Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035145 (1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035141 (1'-(cyclohexylbutyl)-3H-spiro[2-benzofuran-1,4'-pi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50054124 (1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0890 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Bari Curated by ChEMBL | Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane. | J Med Chem 41: 3940-7 (1998) Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50054124 (1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0890 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Bari Curated by ChEMBL | Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane. | J Med Chem 41: 3940-7 (1998) Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035105 (1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035133 (1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035122 (1'-(2-phenylpentyl)-3H-spiro[2-benzofuran-1,4'-pip...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035144 (1'-(2-phenylhexyl)-3H-spiro[2-benzofuran-1,4'-pipe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035129 (1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50421905 (CHEMBL553265) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.251 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellum | J Med Chem 35: 2025-33 (1992) BindingDB Entry DOI: 10.7270/Q2MP54K8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035097 (1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocine | J Med Chem 38: 1998-2008 (1995) BindingDB Entry DOI: 10.7270/Q2SJ1M8P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035097 (1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035134 (1'-(3-(cyclohexylthio)propyl)-3H-spiro[2-benzofura...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035129 (1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50382166 (CHEMBL2023825) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
National and Kapodistrian University of Athens Curated by ChEMBL | Assay Description Displacement of [3H](+)pentazocine from sigma-1 receptor expressed in human Jurkat cell membranes after 2 hrs by liquid scintillation spectroscopy | Bioorg Med Chem 20: 3323-31 (2012) Article DOI: 10.1016/j.bmc.2012.03.038 BindingDB Entry DOI: 10.7270/Q20V8DT0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50040283 (3-Chloro-6-dimethylamino-6-methyl-8-phenyl-5,6,7,8...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description Binding affinity against sigma receptor from guinea pig brain (minus cerebellum) homogenates, using the novel [3H]-(+/-)-4 as radioligand | J Med Chem 36: 2542-51 (1993) BindingDB Entry DOI: 10.7270/Q2C53MGM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035142 (1-[1-(4-fluorophenyl)-1H-3-indolyl]-4-[6-fluorospi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50421907 (CHEMBL540274) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.324 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellum | J Med Chem 35: 2025-33 (1992) BindingDB Entry DOI: 10.7270/Q2MP54K8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035135 (1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035145 (1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50036730 (3-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University Curated by ChEMBL | Assay Description Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]-haloperidol in the presence of 25 nM unlabeled spiperone | J Med Chem 36: 3923-8 (1994) BindingDB Entry DOI: 10.7270/Q2H13122 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50054728 (1,4-Bis-(3-phenyl-propyl)-piperazine | CHEMBL34640...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Binding affinity against sigma receptor using radioligand ([3H](+)-pentazocine) binding assay | J Med Chem 39: 4704-16 (1997) Article DOI: 10.1021/jm960305h BindingDB Entry DOI: 10.7270/Q2QZ2BN6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50040287 ((1R,3S)Dimethyl-(2-methyl-4-phenyl-1,2,3,4-tetrahy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description Binding affinity against sigma receptor from guinea pig brain (minus cerebellum) homogenates, using the novel [3H]-(+/-)-4 as radioligand | J Med Chem 36: 2542-51 (1993) BindingDB Entry DOI: 10.7270/Q2C53MGM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50040287 ((1R,3S)Dimethyl-(2-methyl-4-phenyl-1,2,3,4-tetrahy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand. | J Med Chem 36: 2542-51 (1993) BindingDB Entry DOI: 10.7270/Q2C53MGM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM86029 (trans-H2-PAT(+)) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description The compound was tested for affinity towards sigma-3 receptor | J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM86029 (trans-H2-PAT(+)) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.525 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description The compound was tested for affinity towards sigma-3 receptor | J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035144 (1'-(2-phenylhexyl)-3H-spiro[2-benzofuran-1,4'-pipe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035128 (1'-(2-phenylpropyl)-3H-spiro[2-benzofuran-1,4'-pip...