Found 44 hits of ki data for polymerid = 49000619 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB
MMDB
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| PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Ltd
Curated by ChEMBL
| Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell... |
Bioorg Med Chem Lett 10: 1807-10 (2000)
BindingDB Entry DOI: 10.7270/Q2765FVB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50002369
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 | PDB
MMDB
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| PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50088216
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1 | PDB
MMDB
Reactome pathway
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| 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 3 in HEK293 cells using [3H]-kainate as radio... |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50116040
((7-{3-[3-(4-Nitro-phenyl)-ureidomethyl]-pyrrol-1-y...)Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)C(F)(F)F)-n1ccc(CNC(=O)Nc2ccc(cc2)[N+]([O-])=O)c1 Show InChI InChI=1S/C23H17F3N6O7/c24-23(25,26)15-7-16-18(31(11-19(33)34)21(36)20(35)29-16)8-17(15)30-6-5-12(10-30)9-27-22(37)28-13-1-3-14(4-2-13)32(38)39/h1-8,10H,9,11H2,(H,29,35)(H,33,34)(H2,27,28,37) | PDB
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| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott GmbH & Co. KG
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand |
Bioorg Med Chem Lett 12: 2113-6 (2002)
BindingDB Entry DOI: 10.7270/Q22806XK |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591738
(CHEMBL5193862)Show SMILES Oc1ccccc1C(=O)Nn1c2cc(F)c(cc2[nH]c(=O)c1=O)C(F)(F)F | PDB
MMDB
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| Article
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| 142 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50088197
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1 | PDB
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| 423 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50091474
((2S,4E)-2-amino-4-(2-methylpropylidene)pentanedioi...)Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3+/t7-/m0/s1 | PDB
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| 518 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Ltd
Curated by ChEMBL
| Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell... |
Bioorg Med Chem Lett 10: 1807-10 (2000)
BindingDB Entry DOI: 10.7270/Q2765FVB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50116044
(CHEMBL416685 | {6-Nitro-2,3-dioxo-7-[3-(4-phenyl-p...)Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(CN2CCC(CC2)c2ccccc2)c1 Show InChI InChI=1S/C26H25N5O6/c32-24(33)16-30-21-13-22(23(31(36)37)12-20(21)27-25(34)26(30)35)29-11-6-17(15-29)14-28-9-7-19(8-10-28)18-4-2-1-3-5-18/h1-6,11-13,15,19H,7-10,14,16H2,(H,27,34)(H,32,33) | PDB
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| 530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott GmbH & Co. KG
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand |
Bioorg Med Chem Lett 12: 2113-6 (2002)
BindingDB Entry DOI: 10.7270/Q22806XK |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50088222
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1 | PDB
MMDB
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PC sid
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| 617 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50088222
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1 | PDB
MMDB
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PC sid
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| 617 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Ltd
Curated by ChEMBL
| Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell... |
Bioorg Med Chem Lett 10: 1807-10 (2000)
BindingDB Entry DOI: 10.7270/Q2765FVB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50116042
(CHEMBL63861 | {7-[3-(4-Benzyl-piperazin-1-ylmethyl...)Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(CN2CCN(Cc3ccccc3)CC2)c1 Show InChI InChI=1S/C26H26N6O6/c33-24(34)17-31-21-13-22(23(32(37)38)12-20(21)27-25(35)26(31)36)30-7-6-19(16-30)15-29-10-8-28(9-11-29)14-18-4-2-1-3-5-18/h1-7,12-13,16H,8-11,14-15,17H2,(H,27,35)(H,33,34) | PDB
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| 680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott GmbH & Co. KG
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand |
Bioorg Med Chem Lett 12: 2113-6 (2002)
BindingDB Entry DOI: 10.7270/Q22806XK |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM26431
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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PC sid
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| PubMed
| 789 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A.
