Compile Data Set for Download or QSAR

Found 37 hits of ic50 for UniProtKB: O15303   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50434134 (CHEMBL2381641) Show SMILES N[C@]1(CC(=C)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h4-6H,1-2,10H2,(H,11,12)(H,13,14)/t4-,5-,6-,9-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	267	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...				J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299471 (CHEMBL566136 | Ethyl 2-amino-4-methyl-5-phenylthio...) Show SMILES CCOC(=O)c1c(N)sc(c1C)-c1ccccc1 Show InChI InChI=1S/C14H15NO2S/c1-3-17-14(16)11-9(2)12(18-13(11)15)10-7-5-4-6-8-10/h4-8H,3,15H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50434136 (CHEMBL2381640) Show SMILES N[C@]1(CC(=O)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H9NO5/c9-8(7(13)14)1-2(10)3-4(5(3)8)6(11)12/h3-5H,1,9H2,(H,11,12)(H,13,14)/t3-,4-,5-,8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...				J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50434130 (CHEMBL2381645) Show SMILES N[C@]1(C[C@H](N=[N+]=[N-])[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H10N4O4/c9-8(7(15)16)1-2(11-12-10)3-4(5(3)8)6(13)14/h2-5H,1,9H2,(H,13,14)(H,15,16)/t2-,3-,4-,5-,8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...				J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299477 (CHEMBL568515 | Propyl 2-amino-4-methyl-5-phenylthi...) Show SMILES CCCOC(=O)c1c(N)sc(c1C)-c1ccccc1 Show InChI InChI=1S/C15H17NO2S/c1-3-9-18-15(17)12-10(2)13(19-14(12)16)11-7-5-4-6-8-11/h4-8H,3,9,16H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50434133 (CHEMBL2381643) Show SMILES N[C@]1(C[C@H](O)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H11NO5/c9-8(7(13)14)1-2(10)3-4(5(3)8)6(11)12/h2-5,10H,1,9H2,(H,11,12)(H,13,14)/t2-,3-,4-,5-,8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...				J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50204257 (CHEMBL3947221) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2O)C(O)=O |r| Show InChI InChI=1S/C15H15Cl2NO6/c16-6-2-1-5(3-7(6)17)4-24-12-11(19)8-9(13(20)21)10(8)15(12,18)14(22)23/h1-3,8-12,19H,4,18H2,(H,20,21)(H,22,23)/t8-,9-,10-,11-,12+,15+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu6 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as inhibition of L-AP4-inh...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299481 (2-isothiocyanato-4-methyl-5-phenylthiophene-3-carb...) Show SMILES CCOC(=O)c1c(C)c(sc1N=C=S)-c1ccccc1 Show InChI InChI=1S/C15H13NO2S2/c1-3-18-15(17)12-10(2)13(20-14(12)16-9-19)11-7-5-4-6-8-11/h4-8H,3H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299478 (CHEMBL577069 | Tert-Butyl 2-amino-4-methyl-5-pheny...) Show SMILES Cc1c(sc(N)c1C(=O)OC(C)(C)C)-c1ccccc1 Show InChI InChI=1S/C16H19NO2S/c1-10-12(15(18)19-16(2,3)4)14(17)20-13(10)11-8-6-5-7-9-11/h5-9H,17H2,1-4H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50031704 ((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...) Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50558766 (CHEMBL4751065) Show SMILES Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(F)c(F)c1)[C@H]2O)C(O)=O |r| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	4.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu6 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as reduction in ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299472 (CHEMBL568300 | Methyl 2-amino-4-methyl-5-phenylthi...) Show SMILES COC(=O)c1c(N)sc(c1C)-c1ccccc1 Show InChI InChI=1S/C13H13NO2S/c1-8-10(13(15)16-2)12(14)17-11(8)9-6-4-3-5-7-9/h3-7H,14H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299476 (2-Amino-4,5-diphenyl-thiophene-3-carboxylic acid e...) Show SMILES CCOC(=O)c1c(N)sc(c1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C19H17NO2S/c1-2-22-19(21)16-15(13-9-5-3-6-10-13)17(23-18(16)20)14-11-7-4-8-12-14/h3-12H,2,20H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299475 (CHEMBL566530 | Ethyl 2-amino-5-(2-chlorophenyl)-4-...) Show SMILES CCOC(=O)c1c(N)sc(c1C)-c1ccccc1Cl Show InChI InChI=1S/C14H14ClNO2S/c1-3-18-14(17)11-8(2)12(19-13(11)16)9-6-4-5-7-10(9)15/h4-7H,3,16H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM31772 (1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl...) Show