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Compile Data Set for Download or QSAR

Found 43 hits of ec50 data for polymerid = 469,50000958   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin receptor


(Mus musculus)		BDBM50459972
PNG
(CHEMBL4226003)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(C)C)C(C)C)C(=O)NCC(O)=O |r|
Show InChI InChI=1S/C185H262N46O63S2/c1-88(2)65-118(155(266)200-81-149(261)262)216-162(273)109(44-53-135(187)238)207-158(269)108(34-23-63-194-185(191)192)206-159(270)112(47-56-141(245)246)211-171(282)122(68-94-25-14-12-15-26-94)219-174(285)126(73-99-77-196-106-32-21-19-30-103(99)106)222-176(287)128(75-148(259)260)224-173(284)124(71-97-38-42-101(237)43-39-97)218-172(283)123(69-95-27-16-13-17-28-95)220-178(289)131(85-235)226-164(275)115(50-59-144(251)252)212-175(286)127(74-147(257)258)223-170(281)120(67-90(5)6)217-177(288)130(84-234)203-138(241)79-199-157(268)129(83-233)227-180(291)134-35-24-64-231(134)183(294)133(87-296)204-139(242)80-197-154(265)107(33-22-62-193-184(189)190)202-137(240)78-198-156(267)121(70-96-36-40-100(236)41-37-96)225-182(293)151(92(9)10)230-167(278)117(52-61-146(255)256)213-179(290)132(86-295)228-165(276)116(51-60-145(253)254)214-181(292)150(91(7)8)229-166(277)110(45-54-136(188)239)205-152(263)93(11)201-168(279)125(72-98-76-195-105-31-20-18-29-102(98)105)221-163(274)114(49-58-143(249)250)209-160(271)111(46-55-140(243)244)208-161(272)113(48-57-142(247)248)210-169(280)119(66-89(3)4)215-153(264)104(186)82-232/h12-21,25-32,36-43,76-77,88-93,104,107-134,150-151,195-196,232-237,295-296H,22-24,33-35,44-75,78-87,186H2,1-11H3,(H2,187,238)(H2,188,239)(H,197,265)(H,198,267)(H,199,268)(H,200,266)(H,201,279)(H,202,240)(H,203,241)(H,204,242)(H,205,263)(H,206,270)(H,207,269)(H,208,272)(H,209,271)(H,210,280)(H,211,282)(H,212,286)(H,213,290)(H,214,292)(H,215,264)(H,216,273)(H,217,288)(H,218,283)(H,219,285)(H,220,289)(H,221,274)(H,222,287)(H,223,281)(H,224,284)(H,225,293)(H,226,275)(H,227,291)(H,228,276)(H,229,277)(H,230,278)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H4,189,190,193)(H4,191,192,194)/t93-,104-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,150-,151-/m0/s1
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n/an/an/an/a 4n/an/an/an/a



University of Melbourne

Curated by ChEMBL


Assay Description
Agonist activity at B6D2F1 mouse insulin receptor assessed as increase in glucose incorporation into lipid phase after 2 hrs in presence of D-[3-3H]g...

Bioorg Med Chem 26: 2827-2841 (2018)


Article DOI: 10.1016/j.bmc.2017.09.030
BindingDB Entry DOI: 10.7270/Q2TX3J04
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50377967
PNG
(CHEMBL1627107)
Show SMILES Oc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(=O)(=O)Nc3ccc(Cl)c(c3)S([O-])(=O)=O)ccc12)S(=O)(=O)Nc1ccc(Cl)c(c1)S([O-])(=O)=O
Show InChI InChI=1S/C33H24Cl2N4O13S4/c34-27-7-3-21(13-31(27)55(47,48)49)38-53(43,44)23-11-17-9-19(1-5-25(17)29(40)15-23)36-33(42)37-20-2-6-26-18(10-20)12-24(16-30(26)41)54(45,46)39-22-4-8-28(35)32(14-22)56(50,51)52/h1-16,38-41H,(H2,36,37,42)(H,47,48,49)(H,50,51,52)/p-2
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n/an/an/an/a 5.00E+3n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253185
PNG
(2-Chloro-5-{[(7-{[(7-{[(4-chloro-3-sulfophenyl)ami...)