Curated by ChEMBL
| Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated |
J Med Chem 43: 1958-68 (2000)
BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM17657
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1 | PDB
MMDB
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PC cid
PC sid
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Patents
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| PubMed
| 789 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Ltd
Curated by ChEMBL
| Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell... |
Bioorg Med Chem Lett 10: 1807-10 (2000)
BindingDB Entry DOI: 10.7270/Q2765FVB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591736
(CHEMBL5173718)Show SMILES OCCC#Cc1ccc2n(NC(=O)c3ccccc3)c(=O)c(=O)[nH]c2c1 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591735
(CHEMBL5209119)Show SMILES OCC#Cc1ccc2n(NC(=O)c3ccccc3)c(=O)c(=O)[nH]c2c1 | PDB
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| Article
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| 1.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50116047
((6-Nitro-2,3-dioxo-7-{3-[(3-phenyl-propylamino)-me...)Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(CNCCCc2ccccc2)c1 Show InChI InChI=1S/C24H23N5O6/c30-22(31)15-28-19-12-20(21(29(34)35)11-18(19)26-23(32)24(28)33)27-10-8-17(14-27)13-25-9-4-7-16-5-2-1-3-6-16/h1-3,5-6,8,10-12,14,25H,4,7,9,13,15H2,(H,26,32)(H,30,31) | PDB
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| 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott GmbH & Co. KG
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand |
Bioorg Med Chem Lett 12: 2113-6 (2002)
BindingDB Entry DOI: 10.7270/Q22806XK |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50116048
(CHEMBL67828 | {6-Nitro-2,3-dioxo-7-[3-(4-phenethyl...)Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(CN2CCN(CCc3ccccc3)CC2)c1 Show InChI InChI=1S/C27H28N6O6/c34-25(35)18-32-22-15-23(24(33(38)39)14-21(22)28-26(36)27(32)37)31-9-7-20(17-31)16-30-12-10-29(11-13-30)8-6-19-4-2-1-3-5-19/h1-5,7,9,14-15,17H,6,8,10-13,16,18H2,(H,28,36)(H,34,35) | PDB
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| 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott GmbH & Co. KG
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand |
Bioorg Med Chem Lett 12: 2113-6 (2002)
BindingDB Entry DOI: 10.7270/Q22806XK |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50116043
(3-(6-Nitro-2,3-dioxo-7-pyrrol-1-yl-3,4-dihydro-2H-...)Show SMILES OC(=O)CCn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1cccc1 Show InChI InChI=1S/C15H12N4O6/c20-13(21)3-6-18-10-8-11(17-4-1-2-5-17)12(19(24)25)7-9(10)16-14(22)15(18)23/h1-2,4-5,7-8H,3,6H2,(H,16,22)(H,20,21) | PDB
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PC sid
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Similars
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| 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott GmbH & Co. KG
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand |
Bioorg Med Chem Lett 12: 2113-6 (2002)
BindingDB Entry DOI: 10.7270/Q22806XK |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591737
(CHEMBL5206048)Show SMILES O=C(Nn1c2ccc(cc2[nH]c(=O)c1=O)C#Cc1ccccc1)c1ccccc1 | PDB
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| PC cid
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UniChem
| Article
PubMed
| 2.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50116050
(1-(4-Carboxymethyl-7-nitro-2,3-dioxo-1,2,3,4-tetra...)Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(c1)C(O)=O Show InChI InChI=1S/C15H10N4O8/c20-12(21)6-18-9-4-10(17-2-1-7(5-17)15(24)25)11(19(26)27)3-8(9)16-13(22)14(18)23/h1-5H,6H2,(H,16,22)(H,20,21)(H,24,25) | PDB
MMDB
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Similars
| PubMed
| 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott GmbH & Co. KG
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand |
Bioorg Med Chem Lett 12: 2113-6 (2002)
BindingDB Entry DOI: 10.7270/Q22806XK |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50116041