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035124 (1-[1-(4-fluorophenyl)-1H-3-indolyl]-4-[7-fluorospi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50289537 (1-(3-Phenyl-propyl)-3-((Z)-styryl)-piperidine | CH...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement. | Bioorg Med Chem Lett 7: 1525-1530 (1997) Article DOI: 10.1016/S0960-894X(97)00253-9 BindingDB Entry DOI: 10.7270/Q2N58MCN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50067018 (1-[5-(6-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Bari Curated by ChEMBL | Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane. | J Med Chem 41: 3940-7 (1998) Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocine | J Med Chem 38: 1998-2008 (1995) BindingDB Entry DOI: 10.7270/Q2SJ1M8P | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50054121 (3,3-Dimethyl-1-[4-(1,2,3,4-tetrahydro-naphthalen-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Bari Curated by ChEMBL | Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane. | J Med Chem 41: 3940-7 (1998) Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50040282 (CHEMBL317029 | CHEMBL545249 | cis-3-Chloro-6-dimet...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.708 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description The compound was tested for affinity towards sigma-3 receptor | J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50040282 (CHEMBL317029 | CHEMBL545249 | cis-3-Chloro-6-dimet...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description The compound was tested for affinity towards sigma-3 receptor | J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50421946 (CHEMBL1788383) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.724 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum. | J Med Chem 35: 2033-9 (1992) BindingDB Entry DOI: 10.7270/Q2GX4CVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50289553 (1-Phenethyl-3-((Z)-styryl)-piperidine | CHEMBL3697...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement. | Bioorg Med Chem Lett 7: 1525-1530 (1997) Article DOI: 10.1016/S0960-894X(97)00253-9 BindingDB Entry DOI: 10.7270/Q2N58MCN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035122 (1'-(2-phenylpentyl)-3H-spiro[2-benzofuran-1,4'-pip...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.820 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50172914 ((S)-2-(2-Piperidin-1-yl-ethyl)-3-thioxo-2,3,10,10a...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Lille II Curated by ChEMBL | Assay Description Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ... | Bioorg Med Chem Lett 15: 4833-7 (2005) Article DOI: 10.1016/j.bmcl.2005.07.040 BindingDB Entry DOI: 10.7270/Q2PN9553 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035120 (1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50035134 (1'-(3-(cyclohexylthio)propyl)-3H-spiro[2-benzofura...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. | J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50067019 (1-[3-(3H-Inden-1-yl)-propyl]-3,3-dimethyl-piperidi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.990 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Bari Curated by ChEMBL | Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane. | J Med Chem 41: 3940-7 (1998) Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM22165 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description The compound was tested for affinity towards sigma-3 receptor | J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50282973 (4-Fluoro-N-{1-(4-fluoro-naphthalen-1-yl)-4-[4-(5-f...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | >1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro binding affinity of the compound towards sigma receptor by the displacement of [3H]-PPP from guinea pig brain | Bioorg Med Chem Lett 4: 1941-1946 (1994) Article DOI: 10.1016/S0960-894X(01)80539-4 BindingDB Entry DOI: 10.7270/Q28C9W6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50421940 (CHEMBL62770) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum. | J Med Chem 35: 2033-9 (1992) BindingDB Entry DOI: 10.7270/Q2GX4CVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50074867 ((2-{4-Methoxy-3-[2-(4-methoxy-phenyl)-ethoxy]-phen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membrane | J Med Chem 42: 1076-87 (1999) Article DOI: 10.1021/jm980212v BindingDB Entry DOI: 10.7270/Q29C6Z4V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM21395 (3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description The compound was tested for affinity towards sigma-3 receptor | J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50074846 (CHEMBL545597 | [3-(4-Methoxy-3-phenethyloxy-phenyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membrane | J Med Chem 42: 1076-87 (1999) Article DOI: 10.1021/jm980212v BindingDB Entry DOI: 10.7270/Q29C6Z4V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50074866 ((2-{3-[2-(4-Fluoro-phenyl)-ethoxy]-4-methoxy-pheny...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membrane | J Med Chem 42: 1076-87 (1999) Article DOI: 10.1021/jm980212v BindingDB Entry DOI: 10.7270/Q29C6Z4V | |||||||||||
More data for this Ligand-Target Pair |
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