Show SMILES [O-]S(=O)(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(Cl)c(c4)S([O-])(=O)=O)cc3c2)ccc1Cl
Show InChI InChI=1S/C33H24Cl2N4O11S4/c34-29-11-7-25(17-31(29)53(45,46)47)38-51(41,42)27-9-3-19-1-5-23(13-21(19)15-27)36-33(40)37-24-6-2-20-4-10-28(16-22(20)14-24)52(43,44)39-26-8-12-30(35)32(18-26)54(48,49)50/h1-18,38-39H,(H2,36,37,40)(H,45,46,47)(H,48,49,50)/p-2
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n/an/an/an/a 6.00E+3n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253181
PNG
(2-Hydroxy-5-{[(7-{[(7-sulfo(2-naphthyl))amino]carb...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(O)c(c4)C(O)=O)cc3c2)ccc1O
Show InChI InChI=1S/C35H26N4O11S2/c40-31-11-7-25(17-29(31)33(42)43)38-51(47,48)27-9-3-19-1-5-23(13-21(19)15-27)36-35(46)37-24-6-2-20-4-10-28(16-22(20)14-24)52(49,50)39-26-8-12-32(41)30(18-26)34(44)45/h1-18,38-41H,(H,42,43)(H,44,45)(H2,36,37,46)
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n/an/an/an/a 9.00E+3n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253179
PNG
(5-{[(7-{[(7-{[(3-Carboxy-4-chlorophenyl)amino]sulf...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(Cl)c(c4)C(O)=O)cc3c2)ccc1Cl
Show InChI InChI=1S/C35H24Cl2N4O9S2/c36-31-11-7-25(17-29(31)33(42)43)40-51(47,48)27-9-3-19-1-5-23(13-21(19)15-27)38-35(46)39-24-6-2-20-4-10-28(16-22(20)14-24)52(49,50)41-26-8-12-32(37)30(18-26)34(44)45/h1-18,40-41H,(H,42,43)(H,44,45)(H2,38,39,46)
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n/an/an/an/a 1.60E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253178
PNG
(5-{[(7-{[(7-{[(3-Carboxy-4-chlorophenyl)amino]sulf...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4ccc(Cl)c(c4)C(O)=O)cc3c2)ccc1Cl
Show InChI InChI=1S/C35H24Cl2N4O11S2/c36-29-7-3-21(13-27(29)33(44)45)40-53(49,50)23-11-17-9-19(1-5-25(17)31(42)15-23)38-35(48)39-20-2-6-26-18(10-20)12-24(16-32(26)43)54(51,52)41-22-4-8-30(37)28(14-22)34(46)47/h1-16,40-43H,(H,44,45)(H,46,47)(H2,38,39,48)
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n/an/an/an/a 1.80E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50377968
PNG
(CHEMBL1627106)
Show SMILES [O-]S(=O)(=O)c1cccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4cccc(c4)S([O-])(=O)=O)cc3c2)c1
Show InChI InChI=1S/C33H26N4O11S4/c38-33(34-25-11-7-21-9-13-29(17-23(21)15-25)49(39,40)36-27-3-1-5-31(19-27)51(43,44)45)35-26-12-8-22-10-14-30(18-24(22)16-26)50(41,42)37-28-4-2-6-32(20-28)52(46,47)48/h1-20,36-37H,(H2,34,35,38)(H,43,44,45)(H,46,47,48)/p-2
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n/an/an/an/a 2.20E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253166
PNG
(3-{7-[({7-[(3-carboxyphenyl)sulfamoyl]naphthalen-2...)
Show SMILES OC(=O)c1cccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4cccc(c4)C(O)=O)cc3c2)c1
Show InChI InChI=1S/C35H26N4O9S2/c40-33(41)23-3-1-5-29(15-23)38-49(45,46)31-13-9-21-7-11-27(17-25(21)19-31)36-35(44)37-28-12-8-22-10-14-32(20-26(22)18-28)50(47,48)39-30-6-2-4-24(16-30)34(42)43/h1-20,38-39H,(H,40,41)(H,42,43)(H2,36,37,44)
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n/an/an/an/a 2.40E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253159
PNG
(3-{[(4-Hydroxy-7-{[(5-hydroxy-7-{[(3-sulfophenyl)a...)
