Found 95 hits of ec50 for UniProtKB: Q96P65 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347819
(CHEMBL1802414 | P550)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C126H195N37O37/c1-65(2)49-83(155-122(199)94-35-24-48-163(94)98(174)59-142-107(184)89(60-164)157-103(180)68(7)128)106(183)141-58-97(173)162-101(70(9)169)123(200)156-84(50-66(3)4)113(190)143-69(8)104(181)145-80(40-42-99(175)176)111(188)150-81(41-43-100(177)178)112(189)152-85(51-67(5)6)114(191)158-93(64-168)121(198)161-92(63-167)120(197)154-88(55-74-36-38-75(170)39-37-74)117(194)160-90(61-165)118(195)149-78(33-22-46-137-125(132)133)109(186)147-77(32-21-45-136-124(130)131)108(185)146-76(31-19-20-44-127)105(182)140-56-95(171)139-57-96(172)144-86(53-72-27-15-11-16-28-72)115(192)159-91(62-166)119(196)153-87(54-73-29-17-12-18-30-73)116(193)148-79(34-23-47-138-126(134)135)110(187)151-82(102(129)179)52-71-25-13-10-14-26-71/h10-18,25-30,36-39,65-70,76-94,101,164-170H,19-24,31-35,40-64,127-128H2,1-9H3,(H2,129,179)(H,139,171)(H,140,182)(H,141,183)(H,142,184)(H,143,190)(H,144,172)(H,145,181)(H,146,185)(H,147,186)(H,148,193)(H,149,195)(H,150,188)(H,151,187)(H,152,189)(H,153,196)(H,154,197)(H,155,199)(H,156,200)(H,157,180)(H,158,191)(H,159,192)(H,160,194)(H,161,198)(H,162,173)(H,175,176)(H,177,178)(H4,130,131,136)(H4,132,133,137)(H4,134,135,138)/t68-,69-,70+,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,101-/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469439
(CHEMBL4284294)Show SMILES CNC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C128H197N37O37/c1-67(2)50-84(161-125(201)95-36-25-49-165(95)102(177)63-145-111(187)92(64-166)164-126(202)105(133)71(8)169)109(185)143-62-101(176)149-91(58-97(132)172)122(198)158-85(51-68(3)4)117(193)146-70(7)107(183)150-81(41-43-103(178)179)115(191)155-82(42-44-104(180)181)116(192)157-86(52-69(5)6)118(194)160-90(57-96(131)171)110(186)144-61-100(175)148-88(56-75-37-39-76(170)40-38-75)120(196)162-93(65-167)123(199)154-79(34-23-47-139-127(135)136)113(189)152-78(33-20-22-46-130)112(188)151-77(32-19-21-45-129)108(184)142-59-98(173)141-60-99(174)147-87(54-73-28-15-11-16-29-73)119(195)163-94(66-168)124(200)159-89(55-74-30-17-12-18-31-74)121(197)153-80(35-24-48-140-128(137)138-9)114(190)156-83(106(134)182)53-72-26-13-10-14-27-72/h10-18,26-31,37-40,67-71,77-95,105,166-170H,19-25,32-36,41-66,129-130,133H2,1-9H3,(H2,131,171)(H2,132,172)(H2,134,182)(H,141,173)(H,142,184)(H,143,185)(H,144,186)(H,145,187)(H,146,193)(H,147,174)(H,148,175)(H,149,176)(H,150,183)(H,151,188)(H,152,189)(H,153,197)(H,154,199)(H,155,191)(H,156,190)(H,157,192)(H,158,198)(H,159,200)(H,160,194)(H,161,201)(H,162,196)(H,163,195)(H,164,202)(H,178,179)(H,180,181)(H4,135,136,139)(H3,137,138,140)/t70-,71+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,105-/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 6.90 | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based ... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347818
(CHEMBL1802413 | P518)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C127H195N37O37/c1-66(2)49-83(160-124(200)94-35-24-48-164(94)101(176)62-144-110(186)91(63-165)163-125(201)104(132)70(8)168)108(184)142-61-100(175)148-90(57-96(131)171)121(197)157-84(50-67(3)4)116(192)145-69(7)106(182)149-80(40-42-102(177)178)114(190)154-81(41-43-103(179)180)115(191)156-85(51-68(5)6)117(193)159-89(56-95(130)170)109(185)143-60-99(174)147-87(55-74-36-38-75(169)39-37-74)119(195)161-92(64-166)122(198)153-78(33-22-46-138-126(134)135)112(188)151-77(32-19-21-45-129)111(187)150-76(31-18-20-44-128)107(183)141-58-97(172)140-59-98(173)146-86(53-72-27-14-10-15-28-72)118(194)162-93(65-167)123(199)158-88(54-73-29-16-11-17-30-73)120(196)152-79(34-23-47-139-127(136)137)113(189)155-82(105(133)181)52-71-25-12-9-13-26-71/h9-17,25-30,36-39,66-70,76-94,104,165-169H,18-24,31-35,40-65,128-129,132H2,1-8H3,(H2,130,170)(H2,131,171)(H2,133,181)(H,140,172)(H,141,183)(H,142,184)(H,143,185)(H,144,186)(H,145,192)(H,146,173)(H,147,174)(H,148,175)(H,149,182)(H,150,187)(H,151,188)(H,152,196)(H,153,198)(H,154,190)(H,155,189)(H,156,191)(H,157,197)(H,158,199)(H,159,193)(H,160,200)(H,161,195)(H,162,194)(H,163,201)(H,177,178)(H,179,180)(H4,134,135,138)(H4,136,137,139)/t69-,70+,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,104-/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347818
(CHEMBL1802413 | P518)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C127H195N37O37/c1-66(2)49-83(160-124(200)94-35-24-48-164(94)101(176)62-144-110(186)91(63-165)163-125(201)104(132)70(8)168)108(184)142-61-100(175)148-90(57-96(131)171)121(197)157-84(50-67(3)4)116(192)145-69(7)106(182)149-80(40-42-102(177)178)114(190)154-81(41-43-103(179)180)115(191)156-85(51-68(5)6)117(193)159-89(56-95(130)170)109(185)143-60-99(174)147-87(55-74-36-38-75(169)39-37-74)119(195)161-92(64-166)122(198)153-78(33-22-46-138-126(134)135)112(188)151-77(32-19-21-45-129)111(187)150-76(31-18-20-44-128)107(183)141-58-97(172)140-59-98(173)146-86(53-72-27-14-10-15-28-72)118(194)162-93(65-167)123(199)158-88(54-73-29-16-11-17-30-73)120(196)152-79(34-23-47-139-127(136)137)113(189)155-82(105(133)181)52-71-25-12-9-13-26-71/h9-17,25-30,36-39,66-70,76-94,104,165-169H,18-24,31-35,40-65,128-129,132H2,1-8H3,(H2,130,170)(H2,131,171)(H2,133,181)(H,140,172)(H,141,183)(H,142,184)(H,143,185)(H,144,186)(H,145,192)(H,146,173)(H,147,174)(H,148,175)(H,149,182)(H,150,187)(H,151,188)(H,152,196)(H,153,198)(H,154,190)(H,155,189)(H,156,191)(H,157,197)(H,158,199)(H,159,193)(H,160,200)(H,161,195)(H,162,194)(H,163,201)(H,177,178)(H,179,180)(H4,134,135,138)(H4,136,137,139)/t69-,70+,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,104-/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 10.4 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347822
