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Compile Data Set for Download or QSAR

Found 11 hits of ec50 data for polymerid = 49000820   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM50333098
PNG
(CHEMBL1631926)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C90H145FN32O24/c1-48(125)73(123-86(145)62(40-50-26-28-51(91)29-27-50)111-71(131)45-107-70(130)44-108-75(134)52(95)39-49-17-3-2-4-18-49)88(147)109-46-72(132)110-53-22-8-13-36-104-69(129)43-64(121-87(146)65(47-124)122-82(141)56(21-7-12-34-94)114-79(138)58(116-76(53)135)24-15-37-105-89(99)100)85(144)117-59(25-16-38-106-90(101)102)80(139)112-54(19-5-10-32-92)77(136)115-57-23-9-14-35-103-68(128)42-61(74(98)133)119-83(142)60(30-31-66(96)126)118-84(143)63(41-67(97)127)120-81(140)55(113-78(57)137)20-6-11-33-93/h2-4,17-18,26-29,48,52-65,73,124-125H,5-16,19-25,30-47,92-95H2,1H3,(H2,96,126)(H2,97,127)(H2,98,133)(H,103,128)(H,104,129)(H,107,130)(H,108,134)(H,109,147)(H,110,132)(H,111,131)(H,112,139)(H,113,137)(H,114,138)(H,115,136)(H,116,135)(H,117,144)(H,118,143)(H,119,142)(H,120,140)(H,121,146)(H,122,141)(H,123,145)(H4,99,100,105)(H4,101,102,106)/t48-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,73+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 0.0400n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


J Med Chem 53: 8400-8408 (2010)

More data for this
Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM50333105
PNG
(CHEMBL1631909 | H-FGGF(4-F)TGARKSARKLKNQ-NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C82H136FN29O21/c1-43(2)35-57(76(129)108-53(20-10-13-31-85)74(127)110-59(38-62(89)116)77(130)103-51(67(90)120)28-29-61(88)115)109-73(126)52(19-9-12-30-84)106-72(125)56(23-16-34-96-82(93)94)105-69(122)45(4)101-79(132)60(42-113)111-75(128)54(21-11-14-32-86)107-71(124)55(22-15-33-95-81(91)92)104-68(121)44(3)100-64(118)41-99-80(133)66(46(5)114)112-78(131)58(37-48-24-26-49(83)27-25-48)102-65(119)40-97-63(117)39-98-70(123)50(87)36-47-17-7-6-8-18-47/h6-8,17-18,24-27,43-46,50-60,66,113-114H,9-16,19-23,28-42,84-87H2,1-5H3,(H2,88,115)(H2,89,116)(H2,90,120)(H,97,117)(H,98,123)(H,99,133)(H,100,118)(H,101,132)(H,102,119)(H,103,130)(H,104,121)(H,105,122)(H,106,125)(H,107,124)(H,108,129)(H,109,126)(H,110,127)(H,111,128)(H,112,131)(H4,91,92,95)(H4,93,94,96)/t44-,45-,46+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,66-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 0.360n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


J Med Chem 53: 8400-8408 (2010)

More data for this
Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM50333095
PNG
(CHEMBL1631923)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC1=O)C(N)=O
Show InChI InChI=1S/C87H139N31O24/c1-46-72(129)115-60(39-64(92)122)81(138)113-57(29-30-63(91)121)80(137)114-58(71(93)128)40-65(123)98-33-16-12-26-52(74(131)105-46)108-76(133)53(23-9-13-31-88)109-78(135)56(28-18-36-101-87(96)97)112-82(139)61-41-66(124)99-34-15-11-25-51(75(132)111-55(27-17-35-100-86(94)95)77(134)110-54(24-10-14-32-89)79(136)117-62(45-119)84(141)116-61)106-69(127)44-104-85(142)70(47(2)120)118-83(140)59(38-49-21-7-4-8-22-49)107-68(126)43-102-67(125)42-103-73(130)50(90)37-48-19-5-3-6-20-48/h3-8,19-22,46-47,50-62,70,119-120H,9-18,23-45,88-90H2,1-2H3,(H2,91,121)(H2,92,122)(H2,93,128)(H,98,123)(H,99,124)(H,102,125)(H,103,130)(H,104,142)(H,105,131)(H,106,127)(H,107,126)(H,108,133)(H,109,135)(H,110,134)(H,111,132)(H,112,139)(H,113,138)(H,114,137)(H,115,129)(H,116,141)(H,117,136)(H,118,140)(H4,94,95,100)(H4,96,97,101)/t46-,47+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,70-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 0.610n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