Show SMILES Oc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(=O)(=O)Nc3cccc(c3)S([O-])(=O)=O)ccc12)S(=O)(=O)Nc1cccc(c1)S([O-])(=O)=O
Show InChI InChI=1S/C33H26N4O13S4/c38-31-17-27(51(41,42)36-23-3-1-5-25(15-23)53(45,46)47)13-19-11-21(7-9-29(19)31)34-33(40)35-22-8-10-30-20(12-22)14-28(18-32(30)39)52(43,44)37-24-4-2-6-26(16-24)54(48,49)50/h1-18,36-39H,(H2,34,35,40)(H,45,46,47)(H,48,49,50)/p-2
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n/an/an/an/a 2.60E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253182
PNG
(5-{7-[({7-[(3-carboxy-4-nitrophenyl)sulfamoyl]naph...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(c(c4)C(O)=O)[N+]([O-])=O)cc3c2)ccc1[N+]([O-])=O
Show InChI InChI=1S/C35H24N6O13S2/c42-33(43)29-17-25(7-11-31(29)40(47)48)38-55(51,52)27-9-3-19-1-5-23(13-21(19)15-27)36-35(46)37-24-6-2-20-4-10-28(16-22(20)14-24)56(53,54)39-26-8-12-32(41(49)50)30(18-26)34(44)45/h1-18,38-39H,(H,42,43)(H,44,45)(H2,36,37,46)
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n/an/an/an/a 4.00E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253177
PNG
(2-{7-[({7-[(2-carboxyphenyl)sulfamoyl]naphthalen-2...)
Show SMILES OC(=O)c1ccccc1NS(=O)(=O)c1ccc2ccc(NC(=O)Nc3ccc4ccc(cc4c3)S(=O)(=O)Nc3ccccc3C(O)=O)cc2c1
Show InChI InChI=1S/C35H26N4O9S2/c40-33(41)29-5-1-3-7-31(29)38-49(45,46)27-15-11-21-9-13-25(17-23(21)19-27)36-35(44)37-26-14-10-22-12-16-28(20-24(22)18-26)50(47,48)39-32-8-4-2-6-30(32)34(42)43/h1-20,38-39H,(H,40,41)(H,42,43)(H2,36,37,44)
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n/an/an/an/a 4.10E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253165
PNG
(3-{7-[({7-[(3-carboxyphenyl)sulfamoyl]-5-hydroxyna...)
Show SMILES OC(=O)c1cccc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4cccc(c4)C(O)=O)cc3c2)c1
Show InChI InChI=1S/C35H26N4O11S2/c40-31-17-27(51(47,48)38-25-5-1-3-19(11-25)33(42)43)15-21-13-23(7-9-29(21)31)36-35(46)37-24-8-10-30-22(14-24)16-28(18-32(30)41)52(49,50)39-26-6-2-4-20(12-26)34(44)45/h1-18,38-41H,(H,42,43)(H,44,45)(H2,36,37,46)
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n/an/an/an/a 4.30E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253180
PNG
(5-{[(7-{[(7-{[(3-Carboxy-4-hydroxyphenyl)amino]sul...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4ccc(O)c(c4)C(O)=O)cc3c2)ccc1O
Show InChI InChI=1S/C35H26N4O13S2/c40-29-7-3-21(13-27(29)33(44)45)38-53(49,50)23-11-17-9-19(1-5-25(17)31(42)15-23)36-35(48)37-20-2-6-26-18(10-20)12-24(16-32(26)43)54(51,52)39-22-4-8-30(41)28(14-22)34(46)47/h1-16,38-43H,(H,44,45)(H,46,47)(H2,36,37,48)
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n/an/an/an/a 4.30E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253168
PNG
(1,3-bis(7-{[3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]sul...)