(CHEMBL1802418)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#8])=O |r| Show InChI InChI=1S/C105H158N30O30/c1-56(2)43-71(129-88(149)64(108)49-80(109)139)96(157)120-58(5)87(148)123-69(35-37-85(144)145)94(155)128-70(36-38-86(146)147)95(156)130-72(44-57(3)4)97(158)132-76(50-81(110)140)90(151)119-53-84(143)122-74(47-62-31-33-63(138)34-32-62)99(160)134-78(54-136)101(162)127-67(29-19-41-115-104(111)112)92(153)125-66(28-16-18-40-107)91(152)124-65(27-15-17-39-106)89(150)118-51-82(141)117-52-83(142)121-73(45-59-21-9-6-10-22-59)98(159)135-79(55-137)102(163)131-75(46-60-23-11-7-12-24-60)100(161)126-68(30-20-42-116-105(113)114)93(154)133-77(103(164)165)48-61-25-13-8-14-26-61/h6-14,21-26,31-34,56-58,64-79,136-138H,15-20,27-30,35-55,106-108H2,1-5H3,(H2,109,139)(H2,110,140)(H,117,141)(H,118,150)(H,119,151)(H,120,157)(H,121,142)(H,122,143)(H,123,148)(H,124,152)(H,125,153)(H,126,161)(H,127,162)(H,128,155)(H,129,149)(H,130,156)(H,131,163)(H,132,158)(H,133,154)(H,134,160)(H,135,159)(H,144,145)(H,146,147)(H,164,165)(H4,111,112,115)(H4,113,114,116)/t58-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 30.2 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347823
(CHEMBL1802419)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C92H137N27O25/c1-51(2)40-64(115-84(138)62(33-35-76(129)130)109-78(132)57(95)32-34-75(127)128)85(139)117-68(45-71(96)123)80(134)106-48-74(126)108-66(44-55-28-30-56(122)31-29-55)87(141)118-69(49-120)89(143)113-60(26-16-38-102-91(98)99)82(136)111-59(25-13-15-37-94)81(135)110-58(24-12-14-36-93)79(133)105-46-72(124)104-47-73(125)107-65(42-53-20-8-4-9-21-53)86(140)119-70(50-121)90(144)116-67(43-54-22-10-5-11-23-54)88(142)112-61(27-17-39-103-92(100)101)83(137)114-63(77(97)131)41-52-18-6-3-7-19-52/h3-11,18-23,28-31,51,57-70,120-122H,12-17,24-27,32-50,93-95H2,1-2H3,(H2,96,123)(H2,97,131)(H,104,124)(H,105,133)(H,106,134)(H,107,125)(H,108,126)(H,109,132)(H,110,135)(H,111,136)(H,112,142)(H,113,143)(H,114,137)(H,115,138)(H,116,144)(H,117,139)(H,118,141)(H,119,140)(H,127,128)(H,129,130)(H4,98,99,102)(H4,100,101,103)/t57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-/m0/s1 | UniProtKB/SwissProt
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UniChem
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PubMed
| n/a | n/a | n/a | n/a | 37.5 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347848
(CHEMBL1802480)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6]-c1ccccc1 |r| Show InChI InChI=1S/C134H201N37O37/c1-72(2)54-89(167-131(207)101-40-27-53-171(101)108(183)68-151-117(193)98(69-172)170-132(208)111(139)76(8)175)114(190)149-67-107(182)155-97(62-103(138)178)128(204)163-90(55-73(3)4)123(199)152-75(7)112(188)156-87(45-47-109(184)185)121(197)161-88(46-48-110(186)187)122(198)162-91(56-74(5)6)124(200)166-96(61-102(137)177)116(192)150-66-106(181)154-94(60-80-41-43-82(176)44-42-80)126(202)168-99(70-173)129(205)160-85(38-25-51-144-133(140)141)119(195)158-84(37-22-24-50-136)118(194)157-83(36-21-23-49-135)113(189)148-64-104(179)146-65-105(180)153-93(58-78-30-15-10-16-31-78)125(201)169-100(71-174)130(206)165-95(59-79-32-17-11-18-33-79)127(203)159-86(39-26-52-145-134(142)143)120(196)164-92(57-77-28-13-9-14-29-77)115(191)147-63-81-34-19-12-20-35-81/h9-20,28-35,41-44,72-76,83-101,111,172-176H,21-27,36-40,45-71,135-136,139H2,1-8H3,(H2,137,177)(H2,138,178)(H,146,179)(H,147,191)(H,148,189)(H,149,190)(H,150,192)(H,151,193)(H,152,199)(H,153,180)(H,154,181)(H,155,182)(H,156,188)(H,157,194)(H,158,195)(H,159,203)(H,160,205)(H,161,197)(H,162,198)(H,163,204)(H,164,196)(H,165,206)(H,166,200)(H,167,207)(H,168,202)(H,169,201)(H,170,208)(H,184,185)(H,186,187)(H4,140,141,144)(H4,142,143,145)/t75-,76+,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,111-/m0/s1 | UniProtKB/SwissProt
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PubMed
| n/a | n/a | n/a | n/a | 39 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347821