J Med Chem 53: 8400-8408 (2010)

More data for this
Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM50333098
PNG
(CHEMBL1631926)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C90H145FN32O24/c1-48(125)73(123-86(145)62(40-50-26-28-51(91)29-27-50)111-71(131)45-107-70(130)44-108-75(134)52(95)39-49-17-3-2-4-18-49)88(147)109-46-72(132)110-53-22-8-13-36-104-69(129)43-64(121-87(146)65(47-124)122-82(141)56(21-7-12-34-94)114-79(138)58(116-76(53)135)24-15-37-105-89(99)100)85(144)117-59(25-16-38-106-90(101)102)80(139)112-54(19-5-10-32-92)77(136)115-57-23-9-14-35-103-68(128)42-61(74(98)133)119-83(142)60(30-31-66(96)126)118-84(143)63(41-67(97)127)120-81(140)55(113-78(57)137)20-6-11-33-93/h2-4,17-18,26-29,48,52-65,73,124-125H,5-16,19-25,30-47,92-95H2,1H3,(H2,96,126)(H2,97,127)(H2,98,133)(H,103,128)(H,104,129)(H,107,130)(H,108,134)(H,109,147)(H,110,132)(H,111,131)(H,112,139)(H,113,137)(H,114,138)(H,115,136)(H,116,135)(H,117,144)(H,118,143)(H,119,142)(H,120,140)(H,121,146)(H,122,141)(H,123,145)(H4,99,100,105)(H4,101,102,106)/t48-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,73+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 1n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose in presence of compound 14 by ...


J Med Chem 53: 8400-8408 (2010)

More data for this
Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM50333108
PNG
(CHEMBL1631922)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCNC(=O)C[C@H](NC1=O)C(N)=O)NC(=O)[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccccc2)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N1
Show InChI InChI=1S/C79H128N26O18/c1-44(2)37-57-74(120)102-56(65(83)111)40-60(107)88-33-18-14-28-53(69(115)99-55(30-20-36-91-79(86)87)71(117)98-51(72(118)103-57)25-11-15-31-80)100-75(121)59-41-61(108)89-34-17-13-27-50(68(114)94-45(3)66(112)96-54(29-19-35-90-78(84)85)70(116)97-52(73(119)104-59)26-12-16-32-81)101-77(123)64(46(4)106)105-76(122)58(39-48-23-9-6-10-24-48)95-63(110)43-92-62(109)42-93-67(113)49(82)38-47-21-7-5-8-22-47/h5-10,21-24,44-46,49-59,64,106H,11-20,25-43,80-82H2,1-4H3,(H2,83,111)(H,88,107)(H,89,108)(H,92,109)(H,93,113)(H,94,114)(H,95,110)(H,96,112)(H,97,116)(H,98,117)(H,99,115)(H,100,121)(H,101,123)(H,102,120)(H,103,118)(H,104,119)(H,105,122)(H4,84,85,90)(H4,86,87,91)/t45-,46+,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,64-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 3.10n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


J Med Chem 53: 8400-8408 (2010)