Show SMILES O=C(Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1cccc(c1)-n1cnnn1)Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1cccc(c1)-n1cnnn1
Show InChI InChI=1S/C35H26N12O5S2/c48-35(38-27-11-7-23-9-13-33(17-25(23)15-27)53(49,50)40-29-3-1-5-31(19-29)46-21-36-42-44-46)39-28-12-8-24-10-14-34(18-26(24)16-28)54(51,52)41-30-4-2-6-32(20-30)47-22-37-43-45-47/h1-22,40-41H,(H2,38,39,48)
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n/an/an/an/a 5.40E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253189
PNG
(5-[({7-[3-(7-{[(3-Carboxy-4-chlorophenyl)amino]sul...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(cc3c2)N2CCN(C2=O)c2ccc3ccc(cc3c2)S(=O)(=O)Nc2ccc(Cl)c(c2)C(O)=O)ccc1Cl
Show InChI InChI=1S/C37H26Cl2N4O9S2/c38-33-11-5-25(19-31(33)35(44)45)40-53(49,50)29-9-3-21-1-7-27(15-23(21)17-29)42-13-14-43(37(42)48)28-8-2-22-4-10-30(18-24(22)16-28)54(51,52)41-26-6-12-34(39)32(20-26)36(46)47/h1-12,15-20,40-41H,13-14H2,(H,44,45)(H,46,47)
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n/an/an/an/a 5.60E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253167
PNG
(1,3-bis(5-hydroxy-7-{[3-(1H-1,2,3,4-tetrazol-1-yl)...)
Show SMILES Oc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(=O)(=O)Nc3cccc(c3)-n3cnnn3)ccc12)S(=O)(=O)Nc1cccc(c1)-n1cnnn1
Show InChI InChI=1S/C35H26N12O7S2/c48-33-17-29(55(51,52)40-25-3-1-5-27(15-25)46-19-36-42-44-46)13-21-11-23(7-9-31(21)33)38-35(50)39-24-8-10-32-22(12-24)14-30(18-34(32)49)56(53,54)41-26-4-2-6-28(16-26)47-20-37-43-45-47/h1-20,40-41,48-49H,(H2,38,39,50)
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n/an/an/an/a 7.30E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50377965
PNG
(CHEMBL436679)
Show SMILES Oc1cc(c(N=Nc2ccc(cc2S(O)(=O)=O)N=Nc2ccc(cc2)S(O)(=O)=O)c2cc(NC(=O)Nc3ccc4c(O)c(N=Nc5ccc(cc5S(O)(=O)=O)N=Nc5ccc(cc5)S(O)(=O)=O)c(cc4c3)S(O)(=O)=O)ccc12)S(O)(=O)=O |w:18.19,6.6,43.44,55.57|
Show InChI InChI=1S/C45H32N10O21S6/c56-37-22-41(82(74,75)76)42(54-52-35-15-7-28(20-38(35)79(65,66)67)50-48-24-1-9-30(10-2-24)77(59,60)61)34-19-27(6-14-33(34)37)47-45(58)46-26-5-13-32-23(17-26)18-40(81(71,72)73)43(44(32)57)55-53-36-16-8-29(21-39(36)80(68,69)70)51-49-25-3-11-31(12-4-25)78(62,63)64/h1-22,56-57H,(H2,46,47,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)
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n/an/an/an/a 9.00E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253192
PNG
(CHEMBL505538 | disodium 3-{N-methyl7-[({7-[methyl(...)
Show SMILES CN(c1cccc(c1)S([O-])(=O)=O)S(=O)(=O)c1ccc2ccc(NC(=O)Nc3ccc4ccc(cc4c3)S(=O)(=O)N(C)c3cccc(c3)S([O-])(=O)=O)cc2c1
Show InChI InChI=1S/C35H30N4O11S4/c1-38(29-5-3-7-33(21-29)53(45,46)47)51(41,42)31-15-11-23-9-13-27(17-25(23)19-31)36-35(40)37-28-14-10-24-12-16-32(20-26(24)18-28)52(43,44)39(2)30-6-4-8-34(22-30)54(48,49)50/h3-22H,1-2H3,(H2,36,37,40)(H,45,46,47)(H,48,49,50)/p-2
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n/an/an/an/a 9.10E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253175
PNG
(2-{7-[({7-[(2-carboxyphenyl)sulfamoyl]-5-hydroxyna...)
