Compile Data Set for Download or QSAR

Found 33 hits of ic50 for UniProtKB: P00451   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor VIII (Homo sapiens (Human))	BDBM59162 (8047577) Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Cl)cc2Cl)C1=O Show InChI InChI=1S/C21H10Cl2F3NO2S2/c22-12-4-6-15(16(23)9-12)17-7-5-14(29-17)10-18-19(28)27(20(30)31-18)13-3-1-2-11(8-13)21(24,25)26/h1-10H/b18-10-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	7.9	n/a
University of Washington					Assay Description Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59159 (6190013) Show SMILES [#8-]-[#7+](=O)-c1cc(Cl)c(cc1Cl)-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)o1 Show InChI InChI=1S/C15H7Cl2N3O5S/c16-9-5-11(20(23)24)10(17)4-7(9)12-2-1-6(25-12)3-8-13(21)18-15(26)19-14(8)22/h1-5H,(H2,18,19,21,22,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.11E+3	n/a	n/a	n/a	n/a	8.0	n/a
University of Washington					Assay Description Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59162 (8047577) Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Cl)cc2Cl)C1=O Show InChI InChI=1S/C21H10Cl2F3NO2S2/c22-12-4-6-15(16(23)9-12)17-7-5-14(29-17)10-18-19(28)27(20(30)31-18)13-3-1-2-11(8-13)21(24,25)26/h1-10H/b18-10-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.44E+3	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59162 (8047577) Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Cl)cc2Cl)C1=O Show InChI InChI=1S/C21H10Cl2F3NO2S2/c22-12-4-6-15(16(23)9-12)17-7-5-14(29-17)10-18-19(28)27(20(30)31-18)13-3-1-2-11(8-13)21(24,25)26/h1-10H/b18-10-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.56E+3	n/a	n/a	n/a	n/a	8.0	n/a
University of Washington					Assay Description Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59164 (8048422) Show SMILES [#8-]-[#6](=O)-c1cc(ccc1Cl)-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)o1 Show InChI InChI=1S/C16H9ClN2O5S/c17-11-3-1-7(5-9(11)15(22)23)12-4-2-8(24-12)6-10-13(20)18-16(25)19-14(10)21/h1-6H,(H,22,23)(H2,18,19,20,21,25)/p-1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.89E+3	n/a	n/a	n/a	n/a	8.0	n/a
University of Washington					Assay Description Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59164 (8048422) Show SMILES [#8-]-[#6](=O)-c1cc(ccc1Cl)-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)o1 Show InChI InChI=1S/C16H9ClN2O5S/c17-11-3-1-7(5-9(11)15(22)23)12-4-2-8(24-12)6-10-13(20)18-16(25)19-14(10)21/h1-6H,(H,22,23)(H2,18,19,20,21,25)/p-1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.17E+3	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59154 (5739991) Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O Show InChI InChI=1S/C14H7BrN2O4S2/c15-12-6-5-10(21-12)7-11-13(18)16(14(22)23-11)8-1-3-9(4-2-8)17(19)20/h1-7H/b11-7-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.63E+3	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59163 (6789536) Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C\c2ccc(Sc3ccc(Cl)cc3)o2)C1=O Show InChI InChI=1S/C20H11ClN2O4S3/c21-12-1-8-16(9-2-12)29-18-10-7-15(27-18)11-17-19(24)22(20(28)30-17)13-3-5-14(6-4-13)23(25)26/h1-11H/b17-11+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.81E+3	n/a	n/a	n/a	n/a	8.0	n/a
University of Washington					Assay Description Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59161 (5738875) Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(I)o2)C1=O Show InChI InChI=1S/C15H7F3INO2S2/c16-15(17,18)8-2-1-3-9(6-8)20-13(21)11(24-14(20)23)7-10-4-5-12(19)22-10/h1-7H/b11-7-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	7.9	n/a
University of Washington					Assay Description Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59163 (6789536) Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C\c2ccc(Sc3ccc(Cl)cc3)o2)C1=O Show InChI InChI=1S/C20H11ClN2O4S3/c21-12-1-8-16(9-2-12)29-18-10-7-15(27-18)11-17-19(24)22(20(28)30-17)13-3-5-14(6-4-13)23(25)26/h1-11H/b17-11+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	7.9	n/a