SMILES Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 Show InChI InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299473 (CHEMBL577248 | Ethyl 2-amino-5-(4-methoxyphenyl)-4...) Show SMILES CCOC(=O)c1c(N)sc(c1C)-c1ccc(OC)cc1 Show InChI InChI=1S/C15H17NO3S/c1-4-19-15(17)12-9(2)13(20-14(12)16)10-5-7-11(18-3)8-6-10/h5-8H,4,16H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM212860 (US9278960, 2-7 | US9663506, Example 2-7) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3C(=O)CCC3=O)cc2n1 Show InChI InChI=1S/C21H16FN3O3/c22-14-4-2-13(3-5-14)16-10-18(21(23)28)24-17-9-12(1-6-15(16)17)11-25-19(26)7-8-20(25)27/h1-6,9-10H,7-8,11H2,(H2,23,28)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Antagonist activity at mGluR6 (unknown origin) by FLIPR assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127066 BindingDB Entry DOI: 10.7270/Q2G44TTJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50531687 (CHEMBL4445682) Show SMILES COc1cc(ccc1OCC1CC1)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1 Show InChI InChI=1S/C21H19F3N4O4/c1-30-19-8-14(4-7-18(19)31-10-13-2-3-13)20(29)27-16-9-15(32-21(22,23)24)5-6-17(16)28-12-25-11-26-28/h4-9,11-13H,2-3,10H2,1H3,(H,27,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu6 receptor (unknown origin)				J Med Chem 62: 1690-1695 (2019) Article DOI: 10.1021/acs.jmedchem.8b01810 BindingDB Entry DOI: 10.7270/Q2QC070T
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50523865 (CHEMBL4476495) Show SMILES COc1ccc(cc1OC)-c1nnc(o1)-c1cc(OC(F)(F)F)ccc1-n1ccnc1 Show InChI InChI=1S/C20H15F3N4O4/c1-28-16-6-3-12(9-17(16)29-2)18-25-26-19(30-18)14-10-13(31-20(21,22)23)4-5-15(14)27-8-7-24-11-27/h3-11H,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu6 receptor (unknown origin)				Bioorg Med Chem Lett 29: 1211-1214 (2019) Article DOI: 10.1016/j.bmcl.2019.03.016 BindingDB Entry DOI: 10.7270/Q2WH2TDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50283472 (CHEMBL4160748) Show SMILES COc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1F |(9.45,-43.77,;10.47,-42.62,;9.99,-41.15,;8.48,-40.84,;7.99,-39.38,;9.02,-38.23,;8.54,-36.77,;9.43,-35.53,;10.97,-35.52,;8.53,-34.29,;7.07,-34.77,;5.74,-34,;4.41,-34.77,;4.41,-36.31,;3.08,-37.09,;5.74,-37.08,;7.08,-36.3,;5.74,-32.46,;7.08,-31.68,;4.41,-31.68,;5.73,-30.92,;10.52,-38.54,;11.55,-37.39,;11.01,-40,;12.52,-40.31,)| Show InChI InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK channel assessed as decrease in glutamate-induced thalli...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50280368 (CHEMBL4176971) Show SMILES COc1ccc(cc1OC)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1 Show InChI InChI=1S/C18H15F3N4O4/c1-27-15-6-3-11(7-16(15)28-2)17(26)24-13-8-12(29-18(19,20)21)4-5-14(13)25-10-22-9-23-25/h3-10H,1-2H3,(H,24,26)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description In vitro inhibitory activity against angiotensin I converting enzyme of rats.				ACS Med Chem Lett 8: 1326-1330 (2017) Article DOI: 10.1021/acsmedchemlett.7b00429 BindingDB Entry DOI: 10.7270/Q25X2CG2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299485 (CHEMBL575059 | Ethyl 2-chloro-4-methyl-5-phenylthi...) Show SMILES CCOC(=O)c1c(Cl)sc(c1C)-c1ccccc1 Show InChI InChI=1S/C14H13ClO2S/c1-3-17-14(16)11-9(2)12(18-13(11)15)10-7-5-4-6-8-10/h4-8H,3H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299480 ((2-Amino-4-methyl-5-phenylthiophen-3-yl)(phenyl)me...) Show SMILES Cc1c(C(=O)c2ccccc2)c(N)sc1-c1ccccc1 Show InChI InChI=1S/C18H15NOS/c1-12-15(16(20)13-8-4-2-5-9-13)18(19)21-17(12)14-10-6-3-7-11-14/h2-11H,19H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299474 (CHEMBL565503 | Ethyl 2-amino-5-(4-fluorophenyl)-4-...) Show SMILES CCOC(=O)c1c(N)sc(c1C)-c1ccc(F)cc1 Show InChI InChI=1S/C14H14FNO2S/c1-3-18-14(17)11-8(2)12(19-13(11)16)9-4-6-10(15)7-5-9/h4-7H,3,16H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
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Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299484 (CHEMBL584345 | Ethyl 2-(cyanodiazenyl)-4-methyl-5-...) Show SMILES CCOC(=O)c1c(C)c(sc1N=NC#N)-c1ccccc1 Show InChI InChI=1S/C15H13N3O2S/c1-3-20-15(19)12-10(2)13(11-7-5-4-6-8-11)21-14(12)18-17-9-16/h4-8H,3H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50185321 (6-cyano-7-nitroquinoxaline-2,3-dione | 7-nitro-2,3...) Show SMILES [O-][N+](=O)c1cc2=NC(=O)C(=O)N=c2cc1C#N |c:11,t:5| Show InChI InChI=1S/C9H2N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