Show SMILES OC(=O)c1ccccc1NS(=O)(=O)c1cc(O)c2ccc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(=O)(=O)Nc3ccccc3C(O)=O)cc2c1
Show InChI InChI=1S/C35H26N4O11S2/c40-31-17-23(51(47,48)38-29-7-3-1-5-27(29)33(42)43)15-19-13-21(9-11-25(19)31)36-35(46)37-22-10-12-26-20(14-22)16-24(18-32(26)41)52(49,50)39-30-8-4-2-6-28(30)34(44)45/h1-18,38-41H,(H,42,43)(H,44,45)(H2,36,37,46)
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n/an/an/an/a 9.30E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253173
PNG
(CHEMBL499172 | disodium 4-{7-[({7-[(4-sulfonatophe...)
Show SMILES [O-]S(=O)(=O)c1ccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(cc4)S([O-])(=O)=O)cc3c2)cc1
Show InChI InChI=1S/C33H26N4O11S4/c38-33(34-27-5-1-21-3-11-31(19-23(21)17-27)49(39,40)36-25-7-13-29(14-8-25)51(43,44)45)35-28-6-2-22-4-12-32(20-24(22)18-28)50(41,42)37-26-9-15-30(16-10-26)52(46,47)48/h1-20,36-37H,(H2,34,35,38)(H,43,44,45)(H,46,47,48)/p-2
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n/an/an/an/a 9.40E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253174
PNG
(4-{7-[({7-[(4-carboxyphenyl)sulfamoyl]-5-hydroxyna...)
Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4ccc(cc4)C(O)=O)cc3c2)cc1
Show InChI InChI=1S/C35H26N4O11S2/c40-31-17-27(51(47,48)38-23-5-1-19(2-6-23)33(42)43)15-21-13-25(9-11-29(21)31)36-35(46)37-26-10-12-30-22(14-26)16-28(18-32(30)41)52(49,50)39-24-7-3-20(4-8-24)34(44)45/h1-18,38-41H,(H,42,43)(H,44,45)(H2,36,37,46)
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n/an/an/an/a 1.03E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253184
PNG
(3-{7-[({7-[(3-carboxy-2-chlorophenyl)sulfamoyl]-5-...)
Show SMILES OC(=O)c1cccc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4cccc(C(O)=O)c4Cl)cc3c2)c1Cl
Show InChI InChI=1S/C35H24Cl2N4O11S2/c36-31-25(33(44)45)3-1-5-27(31)40-53(49,50)21-13-17-11-19(7-9-23(17)29(42)15-21)38-35(48)39-20-8-10-24-18(12-20)14-22(16-30(24)43)54(51,52)41-28-6-2-4-26(32(28)37)34(46)47/h1-16,40-43H,(H,44,45)(H,46,47)(H2,38,39,48)
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n/an/an/an/a 1.21E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253183
PNG
(3-{7-[({7-[(3-carboxy-2-hydroxyphenyl)sulfamoyl]na...)
Show SMILES OC(=O)c1cccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4cccc(C(O)=O)c4O)cc3c2)c1O
Show InChI InChI=1S/C35H26N4O11S2/c40-31-27(33(42)43)3-1-5-29(31)38-51(47,48)25-13-9-19-7-11-23(15-21(19)17-25)36-35(46)37-24-12-8-20-10-14-26(18-22(20)16-24)52(49,50)39-30-6-2-4-28(32(30)41)34(44)45/h1-18,38-41H,(H,42,43)(H,44,45)(H2,36,37,46)
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n/an/an/an/a 1.50E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253195
PNG
(5-({[7-({[(7-{[(3-Carboxy-4-chlorophenyl)amino]sul...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=S)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(Cl)c(c4)C(O)=O)cc3c2)ccc1Cl
Show InChI InChI=1S/C35H24Cl2N4O8S3/c36-31-11-7-25(17-29(31)33(42)43)40-51(46,47)27-9-3-19-1-5-23(13-21(19)15-27)38-35(50)39-24-6-2-20-4-10-28(16-22(20)14-24)52(48,49)41-26-8-12-32(37)30(18-26)34(44)45/h1-18,40-41H,(H,42,43)(H,44,45)(H2,38,39,50)
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n/an/an/an/a 1.62E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253196
PNG
(5-{[(7-{2-Amino-1-aza-2-[(7-{[(3-carboxy-4-chlorop...)
