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Compile Data Set for Download or QSAR

Found 1243 hits of ic50 data for polymerid = 49000900,49000902,50000028,50000771   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50021572
PNG
((2S,3S)-2-(3,4-Dimethoxy-phenyl)-3-methyl-5-propyl...)
Show SMILES CCCc1cc2[C@H](C)[C@H](Oc2cc1O)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H24O4/c1-5-6-13-9-15-12(2)20(24-18(15)11-16(13)21)14-7-8-17(22-3)19(10-14)23-4/h7-12,20-21H,5-6H2,1-4H3/t12-,20-/m0/s1
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n/an/a 0n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitor concentration required to block 50% of the specific [3H]PAF binding to rabbit platelet membranes.

J Med Chem 30: 136-42 (1987)


BindingDB Entry DOI: 10.7270/Q25T3M2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50280478
PNG
(BB-823 | CHEMBL157078 | N-((S)-1-Ethoxymethyl-3-me...)
Show SMILES CCOC[C@H](CC(C)C)NS(=O)(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C22H30N4O3S/c1-5-29-15-19(12-16(2)3)25-30(27,28)20-8-6-18(7-9-20)14-26-17(4)24-21-13-23-11-10-22(21)26/h6-11,13,16,19,25H,5,12,14-15H2,1-4H3/t19-/m0/s1
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n/an/a 0.0150n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.

Bioorg Med Chem Lett 2: 597-602 (1992)


Article DOI: 10.1016/S0960-894X(01)81205-1
BindingDB Entry DOI: 10.7270/Q2CF9QK7
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011635
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CCc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H20ClN5OS/c1-17-30-31-24-16-29-26(20-9-3-4-10-22(20)28)21-15-19(35-27(21)33(17)24)8-6-14-32-23-11-5-2-7-18(23)12-13-25(32)34/h2-5,7,9-11,15H,12-14,16H2,1H3
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n/an/a 0.200n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM85035
PNG
(CAS_65154-06-5 | PAF | bloodplatelet-activatingfac...)
Show SMILES CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O |r|
Show InChI InChI=1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
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n/an/a 0.280n/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs

Bioorg Med Chem Lett 23: 1834-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.025
BindingDB Entry DOI: 10.7270/Q2P55PWC
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011650
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2n(C)c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H19ClN6OS/c1-16-29-30-23-15-28-24(18-9-3-4-10-20(18)27)19-14-17(35-25(19)33(16)23)8-7-13-32-22-12-6-5-11-21(22)31(2)26(32)34/h3-6,9-12,14H,13,15H2,1-2H3
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n/an/a 0.300n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033236
PNG
(8,9-Dichloro-2-methyl-5-[4-(2-methyl-imidazo[4,5-c...)
Show SMILES Cc1cn-2c(CC(=Nc3cc(Cl)c(Cl)cc-23)c2ccc(cc2)-n2c(C)nc3cnccc23)n1 |c:6|
Show InChI InChI=1S/C25H18Cl2N6/c1-14-13-32-24-10-19(27)18(26)9-21(24)31-20(11-25(32)29-14)16-3-5-17(6-4-16)33-15(2)30-22-12-28-8-7-23(22)33/h3-10,12-13H,11H2,1-2H3
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n/an/a 0.300n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552615
PNG
(WO2022101377, Example 14)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccc(cc1)C(F)(F)F)c1ccccc1Cl
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WIPO WO2022101377
n/an/a 0.400n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033242
PNG
(3-Cyclohexyl-6-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2c(nn3CCCCN(c23)C(=O)C1)C1CCCCC1 |t:19|
Show InChI InChI=1S/C29H31N7O/c1-19-31-24-18-30-14-13-25(24)36(19)22-11-9-20(10-12-22)23-17-26(37)34-15-5-6-16-35-29(34)28(32-23)27(33-35)21-7-3-2-4-8-21/h9-14,18,21H,2-8,15-17H2,1H3
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50004622
PNG
(4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidaz...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)OCCOC)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7|
Show InChI InChI=1S/C32H31ClN4O5/c1-5-41-32(39)29-28(23-8-6-7-9-24(23)33)27(31(38)42-17-16-40-4)19(2)35-30(29)21-10-12-22(13-11-21)37-20(3)36-25-18-34-15-14-26(25)37/h6-15,18,27-28H,5,16-17H2,1-4H3
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n/an/a 0.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.

