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Compile Data Set for Download or QSAR

Found 8 hits of ec50 for UniProtKB: P22086   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50027031
PNG
((2-Chloro-phenyl)-(4,5-dihydro-1H-imidazol-2-ylmet...)
Show SMILES Clc1ccccc1NCC1=NCCN1 |t:10|
Show InChI InChI=1S/C10H12ClN3/c11-8-3-1-2-4-9(8)14-7-10-12-5-6-13-10/h1-4,14H,5-7H2,(H,12,13)
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n/an/an/an/a 53n/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 1769-72 (1984)


BindingDB Entry DOI: 10.7270/Q2668DRD
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50027035
PNG
(3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)-amino]-phe...)
Show SMILES Oc1cccc(NCC2=NCCN2)c1 |t:8|
Show InChI InChI=1S/C10H13N3O/c14-9-3-1-2-8(6-9)13-7-10-11-4-5-12-10/h1-3,6,13-14H,4-5,7H2,(H,11,12)
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n/an/an/an/a 74n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand


J Med Chem 26: 1769-72 (1984)


BindingDB Entry DOI: 10.7270/Q2668DRD
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM31046
PNG
(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 |t:10|
Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)
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n/an/an/an/a>1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 1769-72 (1984)


BindingDB Entry DOI: 10.7270/Q2668DRD
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50027036
PNG
((4,5-Dihydro-1H-imidazol-2-ylmethyl)-methyl-p-toly...)
Show SMILES CN(CC1=NCCN1)c1ccc(C)cc1 |t:3|
Show InChI InChI=1S/C12H17N3/c1-10-3-5-11(6-4-10)15(2)9-12-13-7-8-14-12/h3-6H,7-9H2,1-2H3,(H,13,14)
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n/an/an/an/a>2.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand


J Med Chem 26: 1769-72 (1984)


BindingDB Entry DOI: 10.7270/Q2668DRD
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50027032
PNG
((4,5-Dihydro-1H-imidazol-2-ylmethyl)-p-tolyl-amine...)
Show SMILES Cc1ccc(NCC2=NCCN2)cc1 |t:7|
Show InChI InChI=1S/C11H15N3/c1-9-2-4-10(5-3-9)14-8-11-12-6-7-13-11/h2-5,14H,6-8H2,1H3,(H,12,13)
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n/an/an/an/a>2.00E+3n/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 1769-72 (1984)


BindingDB Entry DOI: 10.7270/Q2668DRD
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50027037
PNG
((4,5-Dihydro-1H-imidazol-2-ylmethyl)-ethyl-p-tolyl...)
Show SMILES CCN(CC1=NCCN1)c1ccc(C)cc1 |t:4|
Show InChI InChI=1S/C13H19N3/c1-3-16(10-13-14-8-9-15-13)12-6-4-11(2)5-7-12/h4-7H,3,8-10H2,1-2H3,(H,14,15)
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n/an/an/an/a>1.00E+4n/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 1769-72 (1984)


BindingDB Entry DOI: 10.7270/Q2668DRD
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50027034
PNG
((4,5-Dihydro-1H-imidazol-2-ylmethyl)-phenyl-p-toly...)
Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)c1ccccc1 |t:10|
Show InChI InChI=1S/C17H19N3/c1-14-7-9-16(10-8-14)20(13-17-18-11-12-19-17)15-5-3-2-4-6-15/h2-10H,11-13H2,1H3,(H,18,19)
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n/an/an/an/a>1.00E+4n/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 1769-72 (1984)


BindingDB Entry DOI: 10.7270/Q2668DRD
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50027033
PNG
(CHEMBL541208 | Cyclohexyl-(4,5-dihydro-1H-imidazol...)
Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)C1CCCCC1 |t:10|
Show InChI InChI=1S/C17H25N3/c1-14-7-9-16(10-8-14)20(13-17-18-11-12-19-17)15-5-3-2-4-6-15/h7-10,15H,2-6,11-13H2,1H3,(H,18,19)
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n/an/an/an/a>1.00E+4n/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 1769-72 (1984)


BindingDB Entry DOI: 10.7270/Q2668DRD
More data for this
Ligand-Target Pair