University of Washington					Assay Description Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59161 (5738875) Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(I)o2)C1=O Show InChI InChI=1S/C15H7F3INO2S2/c16-15(17,18)8-2-1-3-9(6-8)20-13(21)11(24-14(20)23)7-10-4-5-12(19)22-10/h1-7H/b11-7-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.65E+3	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59163 (6789536) Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C\c2ccc(Sc3ccc(Cl)cc3)o2)C1=O Show InChI InChI=1S/C20H11ClN2O4S3/c21-12-1-8-16(9-2-12)29-18-10-7-15(27-18)11-17-19(24)22(20(28)30-17)13-3-5-14(6-4-13)23(25)26/h1-11H/b17-11+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.85E+3	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59165 (8056354) Show SMILES [#8-]-[#6](=O)-c1cccc(-c2ccc(\[#6]=[#6]-3/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-3=O)o2)c1Cl Show InChI InChI=1S/C16H9ClN2O5S/c17-12-8(2-1-3-9(12)15(22)23)11-5-4-7(24-11)6-10-13(20)18-16(25)19-14(10)21/h1-6H,(H,22,23)(H2,18,19,20,21,25)/p-1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.29E+3	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59165 (8056354) Show SMILES [#8-]-[#6](=O)-c1cccc(-c2ccc(\[#6]=[#6]-3/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-3=O)o2)c1Cl Show InChI InChI=1S/C16H9ClN2O5S/c17-12-8(2-1-3-9(12)15(22)23)11-5-4-7(24-11)6-10-13(20)18-16(25)19-14(10)21/h1-6H,(H,22,23)(H2,18,19,20,21,25)/p-1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.51E+3	n/a	n/a	n/a	n/a	8.0	n/a
University of Washington					Assay Description Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59153 (5737176) Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O Show InChI InChI=1S/C15H7BrF3NO2S2/c16-12-5-4-10(22-12)7-11-13(21)20(14(23)24-11)9-3-1-2-8(6-9)15(17,18)19/h1-7H/b11-7-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.66E+3	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59164 (8048422) Show SMILES [#8-]-[#6](=O)-c1cc(ccc1Cl)-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)o1 Show InChI InChI=1S/C16H9ClN2O5S/c17-11-3-1-7(5-9(11)15(22)23)12-4-2-8(24-12)6-10-13(20)18-16(25)19-14(10)21/h1-6H,(H,22,23)(H2,18,19,20,21,25)/p-1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	7.9	n/a
University of Washington					Assay Description Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59165 (8056354) Show SMILES [#8-]-[#6](=O)-c1cccc(-c2ccc(\[#6]=[#6]-3/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-3=O)o2)c1Cl Show InChI InChI=1S/C16H9ClN2O5S/c17-12-8(2-1-3-9(12)15(22)23)11-5-4-7(24-11)6-10-13(20)18-16(25)19-14(10)21/h1-6H,(H,22,23)(H2,18,19,20,21,25)/p-1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	7.9	n/a
University of Washington					Assay Description Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59161 (5738875) Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(I)o2)C1=O Show InChI InChI=1S/C15H7F3INO2S2/c16-15(17,18)8-2-1-3-9(6-8)20-13(21)11(24-14(20)23)7-10-4-5-12(19)22-10/h1-7H/b11-7-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.83E+3	n/a	n/a	n/a	n/a	8.0	n/a
University of Washington					Assay Description Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59159 (6190013) Show SMILES [#8-]-[#7+](=O)-c1cc(Cl)c(cc1Cl)-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)o1 Show InChI InChI=1S/C15H7Cl2N3O5S/c16-9-5-11(20(23)24)10(17)4-7(9)12-2-1-6(25-12)3-8-13(21)18-15(26)19-14(8)22/h1-5H,(H2,18,19,21,22,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	7.9	n/a
University of Washington					Assay Description Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM50423622 (CHEMBL1614804) Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N |r| Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Maastricht University Curated by ChEMBL					Assay Description Inhibition of human factor 8 binding to immobilized phospholipid by surface plasmon resonance assay				Proc Natl Acad Sci USA 104: 12697-702 (2007) Article DOI: 10.1073/pnas.0701051104 BindingDB Entry DOI: 10.7270/Q2F190MG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Coagulation factor VIII (Homo sapiens (Human))	BDBM59159 (6190013) Show SMILES [#8-]-[#7+](=O)-c1cc(Cl)c(cc1Cl)-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)o1 Show InChI InChI=1S/C15H7Cl2N3O5S/c16-9-5-11(20(23)24)10(17)4-7(9)12-2-1-6(25-12)3-8-13(21)18-15(26)19-14(8)22/h1-5H,(H2,18,19,21,22,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.48E+3	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59153 (5737176) Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O Show InChI InChI=1S/C15H7BrF3NO2S2/c16-12-5-4-10(22-12)7-11-13(21)20(14(23)24-11)9-3-1-2-8(6-9)15(17,18)19/h1-7H/b11-7-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	7.9	n/a