(CHEMBL1800099)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#8])=O |r| Show InChI InChI=1S/C118H179N33O33/c1-63(2)48-79(144-102(169)72-32-21-45-127-72)100(167)132-60-95(160)137-86(56-91(122)156)113(180)146-80(49-64(3)4)108(175)134-66(7)98(165)138-77(39-41-96(161)162)106(173)143-78(40-42-97(163)164)107(174)145-81(50-65(5)6)109(176)148-85(55-90(121)155)101(168)133-59-94(159)136-83(53-70-35-37-71(154)38-36-70)111(178)150-88(61-152)114(181)142-75(33-22-46-128-117(123)124)104(171)140-74(31-18-20-44-120)103(170)139-73(30-17-19-43-119)99(166)131-57-92(157)130-58-93(158)135-82(51-67-24-11-8-12-25-67)110(177)151-89(62-153)115(182)147-84(52-68-26-13-9-14-27-68)112(179)141-76(34-23-47-129-118(125)126)105(172)149-87(116(183)184)54-69-28-15-10-16-29-69/h8-16,24-29,35-38,63-66,72-89,127,152-154H,17-23,30-34,39-62,119-120H2,1-7H3,(H2,121,155)(H2,122,156)(H,130,157)(H,131,166)(H,132,167)(H,133,168)(H,134,175)(H,135,158)(H,136,159)(H,137,160)(H,138,165)(H,139,170)(H,140,171)(H,141,179)(H,142,181)(H,143,173)(H,144,169)(H,145,174)(H,146,180)(H,147,182)(H,148,176)(H,149,172)(H,150,178)(H,151,177)(H,161,162)(H,163,164)(H,183,184)(H4,123,124,128)(H4,125,126,129)/t66-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-/m0/s1 | UniProtKB/SwissProt
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PC cid
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UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 43.2 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469423
(CHEMBL4277648)Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C127H197N37O36/c1-65(2)49-84(157-107(182)70(10)146-125(200)104(71(11)167)164-100(175)62-144-124(199)103(132)68(7)8)109(184)142-61-99(174)149-92(63-165)122(197)159-85(50-66(3)4)116(191)145-69(9)106(181)150-81(41-43-101(176)177)114(189)155-82(42-44-102(178)179)115(190)158-86(51-67(5)6)117(192)161-90(56-94(130)169)110(185)143-60-98(173)148-88(55-75-37-39-76(168)40-38-75)118(193)162-91(57-95(131)170)121(196)154-79(35-25-47-138-126(134)135)112(187)152-78(34-22-24-46-129)111(186)151-77(33-21-23-45-128)108(183)141-58-96(171)140-59-97(172)147-87(53-73-29-17-13-18-30-73)119(194)163-93(64-166)123(198)160-89(54-74-31-19-14-20-32-74)120(195)153-80(36-26-48-139-127(136)137)113(188)156-83(105(133)180)52-72-27-15-12-16-28-72/h12-20,27-32,37-40,65-71,77-93,103-104,165-168H,21-26,33-36,41-64,128-129,132H2,1-11H3,(H2,130,169)(H2,131,170)(H2,133,180)(H,140,171)(H,141,183)(H,142,184)(H,143,185)(H,144,199)(H,145,191)(H,146,200)(H,147,172)(H,148,173)(H,149,174)(H,150,181)(H,151,186)(H,152,187)(H,153,195)(H,154,196)(H,155,189)(H,156,188)(H,157,182)(H,158,190)(H,159,197)(H,160,198)(H,161,192)(H,162,193)(H,163,194)(H,164,175)(H,176,177)(H,178,179)(H4,134,135,138)(H4,136,137,139)/t69-,70-,71+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,103-,104-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 46 | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based ... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469425
(CHEMBL4281420)Show SMILES CNC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C41H55N11O8/c1-45-41(44)46-19-11-18-29(37(57)50-30(36(43)56)20-26-12-5-2-6-13-26)49-39(59)32(22-28-16-9-4-10-17-28)51-40(60)33(25-53)52-38(58)31(21-27-14-7-3-8-15-27)48-35(55)24-47-34(54)23-42/h2-10,12-17,29-33,53H,11,18-25,42H2,1H3,(H2,43,56)(H,47,54)(H,48,55)(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H3,44,45,46)/t29-,30-,31-,32-,33-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 66 | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based ... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347849
(CHEMBL1802482)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-c1ccccc1 |r| Show InChI InChI=1S/C125H192N36O36/c1-66(2)49-82(157-122(196)93-35-24-48-161(93)100(173)62-142-109(183)90(63-162)160-123(197)103(130)70(8)165)107(181)140-61-99(172)146-89(56-95(129)168)119(193)154-83(50-67(3)4)114(188)143-69(7)104(178)147-80(40-42-101(174)175)112(186)152-81(41-43-102(176)177)113(187)153-84(51-68(5)6)115(189)156-88(55-94(128)167)108(182)141-60-98(171)145-86(54-73-36-38-75(166)39-37-73)117(191)158-91(64-163)120(194)151-79(34-23-47-136-125(133)134)111(185)150-78(32-19-21-45-127)110(184)148-76(31-18-20-44-126)106(180)139-58-96(169)137-59-97(170)144-85(52-71-25-12-9-13-26-71)116(190)159-92(65-164)121(195)155-87(53-72-27-14-10-15-28-72)118(192)149-77(33-22-46-135-124(131)132)105(179)138-57-74-29-16-11-17-30-74/h9-17,25-30,36-39,66-70,76-93,103,162-166H,18-24,31-35,40-65,126-127,130H2,1-8H3,(H2,128,167)(H2,129,168)(H,137,169)(H,138,179)(H,139,180)(H,140,181)(H,141,182)(H,142,183)(H,143,188)(H,144,170)(H,145,171)(H,146,172)(H,147,178)(H,148,184)(H,149,192)(H,150,185)(H,151,194)(H,152,186)(H,153,187)(H,154,193)(H,155,195)(H,156,189)(H,157,196)(H,158,191)(H,159,190)(H,160,197)(H,174,175)(H,176,177)(H4,131,132,135)(H4,133,134,136)/t69-,70+,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,103-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 67 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396422
(CHEMBL2170403)Show SMILES [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6](-[#8])-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-1-[#6]-[#6]-[#7]-[#6]-[#6]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C44H62N12O8/c45-40(61)35(23-30-11-4-1-5-12-30)53-41(62)34(17-10-18-49-44(46)47)52-42(63)36(24-31-13-6-2-7-14-31)50-39(60)28-56(26-33(58)29-57)54-43(64)37(25-32-15-8-3-9-16-32)51-38(59)27-55-21-19-48-20-22-55/h1-9,11-16,33-37,48,57-58H,10,17-29H2,(H2,45,61)(H,50,60)(H,51,59)(H,52,63)(H,53,62)(H,54,64)(H4,46,47,49)/t33?,34-,35-,36-,37-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 94 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347824