J Med Chem 35: 3115-29 (1992)


BindingDB Entry DOI: 10.7270/Q28W3DX8
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033211
PNG
(7,8-Dichloro-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(Cl)c(Cl)cc2NC(=S)C1 |t:19|
Show InChI InChI=1S/C22H15Cl2N5S/c1-12-26-20-11-25-7-6-21(20)29(12)14-4-2-13(3-5-14)17-10-22(30)28-19-9-16(24)15(23)8-18(19)27-17/h2-9,11H,10H2,1H3,(H,28,30)
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n/an/a 0.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.

J Med Chem 38: 3514-23 (1995)


BindingDB Entry DOI: 10.7270/Q2PK0GSS
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552651
PNG
(WO2022101377, Example 50)
Show SMILES CCC12CC(C1)(C2)NC(=O)[C@@H]1Cc2sc-3c([C@@H](NCc4nnc(C)n-34)c3ccccc3Cl)c2C1
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n/an/a 0.5n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033257
PNG
(1,8-Dimethyl-5-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES CN1c2c(N=C(CC1=O)c1ccc(cc1)-n1c(C)nc3cnccc13)c(nn2C)-c1ccccc1 |c:4|
Show InChI InChI=1S/C27H23N7O/c1-17-29-22-16-28-14-13-23(22)34(17)20-11-9-18(10-12-20)21-15-24(35)32(2)27-26(30-21)25(31-33(27)3)19-7-5-4-6-8-19/h4-14,16H,15H2,1-3H3
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n/an/a 0.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033212
PNG
(7,8-Dichloro-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1Cc2cc(Cl)c(Cl)cc2NC(=O)C1
Show InChI InChI=1S/C23H18Cl2N4O/c1-13-27-21-12-26-7-6-22(21)29(13)17-4-2-14(3-5-17)15-8-16-9-18(24)19(25)11-20(16)28-23(30)10-15/h2-7,9,11-12,15H,8,10H2,1H3,(H,28,30)
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n/an/a 0.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.

J Med Chem 38: 3514-23 (1995)


BindingDB Entry DOI: 10.7270/Q2PK0GSS
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033213
PNG
(7,8-Dichloro-1-methyl-4-[4-(2-methyl-imidazo[4,5-c...)
Show SMILES CN1c2cc(Cl)c(Cl)cc2CC(CC1=O)c1ccc(cc1)-n1c(C)nc2cnccc12
Show InChI InChI=1S/C24H20Cl2N4O/c1-14-28-21-13-27-8-7-22(21)30(14)18-5-3-15(4-6-18)16-9-17-10-19(25)20(26)12-23(17)29(2)24(31)11-16/h3-8,10,12-13,16H,9,11H2,1-2H3
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n/an/a 0.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.

J Med Chem 38: 3514-23 (1995)


BindingDB Entry DOI: 10.7270/Q2PK0GSS
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033223
PNG
(7,8-Dimethyl-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2NC(=S)C1 |t:19|
Show InChI InChI=1S/C24H21N5S/c1-14-10-20-21(11-15(14)2)28-24(30)12-19(27-20)17-4-6-18(7-5-17)29-16(3)26-22-13-25-9-8-23(22)29/h4-11,13H,12H2,1-3H3,(H,28,30)
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n/an/a 0.600n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.

