Found 561 hits of ic50 for UniProtKB: P21980 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM185167
((4-Methoxycarbonylphenyl)methyl 4-[2-[(2-bromoacet...)Show SMILES COC(=O)c1ccc(COC(=O)N2CCN(CC2)C(=O)CNC(=O)CBr)cc1 Show InChI InChI=1S/C18H22BrN3O6/c1-27-17(25)14-4-2-13(3-5-14)12-28-18(26)22-8-6-21(7-9-22)16(24)11-20-15(23)10-19/h2-5H,6-12H2,1H3,(H,20,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University
| Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... |
Chem Biol 22: 1347-61 (2015)
Article DOI: 10.1016/j.chembiol.2015.08.013
BindingDB Entry DOI: 10.7270/Q2222SJC |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM185170
(N-[2-[4-(adamantane-1-carbonyl)piperazin-1-yl]-2-o...)Show SMILES BrCC(=O)NCC(=O)N1CCN(CC1)C(=O)C12CC3CC(CC(C3)C1)C2 |TLB:19:20:24:18.23.17,23:18:25:22.24.21,23:22:25:19.18.17,THB:19:18:24:25.20.21| Show InChI InChI=1S/C19H28BrN3O3/c20-11-16(24)21-12-17(25)22-1-3-23(4-2-22)18(26)19-8-13-5-14(9-19)7-15(6-13)10-19/h13-15H,1-12H2,(H,21,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University
| Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... |
Chem Biol 22: 1347-61 (2015)
Article DOI: 10.1016/j.chembiol.2015.08.013
BindingDB Entry DOI: 10.7270/Q2222SJC |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM185181
(N-[2-[4-[[5-(dimethylamino)-1-naphthyl]sulfonyl]pi...)Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N1CCN(CC1)C(=O)CNC(=O)C=C Show InChI InChI=1S/C21H26N4O4S/c1-4-20(26)22-15-21(27)24-11-13-25(14-12-24)30(28,29)19-10-6-7-16-17(19)8-5-9-18(16)23(2)3/h4-10H,1,11-15H2,2-3H3,(H,22,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human TG2 by fluorescence assay |
J Med Chem 60: 554-567 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01036
BindingDB Entry DOI: 10.7270/Q2F47RKD |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM185175
(1-Adamantylmethyl 4-[2-[(2-bromoacetyl)amino]acety...)Show SMILES BrCC(=O)NCC(=O)N1CCN(CC1)C(=O)OCC12CC3CC(CC(C3)C1)C2 |TLB:21:22:26:20.25.19,25:20:27:24.26.23,25:24:27:21.20.19,THB:21:20:26:27.22.23| Show InChI InChI=1S/C20H30BrN3O4/c21-11-17(25)22-12-18(26)23-1-3-24(4-2-23)19(27)28-13-20-8-14-5-15(9-20)7-16(6-14)10-20/h14-16H,1-13H2,(H,22,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.29 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University
| Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... |
Chem Biol 22: 1347-61 (2015)
Article DOI: 10.1016/j.chembiol.2015.08.013
BindingDB Entry DOI: 10.7270/Q2222SJC |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM185166
((6-Methoxycarbonyl-2-naphthyl)methyl 4-[2-[(2-chlo...)Show SMILES COC(=O)c1ccc2cc(COC(=O)N3CCN(CC3)C(=O)CNC(=O)CCl)ccc2c1 Show InChI InChI=1S/C22H24ClN3O6/c1-31-21(29)18-5-4-16-10-15(2-3-17(16)11-18)14-32-22(30)26-8-6-25(7-9-26)20(28)13-24-19(27)12-23/h2-5,10-11H,6-9,12-14H2,1H3,(H,24,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.65 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University
| Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... |
Chem Biol 22: 1347-61 (2015)
Article DOI: 10.1016/j.chembiol.2015.08.013
BindingDB Entry DOI: 10.7270/Q2222SJC |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM185171