(CHEMBL303415 | [6-Nitro-2,3-dioxo-7-(3-piperidin-1...)Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(CN2CCCCC2)c1 Show InChI InChI=1S/C20H21N5O6/c26-18(27)12-24-15-9-16(17(25(30)31)8-14(15)21-19(28)20(24)29)23-7-4-13(11-23)10-22-5-2-1-3-6-22/h4,7-9,11H,1-3,5-6,10,12H2,(H,21,28)(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott GmbH & Co. KG
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human GluR7 subunit stably expressed in cultured HEK-293 cells using [3]H-kainate as radioligand |
Bioorg Med Chem Lett 12: 2113-6 (2002)
BindingDB Entry DOI: 10.7270/Q22806XK |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50091477
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)Show SMILES [#7]-[#6@@H](-[#6]\[#6](-[#6](-[#8])=O)=[#6]-1\[#6]-[#6]-[#6]-[#6]-1)-[#6](-[#8])=O Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 5.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Ltd
Curated by ChEMBL
| Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell... |
Bioorg Med Chem Lett 10: 1807-10 (2000)
BindingDB Entry DOI: 10.7270/Q2765FVB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591734
(CHEMBL5208673)Show SMILES OC(=O)c1ccc(cc1)-c1ccc2[nH]c(=O)c(=O)[nH]c2c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50200526
(CHEMBL1234118)Show SMILES OC(=O)[C@@H]1CC(F)(F)CN1C[C@H]1CC[C@H]2CN[C@@H](C[C@H]2C1)C(O)=O |r| Show InChI InChI=1S/C16H24F2N2O4/c17-16(18)5-13(15(23)24)20(8-16)7-9-1-2-10-6-19-12(14(21)22)4-11(10)3-9/h9-13,19H,1-8H2,(H,21,22)(H,23,24)/t9-,10-,11+,12-,13-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
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| CHEMBL
MCE
PC cid
PC sid
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Patents
Similars
| Article
PubMed
| 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University
Curated by ChEMBL
| Assay Description
Inhibition of GluK3 (unknown origin) |
J Med Chem 60: 441-457 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01516
BindingDB Entry DOI: 10.7270/Q2G44SJJ |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591739
(CHEMBL5186117)Show SMILES OC(=O)c1ccccc1\C=C\c1ccc2[nH]c(=O)c(=O)[nH]c2c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM86754
(LY 466195 | LY-466195)Show SMILES OC(=O)C1CC(F)(F)CN1C[C@H]1CC[C@H]2CN[C@@H](C[C@H]2C1)C(O)=O |r| Show InChI InChI=1S/C16H24F2N2O4/c17-16(18)5-13(15(23)24)20(8-16)7-9-1-2-10-6-19-12(14(21)22)4-11(10)3-9/h9-13,19H,1-8H2,(H,21,22)(H,23,24)/t9-,10-,11+,12-,13?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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| PC cid
PC sid
UniChem
| Article
PubMed
| 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 318: 772-81 (2006)
Article DOI: 10.1124/jpet.106.101428
BindingDB Entry DOI: 10.7270/Q2NP230D |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB
MMDB
Reactome pathway
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| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 318: 772-81 (2006)
Article DOI: 10.1124/jpet.106.101428
BindingDB Entry DOI: 10.7270/Q2NP230D |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM86751
(CHEMBL14935 | LY 293558 | LY-293558)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](CCc3nnn[nH]3)CC[C@H]2CN1 Show InChI InChI=1S/C13H21N5O2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14H,1-7H2,(H,19,20)(H,15,16,17,18)/t8-,9+,10-,11+/m1/s1 | PDB
MMDB
Reactome pathway
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PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 318: 772-81 (2006)
Article DOI: 10.1124/jpet.106.101428
BindingDB Entry DOI: 10.7270/Q2NP230D |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50091475
((2S,4Z)-2-amino-4-(2-methylpropylidene)pentanedioi...)Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3-/t7-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Ltd
Curated by ChEMBL
| Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell... |
Bioorg Med Chem Lett 10: 1807-10 (2000)
BindingDB Entry DOI: 10.7270/Q2765FVB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50091473
((S)-2-Amino-4-(1-ethyl-propylidene)-pentanedioic a...)Show SMILES [#6]-[#6]\[#6](-[#6]-[#6])=[#6](/[#6]-[#6@H](-[#7])-[#6](-[#8])=O)-[#6](-[#8])=O Show InChI InChI=1S/C10H17NO4/c1-3-6(4-2)7(9(12)13)5-8(11)10(14)15/h8H,3-5,11H2,1-2H3,(H,12,13)(H,14,15)/t8-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 1.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Ltd
