BindingDB PrimarySearch

Found 37 hits of ec50 data for polymerid = 49000438
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
D(1A) dopamine receptor (RAT)	BDBM50007148 (1-Aminomethyl-3-cyclohexyl-isochroman-5,6-diol \| C...) Show SMILES NC[C@@H]1OC(Cc2c(O)c(O)ccc12)C1CCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.70	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum				J Med Chem 34: 2561-9 (1991) BindingDB Entry DOI: 10.7270/Q2HM57DN
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50007129 ((1R,3S)-1-Aminomethyl-3-phenyl-isochroman-5,6-diol...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.95	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50033116 ((1R,3S)-3-Adamantan-1-yl-1-aminomethyl-isochroman-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.10	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
D(1A) dopamine receptor (RAT)	BDBM50007134 (1-Aminomethyl-3-phenyl-isochroman-5,6-diol \| CHEMB...) Show SMILES NC[C@@H]1OC(Cc2c(O)c(O)ccc12)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	7.10	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum				J Med Chem 34: 2561-9 (1991) BindingDB Entry DOI: 10.7270/Q2HM57DN
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50007147 (3-Adamantan-1-yl-1-aminomethyl-isochroman-5,6-diol...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	8.30	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity using [3H]-spiperone radioligand competitive binding assay against dopamine receptor D2				J Med Chem 34: 2561-9 (1991) BindingDB Entry DOI: 10.7270/Q2HM57DN
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50019389 (3-Allyl-6-chloro-1-(4-hydroxy-phenyl)-2,3,4,5-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...				J Med Chem 30: 35-40 (1987) BindingDB Entry DOI: 10.7270/Q2X92BV6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50007128 (1-Aminomethyl-3-phenethyl-isochroman-5,6-diol \| CH...) Show SMILES NC[C@@H]1OC(CCc2ccccc2)Cc2c(O)c(O)ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1				J Med Chem 34: 2561-9 (1991) BindingDB Entry DOI: 10.7270/Q2HM57DN
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50007146 (1-Aminomethyl-3-hexyl-isochroman-5,6-diol \| CHEMBL...) Show SMILES CCCCCCC1Cc2c(O)c(O)ccc2[C@H](CN)O1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum				J Med Chem 34: 2561-9 (1991) BindingDB Entry DOI: 10.7270/Q2HM57DN
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50004918 ((+/-)-APD3-Allyl-1-phenyl-2,3,4,5-tetrahydro-1H-be...) Show SMILES Oc1cc2CCN(CC=C)CC(c3ccccc3)c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...				J Med Chem 30: 35-40 (1987) BindingDB Entry DOI: 10.7270/Q2X92BV6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50010686 ((6aR,12bS)-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydr...) Show SMILES Oc1cc2CC[C@H]3NCc4ccccc4[C@@H]3c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50007140 (1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...) Show SMILES Oc1ccc2[C@H](CNCC=C)OC(Cc2c1O)C1CCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum				J Med Chem 34: 2561-9 (1991) BindingDB Entry DOI: 10.7270/Q2HM57DN
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50007130 (1-Aminomethyl-3-phenoxymethyl-isochroman-5,6-diol ...) Show SMILES NC[C@@H]1OC(COc2ccccc2)Cc2c(O)c(O)ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum				J Med Chem 34: 2561-9 (1991) BindingDB Entry DOI: 10.7270/Q2HM57DN
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50025696 (3-Allyl-6-bromo-1-(4-hydroxy-phenyl)-2,3,4,5-tetra...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...				J Med Chem 30: 35-40 (1987) BindingDB Entry DOI: 10.7270/Q2X92BV6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50007126 (1-Aminomethyl-3-tert-butyl-isochroman-5,6-diol \| C...) Show SMILES CC(C)(C)C1Cc2c(O)c(O)ccc2[C@H](CN)O1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum				J Med Chem 34: 2561-9 (1991) BindingDB Entry DOI: 10.7270/Q2HM57DN
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM60917 (9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...) Show SMILES Oc1ccc(cc1)C1CNCCc2c(Cl)c(O)c(O)cc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	n/a	n/a	57	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes				J Med Chem 30: 1166-76 (1987) BindingDB Entry DOI: 10.7270/Q2028QJ6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
D(1A) dopamine receptor (RAT)	BDBM50025698 (3-Allyl-6-fluoro-1-(4-hydroxy-phenyl)-2,3,4,5-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...				J Med Chem 30: 35-40 (1987) BindingDB Entry DOI: 10.7270/Q2X92BV6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50004822 ((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...) Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Tested for its affinity towards Dopamine receptor D1 in rat striatal membrane				J Med Chem 37: 2453-60 (1994) BindingDB Entry DOI: 10.7270/Q2KS6QKD