(N-[2-[4-(adamantane-1-carbonyl)piperazin-1-yl]-2-o...)Show SMILES ClCC(=O)NCC(=O)N1CCN(CC1)C(=O)C12CC3CC(CC(C3)C1)C2 |TLB:19:20:24:18.23.17,23:18:25:22.24.21,23:22:25:19.18.17,THB:19:18:24:25.20.21| Show InChI InChI=1S/C19H28ClN3O3/c20-11-16(24)21-12-17(25)22-1-3-23(4-2-22)18(26)19-8-13-5-14(9-19)7-15(6-13)10-19/h13-15H,1-12H2,(H,21,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University
| Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... |
Chem Biol 22: 1347-61 (2015)
Article DOI: 10.1016/j.chembiol.2015.08.013
BindingDB Entry DOI: 10.7270/Q2222SJC |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50083722
(CHEMBL3423198)Show SMILES NC(=O)[C@@H]1O[C@@H]1C(=O)Nc1ccc(Br)c(Cl)c1 |r| Show InChI InChI=1S/C10H8BrClN2O3/c11-5-2-1-4(3-6(5)12)14-10(16)8-7(17-8)9(13)15/h1-3,7-8H,(H2,13,15)(H,14,16)/t7-,8+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leeds
Curated by ChEMBL
| Assay Description
Inhibition of transglutaminase 2 (unknown origin) |
Eur J Med Chem 98: 49-53 (2015)
Article DOI: 10.1016/j.ejmech.2015.05.019
BindingDB Entry DOI: 10.7270/Q261121G |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420459
(CHEMBL2086528)Show SMILES C=CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)C12CC3CC(CC(C3)C1)C2 |TLB:31:22:29:25.26.27,20:22:29:25.26.27,THB:31:26:23.22.30:29,27:26:23:30.28.29,27:28:23:25.31.26| Show InChI InChI=1S/C24H31N3O4S/c1-2-22(28)25-20-3-5-21(6-4-20)32(30,31)27-9-7-26(8-10-27)23(29)24-14-17-11-18(15-24)13-19(12-17)16-24/h2-6,17-19H,1,7-16H2,(H,25,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2/Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM81345
(Z4626 (ZM 39923))Show InChI InChI=1S/C16H10Br2INO/c1-8-11(12-7-10(19)2-3-15(12)20-8)4-9-5-13(17)16(21)14(18)6-9/h2-7,20-21H,1H2/b11-4+ | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | 37 |
Duke University Medical Center
| Assay Description
In order to eliminated fluorescence interference, chemicals were subjected to a secondary screening using colorimetric BP incorporation assay. TGase... |
Chem Biol 15: 969-78 (2008)
Article DOI: 10.1016/j.chembiol.2008.07.015
BindingDB Entry DOI: 10.7270/Q2DR2SZR |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577488
(US11472838, Compound 6)Show SMILES COC(=O)\C=C\CC[C@H](NC(=O)c1cnc(O)c(c1)[N+]([O-])=O)C(=O)N[C@H](C(=O)N1CC(=O)C[C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O)C(C)(C)C |r| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420454
(CHEMBL2086544)Show SMILES C=CC(=O)Nc1ncc(cn1)S(=O)(=O)N1CCN(CC1)C(=O)C12CC3CC(CC(C3)C1)C2 |TLB:31:22:29:25.26.27,THB:31:26:23.22.30:29,27:26:23:30.28.29,27:28:23:25.31.26| Show InChI InChI=1S/C22H29N5O4S/c1-2-19(28)25-21-23-13-18(14-24-21)32(30,31)27-5-3-26(4-6-27)20(29)22-10-15-7-16(11-22)9-17(8-15)12-22/h2,13-17H,1,3-12H2,(H,23,24,25,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50400621
(CHEMBL2203451)Show SMILES Cc1cccc(n1)N1CCN(CC1)C(=O)[C@H](CCCCNC(=O)C=C)NC(=O)Cc1ccccc1 |r| Show InChI InChI=1S/C27H35N5O3/c1-3-25(33)28-15-8-7-13-23(30-26(34)20-22-11-5-4-6-12-22)27(35)32-18-16-31(17-19-32)24-14-9-10-21(2)29-24/h3-6,9-12,14,23H,1,7-8,13,15-20H2,2H3,(H,28,33)(H,30,34)/t23-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Irreversible inhibition of transglutaminase 2 |
ACS Med Chem Lett 3: 1024-1028 (2012)
Article DOI: 10.1021/ml300241m