J Med Chem 38: 3514-23 (1995)


BindingDB Entry DOI: 10.7270/Q2PK0GSS
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011611
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2c(=O)n(C)c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H19ClN6O2S/c1-16-30-31-23-15-29-24(18-9-3-5-11-21(18)28)20-14-17(37-26(20)34(16)23)8-7-13-33-22-12-6-4-10-19(22)25(35)32(2)27(33)36/h3-6,9-12,14H,13,15H2,1-2H3
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n/an/a 0.600n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033240
PNG
(1-Methyl-5-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2c(NC(=O)C1)n(C)nc2-c1ccccc1 |t:19|
Show InChI InChI=1S/C26H21N7O/c1-16-28-21-15-27-13-12-22(21)33(16)19-10-8-17(9-11-19)20-14-23(34)30-26-25(29-20)24(31-32(26)2)18-6-4-3-5-7-18/h3-13,15H,14H2,1-2H3,(H,30,34)
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n/an/a 0.600n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033238
PNG
(3-(4-Chloro-phenyl)-1,8-dimethyl-5-[4-(2-methyl-im...)
Show SMILES CN1c2c(N=C(CC1=O)c1ccc(cc1)-n1c(C)nc3cnccc13)c(nn2C)-c1ccc(Cl)cc1 |c:4|
Show InChI InChI=1S/C27H22ClN7O/c1-16-30-22-15-29-13-12-23(22)35(16)20-10-6-17(7-11-20)21-14-24(36)33(2)27-26(31-21)25(32-34(27)3)18-4-8-19(28)9-5-18/h4-13,15H,14H2,1-3H3
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n/an/a 0.600n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011623
PNG
(2a-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCC12CCCc3cccc(NC1=O)c23)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C29H22ClN5OS/c1-17-33-34-24-16-31-26(20-10-2-3-11-22(20)30)21-15-19(37-27(21)35(17)24)9-6-14-29-13-5-8-18-7-4-12-23(25(18)29)32-28(29)36/h2-4,7,10-12,15H,5,8,13-14,16H2,1H3,(H,32,36)
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n/an/a 0.700n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552674
PNG
(WO2022101377, Example 73)
Show SMILES CCCN(CCC)C(=O)[C@@H]1Cc2sc-3c([C@@H](NCc4nnc(C)n-34)c3ccccc3Cl)c2C1
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TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033214
PNG
(7,8-Dimethyl-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2NC(=O)C1 |t:19|
Show InChI InChI=1S/C24H21N5O/c1-14-10-20-21(11-15(14)2)28-24(30)12-19(27-20)17-4-6-18(7-5-17)29-16(3)26-22-13-25-9-8-23(22)29/h4-11,13H,12H2,1-3H3,(H,28,30)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.

J Med Chem 38: 3514-23 (1995)


BindingDB Entry DOI: 10.7270/Q2PK0GSS
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011634
PNG
(4-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)COc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H18ClN5O2S/c1-16-29-30-23-14-28-25(18-8-2-3-9-20(18)27)19-13-17(35-26(19)32(16)23)7-6-12-31-21-10-4-5-11-22(21)34-15-24(31)33/h2-5,8-11,13H,12,14-15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033264
PNG
(3-Cyclohexyl-1,8-dimethyl-5-[4-(2-methyl-imidazo[4...)
Show SMILES CN1c2c(N=C(CC1=O)c1ccc(cc1)-n1c(C)nc3cnccc13)c(nn2C)C1CCCCC1 |c:4|
Show InChI InChI=1S/C27H29N7O/c1-17-29-22-16-28-14-13-23(22)34(17)20-11-9-18(10-12-20)21-15-24(35)32(2)27-26(30-21)25(31-33(27)3)19-7-5-4-6-8-19/h9-14,16,19H,4-8,15H2,1-3H3
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033260
PNG
(3-Isobutoxymethyl-1,8-dimethyl-5-[4-(2-methyl-imid...)
Show SMILES CC(C)COCc1nn(C)c2N(C)C(=O)CC(=Nc12)c1ccc(cc1)-n1c(C)nc2cnccc12 |c:16|
Show InChI InChI=1S/C26H29N7O2/c1-16(2)14-35-15-22-25-26(32(5)30-22)31(4)24(34)12-20(29-25)18-6-8-19(9-7-18)33-17(3)28-21-13-27-11-10-23(21)33/h6-11,13,16H,12,14-15H2,1-5H3
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033206
PNG
(7,8-Dichloro-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(Cl)c(Cl)cc2NC(=O)C1 |t:19|
Show InChI InChI=1S/C22H15Cl2N5O/c1-12-26-20-11-25-7-6-21(20)29(12)14-4-2-13(3-5-14)17-10-22(30)28-19-9-16(24)15(23)8-18(19)27-17/h2-9,11H,10H2,1H3,(H,28,30)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.