(CHEMBL1802420)Show SMILES [#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C76H112N24O18/c77-30-12-10-22-50(93-67(111)51(23-11-13-31-78)94-68(112)52(24-14-32-86-75(82)83)96-73(117)58(42-101)99-71(115)56(37-47-26-28-48(103)29-27-47)92-63(107)41-89-65(109)49(79)38-60(80)104)66(110)90-39-61(105)88-40-62(106)91-55(35-45-18-6-2-7-19-45)70(114)100-59(43-102)74(118)98-57(36-46-20-8-3-9-21-46)72(116)95-53(25-15-33-87-76(84)85)69(113)97-54(64(81)108)34-44-16-4-1-5-17-44/h1-9,16-21,26-29,49-59,101-103H,10-15,22-25,30-43,77-79H2,(H2,80,104)(H2,81,108)(H,88,105)(H,89,109)(H,90,110)(H,91,106)(H,92,107)(H,93,111)(H,94,112)(H,95,116)(H,96,117)(H,97,113)(H,98,118)(H,99,115)(H,100,114)(H4,82,83,86)(H4,84,85,87)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 95.3 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396420
(CHEMBL2170390)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C40H54N12O8/c41-22-33(54)52-46-23-34(55)47-30(20-26-13-6-2-7-14-26)37(58)51-32(24-53)39(60)50-31(21-27-15-8-3-9-16-27)38(59)48-28(17-10-18-45-40(43)44)36(57)49-29(35(42)56)19-25-11-4-1-5-12-25/h1-9,11-16,28-32,46,53H,10,17-24,41H2,(H2,42,56)(H,47,55)(H,48,59)(H,49,57)(H,50,60)(H,51,58)(H,52,54)(H4,43,44,45)/t28-,29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 136 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396421
(CHEMBL2170249)Show SMILES [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-1-[#6]-[#6]-[#7]-[#6]-[#6]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C42H57N11O7/c43-37(56)32(23-28-11-4-1-5-12-28)50-38(57)31(17-10-18-47-42(44)45)49-40(59)34(25-30-15-8-3-9-16-30)51-41(60)35(27-54)52-39(58)33(24-29-13-6-2-7-14-29)48-36(55)26-53-21-19-46-20-22-53/h1-9,11-16,31-35,46,54H,10,17-27H2,(H2,43,56)(H,48,55)(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H4,44,45,47)/t31-,32-,33-,34-,35-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 138 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347826
(CHEMBL1802416)Show SMILES [#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C70H103N21O15/c71-30-12-10-22-48(84-62(100)49(23-11-13-31-72)85-63(101)50(24-14-32-79-69(75)76)87-67(105)55(40-92)90-60(98)47(73)34-45-26-28-46(94)29-27-45)61(99)82-38-57(95)81-39-58(96)83-53(36-43-18-6-2-7-19-43)65(103)91-56(41-93)68(106)89-54(37-44-20-8-3-9-21-44)66(104)86-51(25-15-33-80-70(77)78)64(102)88-52(59(74)97)35-42-16-4-1-5-17-42/h1-9,16-21,26-29,47-56,92-94H,10-15,22-25,30-41,71-73H2,(H2,74,97)(H,81,95)(H,82,99)(H,83,96)(H,84,100)(H,85,101)(H,86,104)(H,87,105)(H,88,102)(H,89,106)(H,90,98)(H,91,103)(H4,75,76,79)(H4,77,78,80)/t47-,48-,49-,50-,51-,52-,53-,54-,55-,56-/m0/s1 | UniProtKB/SwissProt
antibodypedia
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| n/a | n/a | n/a | n/a | 138 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396423
(CHEMBL2170402)Show SMILES [#6]-[#6]-[#6]-[#7](-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-1-[#6]-[#6]-[#7]-[#6]-[#6]-1 |r| Show InChI InChI=1S/C44H62N12O6/c1-2-23-56(54-43(62)37(28-33-17-10-5-11-18-33)51-38(57)29-55-24-21-48-22-25-55)30-39(58)50-36(27-32-15-8-4-9-16-32)42(61)52-34(19-12-20-49-44(46)47)41(60)53-35(40(45)59)26-31-13-6-3-7-14-31/h3-11,13-18,34-37,48H,2,12,19-30H2,1H3,(H2,45,59)(H,50,58)(H,51,57)(H,52,61)(H,53,60)(H,54,62)(H4,46,47,49)/t34-,35-,36-,37-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 164 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347844
(CHEMBL1802373)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7](-[#6]-c1ccccc1)-[#6]-c1ccccc1 |r| Show InChI InChI=1S/C141H207N37O37/c1-78(2)59-96(172-137(213)108-45-30-58-178(108)115(190)72-157-123(199)105(75-179)176-138(214)118(146)82(8)182)121(197)155-71-114(189)161-103(67-110(145)185)134(210)169-97(60-79(3)4)129(205)158-81(7)119(195)162-94(50-52-116(191)192)127(203)167-95(51-53-117(193)194)128(204)168-98(61-80(5)6)130(206)171-102(66-109(144)184)122(198)156-70-113(188)160-100(64-86-46-48-89(183)49-47-86)132(208)174-106(76-180)135(211)166-92(43-28-56-151-140(147)148)125(201)164-91(42-25-27-55-143)124(200)163-90(41-24-26-54-142)120(196)154-68-111(186)153-69-112(187)159-99(62-83-31-14-9-15-32-83)131(207)175-107(77-181)136(212)170-101(63-84-33-16-10-17-34-84)133(209)165-93(44-29-57-152-141(149)150)126(202)173-104(65-85-35-18-11-19-36-85)139(215)177(73-87-37-20-12-21-38-87)74-88-39-22-13-23-40-88/h9-23,31-40,46-49,78-82,90-108,118,179-183H,24-30,41-45,50-77,142-143,146H2,1-8H3,(H2,144,184)(H2,145,185)(H,153,186)(H,154,196)(H,155,197)(H,156,198)(H,157,199)(H,158,205)(H,159,187)(H,160,188)(H,161,189)(H,162,195)(H,163,200)(H,164,201)(H,165,209)(H,166,211)(H,167,203)(H,168,204)(H,169,210)(H,170,212)(H,171,206)(H,172,213)(H,173,202)(H,174,208)(H,175,207)(H,176,214)(H,191,192)(H,193,194)(H4,147,148,151)(H4,149,150,152)/t81-,82+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,118-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347825
(CHEMBL1802417)Show SMILES [#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C72H106N22O16/c73-30-12-10-22-48(87-63(103)49(23-11-13-31-74)88-64(104)50(24-14-32-81-71(77)78)90-69(109)56(41-95)93-66(106)53(85-58(98)38-75)37-46-26-28-47(97)29-27-46)62(102)84-39-59(99)83-40-60(100)86-54(35-44-18-6-2-7-19-44)67(107)94-57(42-96)70(110)92-55(36-45-20-8-3-9-21-45)68(108)89-51(25-15-33-82-72(79)80)65(105)91-52(61(76)101)34-43-16-4-1-5-17-43/h1-9,16-21,26-29,48-57,95-97H,10-15,22-25,30-42,73-75H2,(H2,76,101)(H,83,99)(H,84,102)(H,85,98)(H,86,100)(H,87,103)(H,88,104)(H,89,108)(H,90,109)(H,91,105)(H,92,110)(H,93,106)(H,94,107)(H4,77,78,81)(H4,79,80,82)/t48-,49-,50-,51-,52-,53-,54-,55-,56-,57-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 185 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347858
(CHEMBL1802423)Show SMILES [#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C52H77N15O10/c53-24-12-10-21-36(55)46(72)63-37(22-11-13-25-54)47(73)61-30-43(69)60-31-44(70)62-40(28-34-17-6-2-7-18-34)49(75)67-42(32-68)51(77)66-41(29-35-19-8-3-9-20-35)50(76)64-38(23-14-26-59-52(57)58)48(74)65-39(45(56)71)27-33-15-4-1-5-16-33/h1-9,15-20,36-42,68H,10-14,21-32,53-55H2,(H2,56,71)(H,60,69)(H,61,73)(H,62,70)(H,63,72)(H,64,76)(H,65,74)(H,66,77)(H,67,75)(H4,57,58,59)/t36-,37-,38-,39-,40-,41-,42-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 233 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347841
(CHEMBL1802369)Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C42H57N11O7/c1-2-13-30(50-40(59)33(23-28-16-8-4-9-17-28)49-36(55)26-48-35(54)25-43)38(57)53-34(24-29-18-10-5-11-19-29)41(60)51-31(20-12-21-47-42(45)46)39(58)52-32(37(44)56)22-27-14-6-3-7-15-27/h3-11,14-19,30-34H,2,12-13,20-26,43H2,1H3,(H2,44,56)(H,48,54)(H,49,55)(H,50,59)(H,51,60)(H,52,58)(H,53,57)(H4,45,46,47)/t30-,31-,32-,33-,34-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 233 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347827
(CHEMBL1802421)Show SMILES [#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#8])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C61H94N20O13/c62-26-12-10-22-41(76-54(89)42(23-11-13-27-63)77-55(90)43(24-14-28-70-60(66)67)75-52(87)40(64)35-82)53(88)73-33-49(84)72-34-50(85)74-46(31-38-18-6-2-7-19-38)57(92)81-48(36-83)59(94)80-47(32-39-20-8-3-9-21-39)58(93)78-44(25-15-29-71-61(68)69)56(91)79-45(51(65)86)30-37-16-4-1-5-17-37/h1-9,16-21,40-48,82-83H,10-15,22-36,62-64H2,(H2,65,86)(H,72,84)(H,73,88)(H,74,85)(H,75,87)(H,76,89)(H,77,90)(H,78,93)(H,79,91)(H,80,94)(H,81,92)(H4,66,67,70)(H4,68,69,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347845
(CHEMBL1802476)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7](-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1 |r| Show InChI InChI=1S/C137H213N39O37/c1-76(2)59-92(168-133(211)104-41-30-58-175(104)111(188)72-153-119(197)101(73-177)172-134(212)114(142)80(8)180)117(195)151-71-110(187)157-99(67-106(141)183)130(208)165-93(60-77(3)4)125(203)154-79(7)115(193)158-90(46-48-112(189)190)123(201)163-91(47-49-113(191)192)124(202)164-94(61-78(5)6)126(204)167-98(66-105(140)182)118(196)152-70-109(186)156-96(64-84-42-44-85(181)45-43-84)128(206)170-102(74-178)131(209)162-88(39-28-52-147-136(143)144)121(199)160-87(38-21-23-51-139)120(198)159-86(37-20-22-50-138)116(194)150-68-107(184)149-69-108(185)155-95(62-81-31-14-9-15-32-81)127(205)171-103(75-179)132(210)166-97(63-82-33-16-10-17-34-82)129(207)161-89(40-29-53-148-137(145)146)122(200)169-100(65-83-35-18-11-19-36-83)135(213)176(173-54-24-12-25-55-173)174-56-26-13-27-57-174/h9-11,14-19,31-36,42-45,76-80,86-104,114,177-181H,12-13,20-30,37-41,46-75,138-139,142H2,1-8H3,(H2,140,182)(H2,141,183)(H,149,184)(H,150,194)(H,151,195)(H,152,196)(H,153,197)(H,154,203)(H,155,185)(H,156,186)(H,157,187)(H,158,193)(H,159,198)(H,160,199)(H,161,207)(H,162,209)(H,163,201)(H,164,202)(H,165,208)(H,166,210)(H,167,204)(H,168,211)(H,169,200)(H,170,206)(H,171,205)(H,172,212)(H,189,190)(H,191,192)(H4,143,144,147)(H4,145,146,148)/t79-,80+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,114-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 282 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347828
(CHEMBL1802422)Show SMILES [#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C58H89N19O11/c59-26-12-10-23-40(73-52(84)41(24-11-13-27-60)72-50(82)39(61)22-14-28-67-57(63)64)51(83)70-33-47(79)69-34-48(80)71-44(31-37-18-6-2-7-19-37)54(86)77-46(35-78)56(88)76-45(32-38-20-8-3-9-21-38)55(87)74-42(25-15-29-68-58(65)66)53(85)75-43(49(62)81)30-36-16-4-1-5-17-36/h1-9,16-21,39-46,78H,10-15,22-35,59-61H2,(H2,62,81)(H,69,79)(H,70,83)(H,71,80)(H,72,82)(H,73,84)(H,74,87)(H,75,85)(H,76,88)(H,77,86)(H4,63,64,67)(H4,65,66,68)/t39-,40-,41-,42-,43-,44-,45-,46-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 282 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396428
(CHEMBL2170396)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#7](-[#6]-[#6](-[#8])-[#6]-[#8])-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C42H58N12O9/c43-22-35(57)48-23-36(58)49-34(21-29-15-8-3-9-16-29)41(63)53-54(24-30(56)26-55)25-37(59)50-33(20-28-13-6-2-7-14-28)40(62)51-31(17-10-18-47-42(45)46)39(61)52-32(38(44)60)19-27-11-4-1-5-12-27/h1-9,11-16,30-34,55-56H,10,17-26,43H2,(H2,44,60)(H,48,57)(H,49,58)(H,50,59)(H,51,62)(H,52,61)(H,53,63)(H4,45,46,47)/t30?,31-,32-,33-,34-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347842