University of Washington					Assay Description Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM50376417 (CHEMBL261865) Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1 |w:16.16| Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Maastricht University Curated by ChEMBL					Assay Description Inhibition of human factor 8 binding to immobilized phospholipid by surface plasmon resonance assay				Proc Natl Acad Sci USA 104: 12697-702 (2007) Article DOI: 10.1073/pnas.0701051104 BindingDB Entry DOI: 10.7270/Q2F190MG
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59153 (5737176) Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O Show InChI InChI=1S/C15H7BrF3NO2S2/c16-12-5-4-10(22-12)7-11-13(21)20(14(23)24-11)9-3-1-2-8(6-9)15(17,18)19/h1-7H/b11-7-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.25E+3	n/a	n/a	n/a	n/a	8.0	n/a
University of Washington					Assay Description Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59154 (5739991) Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O Show InChI InChI=1S/C14H7BrN2O4S2/c15-12-6-5-10(21-12)7-11-13(18)16(14(22)23-11)8-1-3-9(4-2-8)17(19)20/h1-7H/b11-7-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	8.0	n/a
University of Washington					Assay Description Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59154 (5739991) Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O Show InChI InChI=1S/C14H7BrN2O4S2/c15-12-6-5-10(21-12)7-11-13(18)16(14(22)23-11)8-1-3-9(4-2-8)17(19)20/h1-7H/b11-7-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.17E+4	n/a	n/a	n/a	n/a	7.9	n/a
University of Washington					Assay Description Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59157 (6126765) Show SMILES COc1cc(\C=C2\SC(=S)N(CC(=O)Nc3ccccn3)C2=O)cc(OC)c1OC Show InChI InChI=1S/C20H19N3O5S2/c1-26-13-8-12(9-14(27-2)18(13)28-3)10-15-19(25)23(20(29)30-15)11-17(24)22-16-6-4-5-7-21-16/h4-10H,11H2,1-3H3,(H,21,22,24)/b15-10+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.19E+4	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59160 (6209549) Show SMILES COc1cc(C=Nn2c(O)csc2=S)ccc1OCCOc1ccc(cc1)C(C)(C)C |w:6.6| Show InChI InChI=1S/C23H26N2O4S2/c1-23(2,3)17-6-8-18(9-7-17)28-11-12-29-19-10-5-16(13-20(19)27-4)14-24-25-21(26)15-31-22(25)30/h5-10,13-15,26H,11-12H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.24E+4	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59155 (5924029) Show SMILES Fc1ccc(C=NNC(=N)NN=Cc2ccc(F)cc2)cc1 |w:11.10,6.6| Show InChI InChI=1S/C15H13F2N5/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12/h1-10H,(H3,18,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.45E+4	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59156 (6072484 | cid_726942) Show SMILES CCOc1ccc(cc1)-c1cc(C)n2nc(cc2n1)C(N)=O Show InChI InChI=1S/C16H16N4O2/c1-3-22-12-6-4-11(5-7-12)13-8-10(2)20-15(18-13)9-14(19-20)16(17)21/h4-9H,3H2,1-2H3,(H2,17,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.68E+4	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59152 (5523453) Show SMILES CCOC(=O)c1c(NC(=S)NC(=O)c2ccccc2)sc2CC(C)CCc12 Show InChI InChI=1S/C20H22N2O3S2/c1-3-25-19(24)16-14-10-9-12(2)11-15(14)27-18(16)22-20(26)21-17(23)13-7-5-4-6-8-13/h4-8,12H,3,9-11H2,1-2H3,(H2,21,22,23,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.77E+4	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59158 (6168356) Show SMILES CCOc1ccc(Cl)cc1\C=C1\SC(=S)N(CC)C1=O Show InChI InChI=1S/C14H14ClNO2S2/c1-3-16-13(17)12(20-14(16)19)8-9-7-10(15)5-6-11(9)18-4-2/h5-8H,3-4H2,1-2H3/b12-8+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.96E+4	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair
Coagulation factor VIII (Homo sapiens (Human))	BDBM59151 (5247489) Show SMILES CC(C=Cc1ccco1)=NCCCCNC(=O)C=Cc1ccco1 |w:18.19,9.10,2.1| Show InChI InChI=1S/C19H22N2O3/c1-16(8-9-17-6-4-14-23-17)20-12-2-3-13-21-19(22)11-10-18-7-5-15-24-18/h4-11,14-15H,2-3,12-13H2,1H3,(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.61E+4	n/a	n/a	n/a	n/a	n/a	37
University of Washington					Assay Description Inhibition of factor VIII C2 domain.				Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1
					More data for this Ligand-Target Pair