Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456266 (((R)-1-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dih...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456266 (((R)-1-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dih...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456149 (US10723723, Example 35) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456226 ((R)-5'-(((2-hydroxy-2-(4- methyl-1-oxo-1,3- dihydr...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456268 ((R)-1-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456260 ((R)-6-(4-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM195013 (US9206198, 78 | US9206198, 79) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ... | US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM265526 (US9718808, 44) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ... | US Patent US9718808 (2017) BindingDB Entry DOI: 10.7270/Q2DJ5HNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM265519 (US9718808, 41) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ... | US Patent US9718808 (2017) BindingDB Entry DOI: 10.7270/Q2DJ5HNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM266980 (US9718808, 109) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ... | US Patent US9718808 (2017) BindingDB Entry DOI: 10.7270/Q2DJ5HNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456268 ((R)-1-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456264 ((R)-3-(difluoromethoxy)- 1-(5-(((2-hydroxy-2-(4- m...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM363473 ((S)-9-(2-(6-(1H-tetrazol-1- yl)pyridin-3-yl)-2-hyd...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks... | US Patent US9850245 (2017) BindingDB Entry DOI: 10.7270/Q2H70J3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM194951 (US9206198, 5) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ROMK expressed in CHO cells by whole cell voltage clamp electrophysiology assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00406 BindingDB Entry DOI: 10.7270/Q24M98D5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456277 (6-(4-(((1-hydroxy-1-(4- methyl-1-oxo-1,3- dihydroi...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM50249205 (CHEMBL4062753) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co. Curated by ChEMBL | Assay Description Inhibition of human ROMK expressed in CHO cells at -70 mV holding potential after 6 mins by whole cell patch clamp Qpatch method | Bioorg Med Chem Lett 27: 2559-2566 (2017) Article DOI: 10.1016/j.bmcl.2017.03.086 BindingDB Entry DOI: 10.7270/Q2BV7K1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM194963 (US9206198, 18) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ... | US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM194951 (US9206198, 5) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ... | US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM194967 (US9206198, 22) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ... | US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM265547 (US9718808, 51) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ... | US Patent US9718808 (2017) BindingDB Entry DOI: 10.7270/Q2DJ5HNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM338554 (US9751881, Example 83) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ... | US Patent US9751881 (2017) BindingDB Entry DOI: 10.7270/Q26M38ZP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM423209 ((R)-4-methyl-5-(4-((6- (4-methyl-1H-imidazol- 1-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC... | US Patent US10501449 (2019) BindingDB Entry DOI: 10.7270/Q2M32Z4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456141 (US10723723, Example 7-I | US10723723, Example 7-II) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM363475 (9-(2-(4-(1H-tetrazol-1- yl)phenyl)-2-hydroxyethyl)...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks... | US Patent US9850245 (2017) BindingDB Entry DOI: 10.7270/Q2H70J3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM423206 ((R)-4-methoxy-6-(4- ((3-(4-methyl-1-oxo-1,3- dihyd...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC... | US Patent US10501449 (2019) BindingDB Entry DOI: 10.7270/Q2M32Z4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM423204 (US10501449, Example 23-I | US10501449, Example 255...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC... | US Patent US10501449 (2019) BindingDB Entry DOI: 10.7270/Q2M32Z4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM194954 (US9206198, 7) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ROMK expressed in CHO cells by whole cell voltage clamp electrophysiology assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00406 BindingDB Entry DOI: 10.7270/Q24M98D5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM50249244 (CHEMBL4103004) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co. Curated by ChEMBL | Assay Description Inhibition of human ROMK expressed in CHO cells at -70 mV holding potential after 6 mins by whole cell patch clamp Qpatch method | Bioorg Med Chem Lett 27: 2559-2566 (2017) Article DOI: 10.1016/j.bmcl.2017.03.086 BindingDB Entry DOI: 10.7270/Q2BV7K1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM423199 (US10501449, Example 