BindingDB Entry DOI: 10.7270/Q2TB1823 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM204888
(US9260454, 21)Show SMILES [O-][n+]1cccc2c1sn(C(=O)N1CCN(CC1)C(=O)CCOc1ccccc1)c2=O Show InChI InChI=1S/C20H20N4O5S/c25-17(8-14-29-15-5-2-1-3-6-15)21-10-12-22(13-11-21)20(27)24-18(26)16-7-4-9-23(28)19(16)30-24/h1-7,9H,8,10-14H2 | PDB
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KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.5 | 25 |
SANOFI
US Patent
| Assay Description
2 ul of a solution of different concentrations of the test compound in dimethyl sulfoxide was added to 28 ul of buffer (50 mM TRIS, 100 mM NaCl, 10 m... |
US Patent US9260454 (2016)
BindingDB Entry DOI: 10.7270/Q2DN43VV |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577487
(US11472838, Compound 4)Show SMILES COC(=O)\C=C\CC[C@H](NC(=O)c1cc(cc(c1)[N+]([O-])=O)C(O)=O)C(=O)N[C@H](C(=O)N1CC(=O)C[C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O)C(C)(C)C |r| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM185163
((6-Methoxycarbonyl-2-naphthyl)methyl 4-[2-[(2-brom...)Show SMILES COC(=O)c1ccc2cc(COC(=O)N3CCN(CC3)C(=O)CNC(=O)CBr)ccc2c1 Show InChI InChI=1S/C22H24BrN3O6/c1-31-21(29)18-5-4-16-10-15(2-3-17(16)11-18)14-32-22(30)26-8-6-25(7-9-26)20(28)13-24-19(27)12-23/h2-5,10-11H,6-9,12-14H2,1H3,(H,24,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University
| Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... |
Chem Biol 22: 1347-61 (2015)
Article DOI: 10.1016/j.chembiol.2015.08.013
BindingDB Entry DOI: 10.7270/Q2222SJC |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420451
(CHEMBL2086541)Show SMILES C=CC(=O)Nc1ccc(cn1)S(=O)(=O)N1CCN(CC1)C(=O)C12CC3CC(CC(C3)C1)C2 |TLB:31:22:29:25.26.27,THB:31:26:23.22.30:29,27:26:23:30.28.29,27:28:23:25.31.26| Show InChI InChI=1S/C23H30N4O4S/c1-2-21(28)25-20-4-3-19(15-24-20)32(30,31)27-7-5-26(6-8-27)22(29)23-12-16-9-17(13-23)11-18(10-16)14-23/h2-4,15-18H,1,5-14H2,(H,24,25,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577512
(US11472838, Compound 30)Show SMILES COC(=O)\C=C\CC[C@H](NC(=O)c1ccc(cc1C(O)=O)[N+]([O-])=O)C(=O)N[C@H](C(=O)N1COC[C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O)C(C)(C)C |r| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577486
(US11472838, Compound 3)Show SMILES COC(=O)\C=C\CC[C@H](NC(=O)c1nccnc1C(O)=O)C(=O)N[C@H](C(=O)N1CC(=O)C[C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O)C(C)(C)C |r,$;;;;;;;;;N;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;N;;;;;;;;;;;;;;$| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50444514
(CHEMBL3092843)Show SMILES CCOC(=O)\C=C\CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)OC |r| Show InChI InChI=1S/C34H49N5O10/c1-5-48-29(41)16-10-9-14-24(38-34(46)49-21-23-12-7-6-8-13-23)30(42)36-25(17-18-28(35)40)32(44)39-19-11-15-27(39)31(43)37-26(20-22(2)3)33(45)47-4/h6-8,10,12-13,16,22,24-27H,5,9,11,14-15,17-21H2,1-4H3,(H2,35,40)(H,36,42)(H,37,43)(H,38,46)/b16-10+/t24-,25-,26-,27-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human TGase2 |
Bioorg Med Chem Lett 23: 6528-43 (2014)
BindingDB Entry DOI: 10.7270/Q2K64KJP |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420515
