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Compile Data Set for Download or QSAR

Found 419 hits of ic50 for UniProtKB: P35563   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 3A


(RAT)		BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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n/an/a 0.160n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Binding affinity to rat 5HT3A receptor

J Med Chem 54: 3206-21 (2011)


Article DOI: 10.1021/jm101459g
BindingDB Entry DOI: 10.7270/Q2W37XFC
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 3A


(RAT)		BDBM50400902
PNG
(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Show SMILES Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1
Show InChI InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3
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n/an/a 0.180n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Binding affinity to rat 5HT3A receptor

J Med Chem 54: 3206-21 (2011)


Article DOI: 10.1021/jm101459g
BindingDB Entry DOI: 10.7270/Q2W37XFC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081969
PNG
(9-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cccc(C)c2n2cccc12
Show InChI InChI=1S/C17H20N4/c1-13-5-3-6-14-16(13)21-8-4-7-15(21)17(18-14)20-11-9-19(2)10-12-20/h3-8H,9-12H2,1-2H3
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n/an/a 0.260n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
The compound was tested for binding affinity against 5-hydroxytryptamine 3 receptor from NG108-15 cells using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(RAT)		BDBM50060686
PNG
(4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinolin...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2n2cccc12
Show InChI InChI=1S/C16H18N4/c1-18-9-11-19(12-10-18)16-15-7-4-8-20(15)14-6-3-2-5-13(14)17-16/h2-8H,9-12H2,1H3
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n/an/a 0.370n/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-BRL 43694 from 5-HT3 receptor in rat cortex membrane incubated for 30 mins by liquid scintillation counting method

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50060686
PNG
(4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinolin...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2n2cccc12
Show InChI InChI=1S/C16H18N4/c1-18-9-11-19(12-10-18)16-15-7-4-8-20(15)14-6-3-2-5-13(14)17-16/h2-8H,9-12H2,1H3
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n/an/a 0.370n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.

J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50060685
PNG
(9-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cccc(F)c2n2cccc12
Show InChI InChI=1S/C16H17FN4/c1-19-8-10-20(11-9-19)16-14-6-3-7-21(14)15-12(17)4-2-5-13(15)18-16/h2-7H,8-11H2,1H3
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n/an/a 0.440n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.

J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50014407
PNG
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Show SMILES C1CN(CCN1)c1ccc2ccccc2n1
Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
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n/an/a 0.447n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor

J Med Chem 39: 2068-80 (1996)