2-I) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC... | US Patent US10501449 (2019) BindingDB Entry DOI: 10.7270/Q2M32Z4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM265571 (US9718808, 59) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ... | US Patent US9718808 (2017) BindingDB Entry DOI: 10.7270/Q2DJ5HNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM155921 (US9018211, 2A) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of ROMK (unknown origin) after 30 mins by Tl+ influx assay | ACS Med Chem Lett 7: 697-701 (2016) Article DOI: 10.1021/acsmedchemlett.6b00122 BindingDB Entry DOI: 10.7270/Q25X2DF1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM155921 (US9018211, 2A) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of ROMK (unknown origin) after 30 mins by Tl+ influx assay | ACS Med Chem Lett 7: 697-701 (2016) Article DOI: 10.1021/acsmedchemlett.6b00122 BindingDB Entry DOI: 10.7270/Q25X2DF1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM350315 (US10208064, Example 30) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi AppTec (Shanghai) Co Ltd US Patent | Assay Description A Thallium Flux Assay was performed on the compounds of the Examples. This assay has been described previously; see, e.g., PCT Published Application ... | US Patent US10208064 (2019) BindingDB Entry DOI: 10.7270/Q26T0PSB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM194970 (US9206198, 25) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ROMK expressed in CHO cells by whole cell voltage clamp electrophysiology assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00406 BindingDB Entry DOI: 10.7270/Q24M98D5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456159 ((R)-6-(4-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456278 ((R)-4-ethoxy-6-(4-(((2- hydroxy-2-(4-methyl-1- oxo...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM50505266 (CHEMBL4548110) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center Curated by ChEMBL | Assay Description Inhibition of human ROMK1 expressed in CHO cells by Tl+ flux assay | J Med Chem 62: 8682-8694 (2019) Article DOI: 10.1021/acs.jmedchem.8b01891 BindingDB Entry DOI: 10.7270/Q2GH9N7J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456205 ((R)-1-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM363474 ((R)-9-(2-hydroxy-2-(4-methyl-1- oxo-1,3-dihydroiso...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks... | US Patent US9850245 (2017) BindingDB Entry DOI: 10.7270/Q2H70J3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456221 ((R)-6-(5-(((2-hydroxy-2- (4-methyl-1-oxo-1,3- dihy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM50505267 (CHEMBL4563446) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center Curated by ChEMBL | Assay Description Inhibition of human ROMK1 expressed in CHO cells by Tl+ flux assay | J Med Chem 62: 8682-8694 (2019) Article DOI: 10.1021/acs.jmedchem.8b01891 BindingDB Entry DOI: 10.7270/Q2GH9N7J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM50505268 (CHEMBL4549009) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center Curated by ChEMBL | Assay Description Inhibition of human ROMK1 expressed in CHO cells by Tl+ flux assay | J Med Chem 62: 8682-8694 (2019) Article DOI: 10.1021/acs.jmedchem.8b01891 BindingDB Entry DOI: 10.7270/Q2GH9N7J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM363472 (US9850245, Example 6A) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks... | US Patent US9850245 (2017) BindingDB Entry DOI: 10.7270/Q2H70J3N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM338561 (US9751881, Example 90) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ... | US Patent US9751881 (2017) BindingDB Entry DOI: 10.7270/Q26M38ZP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM456083 (US10723723, Example 27-I | US10723723, Example 27-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2), 1 Mg... | US Patent US10723723 (2020) BindingDB Entry DOI: 10.7270/Q22Z18K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM423212 (US10501449, Example 83-I) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC... | US Patent US10501449 (2019) BindingDB Entry DOI: 10.7270/Q2M32Z4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM50589226 (CHEMBL5205738) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.bmc.2022.116815 BindingDB Entry DOI: 10.7270/Q2BZ6B0S | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM350299 (US10208064, Example 18) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi AppTec (Shanghai) Co Ltd US Patent | Assay Description A Thallium Flux Assay was performed on the compounds of the Examples. This assay has been described previously; see, e.g., PCT Published Application ... | US Patent US10208064 (2019) BindingDB Entry DOI: 10.7270/Q26T0PSB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM265592 (US9718808, 66) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ... | US Patent US9718808 (2017) BindingDB Entry DOI: 10.7270/Q2DJ5HNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM265664 (US9718808, 88) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ... | US Patent US9718808 (2017) BindingDB Entry DOI: 10.7270/Q2DJ5HNG | |||||||||||
More data for this Ligand-Target Pair |
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