(CHEMBL2086523)Show SMILES C=CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)N1CCC2CCCCC2C1 Show InChI InChI=1S/C23H32N4O4S/c1-2-22(28)24-20-7-9-21(10-8-20)32(30,31)27-15-13-25(14-16-27)23(29)26-12-11-18-5-3-4-6-19(18)17-26/h2,7-10,18-19H,1,3-6,11-17H2,(H,24,28) | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50444514
(CHEMBL3092843)Show SMILES CCOC(=O)\C=C\CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)OC |r| Show InChI InChI=1S/C34H49N5O10/c1-5-48-29(41)16-10-9-14-24(38-34(46)49-21-23-12-7-6-8-13-23)30(42)36-25(17-18-28(35)40)32(44)39-19-11-15-27(39)31(43)37-26(20-22(2)3)33(45)47-4/h6-8,10,12-13,16,22,24-27H,5,9,11,14-15,17-21H2,1-4H3,(H2,35,40)(H,36,42)(H,37,43)(H,38,46)/b16-10+/t24-,25-,26-,27-/m0/s1 | PDB
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Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)
Curated by ChEMBL
| Assay Description
Inhibition of human TG2 using glycine methyl ester/Abz-APE as substrate after 5 mins |
J Med Chem 60: 554-567 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01036
BindingDB Entry DOI: 10.7270/Q2F47RKD |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420474
(CHEMBL2086889 | US9073941, 607)Show InChI InChI=1S/C15H15N5O3/c1-4-20-13-11(14(21)19(2)15(22)17-13)16-12(18-20)9-5-7-10(23-3)8-6-9/h5-8H,4H2,1-3H3 | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420471
(CHEMBL2086530)Show SMILES Cc1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C19H22N4O3S/c1-3-18(24)21-16-6-8-17(9-7-16)27(25,26)23-13-11-22(12-14-23)19-15(2)5-4-10-20-19/h3-10H,1,11-14H2,2H3,(H,21,24) | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420452
(CHEMBL2086542)Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)S(=O)(=O)c1cnc(NC(=O)C=C)nc1 Show InChI InChI=1S/C16H23N5O5S/c1-5-13(22)19-14-17-10-12(11-18-14)27(24,25)21-8-6-20(7-9-21)15(23)26-16(2,3)4/h5,10-11H,1,6-9H2,2-4H3,(H,17,18,19,22) | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577529
(US11472838, Compound Ref. 09)Show SMILES CCOC(=O)\C=C\CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C1CCCCC1)C(N)=O |r| | PDB
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TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420468
(CHEMBL2086524)Show SMILES C=CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)N1CCCC2CCCCC12 Show InChI InChI=1S/C23H32N4O4S/c1-2-22(28)24-19-9-11-20(12-10-19)32(30,31)26-16-14-25(15-17-26)23(29)27-13-5-7-18-6-3-4-8-21(18)27/h2,9-12,18,21H,1,3-8,13-17H2,(H,24,28) | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577509
(US11472838, Compound 27 | US11472838, Compound 31a...)Show SMILES COC(=O)\C=C\CC[C@H](NC(=O)c1cncc(c1)C(O)=O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O)C(C)(C)C |r| | PDB
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TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM185160
(2-Naphthylmethyl 4-[2-[(2-bromoacetyl)amino]acetyl...)Show SMILES BrCC(=O)NCC(=O)N1CCN(CC1)C(=O)OCc1ccc2ccccc2c1 Show InChI InChI=1S/C20H22BrN3O4/c21-12-18(25)22-13-19(26)23-7-9-24(10-8-23)20(27)28-14-15-5-6-16-3-1-2-4-17(16)11-15/h1-6,11H,7-10,12-14H2,(H,22,25) | PDB
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Aston University
| Assay Description
For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... |
Chem Biol 22: 1347-61 (2015)
Article DOI: 10.1016/j.chembiol.2015.08.013