Article DOI: 10.1021/jm950543x
BindingDB Entry DOI: 10.7270/Q2T72JNC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50123805
PNG
(5-Chloro-2-ethoxy-N-(1-ethyl-4-methyl-[1,4]diazepa...)
Show SMILES CCOc1nc(NC)c(Cl)cc1C(=O)NC1CN(C)CCN(CC)C1
Show InChI InChI=1S/C17H28ClN5O2/c1-5-23-8-7-22(4)10-12(11-23)20-16(24)13-9-14(18)15(19-3)21-17(13)25-6-2/h9,12H,5-8,10-11H2,1-4H3,(H,19,21)(H,20,24)
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n/an/a 0.550n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50123797
PNG
(5-Bromo-N-(1,4-diethyl-[1,4]diazepan-6-yl)-2-metho...)
Show SMILES CCN1CCN(CC)CC(C1)NC(=O)c1cc(Br)c(NC)nc1OC
Show InChI InChI=1S/C17H28BrN5O2/c1-5-22-7-8-23(6-2)11-12(10-22)20-16(24)13-9-14(18)15(19-3)21-17(13)25-4/h9,12H,5-8,10-11H2,1-4H3,(H,19,21)(H,20,24)
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n/an/a 0.590n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50123810
PNG
(5-Chloro-N-(1,4-diethyl-[1,4]diazepan-6-yl)-2-meth...)
Show SMILES CCN1CCN(CC)CC(C1)NC(=O)c1cc(Cl)c(NC)nc1OC
Show InChI InChI=1S/C17H28ClN5O2/c1-5-22-7-8-23(6-2)11-12(10-22)20-16(24)13-9-14(18)15(19-3)21-17(13)25-4/h9,12H,5-8,10-11H2,1-4H3,(H,19,21)(H,20,24)
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n/an/a 0.650n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081973
PNG
(4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxal...)
Show SMILES CN1CCN(CC1)c1nc2cc(O)ccc2n2cccc12
Show InChI InChI=1S/C16H18N4O/c1-18-7-9-19(10-8-18)16-15-3-2-6-20(15)14-5-4-12(21)11-13(14)17-16/h2-6,11,21H,7-10H2,1H3
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n/an/a 0.670n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50123811
PNG
(5-Bromo-N-(1-ethyl-4-propyl-[1,4]diazepan-6-yl)-2-...)
Show SMILES CCCN1CCN(CC)CC(C1)NC(=O)c1cc(Br)c(NC)nc1OC
Show InChI InChI=1S/C18H30BrN5O2/c1-5-7-24-9-8-23(6-2)11-13(12-24)21-17(25)14-10-15(19)16(20-3)22-18(14)26-4/h10,13H,5-9,11-12H2,1-4H3,(H,20,22)(H,21,25)
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n/an/a 0.690n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50452955
PNG
(CHEMBL36271)
Show SMILES [I-].Cn1cc(-c2noc(C[N+](C)(C)C)n2)c2ccccc12
Show InChI InChI=1S/C15H19N4O.HI/c1-18-9-12(11-7-5-6-8-13(11)18)15-16-14(20-17-15)10-19(2,3)4;/h5-9H,10H2,1-4H3;1H/q+1;/p-1
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n/an/a 0.708n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50123813
PNG
(5-Bromo-2-methoxy-6-methylamino-N-(1-methyl-4-prop...)
Show SMILES CCCN1CCN(C)CC(C1)NC(=O)c1cc(Br)c(NC)nc1OC
Show InChI InChI=1S/C17H28BrN5O2/c1-5-6-23-8-7-22(3)10-12(11-23)20-16(24)13-9-14(18)15(19-2)21-17(13)25-4/h9,12H,5-8,10-11H2,1-4H3,(H,19,21)(H,20,24)
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n/an/a 0.760n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081969
PNG
(9-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cccc(C)c2n2cccc12
Show InChI InChI=1S/C17H20N4/c1-13-5-3-6-14-16(13)21-8-4-7-15(21)17(18-14)20-11-9-19(2)10-12-20/h3-8H,9-12H2,1-2H3
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n/an/a 0.790n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50060688
PNG
(7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C16H17FN4/c1-19-7-9-20(10-8-19)16-15-3-2-6-21(15)14-5-4-12(17)11-13(14)18-16/h2-6,11H,7-10H2,1H3
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n/an/a 0.810n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50060688
PNG
(7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C16H17FN4/c1-19-7-9-20(10-8-19)16-15-3-2-6-21(15)14-5-4-12(17)11-13(14)18-16/h2-6,11H,7-10H2,1H3
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n/an/a 0.810n/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.

J Med Chem 40: 3670-8 (1997)


Article DOI: 10.1021/jm970376w
BindingDB Entry DOI: 10.7270/Q24Q7VP2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50407784
PNG
(CHEMBL51118)
Show SMILES C=CCN1CCN(CC1)c1nc2sccc2n2cccc12
Show InChI InChI=1S/C16H18N4S/c1-2-6-18-8-10-19(11-9-18)15-13-4-3-7-20(13)14-5-12-21-16(14)17-15/h2-5,7,12H,1,6,8-11H2
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n/an/a 0.912n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor

J Med Chem 39: 2068-80 (1996)


Article DOI: 10.1021/jm950543x
BindingDB Entry DOI: 10.7270/Q2T72JNC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070574
PNG
(5-Bromo-N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-2-...)
Show SMILES CCN1CCN(C)CC(C1)NC(=O)c1cc(Br)c(NC)nc1OC
Show InChI InChI=1S/C16H26BrN5O2/c1-5-22-7-6-21(3)9-11(10-22)19-15(23)12-8-13(17)14(18-2)20-16(12)24-4/h8,11H,5-7,9-10H2,1-4H3,(H,18,20)(H,19,23)
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n/an/a 0.970n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070574
PNG
(5-Bromo-N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-2-...)
Show SMILES CCN1CCN(C)CC(C1)NC(=O)c1cc(Br)c(NC)nc1OC
Show InChI InChI=1S/C16H26BrN5O2/c1-5-22-7-6-21(3)9-11(10-22)19-15(23)12-8-13(17)14(18-2)20-16(12)24-4/h8,11H,5-7,9-10H2,1-4H3,(H,18,20)(H,19,23)
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n/an/a 1n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- GR 65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptor

Bioorg Med Chem Lett 8: 1551-4 (1999)


BindingDB Entry DOI: 10.7270/Q2CF9P7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50407762
PNG
(CHEMBL292725)
Show SMILES C(N1CCN(CC1)c1nc2sccc2n2cccc12)c1ccc2OCOc2c1
Show InChI InChI=1S/C21H20N4O2S/c1-2-16-20(22-21-17(5-11-28-21)25(16)6-1)24-9-7-23(8-10-24)13-15-3-4-18-19(12-15)27-14-26-18/h1-6,11-12H,7-10,13-14H2
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n/an/a 1n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor

J Med Chem 39: 2068-80 (1996)


Article DOI: 10.1021/jm950543x
BindingDB Entry DOI: 10.7270/Q2T72JNC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081975
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)14-12(17-15)4-2-6-16-14/h2-7H,8-11H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50455940
PNG
(CHEMBL8250)
Show SMILES Cn1cc(C2=NCC3(CCN4CCCC3C4)O2)c2ccccc12 |t:4,TLB:16:7:15:11.13.12,THB:6:7:15:11.13.12|
Show InChI InChI=1S/C19H23N3O/c1-21-12-16(15-6-2-3-7-17(15)21)18-20-13-19(23-18)8-10-22-9-4-5-14(19)11-22/h2-3,6-7,12,14H,4-5,8-11,13H2,1H3
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Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was evaluated for the displacement of [3H]Q-ICS-205-930 from 5-HT3 recognition sites in rat brain membranes

J Med Chem 35: 1019-31 (1992)


BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070571
PNG
(5-Bromo-N-((R)-1-ethyl-4-methyl-[1,4]diazepan-6-yl...)
Show SMILES CCN1CCN(C)C[C@H](C1)NC(=O)c1cc(Br)c(NC)nc1OC
Show InChI InChI=1S/C16H26BrN5O2/c1-5-22-7-6-21(3)9-11(10-22)19-15(23)12-8-13(17)14(18-2)20-16(12)24-4/h8,11H,5-7,9-10H2,1-4H3,(H,18,20)(H,19,23)/t11-/m1/s1
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Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- GR 65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptor

Bioorg Med Chem Lett 8: 1551-4 (1999)


BindingDB Entry DOI: 10.7270/Q2CF9P7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081972
PNG
(9-Methyl-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Cc1cccc2nc(N3CCNCC3)c3cccn3c12
Show InChI InChI=1S/C16H18N4/c1-12-4-2-5-13-15(12)20-9-3-6-14(20)16(18-13)19-10-7-17-8-11-19/h2-6,9,17H,7-8,10-11H2,1H3
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n/an/a 1.13n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070571
PNG
(5-Bromo-N-((R)-1-ethyl-4-methyl-[1,4]diazepan-6-yl...)
Show SMILES CCN1CCN(C)C[C@H](C1)NC(=O)c1cc(Br)c(NC)nc1OC
Show InChI InChI=1S/C16H26BrN5O2/c1-5-22-7-6-21(3)9-11(10-22)19-15(23)12-8-13(17)14(18-2)20-16(12)24-4/h8,11H,5-7,9-10H2,1-4H3,(H,18,20)(H,19,23)/t11-/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50407789
PNG
(CHEMBL52772)
Show SMILES Fc1ccc(CN2CCN(CC2)c2nc3sccc3n3cccc23)cc1
Show InChI InChI=1S/C20H19FN4S/c21-16-5-3-15(4-6-16)14-23-9-11-24(12-10-23)19-17-2-1-8-25(17)18-7-13-26-20(18)22-19/h1-8,13H,9-12,14H2
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Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor

J Med Chem 39: 2068-80 (1996)