Curated by ChEMBL
| Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell... |
Bioorg Med Chem Lett 10: 1807-10 (2000)
BindingDB Entry DOI: 10.7270/Q2765FVB |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50207594
(2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...)Show SMILES NS(=O)(=O)c1cccc2c1c(cc1[nH]c(=O)c(=O)[nH]c21)[N+]([O-])=O Show InChI InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22) | PDB
MMDB
Reactome pathway
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KEGG
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| Article
PubMed
| 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description
Displacement of [3H]kainate from human GLUK7 receptor expressed in HEK293 cells |
J Med Chem 48: 7867-81 (2005)
Article DOI: 10.1021/jm050584l
BindingDB Entry DOI: 10.7270/Q2V69KCT |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591732
(CHEMBL5198336)Show SMILES OC(=O)c1cc(ccc1Cl)-c1ccc2[nH]c(=O)c(=O)[nH]c2c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591730
(CHEMBL5177751)Show SMILES N[C@@H](CCc1ccc2[nH]c(=O)c(=O)[nH]c2c1)C(O)=O |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| 5.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591733
(CHEMBL5190991)Show SMILES OP(O)(=O)c1cccc(c1)-c1ccc2[nH]c(=O)c(=O)[nH]c2c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591731
(CHEMBL5174264)Show SMILES Cc1ccc(cc1-c1ccc2[nH]c(=O)c(=O)[nH]c2c1)C(O)=O | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591744
(CHEMBL5195778)Show SMILES OC(=O)Cc1cccc(c1)-c1ccc2[nH]c(=O)c(=O)[nH]c2c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591743
(CHEMBL1375097) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591742
(CHEMBL5199355)Show SMILES OP(O)(=O)C\C=C\c1ccc2[nH]c(=O)c(=O)[nH]c2c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591741
(CHEMBL5187440) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM86751
(CHEMBL14935 | LY 293558 | LY-293558)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](CCc3nnn[nH]3)CC[C@H]2CN1 Show InChI InChI=1S/C13H21N5O2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14H,1-7H2,(H,19,20)(H,15,16,17,18)/t8-,9+,10-,11+/m1/s1 | PDB
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| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Binding affinity to GluR7 |
J Med Chem 53: 5367-82 (2010)
Article DOI: 10.1021/jm901688m
BindingDB Entry DOI: 10.7270/Q2FX79NV |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591729
(CHEMBL5188085)Show SMILES N[C@@H](Cc1ccc2[nH]c(=O)c(=O)[nH]c2c1)C(O)=O |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50591740
(CHEMBL5179605) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| PC cid
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UniChem
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50185318
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...)Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccsc2C(O)=O)c1=O)C(O)=O Show InChI InChI=1S/C13H13N3O6S/c14-8(11(18)19)6-15-3-1-9(17)16(13(15)22)5-7-2-4-23-10(7)12(20)21/h1-4,8H,5-6,14H2,(H,18,19)(H,20,21)/t8-/m0/s1 | PDB
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Reactome pathway
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PC cid
PC sid
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Similars
| Article
PubMed
| 1.11E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description
Displacement of [3H]kainate from human GLUK7 expressed in HEK293 cell membranes |
J Med Chem 49: 2579-92 (2006)
Article DOI: 10.1021/jm051086f
BindingDB Entry DOI: 10.7270/Q2FQ9W76 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 3
(Homo sapiens (Human)) | BDBM50178148
((RS)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl...)Show InChI InChI=1S/C15H15N3O6/c16-11(14(22)23)8-17-6-5-12(19)18(15(17)24)7-9-3-1-2-4-10(9)13(20)21/h1-6,11H,7-8,16H2,(H,20,21)(H,22,23) | PDB
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PubMed
| 3.74E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description
Displacement of [3H]kainate from human GLUK7 receptor expressed in HEK293 cells |
J Med Chem 48: 7867-81 (2005)
Article DOI: 10.1021/jm050584l
BindingDB Entry DOI: 10.7270/Q2V69KCT |
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