(CHEMBL1802370)Show SMILES [#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C41H55N11O7/c1-2-29(49-39(58)32(22-27-15-8-4-9-16-27)48-35(54)25-47-34(53)24-42)37(56)52-33(23-28-17-10-5-11-18-28)40(59)50-30(19-12-20-46-41(44)45)38(57)51-31(36(43)55)21-26-13-6-3-7-14-26/h3-11,13-18,29-33H,2,12,19-25,42H2,1H3,(H2,43,55)(H,47,53)(H,48,54)(H,49,58)(H,50,59)(H,51,57)(H,52,56)(H4,44,45,46)/t29-,30-,31-,32-,33-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347859
(CHEMBL1802372)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C41H55N11O8/c42-24-34(54)47-25-35(55)48-32(22-27-13-6-2-7-14-27)39(59)50-30(18-20-53)38(58)52-33(23-28-15-8-3-9-16-28)40(60)49-29(17-10-19-46-41(44)45)37(57)51-31(36(43)56)21-26-11-4-1-5-12-26/h1-9,11-16,29-33,53H,10,17-25,42H2,(H2,43,56)(H,47,54)(H,48,55)(H,49,60)(H,50,59)(H,51,57)(H,52,58)(H4,44,45,46)/t29-,30-,31-,32-,33-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396424
(CHEMBL2170401)Show SMILES [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6](-[#8])-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C43H60N12O8/c44-39(60)34(22-29-12-4-1-5-13-29)52-40(61)33(18-10-19-47-43(45)46)51-41(62)35(23-30-14-6-2-7-15-30)49-38(59)27-55(25-32(57)28-56)53-42(63)36(24-31-16-8-3-9-17-31)50-37(58)26-54-21-11-20-48-54/h1-9,12-17,32-36,48,56-57H,10-11,18-28H2,(H2,44,60)(H,49,59)(H,50,58)(H,51,62)(H,52,61)(H,53,63)(H4,45,46,47)/t32?,33-,34-,35-,36-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396431
(CHEMBL2170389)Show SMILES [#7]-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C40H54N12O8/c41-35(56)29(19-25-11-4-1-5-12-25)50-36(57)28(17-10-18-45-40(42)43)49-38(59)31(21-27-15-8-3-9-16-27)51-39(60)32(24-53)52-37(58)30(20-26-13-6-2-7-14-26)48-34(55)22-46-33(54)23-47-44/h1-9,11-16,28-32,47,53H,10,17-24,44H2,(H2,41,56)(H,46,54)(H,48,55)(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H4,42,43,45)/t28-,29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347856
(CHEMBL1802379)Show SMILES [#6]-[#7](-[#6])-[#6](=[#7]\[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O)\[#7](-[#6])-[#6] |r| Show InChI InChI=1S/C43H60N12O7/c1-54(2)43(55(3)4)48-26-36(57)49-33(24-29-17-10-6-11-18-29)39(60)53-35(27-56)41(62)52-34(25-30-19-12-7-13-20-30)40(61)50-31(21-14-22-47-42(45)46)38(59)51-32(37(44)58)23-28-15-8-5-9-16-28/h5-13,15-20,31-35,56H,14,21-27H2,1-4H3,(H2,44,58)(H,49,57)(H,50,61)(H,51,59)(H,52,62)(H,53,60)(H4,45,46,47)/t31-,32-,33-,34-,35-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 455 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347854
(CHEMBL1802377)Show SMILES [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)C12[#6]-[#6]-3-[#6]-[#6](-[#6]-[#6](-[#6]-3)-[#6]1)-[#6]2)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r,TLB:45:47:50.49.54:52,THB:48:49:52:56.47.55,48:47:50.49.54:52,55:47:50:54.53.52,55:53:50:56.48.47| Show InChI InChI=1S/C51H67N11O9/c52-44(66)38(22-31-11-4-1-5-12-31)60-45(67)37(17-10-18-55-50(53)54)59-47(69)40(24-33-15-8-3-9-16-33)61-48(70)41(30-63)62-46(68)39(23-32-13-6-2-7-14-32)58-43(65)29-56-42(64)28-57-49(71)51-25-34-19-35(26-51)21-36(20-34)27-51/h1-9,11-16,34-41,63H,10,17-30H2,(H2,52,66)(H,56,64)(H,57,71)(H,58,65)(H,59,69)(H,60,67)(H,61,70)(H,62,68)(H4,53,54,55)/t34?,35?,36?,37-,38-,39-,40-,41-,51?/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347855
(CHEMBL1802378)Show SMILES [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-c1ccco1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C45H55N11O10/c46-39(60)32(22-28-12-4-1-5-13-28)54-40(61)31(18-10-20-49-45(47)48)53-42(63)34(24-30-16-8-3-9-17-30)55-43(64)35(27-57)56-41(62)33(23-29-14-6-2-7-15-29)52-38(59)26-50-37(58)25-51-44(65)36-19-11-21-66-36/h1-9,11-17,19,21,31-35,57H,10,18,20,22-27H2,(H2,46,60)(H,50,58)(H,51,65)(H,52,59)(H,53,63)(H,54,61)(H,55,64)(H,56,62)(H4,47,48,49)/t31-,32-,33-,34-,35-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 695 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347852
(CHEMBL1802375)Show SMILES [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C47H57N11O9/c48-41(62)35(24-30-14-5-1-6-15-30)56-43(64)34(22-13-23-51-47(49)50)55-45(66)37(26-32-18-9-3-10-19-32)57-46(67)38(29-59)58-44(65)36(25-31-16-7-2-8-17-31)54-40(61)28-52-39(60)27-53-42(63)33-20-11-4-12-21-33/h1-12,14-21,34-38,59H,13,22-29H2,(H2,48,62)(H,52,60)(H,53,63)(H,54,61)(H,55,66)(H,56,64)(H,57,67)(H,58,65)(H4,49,50,51)/t34-,35-,36-,37-,38-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347830
(CHEMBL1802425)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C40H53N11O8/c41-22-33(53)46-23-34(54)47-30(20-26-13-6-2-7-14-26)37(57)51-32(24-52)39(59)50-31(21-27-15-8-3-9-16-27)38(58)48-28(17-10-18-45-40(43)44)36(56)49-29(35(42)55)19-25-11-4-1-5-12-25/h1-9,11-16,28-32,52H,10,17-24,41H2,(H2,42,55)(H,46,53)(H,47,54)(H,48,58)(H,49,56)(H,50,59)(H,51,57)(H4,43,44,45)/t28-,29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 739 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347830
(CHEMBL1802425)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C40H53N11O8/c41-22-33(53)46-23-34(54)47-30(20-26-13-6-2-7-14-26)37(57)51-32(24-52)39(59)50-31(21-27-15-8-3-9-16-27)38(58)48-28(17-10-18-45-40(43)44)36(56)49-29(35(42)55)19-25-11-4-1-5-12-25/h1-9,11-16,28-32,52H,10,17-24,41H2,(H2,42,55)(H,46,53)(H,47,54)(H,48,58)(H,49,56)(H,50,59)(H,51,57)(H4,43,44,45)/t28-,29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 739 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347837
(CHEMBL1802365)Show SMILES [#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C43H59N11O7/c1-2-3-20-31(51-41(60)34(24-29-16-9-5-10-17-29)50-37(56)27-49-36(55)26-44)40(59)54-35(25-30-18-11-6-12-19-30)42(61)52-32(21-13-22-48-43(46)47)39(58)53-33(38(45)57)23-28-14-7-4-8-15-28/h4-12,14-19,31-35H,2-3,13,20-27,44H2,1H3,(H2,45,57)(H,49,55)(H,50,56)(H,51,60)(H,52,61)(H,53,58)(H,54,59)(H4,46,47,48)/t31-,32-,33-,34-,35-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347838
(CHEMBL1802366)Show SMILES [#6]-[#6]-[#6@@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C43H59N11O7/c1-3-27(2)37(54-41(60)33(23-29-16-9-5-10-17-29)50-36(56)26-49-35(55)25-44)42(61)53-34(24-30-18-11-6-12-19-30)40(59)51-31(20-13-21-48-43(46)47)39(58)52-32(38(45)57)22-28-14-7-4-8-15-28/h4-12,14-19,27,31-34,37H,3,13,20-26,44H2,1-2H3,(H2,45,57)(H,49,55)(H,50,56)(H,51,59)(H,52,58)(H,53,61)(H,54,60)(H4,46,47,48)/t27-,31+,32+,33+,34+,37+/m1/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347853
(CHEMBL1802376)Show SMILES [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#8]-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C48H59N11O10/c49-42(63)36(24-31-14-5-1-6-15-31)57-43(64)35(22-13-23-52-47(50)51)56-45(66)38(26-33-18-9-3-10-19-33)58-46(67)39(29-60)59-44(65)37(25-32-16-7-2-8-17-32)55-41(62)28-53-40(61)27-54-48(68)69-30-34-20-11-4-12-21-34/h1-12,14-21,35-39,60H,13,22-30H2,(H2,49,63)(H,53,61)(H,54,68)(H,55,62)(H,56,66)(H,57,64)(H,58,67)(H,59,65)(H4,50,51,52)/t35-,36-,37-,38-,39-/m0/s1 | UniProtKB/SwissProt
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INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347857
(CHEMBL1802380)Show SMILES [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-c1ccc(F)cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C48H58FN11O9/c49-34-20-18-33(19-21-34)26-40(62)54-27-41(63)55-28-42(64)56-37(24-31-13-6-2-7-14-31)45(67)60-39(29-61)47(69)59-38(25-32-15-8-3-9-16-32)46(68)57-35(17-10-22-53-48(51)52)44(66)58-36(43(50)65)23-30-11-4-1-5-12-30/h1-9,11-16,18-21,35-39,61H,10,17,22-29H2,(H2,50,65)(H,54,62)(H,55,63)(H,56,64)(H,57,68)(H,58,66)(H,59,69)(H,60,67)(H4,51,52,53)/t35-,36-,37-,38-,39-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 830 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347847
(CHEMBL1802479)Show SMILES [#6]-[#6]-[#7](-[#6]-c1ccccc1)-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7] |r| Show InChI InChI=1S/C49H63N11O8/c1-2-60(31-36-22-13-6-14-23-36)48(68)40(28-35-20-11-5-12-21-35)58-44(64)37(24-15-25-53-49(51)52)56-46(66)39(27-34-18-9-4-10-19-34)57-47(67)41(32-61)59-45(65)38(26-33-16-7-3-8-17-33)55-43(63)30-54-42(62)29-50/h3-14,16-23,37-41,61H,2,15,24-32,50H2,1H3,(H,54,62)(H,55,63)(H,56,66)(H,57,67)(H,58,64)(H,59,65)(H4,51,52,53)/t37-,38-,39-,40-,41-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396429
(CHEMBL2170392)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#7](-[#6]-[#6]-[#8])-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C41H56N12O8/c42-24-34(55)47-25-35(56)48-33(23-29-15-8-3-9-16-29)40(61)52-53(19-20-54)26-36(57)49-32(22-28-13-6-2-7-14-28)39(60)50-30(17-10-18-46-41(44)45)38(59)51-31(37(43)58)21-27-11-4-1-5-12-27/h1-9,11-16,30-33,54H,10,17-26,42H2,(H2,43,58)(H,47,55)(H,48,56)(H,49,57)(H,50,60)(H,51,59)(H,52,61)(H4,44,45,46)/t30-,31-,32-,33-/m0/s1 | UniProtKB/SwissProt
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PubMed
| n/a | n/a | n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396427
(CHEMBL2170397)Show SMILES [#6]-[#7](-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7] |r| Show InChI InChI=1S/C40H54N12O7/c1-52(51-39(59)32(22-28-16-9-4-10-17-28)47-34(54)24-46-33(53)23-41)25-35(55)48-31(21-27-14-7-3-8-15-27)38(58)49-29(18-11-19-45-40(43)44)37(57)50-30(36(42)56)20-26-12-5-2-6-13-26/h2-10,12-17,29-32H,11,18-25,41H2,1H3,(H2,42,56)(H,46,53)(H,47,54)(H,48,55)(H,49,58)(H,50,57)(H,51,59)(H4,43,44,45)/t29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347843
(CHEMBL1802371)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C46H63N11O7/c47-28-39(58)52-29-40(59)53-36(25-31-16-7-2-8-17-31)43(62)56-38(27-33-20-11-4-12-21-33)45(64)57-37(26-32-18-9-3-10-19-32)44(63)54-34(22-13-23-51-46(49)50)42(61)55-35(41(48)60)24-30-14-5-1-6-15-30/h1-3,5-10,14-19,33-38H,4,11-13,20-29,47H2,(H2,48,60)(H,52,58)(H,53,59)(H,54,63)(H,55,61)(H,56,62)(H,57,64)(H4,49,50,51)/t34-,35-,36-,37-,38-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347846
