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Compile Data Set for Download or QSAR

Found 2 hits of ec50 for UniProtKB: P35563   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(RAT)
BDBM50363325
PNG
(CHEMBL1945843)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cnn(-c2ccccn2)c(=O)c1 |r|
Show InChI InChI=1S/C23H26N4O2/c1-18-6-4-13-26(18)14-5-15-29-21-10-8-19(9-11-21)20-16-23(28)27(25-17-20)22-7-2-3-12-24-22/h2-3,7-12,16-18H,4-6,13-15H2,1H3/t18-/m1/s1
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PC sid
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Article
PubMed
n/an/an/an/a 1.60n/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant 5HT3 receptor assessed as inhibition of RAMH-induced [35S]GTPgammaS binding


J Med Chem 55: 414-23 (2012)


Article DOI: 10.1021/jm201295j
BindingDB Entry DOI: 10.7270/Q2S46SFR
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(RAT)
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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CHEMBL
KEGG
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/an/an/a 1.20E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Response at rat 5-hydroxytryptamine 3a receptor expressed in xenopus oocytes


Bioorg Med Chem Lett 14: 1849-53 (2004)


Article DOI: 10.1016/j.bmcl.2003.09.104
BindingDB Entry DOI: 10.7270/Q2PK0GQW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)