Show SMILES NC(Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O)=Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O |w:27.30|
Show InChI InChI=1S/C35H25Cl2N5O8S2/c36-31-11-7-25(17-29(31)33(43)44)41-51(47,48)27-9-3-19-1-5-23(13-21(19)15-27)39-35(38)40-24-6-2-20-4-10-28(16-22(20)14-24)52(49,50)42-26-8-12-32(37)30(18-26)34(45)46/h1-18,41-42H,(H,43,44)(H,45,46)(H3,38,39,40)
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n/an/an/an/a 1.79E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253176
PNG
(4-{7-[({7-[(4-carboxyphenyl)sulfamoyl]naphthalen-2...)
Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(cc4)C(O)=O)cc3c2)cc1
Show InChI InChI=1S/C35H26N4O9S2/c40-33(41)23-3-9-27(10-4-23)38-49(45,46)31-15-7-21-1-13-29(17-25(21)19-31)36-35(44)37-30-14-2-22-8-16-32(20-26(22)18-30)50(47,48)39-28-11-5-24(6-12-28)34(42)43/h1-20,38-39H,(H,40,41)(H,42,43)(H2,36,37,44)
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n/an/an/an/a 1.83E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253164
PNG
(1,3-bis(5-hydroxy-7-{[3-(trifluoromethyl)phenyl]su...)
Show SMILES Oc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(=O)(=O)Nc3cccc(c3)C(F)(F)F)ccc12)S(=O)(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C35H24F6N4O7S2/c36-34(37,38)21-3-1-5-25(15-21)44-53(49,50)27-13-19-11-23(7-9-29(19)31(46)17-27)42-33(48)43-24-8-10-30-20(12-24)14-28(18-32(30)47)54(51,52)45-26-6-2-4-22(16-26)35(39,40)41/h1-18,44-47H,(H2,42,43,48)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253163
PNG
(1,3-bis({7-[(3-cyanophenyl)sulfamoyl]naphthalen-2-...)
Show SMILES O=C(Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1cccc(c1)C#N)Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1cccc(c1)C#N
Show InChI InChI=1S/C35H24N6O5S2/c36-21-23-3-1-5-31(15-23)40-47(43,44)33-13-9-25-7-11-29(17-27(25)19-33)38-35(42)39-30-12-8-26-10-14-34(20-28(26)18-30)48(45,46)41-32-6-2-4-24(16-32)22-37/h1-20,40-41H,(H2,38,39,42)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253188
PNG
(CHEMBL453256 | sodium 7-[({7-[(3-carboxy-4-hydroxy...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S([O-])(=O)=O)cc3c2)ccc1O
Show InChI InChI=1S/C28H21N3O9S2/c32-26-10-7-22(15-25(26)27(33)34)31-41(36,37)23-8-3-16-1-5-20(11-18(16)13-23)29-28(35)30-21-6-2-17-4-9-24(42(38,39)40)14-19(17)12-21/h1-15,31-32H,(H,33,34)(H2,29,30,35)(H,38,39,40)/p-1
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253191
PNG
(CHEMBL442662 | disodium 3-{7-[({7-[(3-sulfonatophe...)
Show SMILES [O-]S(=O)(=O)c1cccc(NC(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)C(=O)Nc4cccc(c4)S([O-])(=O)=O)cc3c2)c1
Show InChI InChI=1S/C35H26N4O9S2/c40-33(36-27-3-1-5-31(19-27)49(43,44)45)23-9-7-21-11-13-29(17-25(21)15-23)38-35(42)39-30-14-12-22-8-10-24(16-26(22)18-30)34(41)37-28-4-2-6-32(20-28)50(46,47)48/h1-20H,(H,36,40)(H,37,41)(H2,38,39,42)(H,43,44,45)(H,46,47,48)/p-2
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253169
PNG
(1,3-bis(5-hydroxy-7-{[3-(hydroxymethyl)phenyl]sulf...)