BindingDB Entry DOI: 10.7270/Q2222SJC |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50444513
(CHEMBL3092841)Show SMILES CCOC(=O)\C=C\CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)OC |r| Show InChI InChI=1S/C34H50N4O9/c1-7-46-28(39)18-12-11-16-25(36-34(44)47-21-24-14-9-8-10-15-24)30(40)37-29(23(4)5)32(42)38-19-13-17-27(38)31(41)35-26(20-22(2)3)33(43)45-6/h8-10,12,14-15,18,22-23,25-27,29H,7,11,13,16-17,19-21H2,1-6H3,(H,35,41)(H,36,44)(H,37,40)/b18-12+/t25-,26-,27-,29-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human TGase2 |
Bioorg Med Chem Lett 23: 6528-43 (2014)
BindingDB Entry DOI: 10.7270/Q2K64KJP |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50444513
(CHEMBL3092841)Show SMILES CCOC(=O)\C=C\CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)OC |r| Show InChI InChI=1S/C34H50N4O9/c1-7-46-28(39)18-12-11-16-25(36-34(44)47-21-24-14-9-8-10-15-24)30(40)37-29(23(4)5)32(42)38-19-13-17-27(38)31(41)35-26(20-22(2)3)33(43)45-6/h8-10,12,14-15,18,22-23,25-27,29H,7,11,13,16-17,19-21H2,1-6H3,(H,35,41)(H,36,44)(H,37,40)/b18-12+/t25-,26-,27-,29-/m0/s1 | PDB
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Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)
Curated by ChEMBL
| Assay Description
Inhibition of human TG2 using glycine methyl ester/Abz-APE as substrate after 5 mins |
J Med Chem 60: 554-567 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01036
BindingDB Entry DOI: 10.7270/Q2F47RKD |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420463
(CHEMBL2086480)Show SMILES C=CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)C1CCCC1 Show InChI InChI=1S/C19H25N3O4S/c1-2-18(23)20-16-7-9-17(10-8-16)27(25,26)22-13-11-21(12-14-22)19(24)15-5-3-4-6-15/h2,7-10,15H,1,3-6,11-14H2,(H,20,23) | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577511
(US11472838, Compound 29 | US11472838, Compound 32a...)Show SMILES COC(=O)\C=C\CC[C@H](NC(=O)c1cc(Cl)c(Cl)cc1C(O)=O)C(=O)N[C@H](C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O)C2(C)C)C(C)(C)C |r| | PDB
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TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577526
(US11472838, Compound Ref. 7)Show SMILES CCOC(=O)\C=C\CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CC(C)C)C(N)=O |r| | PDB
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TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420467
(CHEMBL2086521)Show SMILES C=CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)C1C[C@@H]1c1ccccc1 |r| Show InChI InChI=1S/C23H25N3O4S/c1-2-22(27)24-18-8-10-19(11-9-18)31(29,30)26-14-12-25(13-15-26)23(28)21-16-20(21)17-6-4-3-5-7-17/h2-11,20-21H,1,12-16H2,(H,24,27)/t20-,21?/m1/s1 | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577507
(US11472838, Compound 25a/b)Show SMILES COC(=O)\C=C\CC[C@H](NC(=O)c1cc(ccc1C(O)=O)[N+]([O-])=O)C(=O)N[C@H](C(=O)N1CCOC[C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O)C(C)(C)C |r,$;;;;;;;;;N;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;N;;;;;;;;;;;;;;$| | PDB
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TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420518
(CHEMBL2086531)Show SMILES Cc1cccc(n1)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C19H22N4O3S/c1-3-19(24)21-16-7-9-17(10-8-16)27(25,26)23-13-11-22(12-14-23)18-6-4-5-15(2)20-18/h3-10H,1,11-14H2,2H3,(H,21,24) | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577527