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50509151 (CHEMBL3421730) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	162	n/a	n/a	n/a	n/a
UCB Pharma Curated by ChEMBL					Assay Description Positive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF ...				J Med Chem 62: 128-140 (2019) Article DOI: 10.1021/acs.jmedchem.8b01767 BindingDB Entry DOI: 10.7270/Q2BC42XZ
UCB Pharma Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50020679 (7-(2-Amino-ethyl)-4-hydroxy-3H-benzothiazol-2-one ...) Show SMILES NCCc1ccc(O)c2[nH]c(=O)sc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	295	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist...				J Med Chem 30: 1166-76 (1987) BindingDB Entry DOI: 10.7270/Q2028QJ6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50518422 (CHEMBL4448100) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	332	n/a	n/a	n/a	n/a
UCB Pharma Curated by ChEMBL					Assay Description Positive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to control				J Med Chem 62: 128-140 (2019) Article DOI: 10.1021/acs.jmedchem.8b01767 BindingDB Entry DOI: 10.7270/Q2BC42XZ
UCB Pharma Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50025695 (3-Allyl-1-(4-hydroxy-phenyl)-6-methyl-2,3,4,5-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...				J Med Chem 30: 35-40 (1987) BindingDB Entry DOI: 10.7270/Q2X92BV6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50025697 (3-Allyl-1-(4-hydroxy-phenyl)-2,3,4,5-tetrahydro-1H...) Show SMILES Oc1ccc(cc1)C1CN(CC=C)CCc2cc(O)c(O)cc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...				J Med Chem 30: 35-40 (1987) BindingDB Entry DOI: 10.7270/Q2X92BV6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50049048 ((R)-3-Allyl-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	491	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50010689 ((S)-4-(4,5,6,7-Tetrahydro-thieno[2,3-c]pyridin-4-y...) Show SMILES Oc1ccc(cc1O)[C@@H]1CNCc2sccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50049045 (6-Benzylamino-5,6,7,8-tetrahydro-naphthalene-1,2-d...) Show SMILES Oc1ccc2CC(CCc2c1O)NCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM55121 (3-HYDROXYTYRAMINE HYDROCHLORIDE \| 4-(2-aminoethyl)...) Show SMILES NCCc1ccc(O)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes				J Med Chem 30: 1166-76 (1987) BindingDB Entry DOI: 10.7270/Q2028QJ6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
D(1A) dopamine receptor (RAT)	BDBM50020686 (4-(2-Amino-ethyl)-7-hydroxy-1,3-dihydro-indol-2-on...) Show SMILES NCCc1ccc(O)c2NC(=O)Cc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	4.65E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist...				J Med Chem 30: 1166-76 (1987) BindingDB Entry DOI: 10.7270/Q2028QJ6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM55121 (3-HYDROXYTYRAMINE HYDROCHLORIDE \| 4-(2-aminoethyl)...) Show SMILES NCCc1ccc(O)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
D(1A) dopamine receptor (RAT)	BDBM50010685 ((+/-)-trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahyd...) Show SMILES Oc1cc2CC[C@H]3NCc4ccccc4[C@H]3c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50035644 ((6aR,12bR)-6-Methyl-5,6,6a,7,8,12b-hexahydro-benzo...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50010688 (6-Benzylamino-5,6,7,8-tetrahydro-naphthalene-2,3-d...) Show SMILES Oc1cc2CCC(Cc2cc1O)NCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50518420 (CHEMBL4555682) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
UCB Pharma Curated by ChEMBL					Assay Description Positive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to control				J Med Chem 62: 128-140 (2019) Article DOI: 10.1021/acs.jmedchem.8b01767 BindingDB Entry DOI: 10.7270/Q2BC42XZ
UCB Pharma Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50010684 ((6aR,12bS)-6-Propyl-5,6,6a,7,8,12b-hexahydro-benzo...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50049046 ((6aR,12bS)-6-Allyl-5,6,6a,7,8,12b-hexahydro-benzo[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti...				J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50019396 (4-(2-Dipropylamino-ethyl)-benzene-1,2-diol \| 4-(2-...) Show SMILES CCCN(CCC)CCc1ccc(O)c(O)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.25E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes				J Med Chem 30: 1166-76 (1987) BindingDB Entry DOI: 10.7270/Q2028QJ6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50019393 (4-(2-Dipropylamino-ethyl)-7-hydroxy-1,3-dihydro-in...) Show SMILES CCCN(CCC)CCc1ccc(O)c2NC(=O)Cc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes				J Med Chem 30: 1166-76 (1987) BindingDB Entry DOI: 10.7270/Q2028QJ6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50378584 (STEPHOLIDINE) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.11E+4	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity				Bioorg Med Chem 20: 4862-71 (2012) Article DOI: 10.1016/j.bmc.2012.05.057 BindingDB Entry DOI: 10.7270/Q28P61K9
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair