Found 29 hits of ic50 data for polymerid = 49000611 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599750
(CHEMBL5180445)Show SMILES FC(F)(F)c1cc(Cl)n(Cc2cc(=O)n3c([C@@H]4C[C@@H]4C#N)c(Cl)ccc3n2)n1 |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599754
(CHEMBL5197314) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599759
(CHEMBL5199303)Show SMILES CCN(Cc1cc2cc(C)n(CCC#N)c(=O)c2s1)c1ccc(F)cc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599749
(CHEMBL5171984)Show SMILES FC(F)(F)c1cc(Cl)n(Cc2cc(=O)n3c([C@@H]4C[C@@H]4C#N)c(sc3n2)C(F)(F)F)n1 |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50253632
(6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione |...)Show SMILES [O-][N+](=O)c1cc2[nH]c(=O)c(=O)[nH]c2cc1[N-][N+]#N Show InChI InChI=1S/C8H4N6O4/c9-13-12-5-1-3-4(2-6(5)14(17)18)11-8(16)7(15)10-3/h1-2H,(H,10,15)(H,11,16) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California San Francisco
Curated by ChEMBL
| Assay Description Inhibition of GluR2 receptor (unknown origin) |
J Med Chem 51: 5856-60 (2008)
Article DOI: 10.1021/jm701517b BindingDB Entry DOI: 10.7270/Q2W095R1 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599748
(CHEMBL5202949)Show SMILES CCN(Cc1ccc(s1)C(=O)N1CCC[C@@H]1C#N)c1ccc(F)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50207594
(2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...)Show SMILES NS(=O)(=O)c1cccc2c1c(cc1[nH]c(=O)c(=O)[nH]c21)[N+]([O-])=O Show InChI InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22) | PDB
UniProtKB/SwissProt
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CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Inhibition of glutamate-induced calcium influx in HEK293 cells expressing human GLUA2 |
J Med Chem 49: 2579-92 (2006)
Article DOI: 10.1021/jm051086f BindingDB Entry DOI: 10.7270/Q2FQ9W76 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50207594
(2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...)Show SMILES NS(=O)(=O)c1cccc2c1c(cc1[nH]c(=O)c(=O)[nH]c21)[N+]([O-])=O Show InChI InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ... |
J Med Chem 50: 1558-70 (2007)
Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599756
(CHEMBL5203039)Show SMILES CCN(Cc1cc2n(n1)c(F)cn(CCC#N)c2=O)c1ccc(F)cc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50253650
(CHEMBL462490 | [1,2,5]oxadiazolo[3,4-g]quinoxaline...)Show InChI InChI=1S/C8H4N4O4/c13-7-8(14)10-4-2-6-5(1-3(4)9-7)11-16-12(6)15/h1-2H,(H,9,13)(H,10,14) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California San Francisco
Curated by ChEMBL
| Assay Description Inhibition of GluR2 receptor (unknown origin) |
J Med Chem 51: 5856-60 (2008)
Article DOI: 10.1021/jm701517b BindingDB Entry DOI: 10.7270/Q2W095R1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599764
(CHEMBL5196410)Show SMILES Cc1cn(CCC#N)c(=O)c2cc(Cn3nc(cc3Cl)C(F)(F)F)nn12 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599755
(CHEMBL5196482) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599760
(CHEMBL5194021)Show SMILES CCN(Cc1cc2n(n1)c(C)cn(CCC#N)c2=O)c1ccc(F)cc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599751
(CHEMBL5092058)Show SMILES C[C@H](CC#N)n1cc(C)n2nc(Cn3nc(cc3Cl)C(F)F)cc2c1=O | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599752
(CHEMBL5192117) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599753
(CHEMBL5177597) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599766
(CHEMBL5077022)Show SMILES C[C@@H](CC#N)n1cc(C)n2nc(Cn3nc(cc3Cl)C(F)F)cc2c1=O | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599765
(CHEMBL5202402) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599763
(CHEMBL5206364)Show SMILES Cc1cn(CCC#N)c(=O)c2cc(Cn3nc(cc3Cl)C(F)F)nn12 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599762
(CHEMBL5204122) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599761
(CHEMBL5172392) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599757
(CHEMBL5189104)Show SMILES CCN(Cc1cc2c(C)cn(CCC#N)c(=O)c2s1)c1ccc(F)cc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50599758
(CHEMBL5191480)Show SMILES CCN(Cc1cc2c(CC)cn(CCC#N)c(=O)c2s1)c1ccc(F)cc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116576 BindingDB Entry DOI: 10.7270/Q2FR01N5 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50137124
(4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...)Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against Ionotropic glutamate receptor AMPA 2 of HEK293 cells in FLIPR assay |
J Med Chem 46: 5834-43 (2003)
Article DOI: 10.1021/jm030428j BindingDB Entry DOI: 10.7270/Q2KK9B60 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50137125
(2-(3-(3-bromophenyl)ureido)-4-chlorobenzoic acid |...)Show InChI InChI=1S/C14H10BrClN2O3/c15-8-2-1-3-10(6-8)17-14(21)18-12-7-9(16)4-5-11(12)13(19)20/h1-7H,(H,19,20)(H2,17,18,21) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against Ionotropic glutamate receptor AMPA 2 of HEK293 cells in FLIPR assay |
J Med Chem 46: 5834-43 (2003)
Article DOI: 10.1021/jm030428j BindingDB Entry DOI: 10.7270/Q2KK9B60 |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50207591
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxy-5-phen...)Show SMILES Cc1cn(C[C@H](N)C(O)=O)c(=O)n(Cc2cc(sc2C(O)=O)-c2ccccc2)c1=O Show InChI InChI=1S/C20H19N3O6S/c1-11-8-22(10-14(21)18(25)26)20(29)23(17(11)24)9-13-7-15(30-16(13)19(27)28)12-5-3-2-4-6-12/h2-8,14H,9-10,21H2,1H3,(H,25,26)(H,27,28)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
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CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ... |
J Med Chem 50: 1558-70 (2007)
Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50207593
((S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHEN...)Show SMILES Cc1cn(C[C@H](N)C(O)=O)c(=O)n(Cc2ccsc2C(O)=O)c1=O Show InChI InChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ... |
J Med Chem 50: 1558-70 (2007)
Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50185318
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...)Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccsc2C(O)=O)c1=O)C(O)=O Show InChI InChI=1S/C13H13N3O6S/c14-8(11(18)19)6-15-3-1-9(17)16(13(15)22)5-7-2-4-23-10(7)12(20)21/h1-4,8H,5-6,14H2,(H,18,19)(H,20,21)/t8-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ... |
J Med Chem 50: 1558-70 (2007)
Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Homo sapiens (Human)) | BDBM50178136
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)...)Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccccc2C(O)=O)c1=O)C(O)=O Show InChI InChI=1S/C15H15N3O6/c16-11(14(22)23)8-17-6-5-12(19)18(15(17)24)7-9-3-1-2-4-10(9)13(20)21/h1-6,11H,7-8,16H2,(H,20,21)(H,22,23)/t11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ... |
J Med Chem 50: 1558-70 (2007)
Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q |
More data for this Ligand-Target Pair | |