Article DOI: 10.1021/jm950543x
BindingDB Entry DOI: 10.7270/Q2T72JNC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070566
PNG
(5-Bromo-N-((S)-1-ethyl-4-methyl-[1,4]diazepan-6-yl...)
Show SMILES CCN1CCN(C)C[C@@H](C1)NC(=O)c1cc(Br)c(NC)nc1OC
Show InChI InChI=1S/C16H26BrN5O2/c1-5-22-7-6-21(3)9-11(10-22)19-15(23)12-8-13(17)14(18-2)20-16(12)24-4/h8,11H,5-7,9-10H2,1-4H3,(H,18,20)(H,19,23)/t11-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- GR 65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptor

Bioorg Med Chem Lett 8: 1551-4 (1999)


BindingDB Entry DOI: 10.7270/Q2CF9P7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070565
PNG
(5-Chloro-N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-2...)
Show SMILES CCN1CCN(C)CC(C1)NC(=O)c1cc(Cl)c(NC)nc1OC
Show InChI InChI=1S/C16H26ClN5O2/c1-5-22-7-6-21(3)9-11(10-22)19-15(23)12-8-13(17)14(18-2)20-16(12)24-4/h8,11H,5-7,9-10H2,1-4H3,(H,18,20)(H,19,23)
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n/an/a 1.26n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070566
PNG
(5-Bromo-N-((S)-1-ethyl-4-methyl-[1,4]diazepan-6-yl...)
Show SMILES CCN1CCN(C)C[C@@H](C1)NC(=O)c1cc(Br)c(NC)nc1OC
Show InChI InChI=1S/C16H26BrN5O2/c1-5-22-7-6-21(3)9-11(10-22)19-15(23)12-8-13(17)14(18-2)20-16(12)24-4/h8,11H,5-7,9-10H2,1-4H3,(H,18,20)(H,19,23)/t11-/m0/s1
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n/an/a 1.28n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50123802
PNG
(5-Chloro-N-(1,4-dimethyl-[1,4]diazepan-6-yl)-2-met...)
Show SMILES CNc1nc(OC)c(cc1Cl)C(=O)NC1CN(C)CCN(C)C1
Show InChI InChI=1S/C15H24ClN5O2/c1-17-13-12(16)7-11(15(19-13)23-4)14(22)18-10-8-20(2)5-6-21(3)9-10/h7,10H,5-6,8-9H2,1-4H3,(H,17,19)(H,18,22)
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n/an/a 1.30n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50108392
PNG
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12 |r,THB:9:7:4.3:1|
Show InChI InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes

J Med Chem 35: 1019-31 (1992)


BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070565
PNG
(5-Chloro-N-(1-ethyl-4-methyl-[1,4]diazepan-6-yl)-2...)
Show SMILES CCN1CCN(C)CC(C1)NC(=O)c1cc(Cl)c(NC)nc1OC
Show InChI InChI=1S/C16H26ClN5O2/c1-5-22-7-6-21(3)9-11(10-22)19-15(23)12-8-13(17)14(18-2)20-16(12)24-4/h8,11H,5-7,9-10H2,1-4H3,(H,18,20)(H,19,23)
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Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- GR 65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptor

Bioorg Med Chem Lett 8: 1551-4 (1999)


BindingDB Entry DOI: 10.7270/Q2CF9P7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50062446
PNG
(3-[3-(1-Methyl-1H-indol-3-yl)-[1,2,4]oxadiazol-5-y...)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2CC3)c2ccccc12 |TLB:7:9:13.12:15.16,(12.88,-12.88,;12.86,-11.36,;14.15,-10.61,;14.15,-9.1,;15.23,-8.03,;15.22,-6.52,;17.81,-6.52,;17.81,-8.01,;16.53,-8.78,;19.22,-8.8,;19.22,-10.41,;20.52,-11.16,;21.34,-9.77,;19.78,-9.35,;20.6,-7.97,;22.01,-8.78,;22.01,-10.39,;11.53,-9.11,;10.22,-8.34,;8.91,-9.11,;8.91,-10.63,;10.22,-11.4,;11.55,-10.63,)|
Show InChI InChI=1S/C18H20N4O/c1-21-10-15(13-4-2-3-5-16(13)21)17-19-18(23-20-17)14-11-22-8-6-12(14)7-9-22/h2-5,10,12,14H,6-9,11H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex.