Show SMILES OCc1cccc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4cccc(CO)c4)cc3c2)c1
Show InChI InChI=1S/C35H30N4O9S2/c40-19-21-3-1-5-27(11-21)38-49(45,46)29-15-23-13-25(7-9-31(23)33(42)17-29)36-35(44)37-26-8-10-32-24(14-26)16-30(18-34(32)43)50(47,48)39-28-6-2-4-22(12-28)20-41/h1-18,38-43H,19-20H2,(H2,36,37,44)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253190
PNG
(3-({7-[(N-{7-[N-(3-Carboxyphenyl)carbamoyl]-2-naph...)
Show SMILES OC(=O)c1cccc(NC(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)C(=O)Nc4cccc(c4)C(O)=O)cc3c2)c1
Show InChI InChI=1S/C37H26N4O7/c42-33(38-29-5-1-3-25(17-29)35(44)45)23-9-7-21-11-13-31(19-27(21)15-23)40-37(48)41-32-14-12-22-8-10-24(16-28(22)20-32)34(43)39-30-6-2-4-26(18-30)36(46)47/h1-20H,(H,38,42)(H,39,43)(H,44,45)(H,46,47)(H2,40,41,48)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253171
PNG
(1,3-bis({7-[(3-sulfamoylphenyl)sulfamoyl]naphthale...)
Show SMILES NS(=O)(=O)c1cccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4cccc(c4)S(N)(=O)=O)cc3c2)c1
Show InChI InChI=1S/C33H28N6O9S4/c34-49(41,42)29-5-1-3-27(19-29)38-51(45,46)31-13-9-21-7-11-25(15-23(21)17-31)36-33(40)37-26-12-8-22-10-14-32(18-24(22)16-26)52(47,48)39-28-4-2-6-30(20-28)50(35,43)44/h1-20,38-39H,(H2,34,41,42)(H2,35,43,44)(H2,36,37,40)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253193
PNG
(5-({[7-(N-{2-[N-(7-{[(3-Carboxy-4-chlorophenyl)ami...)
Show SMILES CC(=O)N(CCN(C(C)=O)c1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O)c1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C40H32Cl2N4O10S2/c1-23(47)45(31-9-3-25-5-11-33(19-27(25)17-31)57(53,54)43-29-7-13-37(41)35(21-29)39(49)50)15-16-46(24(2)48)32-10-4-26-6-12-34(20-28(26)18-32)58(55,56)44-30-8-14-38(42)36(22-30)40(51)52/h3-14,17-22,43-44H,15-16H2,1-2H3,(H,49,50)(H,51,52)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253170
PNG
(1,3-bis({7-[(3-hydroxyphenyl)sulfamoyl]naphthalen-...)
Show SMILES Oc1cccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4cccc(O)c4)cc3c2)c1
Show InChI InChI=1S/C33H26N4O7S2/c38-29-5-1-3-27(19-29)36-45(41,42)31-13-9-21-7-11-25(15-23(21)17-31)34-33(40)35-26-12-8-22-10-14-32(18-24(22)16-26)46(43,44)37-28-4-2-6-30(39)20-28/h1-20,36-39H,(H2,34,35,40)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253172
PNG
(2-[3-(7-{[(7-{[3-(carboxymethyl)phenyl]sulfamoyl}-...)
Show SMILES OC(=O)Cc1cccc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4cccc(CC(O)=O)c4)cc3c2)c1
Show InChI InChI=1S/C37H30N4O11S2/c42-33-19-29(53(49,50)40-27-5-1-3-21(11-27)13-35(44)45)17-23-15-25(7-9-31(23)33)38-37(48)39-26-8-10-32-24(16-26)18-30(20-34(32)43)54(51,52)41-28-6-2-4-22(12-28)14-36(46)47/h1-12,15-20,40-43H,13-14H2,(H,44,45)(H,46,47)(H2,38,39,48)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253194
PNG
(5-({[7-({2-[(7-{[(3-Carboxy-4-chlorophenyl)amino]s...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NCCNc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(Cl)c(c4)C(O)=O)cc3c2)ccc1Cl
Show InChI InChI=1S/C36H28Cl2N4O8S2/c37-33-11-7-27(19-31(33)35(43)44)41-51(47,48)29-9-3-21-1-5-25(15-23(21)17-29)39-13-14-40-26-6-2-22-4-10-30(18-24(22)16-26)52(49,50)42-28-8-12-34(38)32(20-28)36(45)46/h1-12,15-20,39-42H,13-14H2,(H,43,44)(H,45,46)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253199
PNG
(5-{[(7-{[N-(7-{[(3-Carboxy-4-chlorophenyl)amino]su...)