(CHEMBL1802478)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7](-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1 |r| Show InChI InChI=1S/C50H71N13O8/c51-32-43(65)55-33-44(66)56-39(29-35-17-6-1-7-18-35)46(68)60-42(34-64)48(70)58-40(30-36-19-8-2-9-20-36)47(69)57-38(23-16-24-54-50(52)53)45(67)59-41(31-37-21-10-3-11-22-37)49(71)63(61-25-12-4-13-26-61)62-27-14-5-15-28-62/h1-3,6-11,17-22,38-42,64H,4-5,12-16,23-34,51H2,(H,55,65)(H,56,66)(H,57,69)(H,58,70)(H,59,67)(H,60,68)(H4,52,53,54)/t38-,39-,40-,41-,42-/m0/s1 | UniProtKB/SwissProt
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PubMed
| n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347834
(CHEMBL1802412)Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C40H53N11O7/c1-25(47-38(57)31(21-27-14-7-3-8-15-27)48-34(53)24-46-33(52)23-41)36(55)51-32(22-28-16-9-4-10-17-28)39(58)49-29(18-11-19-45-40(43)44)37(56)50-30(35(42)54)20-26-12-5-2-6-13-26/h2-10,12-17,25,29-32H,11,18-24,41H2,1H3,(H2,42,54)(H,46,52)(H,47,57)(H,48,53)(H,49,58)(H,50,56)(H,51,55)(H4,43,44,45)/t25-,29-,30-,31-,32-/m0/s1 | UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
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UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347833
(CHEMBL1802433)Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C34H49N11O8/c1-20(41-28(48)18-40-27(47)17-35)30(50)45-26(19-46)33(53)44-25(16-22-11-6-3-7-12-22)32(52)42-23(13-8-14-39-34(37)38)31(51)43-24(29(36)49)15-21-9-4-2-5-10-21/h2-7,9-12,20,23-26,46H,8,13-19,35H2,1H3,(H2,36,49)(H,40,47)(H,41,48)(H,42,52)(H,43,51)(H,44,53)(H,45,50)(H4,37,38,39)/t20-,23-,24-,25-,26-/m0/s1 | UniProtKB/SwissProt
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PubMed
| n/a | n/a | n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50396425
(CHEMBL2170400)Show SMILES [#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#7](-[#6]-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C46H64N12O7/c47-27-39(59)52-28-40(60)53-38(26-33-18-9-3-10-19-33)45(65)57-58(29-34-20-11-4-12-21-34)30-41(61)54-37(25-32-16-7-2-8-17-32)44(64)55-35(22-13-23-51-46(49)50)43(63)56-36(42(48)62)24-31-14-5-1-6-15-31/h1-3,5-10,14-19,34-38H,4,11-13,20-30,47H2,(H2,48,62)(H,52,59)(H,53,60)(H,54,61)(H,55,64)(H,56,63)(H,57,65)(H4,49,50,51)/t35-,36-,37-,38-/m0/s1 | UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.37E+3 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 min... |
J Med Chem 55: 7516-24 (2012)
Article DOI: 10.1021/jm300507d
BindingDB Entry DOI: 10.7270/Q2K35VSG |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469453
(CHEMBL4287860)Show SMILES CCNC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C42H57N11O8/c1-2-46-42(45)47-20-12-19-30(38(58)51-31(37(44)57)21-27-13-6-3-7-14-27)50-40(60)33(23-29-17-10-5-11-18-29)52-41(61)34(26-54)53-39(59)32(22-28-15-8-4-9-16-28)49-36(56)25-48-35(55)24-43/h3-11,13-18,30-34,54H,2,12,19-26,43H2,1H3,(H2,44,57)(H,48,55)(H,49,56)(H,50,60)(H,51,58)(H,52,61)(H,53,59)(H3,45,46,47)/t30-,31-,32-,33-,34-/m0/s1 | UniProtKB/SwissProt
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UniChem
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| n/a | n/a | n/a | n/a | 1.37E+3 | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based ... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50469436
(CHEMBL4281383)Show SMILES CCCNC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C43H59N11O8/c1-2-20-47-43(46)48-21-12-19-31(39(59)52-32(38(45)58)22-28-13-6-3-7-14-28)51-41(61)34(24-30-17-10-5-11-18-30)53-42(62)35(27-55)54-40(60)33(23-29-15-8-4-9-16-29)50-37(57)26-49-36(56)25-44/h3-11,13-18,31-35,55H,2,12,19-27,44H2,1H3,(H2,45,58)(H,49,56)(H,50,57)(H,51,61)(H,52,59)(H,53,62)(H,54,60)(H3,46,47,48)/t31-,32-,33-,34-,35-/m0/s1 | UniProtKB/SwissProt
antibodypedia
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AffyNet
| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a |
Normandy University
Curated by ChEMBL
| Assay Description
Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based ... |
J Med Chem 61: 10185-10197 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01332
BindingDB Entry DOI: 10.7270/Q2222XG4 |
More data for this
Ligand-Target Pair | |
Pyroglutamylated RF-amide peptide receptor
(Homo sapiens (Human)) | BDBM50347850
(CHEMBL1802484)Show SMILES [#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O |r| Show InChI InChI=1S/C42H55N11O9/c1-26(55)47-23-35(56)48-24-36(57)49-32(21-28-14-7-3-8-15-28)39(60)53-34(25-54)41(62)52-33(22-29-16-9-4-10-17-29)40(61)50-30(18-11-19-46-42(44)45)38(59)51-31(37(43)58)20-27-12-5-2-6-13-27/h2-10,12-17,30-34,54H,11,18-25H2,1H3,(H2,43,58)(H,47,55)(H,48,56)(H,49,57)(H,50,61)(H,51,59)(H,52,62)(H,53,60)(H4,44,45,46)/t30-,31-,32-,33-,34-/m0/s1 | UniProtKB/SwissProt
antibodypedia
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PC cid
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UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.44E+3 | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description
Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calci... |
J Med Chem 54: 4806-14 (2011)
Article DOI: 10.1021/jm200418c
BindingDB Entry DOI: 10.7270/Q2V40VJ8 |
More data for this
Ligand-Target Pair | |
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