More data for this
Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM50333107
PNG
(CHEMBL1631921 | H-FGGFTGARKSARKAANQA-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C79H129N29O22/c1-40(63(85)116)96-70(123)53(27-28-57(83)111)105-74(127)55(35-58(84)112)106-67(120)43(4)97-64(117)42(3)98-69(122)49(23-13-15-29-80)103-71(124)52(26-18-32-91-79(88)89)102-66(119)44(5)99-76(129)56(39-109)107-73(126)50(24-14-16-30-81)104-72(125)51(25-17-31-90-78(86)87)101-65(118)41(2)95-60(114)38-94-77(130)62(45(6)110)108-75(128)54(34-47-21-11-8-12-22-47)100-61(115)37-92-59(113)36-93-68(121)48(82)33-46-19-9-7-10-20-46/h7-12,19-22,40-45,48-56,62,109-110H,13-18,23-39,80-82H2,1-6H3,(H2,83,111)(H2,84,112)(H2,85,116)(H,92,113)(H,93,121)(H,94,130)(H,95,114)(H,96,123)(H,97,117)(H,98,122)(H,99,129)(H,100,115)(H,101,118)(H,102,119)(H,103,124)(H,104,125)(H,105,127)(H,106,120)(H,107,126)(H,108,128)(H4,86,87,90)(H4,88,89,91)/t40-,41-,42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,62-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 3.80n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


J Med Chem 53: 8400-8408 (2010)

More data for this
Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM50106479
PNG
(CHEMBL384755 | FGGFTGARKSARK | H-FGGFTGARKSARK-NH2...)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C61H100N22O15/c1-34(75-47(87)32-74-59(98)49(36(3)85)83-57(96)44(29-38-18-8-5-9-19-38)77-48(88)31-72-46(86)30-73-53(92)39(64)28-37-16-6-4-7-17-37)51(90)79-43(23-15-27-71-61(68)69)55(94)81-41(21-11-13-25-63)56(95)82-45(33-84)58(97)76-35(2)52(91)80-42(22-14-26-70-60(66)67)54(93)78-40(50(65)89)20-10-12-24-62/h4-9,16-19,34-36,39-45,49,84-85H,10-15,20-33,62-64H2,1-3H3,(H2,65,89)(H,72,86)(H,73,92)(H,74,98)(H,75,87)(H,76,97)(H,77,88)(H,78,93)(H,79,90)(H,80,91)(H,81,94)(H,82,95)(H,83,96)(H4,66,67,70)(H4,68,69,71)/t34-,35-,36+,39-,40-,41-,42-,43-,44-,45-,49-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 11n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


J Med Chem 53: 8400-8408 (2010)

More data for this
Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM50333104
PNG
(CHEMBL389521 | H-FGGFTGARKSARKLANQ-NH2 | N/OFQ-NH2...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C79H130N28O21/c1-41(2)33-54(73(124)96-44(5)67(118)104-56(36-59(84)111)74(125)99-49(64(85)115)27-28-58(83)110)105-71(122)50(23-13-15-29-80)102-70(121)53(26-18-32-91-79(88)89)101-66(117)43(4)97-76(127)57(40-108)106-72(123)51(24-14-16-30-81)103-69(120)52(25-17-31-90-78(86)87)100-65(116)42(3)95-61(113)39-94-77(128)63(45(6)109)107-75(126)55(35-47-21-11-8-12-22-47)98-62(114)38-92-60(112)37-93-68(119)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,108-109H,13-18,23-40,80-82H2,1-6H3,(H2,83,110)(H2,84,111)(H2,85,115)(H,92,112)(H,93,119)(H,94,128)(H,95,113)(H,96,124)(H,97,127)(H,98,114)(H,99,125)(H,100,116)(H,101,117)(H,102,121)(H,103,120)(H,104,118)(H,105,122)(H,106,123)(H,107,126)(H4,86,87,90)(H4,88,89,91)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 11n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


J Med Chem 53: 8400-8408 (2010)