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Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50094841 ((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@@H]1F)[C@@H]2C(O)=O)C(O)=O Show InChI InChI=1S/C8H10FNO4/c9-3-1-2-4(6(11)12)5(2)8(3,10)7(13)14/h2-5H,1,10H2,(H,11,12)(H,13,14)/t2-,3-,4-,5-,8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human mGlu6 receptor expressed in HEK293T cell membranes in presence of glutamate by GTPgammaS binding assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112521 BindingDB Entry DOI: 10.7270/Q2CR5Z03
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50116512 (CHEMBL3609741) Show SMILES FCOc1cc(NC(=O)c2ccccn2)ccc1Cl Show InChI InChI=1S/C13H10ClFN2O2/c14-10-5-4-9(7-12(10)19-8-15)17-13(18)11-3-1-2-6-16-11/h1-7H,8H2,(H,17,18)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Activity at mGlu6 receptor (unknown origin) expressed in HEK293 cells pre-treated for 15 mins before addition of EC80 concentration of reference agon...				Bioorg Med Chem Lett 25: 3956-60 (2015) Article DOI: 10.1016/j.bmcl.2015.07.031 BindingDB Entry DOI: 10.7270/Q28C9Z1B
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Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu6R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50503462 (CHEMBL4527834) Show SMILES C[C@H]1CN(Cc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)C[C@@H](C)O1 |r| Show InChI InChI=1S/C21H22FN3O2S/c1-12-9-25(10-13(2)27-12)11-16-7-18-20(28-16)17(8-19(24-18)21(23)26)14-3-5-15(22)6-4-14/h3-8,12-13H,9-11H2,1-2H3,(H2,23,26)/t12-,13+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50503456 (CHEMBL4435396) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)n2nc(COc3ccnc(c3)C(F)(F)F)cc2n1 Show InChI InChI=1S/C20H13F4N5O2/c21-12-3-1-11(2-4-12)16-9-15(19(25)30)27-18-7-13(28-29(16)18)10-31-14-5-6-26-17(8-14)20(22,23)24/h1-9H,10H2,(H2,25,30)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299482 (CHEMBL567862 | Ethyl 2-(3,3-dimethyltriaz-1-enyl)-...) Show SMILES CCOC(=O)c1c(C)c(sc1N=NN(C)C)-c1ccccc1 Show InChI InChI=1S/C16H19N3O2S/c1-5-21-16(20)13-11(2)14(12-9-7-6-8-10-12)22-15(13)17-18-19(3)4/h6-10H,5H2,1-4H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299483 (CHEMBL566754 | Ethyl 4-methyl-2-(morpholinodiazeny...) Show SMILES CCOC(=O)c1c(C)c(sc1N=NN1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C18H21N3O3S/c1-3-24-18(22)15-13(2)16(14-7-5-4-6-8-14)25-17(15)19-20-21-9-11-23-12-10-21/h4-8H,3,9-12H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50299479 (2-Amino-4-methyl-5-phenylthiophene-3-carbonitrile ...) Show SMILES Cc1c(C#N)c(N)sc1-c1ccccc1 Show InChI InChI=1S/C12H10N2S/c1-8-10(7-13)12(14)15-11(8)9-5-3-2-4-6-9/h2-6H,14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50207594 (2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...) Show SMILES NS(=O)(=O)c1cccc2c1c(cc1[nH]c(=O)c(=O)[nH]c21)[N+]([O-])=O Show InChI InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Leipzig Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...				Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50288204 ((2S,3S)-3-Carboxymethyl-azetidine-2-carboxylic aci...) Show SMILES OC(=O)C[C@H]1CN[C@@H]1C(O)=O Show InChI InChI=1S/C6H9NO4/c8-4(9)1-3-2-7-5(3)6(10)11/h3,5,7H,1-2H2,(H,8,9)(H,10,11)/t3-,5-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its agonist activity against mGluR 6 receptor in CHO cells.				Bioorg Med Chem Lett 6: 2559-2564 (1996) Article DOI: 10.1016/0960-894X(96)00464-7 BindingDB Entry DOI: 10.7270/Q2HX1CN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50288204 ((2S,3S)-3-Carboxymethyl-azetidine-2-carboxylic aci...) Show SMILES OC(=O)C[C@H]1CN[C@@H]1C(O)=O Show InChI InChI=1S/C6H9NO4/c8-4(9)1-3-2-7-5(3)6(10)11/h3,5,7H,1-2H2,(H,8,9)(H,10,11)/t3-,5-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its agonist activity against mGluR 2 receptor in CHO cells.				Bioorg Med Chem Lett 6: 2559-2564 (1996) Article DOI: 10.1016/0960-894X(96)00464-7 BindingDB Entry DOI: 10.7270/Q2HX1CN1
					More data for this Ligand-Target Pair