J Med Chem 41: 311-7 (1998)


Article DOI: 10.1021/jm9705418
BindingDB Entry DOI: 10.7270/Q2N29XMV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50108392
PNG
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12 |r,THB:9:7:4.3:1|
Show InChI InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+
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n/an/a 1.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 5-HT (1 ug/mL) induced depolarization in rat vagus nerve (5-hydroxytryptamine 3 receptor antagonism)

Bioorg Med Chem Lett 4: 695-698 (1994)


Article DOI: 10.1016/S0960-894X(01)80182-7
BindingDB Entry DOI: 10.7270/Q24M9510
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50062446
PNG
(3-[3-(1-Methyl-1H-indol-3-yl)-[1,2,4]oxadiazol-5-y...)
Show SMILES Cn1cc(-c2noc(n2)C2CN3CCC2CC3)c2ccccc12 |TLB:7:9:13.12:15.16,(12.88,-12.88,;12.86,-11.36,;14.15,-10.61,;14.15,-9.1,;15.23,-8.03,;15.22,-6.52,;17.81,-6.52,;17.81,-8.01,;16.53,-8.78,;19.22,-8.8,;19.22,-10.41,;20.52,-11.16,;21.34,-9.77,;19.78,-9.35,;20.6,-7.97,;22.01,-8.78,;22.01,-10.39,;11.53,-9.11,;10.22,-8.34,;8.91,-9.11,;8.91,-10.63,;10.22,-11.4,;11.55,-10.63,)|
Show InChI InChI=1S/C18H20N4O/c1-21-10-15(13-4-2-3-5-16(13)21)17-19-18(23-20-17)14-11-22-8-6-12(14)7-9-22/h2-5,10,12,14H,6-9,11H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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n/an/a 1.40n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 receptor in rat cortical membrane using [3H]GR-65630 as radioligand

Bioorg Med Chem Lett 8: 619-24 (1999)


BindingDB Entry DOI: 10.7270/Q25Q4WN6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50407786
PNG
(CHEMBL54720)
Show SMILES C(N1CCN(CC1)c1nc2ccsc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C20H20N4S/c1-2-5-16(6-3-1)15-22-10-12-23(13-11-22)19-18-7-4-9-24(18)20-17(21-19)8-14-25-20/h1-9,14H,10-13,15H2
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n/an/a 1.40n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor

J Med Chem 39: 2068-80 (1996)


Article DOI: 10.1021/jm950543x
BindingDB Entry DOI: 10.7270/Q2T72JNC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50123799
PNG
(5-Bromo-2-ethoxy-N-(1-ethyl-4-methyl-[1,4]diazepan...)
Show SMILES CCOc1nc(NC)c(Br)cc1C(=O)NC1CN(C)CCN(CC)C1
Show InChI InChI=1S/C17H28BrN5O2/c1-5-23-8-7-22(4)10-12(11-23)20-16(24)13-9-14(18)15(19-3)21-17(13)25-6-2/h9,12H,5-8,10-11H2,1-4H3,(H,19,21)(H,20,24)
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n/an/a 1.48n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50366571
PNG
(CHEMBL1788261)
Show SMILES CCN1CCN(C)C[C@@H](C1)NC(=O)c1cc(Cl)c(NC)cc1OC |r|
Show InChI InChI=1S/C17H27ClN4O2/c1-5-22-7-6-21(3)10-12(11-22)20-17(23)13-8-14(18)15(19-2)9-16(13)24-4/h8-9,12,19H,5-7,10-11H2,1-4H3,(H,20,23)/t12-/m0/s1
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Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 receptor in rat cortical membrane using [3H]GR-65630 as radioligand

Bioorg Med Chem Lett 8: 619-24 (1999)


BindingDB Entry DOI: 10.7270/Q25Q4WN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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n/an/a 1.54n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070569
PNG
(5-Chloro-N-((R)-1-ethyl-4-methyl-[1,4]diazepan-6-y...)
Show SMILES CCN1CCN(C)C[C@H](C1)NC(=O)c1cc(Cl)c(NC)nc1OC
Show InChI InChI=1S/C16H26ClN5O2/c1-5-22-7-6-21(3)9-11(10-22)19-15(23)12-8-13(17)14(18-2)20-16(12)24-4/h8,11H,5-7,9-10H2,1-4H3,(H,18,20)(H,19,23)/t11-/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- GR 65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptor

Bioorg Med Chem Lett 8: 1551-4 (1999)


BindingDB Entry DOI: 10.7270/Q2CF9P7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081989
PNG
(5-(4-Methyl-piperazin-1-yl)-pyrazolo[1,5-c]quinazo...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c2ccnn12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-17-13-5-3-2-4-12(13)14-6-7-16-20(14)15/h2-7H,8-11H2,1H3
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n/an/a 1.60n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070569
PNG
(5-Chloro-N-((R)-1-ethyl-4-methyl-[1,4]diazepan-6-y...)
Show SMILES CCN1CCN(C)C[C@H](C1)NC(=O)c1cc(Cl)c(NC)nc1OC
Show InChI InChI=1S/C16H26ClN5O2/c1-5-22-7-6-21(3)9-11(10-22)19-15(23)12-8-13(17)14(18-2)20-16(12)24-4/h8,11H,5-7,9-10H2,1-4H3,(H,18,20)(H,19,23)/t11-/m1/s1
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n/an/a 1.62n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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n/an/a 1.90n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes

J Med Chem 35: 1019-31 (1992)


BindingDB Entry DOI: 10.7270/Q2833THX
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50069286
PNG
(5-Chloro-4-ethylamino-N-(1-ethyl-4-methyl-[1,4]dia...)
Show SMILES CCNc1cc(OC)c(cc1Cl)C(=O)NC1CN(C)CCN(CC)C1
Show InChI InChI=1S/C18H29ClN4O2/c1-5-20-16-10-17(25-4)14(9-15(16)19)18(24)21-13-11-22(3)7-8-23(6-2)12-13/h9-10,13,20H,5-8,11-12H2,1-4H3,(H,21,24)
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n/an/a 1.90n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 receptor in rat cortical membrane using [3H]GR-65630 as radioligand

Bioorg Med Chem Lett 8: 619-24 (1999)


BindingDB Entry DOI: 10.7270/Q25Q4WN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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n/an/a 1.90n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.

J Med Chem 34: 140-51 (1991)


BindingDB Entry DOI: 10.7270/Q2DV1MD5
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070573
PNG
(5-Chloro-6-ethylamino-N-(1-ethyl-4-methyl-[1,4]dia...)
Show SMILES CCNc1nc(OC)c(cc1Cl)C(=O)NC1CN(C)CCN(CC)C1
Show InChI InChI=1S/C17H28ClN5O2/c1-5-19-15-14(18)9-13(17(21-15)25-4)16(24)20-12-10-22(3)7-8-23(6-2)11-12/h9,12H,5-8,10-11H2,1-4H3,(H,19,21)(H,20,24)
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n/an/a 1.96n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070573
PNG
(5-Chloro-6-ethylamino-N-(1-ethyl-4-methyl-[1,4]dia...)
Show SMILES CCNc1nc(OC)c(cc1Cl)C(=O)NC1CN(C)CCN(CC)C1
Show InChI InChI=1S/C17H28ClN5O2/c1-5-19-15-14(18)9-13(17(21-15)25-4)16(24)20-12-10-22(3)7-8-23(6-2)11-12/h9,12H,5-8,10-11H2,1-4H3,(H,19,21)(H,20,24)
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n/an/a 2n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- GR 65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptor

Bioorg Med Chem Lett 8: 1551-4 (1999)


BindingDB Entry DOI: 10.7270/Q2CF9P7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50070564
PNG
(5-Chloro-N-((S)-1-ethyl-4-methyl-[1,4]diazepan-6-y...)
Show SMILES CCN1CCN(C)C[C@@H](C1)NC(=O)c1cc(Cl)c(NC)nc1OC
Show InChI InChI=1S/C16H26ClN5O2/c1-5-22-7-6-21(3)9-11(10-22)19-15(23)12-8-13(17)14(18-2)20-16(12)24-4/h8,11H,5-7,9-10H2,1-4H3,(H,18,20)(H,19,23)/t11-/m0/s1
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n/an/a 2.05n/an/an/an/an/an/a



Dainippon Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...

J Med Chem 46: 702-15 (2003)


Article DOI: 10.1021/jm020270n
BindingDB Entry DOI: 10.7270/Q25H7H06
More data for this
Ligand-Target Pair
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