Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152773 (4-(3-Morpholinopropoxy)-N-(3-chloro-4-fluorophenyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10.4 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM5447 (CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 12.1 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152779 (4-(3-(Piperidin-1-yl)propoxy)-N-(3-chloro-4-fluoro...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15.4 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152777 (4-(3-(Piperidin-1-yl)propoxy)-N-(m-tolyl)-2-hydrox...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22.4 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152780 (4-(3-(Piperidin-1-yl)propoxy)-N-(2-chloro-4-nitrop...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152772 (4-(3-Morpholinopropoxy)-N-(3-(trifluoromethyl)phen...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 34.6 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152778 (4-(3-(Piperidin-1-yl)propoxy)-N-(3-(trifluoromethy...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 35.2 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152775 (4-(3-(Piperidin-1-yl)propoxy)-N-(3-bromophenyl)-2-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 45.7 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152776 (4-(3-(Piperidin-1-yl)propoxy)-N-(3-chlorophenyl)-2...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 63.9 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152774 (4-(3-Morpholinopropoxy)-N-(2-chloro-4-nitrophenyl)...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 84.8 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152769 (4-(3-morpholinopropoxy)-N-(3-bromophenyl)-2-hydrox...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 85.8 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152771 (4-(3-Morpholinopropoxy)-N-(m-tolyl)-2-hydroxybenza...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 142 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM152770 (4-(3-Morpholinopropoxy)-N-(3-chlorophenyl)-2-hydro...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 196 | n/a | n/a | n/a | n/a | n/a | 25 |
Anhui University of Chinese Medicine | Assay Description The experiments were performed according to the instructions of the manufacturer. The EGFR TK activity was performed using Kinase-Glo Plus luminescen... | Chem Biol Drug Des 85: 280-9 (2015) Article DOI: 10.1111/cbdd.12383 BindingDB Entry DOI: 10.7270/Q2JD4VJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor protein-tyrosine kinase (Homo sapiens (Human)) | BDBM108059 (N-carbamimidoyl-4-((4-((2,3-dimethyl-2H-indazole- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.37E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Shandong Institute of Pharmaceutical Industry, Ji'nan, Shandong, 250101, China. | Assay Description To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t... | Chem Biol Drug Des 83: 306-16 (2014) Article DOI: 10.1111/cbdd.12243 BindingDB Entry DOI: 10.7270/Q2PR7TM2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.99E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor protein-tyrosine kinase (Homo sapiens (Human)) | BDBM26474 (5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.95E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Shandong Institute of Pharmaceutical Industry, Ji'nan, Shandong, 250101, China. | Assay Description To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t... | Chem Biol Drug Des 83: 306-16 (2014) Article DOI: 10.1111/cbdd.12243 BindingDB Entry DOI: 10.7270/Q2PR7TM2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM191572 (6-(3-chlorophenyl)pteridine-2,4,7-triamine (15) | ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Molecular Physiology | Assay Description Single-point measurement analyses of Epiblastin A against a panel of 123 kinases was performed at Eurofins (former Milipore) using a radiometric-base... | Cell Chem Biol 23: 494-507 (2016) Article DOI: 10.1016/j.chembiol.2016.02.015 BindingDB Entry DOI: 10.7270/Q2GQ6WJD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM120816 ((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM110206 (1-[2-(Dimethylamino)ethyl]-5-(2-hydroxy-4-methoxyb...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
University of Delhi, Delhi 110007, India | Assay Description EGFR was incubated with 8 mM MOPS (pH 7.0), 0.2 mM EDTA, 10 mM MnCl2, 0.1 mg/mL poly(Glu, Tyr) 4:1. MAPK1 was incubated with 25 mM Tris (pH 7.5), 0.0... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair |