CCCCC2)n[nH]1 Show InChI InChI=1S/C22H27N9O/c1-14-13-18(30-29-14)25-21-26-20(27-22(28-21)31-11-3-2-4-12-31)24-17-9-7-16(8-10-17)23-19(32)15-5-6-15/h7-10,13,15H,2-6,11-12H2,1H3,(H,23,32)(H3,24,25,26,27,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263134 (CHEMBL4092326) Show SMILES Cc1[nH]nc(Nc2nc(Nc3ccc(NC(=O)C4CCCCC4)cc3)nc(n2)N2CCOCC2)c1C Show InChI InChI=1S/C25H33N9O2/c1-16-17(2)32-33-21(16)28-24-29-23(30-25(31-24)34-12-14-36-15-13-34)27-20-10-8-19(9-11-20)26-22(35)18-6-4-3-5-7-18/h8-11,18H,3-7,12-15H2,1-2H3,(H,26,35)(H3,27,28,29,30,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263160 (CHEMBL4095144) Show SMILES CN1CCN(CC1)c1nc(Nc2n[nH]c(C)c2C)nc(Nc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H30N10O/c1-14-15(2)30-31-19(14)26-22-27-21(28-23(29-22)33-12-10-32(3)11-13-33)25-18-8-6-17(7-9-18)24-20(34)16-4-5-16/h6-9,16H,4-5,10-13H2,1-3H3,(H,24,34)(H3,25,26,27,28,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263118 (CHEMBL4076918) Show SMILES CN1CCN(CC1)c1nc(Nc2cc(C)[nH]n2)nc(Nc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C22H28N10O/c1-14-13-18(30-29-14)25-21-26-20(27-22(28-21)32-11-9-31(2)10-12-32)24-17-7-5-16(6-8-17)23-19(33)15-3-4-15/h5-8,13,15H,3-4,9-12H2,1-2H3,(H,23,33)(H3,24,25,26,27,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263137 (CHEMBL4075805) Show SMILES Cc1[nH]nc(Nc2cc(nc(Nc3ccc(NC(=O)C4CC4)cc3)n2)N2CCCCC2)c1C Show InChI InChI=1S/C24H30N8O/c1-15-16(2)30-31-22(15)27-20-14-21(32-12-4-3-5-13-32)29-24(28-20)26-19-10-8-18(9-11-19)25-23(33)17-6-7-17/h8-11,14,17H,3-7,12-13H2,1-2H3,(H,25,33)(H3,26,27,28,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263083 (CHEMBL4061551) Show SMILES CN1CCN(CC1)c1cc(Nc2n[nH]c(C)c2C)nc(Nc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C24H31N9O/c1-15-16(2)30-31-22(15)27-20-14-21(33-12-10-32(3)11-13-33)29-24(28-20)26-19-8-6-18(7-9-19)25-23(34)17-4-5-17/h6-9,14,17H,4-5,10-13H2,1-3H3,(H,25,34)(H3,26,27,28,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263156 (CHEMBL4098058) Show SMILES Cc1[nH]nc(Nc2nc(Sc3ccc(NC(=O)C4CCCCC4)cc3)nc(n2)N2CCOCC2)c1C Show InChI InChI=1S/C25H32N8O2S/c1-16-17(2)31-32-21(16)27-23-28-24(33-12-14-35-15-13-33)30-25(29-23)36-20-10-8-19(9-11-20)26-22(34)18-6-4-3-5-7-18/h8-11,18H,3-7,12-15H2,1-2H3,(H,26,34)(H2,27,28,29,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263164 (CHEMBL4086975) Show SMILES CN1CCN(CC1)c1nc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C22H27N9OS/c1-14-13-18(29-28-14)24-20-25-21(31-11-9-30(2)10-12-31)27-22(26-20)33-17-7-5-16(6-8-17)23-19(32)15-3-4-15/h5-8,13,15H,3-4,9-12H2,1-2H3,(H,23,32)(H2,24,25,26,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263135 (CHEMBL4076117) Show SMILES CN1CCN(CC1)c1nc(Nc2n[nH]c(C)c2C)nc(Nc2ccc(NC(=O)C3CCCCC3)cc2)n1 Show InChI InChI=1S/C26H36N10O/c1-17-18(2)33-34-22(17)29-25-30-24(31-26(32-25)36-15-13-35(3)14-16-36)28-21-11-9-20(10-12-21)27-23(37)19-7-5-4-6-8-19/h9-12,19H,4-8,13-16H2,1-3H3,(H,27,37)(H3,28,29,30,31,32,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263060 (CHEMBL4098445) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CCCCC3)cc2)n1 Show InChI InChI=1S/C26H34N8OS/c1-18-16-23(32-31-18)28-22-17-24(34-14-12-33(2)13-15-34)30-26(29-22)36-21-10-8-20(9-11-21)27-25(35)19-6-4-3-5-7-19/h8-11,16-17,19H,3-7,12-15H2,1-2H3,(H,27,35)(H2,28,29,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263081 (CHEMBL4061046) Show SMILES CN1CCN(CC1)c1cc(Nc2n[nH]c(C)c2C)nc(Sc2ccc(NC(=O)C3CCCCC3)cc2)n1 Show InChI InChI=1S/C27H36N8OS/c1-18-19(2)32-33-25(18)29-23-17-24(35-15-13-34(3)14-16-35)31-27(30-23)37-22-11-9-21(10-12-22)28-26(36)20-7-5-4-6-8-20/h9-12,17,20H,4-8,13-16H2,1-3H3,(H,28,36)(H2,29,30,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mus musculus)	BDBM50263080 (CHEMBL4075303) Show SMILES Cc1[nH]nc(Nc2cc(nc(Sc3ccc(NC(=O)C4CCCCC4)cc3)n2)N2CCOCC2)c1C Show InChI InChI=1S/C26H33N7O2S/c1-17-18(2)31-32-24(17)28-22-16-23(33-12-14-35-15-13-33)30-26(29-22)36-21-10-8-20(9-11-21)27-25(34)19-6-4-3-5-7-19/h8-11,16,19H,3-7,12-15H2,1-2H3,(H,27,34)(H2,28,29,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , Wilrijk-Antwerp 2610 , Belgium. Curated by ChEMBL					Assay Description Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...				J Med Chem 61: 1895-1920 (2018) Article DOI: 10.1021/acs.jmedchem.7b01449 BindingDB Entry DOI: 10.7270/Q2930WNQ
					More data for this Ligand-Target Pair

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