More data for this
Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM50333096
PNG
(CHEMBL1631924)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC(=O)NCCCC[C@@H](CC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N2)C(N)=O
Show InChI InChI=1S/C73H116N24O17/c1-42(98)61(97-70(113)53(35-44-20-6-3-7-21-44)90-59(103)40-86-58(102)39-87-64(107)46(76)34-43-18-4-2-5-19-43)71(114)88-41-60(104)89-48-25-11-15-31-82-56(100)37-52(62(77)105)95-68(111)49(24-9-13-29-75)92-67(110)51(27-17-33-85-73(80)81)94-69(112)54-38-57(101)83-30-14-10-22-45(63(106)96-54)36-55(99)47(23-8-12-28-74)91-66(109)50(93-65(48)108)26-16-32-84-72(78)79/h2-7,18-21,42,45-54,61,98H,8-17,22-41,74-76H2,1H3,(H2,77,105)(H,82,100)(H,83,101)(H,86,102)(H,87,107)(H,88,114)(H,89,104)(H,90,103)(H,91,109)(H,92,110)(H,93,108)(H,94,112)(H,95,111)(H,96,106)(H,97,113)(H4,78,79,84)(H4,80,81,85)/t42-,45+,46+,47+,48+,49+,50+,51+,52+,53+,54+,61+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 14n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


J Med Chem 53: 8400-8408 (2010)

More data for this
Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM50333097
PNG
(CHEMBL1631925)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C65H105N23O16/c1-37(90)53(88-61(102)46(31-39-18-6-3-7-19-39)81-51(93)34-77-50(92)33-78-55(96)40(68)30-38-16-4-2-5-17-38)63(104)79-35-52(94)80-42-22-10-13-27-74-49(91)32-47(60(101)85-44(23-14-28-75-64(70)71)57(98)82-41(54(69)95)20-8-11-25-66)86-62(103)48(36-89)87-59(100)43(21-9-12-26-67)83-58(99)45(84-56(42)97)24-15-29-76-65(72)73/h2-7,16-19,37,40-48,53,89-90H,8-15,20-36,66-68H2,1H3,(H2,69,95)(H,74,91)(H,77,92)(H,78,96)(H,79,104)(H,80,94)(H,81,93)(H,82,98)(H,83,99)(H,84,97)(H,85,101)(H,86,103)(H,87,100)(H,88,102)(H4,70,71,75)(H4,72,73,76)/t37-,40+,41+,42+,43+,44+,45+,46+,47+,48+,53+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 30n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


J Med Chem 53: 8400-8408 (2010)

More data for this
Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor


(MOUSE)
BDBM50333106
PNG
(CHEMBL1631920 | H-FGGFTGK(Ac)RKSNRKK(Ac)ANQN-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(N)=O
Show InChI InChI=1S/C91H149N33O26/c1-48(76(137)121-64(42-69(97)131)85(146)119-61(31-32-67(95)129)84(145)120-62(75(99)136)41-68(96)130)111-78(139)56(28-14-18-36-105-51(4)128)114-80(141)57(25-11-15-33-92)115-82(143)60(30-20-38-107-91(102)103)118-86(147)65(43-70(98)132)122-88(149)66(47-125)123-83(144)58(26-12-16-34-93)116-81(142)59(29-19-37-106-90(100)101)117-79(140)55(27-13-17-35-104-50(3)127)112-73(135)46-110-89(150)74(49(2)126)124-87(148)63(40-53-23-9-6-10-24-53)113-72(134)45-108-71(133)44-109-77(138)54(94)39-52-21-7-5-8-22-52/h5-10,21-24,48-49,54-66,74,125-126H,11-20,25-47,92-94H2,1-4H3,(H2,95,129)(H2,96,130)(H2,97,131)(H2,98,132)(H2,99,136)(H,104,127)(H,105,128)(H,108,133)(H,109,138)(H,110,150)(H,111,139)(H,112,135)(H,113,134)(H,114,141)(H,115,143)(H,116,142)(H,117,140)(H,118,147)(H,119,146)(H,120,145)(H,121,137)(H,122,149)(H,123,144)(H,124,148)(H4,100,101,106)(H4,102,103,107)/t48-,49+,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,74-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 355n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


J Med Chem 53: 8400-8408 (2010)

More data for this
Ligand-Target Pair