(US11472838, Compound Ref. 08)Show SMILES CCOC(=O)\C=C\CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C1CCCCC1)C(N)=O |r| | PDB
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TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420469
(CHEMBL2086525)Show SMILES C=CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)N1CCCCC1 Show InChI InChI=1S/C19H26N4O4S/c1-2-18(24)20-16-6-8-17(9-7-16)28(26,27)23-14-12-22(13-15-23)19(25)21-10-4-3-5-11-21/h2,6-9H,1,3-5,10-15H2,(H,20,24) | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577492
(US11472838, Compound 10a/b)Show SMILES COC(=O)\C=C\CC[C@H](NC(=O)c1cc(ccc1C(O)=O)[N+]([O-])=O)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O)Oc1ccccc1)C(C)(C)C |r| | PDB
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TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420470
(CHEMBL2086526)Show SMILES FC1(F)CCN(CC1)C(=O)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C19H24F2N4O4S/c1-2-17(26)22-15-3-5-16(6-4-15)30(28,29)25-13-11-24(12-14-25)18(27)23-9-7-19(20,21)8-10-23/h2-6H,1,7-14H2,(H,22,26) | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577510
(US11472838, Compound 28)Show SMILES COC(=O)\C=C\CC[C@H](NC(=O)c1cnc(O)c(c1)[N+]([O-])=O)C(=O)N[C@H](C(=O)N1C[C@@H]2CCC[C@@H]2[C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O)C(C)(C)C |r| | PDB
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TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420519
(CHEMBL2086519)Show SMILES C=CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)OC1CCCC1 Show InChI InChI=1S/C19H25N3O5S/c1-2-18(23)20-15-7-9-17(10-8-15)28(25,26)22-13-11-21(12-14-22)19(24)27-16-5-3-4-6-16/h2,7-10,16H,1,3-6,11-14H2,(H,20,23) | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50245478
(CHEMBL4081588 | US11472838, Compound Ref. 25)Show SMILES CCC(CC)CNC(=O)Cn1cccc(NC(=O)[C@H](CC\C=C\C(=O)OC)NC(=O)c2cncn2C)c1=O |r| Show InChI InChI=1S/C26H36N6O6/c1-5-18(6-2)14-28-22(33)16-32-13-9-11-20(26(32)37)30-24(35)19(10-7-8-12-23(34)38-4)29-25(36)21-15-27-17-31(21)3/h8-9,11-13,15,17-19H,5-7,10,14,16H2,1-4H3,(H,28,33)(H,29,36)(H,30,35)/b12-8+/t19-/m0/s1 | PDB
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TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50245478
(CHEMBL4081588 | US11472838, Compound Ref. 25)Show SMILES CCC(CC)CNC(=O)Cn1cccc(NC(=O)[C@H](CC\C=C\C(=O)OC)NC(=O)c2cncn2C)c1=O |r| Show InChI InChI=1S/C26H36N6O6/c1-5-18(6-2)14-28-22(33)16-32-13-9-11-20(26(32)37)30-24(35)19(10-7-8-12-23(34)38-4)29-25(36)21-15-27-17-31(21)3/h8-9,11-13,15,17-19H,5-7,10,14,16H2,1-4H3,(H,28,33)(H,29,36)(H,30,35)/b12-8+/t19-/m0/s1 | PDB
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Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)
Curated by ChEMBL
| Assay Description
Inhibition of human TG2 using glycine methyl ester/Abz-APE as substrate after 5 mins |
J Med Chem 60: 554-567 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01036
BindingDB Entry DOI: 10.7270/Q2F47RKD |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM204894