Show SMILES CN(C(=O)N(C)c1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O)c1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C37H28Cl2N4O9S2/c1-42(27-9-3-21-5-11-29(17-23(21)15-27)53(49,50)40-25-7-13-33(38)31(19-25)35(44)45)37(48)43(2)28-10-4-22-6-12-30(18-24(22)16-28)54(51,52)41-26-8-14-34(39)32(20-26)36(46)47/h3-20,40-41H,1-2H3,(H,44,45)(H,46,47)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253162
PNG
(1,3-bis({7-[(3-nitrophenyl)sulfamoyl]naphthalen-2-...)
Show SMILES [O-][N+](=O)c1cccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4cccc(c4)[N+]([O-])=O)cc3c2)c1
Show InChI InChI=1S/C33H24N6O9S2/c40-33(34-25-11-7-21-9-13-31(17-23(21)15-25)49(45,46)36-27-3-1-5-29(19-27)38(41)42)35-26-12-8-22-10-14-32(18-24(22)16-26)50(47,48)37-28-4-2-6-30(20-28)39(43)44/h1-20,36-37H,(H2,34,35,40)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253161
PNG
(7,7'-carbonylbis(azanediyl)bis(N-phenylnaphthalene...)
Show SMILES O=C(Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccccc1)Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C33H26N4O5S2/c38-33(34-29-15-11-23-13-17-31(21-25(23)19-29)43(39,40)36-27-7-3-1-4-8-27)35-30-16-12-24-14-18-32(22-26(24)20-30)44(41,42)37-28-9-5-2-6-10-28/h1-22,36-37H,(H2,34,35,38)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253198
PNG
(5-[7-(1-{7-[(3-carboxy-4-chlorophenyl)sulfamoyl]na...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(NC#N)=Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(Cl)c(c4)C(O)=O)cc3c2)ccc1Cl |w:22.22|
Show InChI InChI=1S/C36H24Cl2N6O8S2/c37-32-11-7-26(17-30(32)34(45)46)43-53(49,50)28-9-3-20-1-5-24(13-22(20)15-28)41-36(40-19-39)42-25-6-2-21-4-10-29(16-23(21)14-25)54(51,52)44-27-8-12-33(38)31(18-27)35(47)48/h1-18,43-44H,(H,45,46)(H,47,48)(H2,40,41,42)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50253197
PNG
(5-[7-(1-{7-[(3-carboxy-4-chlorophenyl)sulfamoyl]na...)
Show SMILES CNC(Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O)=Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O |w:28.31|
Show InChI InChI=1S/C36H27Cl2N5O8S2/c1-39-36(40-24-6-2-20-4-10-28(16-22(20)14-24)52(48,49)42-26-8-12-32(37)30(18-26)34(44)45)41-25-7-3-21-5-11-29(17-23(21)15-25)53(50,51)43-27-9-13-33(38)31(19-27)35(46)47/h2-19,42-43H,1H3,(H,44,45)(H,46,47)(H2,39,40,41)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)		BDBM50377966
PNG
(CHEMBL1627108)
Show SMILES [O-]S(=O)(=O)c1ccc2ccc(NC(=O)Nc3ccc4ccc(cc4c3)S(=O)(=O)Nc3ccc(Cl)c(c3)S([O-])(=O)=O)cc2c1
Show InChI InChI=1S/C27H20ClN3O9S3/c28-25-10-7-22(15-26(25)43(38,39)40)31-41(33,34)23-8-3-16-1-5-20(11-18(16)13-23)29-27(32)30-21-6-2-17-4-9-24(42(35,36)37)14-19(17)12-21/h1-15,31H,(H2,29,30,32)(H,35,36,37)(H,38,39,40)/p-2
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PubMed
n/an/an/an/a>2.00E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin

J Med Chem 51: 6173-87 (2008)


Article DOI: 10.1021/jm800600v
BindingDB Entry DOI: 10.7270/Q2ZG6T5K
More data for this
Ligand-Target Pair