(US9260454, 28)Show SMILES [O-][n+]1cccc2c1sn(C(=O)N1CCN(CC1)C(=O)C1CC1)c2=O Show InChI InChI=1S/C15H16N4O4S/c20-12(10-3-4-10)16-6-8-17(9-7-16)15(22)19-13(21)11-2-1-5-18(23)14(11)24-19/h1-2,5,10H,3-4,6-9H2 | PDB
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SANOFI
US Patent
| Assay Description
2 ul of a solution of different concentrations of the test compound in dimethyl sulfoxide was added to 28 ul of buffer (50 mM TRIS, 100 mM NaCl, 10 m... |
US Patent US9260454 (2016)
BindingDB Entry DOI: 10.7270/Q2DN43VV |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50083728
(CHEMBL3423193)Show SMILES NC(=O)[C@H]1O[C@H]1C(=O)Nc1ccc(Oc2ccccc2)cc1 |r| Show InChI InChI=1S/C16H14N2O4/c17-15(19)13-14(22-13)16(20)18-10-6-8-12(9-7-10)21-11-4-2-1-3-5-11/h1-9,13-14H,(H2,17,19)(H,18,20)/t13-,14+/m0/s1 | PDB
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University of Leeds
Curated by ChEMBL
| Assay Description
Inhibition of transglutaminase 2 (unknown origin) |
Eur J Med Chem 98: 49-53 (2015)
Article DOI: 10.1016/j.ejmech.2015.05.019
BindingDB Entry DOI: 10.7270/Q261121G |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50420464
(CHEMBL2086506)Show SMILES Fc1cccc(COC(=O)N2CCN(CC2)S(=O)(=O)c2ccc(NC(=O)C=C)cc2)c1F Show InChI InChI=1S/C21H21F2N3O5S/c1-2-19(27)24-16-6-8-17(9-7-16)32(29,30)26-12-10-25(11-13-26)21(28)31-14-15-4-3-5-18(22)20(15)23/h2-9H,1,10-14H2,(H,24,27) | PDB
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Evotec (UK) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TG2 by fluorescent transamidation assay |
J Med Chem 55: 1021-46 (2012)
Article DOI: 10.1021/jm201310y
BindingDB Entry DOI: 10.7270/Q2CN7560 |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50083726
(CHEMBL3423194)Show InChI InChI=1S/C10H9ClN2O3/c11-5-2-1-3-6(4-5)13-10(15)8-7(16-8)9(12)14/h1-4,7-8H,(H2,12,14)(H,13,15)/t7-,8+/m0/s1 | PDB
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University of Leeds
Curated by ChEMBL
| Assay Description
Inhibition of transglutaminase 2 (unknown origin) |
Eur J Med Chem 98: 49-53 (2015)
Article DOI: 10.1016/j.ejmech.2015.05.019
BindingDB Entry DOI: 10.7270/Q261121G |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM50083718
(CHEMBL3423202)Show SMILES NC(=O)[C@@H]1O[C@@H]1C(=O)Nc1ccc(Oc2ccc(N)cc2)cc1 |r| Show InChI InChI=1S/C16H15N3O4/c17-9-1-5-11(6-2-9)22-12-7-3-10(4-8-12)19-16(21)14-13(23-14)15(18)20/h1-8,13-14H,17H2,(H2,18,20)(H,19,21)/t13-,14+/m1/s1 | PDB
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University of Leeds
Curated by ChEMBL
| Assay Description
Inhibition of transglutaminase 2 (unknown origin) |
Eur J Med Chem 98: 49-53 (2015)
Article DOI: 10.1016/j.ejmech.2015.05.019
BindingDB Entry DOI: 10.7270/Q261121G |
More data for this
Ligand-Target Pair | |
Protein-glutamine gamma-glutamyltransferase 2
(Homo sapiens (Human)) | BDBM577525
(US11472838, Compound Ref. 6)Show SMILES CCOC(=O)\C=C\CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)OC |r| | PDB
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TBA
| Assay Description
FXIIIa activity has been determined using substrate A101 (Zedira GmbH, Darmstadt, Germany), which is based on the N-terminal dodecapeptide of α2... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WW7MZ9 |
More data for this
Ligand-Target Pair | |
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