J Med Chem 38: 3514-23 (1995)


BindingDB Entry DOI: 10.7270/Q2PK0GSS
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013923
PNG
(3-(1-Butyl-4-methoxy-naphthalen-2-yl)-N-(1-methyl-...)
Show SMILES CCCCc1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccccc12
Show InChI InChI=1S/C28H34N2O2/c1-4-5-13-24-23(19-27(32-3)26-15-7-6-14-25(24)26)16-17-28(31)30-21(2)10-8-11-22-12-9-18-29-20-22/h6-7,9,12,14-21H,4-5,8,10-11,13H2,1-3H3,(H,30,31)/b17-16+/t21-/m0/s1
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Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033234
PNG
(1,3-Dimethyl-7-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nn(C)c2N=C(CC(=O)Nc12)c1ccc(cc1)-n1c(C)nc2cnccc12 |c:6|
Show InChI InChI=1S/C21H19N7O/c1-12-20-21(27(3)26-12)24-16(10-19(29)25-20)14-4-6-15(7-5-14)28-13(2)23-17-11-22-9-8-18(17)28/h4-9,11H,10H2,1-3H3,(H,25,29)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011603
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2n(-c2ccccc2)c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C31H21ClN6OS/c1-20-34-35-28-19-33-29(23-13-5-6-14-25(23)32)24-18-22(40-30(24)37(20)28)12-9-17-36-26-15-7-8-16-27(26)38(31(36)39)21-10-3-2-4-11-21/h2-8,10-11,13-16,18H,17,19H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50280339
PNG
((S)-2-[4-(2-Benzenesulfonyl-ethoxy)-3-methoxy-5-(p...)
Show SMILES CCCS(=O)(=O)c1cc(cc(OC)c1OCCS(=O)(=O)c1ccccc1)C1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C31H38O10S2/c1-6-15-43(34,35)29-20-22(19-28(38-4)31(29)40-14-16-42(32,33)23-10-8-7-9-11-23)25-13-12-24(41-25)21-17-26(36-2)30(39-5)27(18-21)37-3/h7-11,17-20,24-25H,6,12-16H2,1-5H3/t24-,25?/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptor

Bioorg Med Chem Lett 2: 181-184 (1992)


Article DOI: 10.1016/S0960-894X(01)80446-7
BindingDB Entry DOI: 10.7270/Q24X588Z
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011653
PNG
(2-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1ccc2ccccc2c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H18ClN5OS/c1-17-30-31-24-16-29-25(21-10-4-5-11-23(21)28)22-15-19(35-27(22)33(17)24)8-6-13-32-14-12-18-7-2-3-9-20(18)26(32)34/h2-5,7,9-12,14-15H,13,16H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011640
PNG
(4-(2-Chloro-phenyl)-2-(3-indazol-1-yl-prop-1-ynyl)...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1ncc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C25H17ClN6S/c1-16-29-30-23-15-27-24(19-9-3-4-10-21(19)26)20-13-18(33-25(20)32(16)23)8-6-12-31-22-11-5-2-7-17(22)14-28-31/h2-5,7,9-11,13-14H,12,15H2,1H3
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Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552632
PNG
(WO2022101377, Example 31)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccccc1)c1ccccc1Cl
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TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033233
PNG
(8,9-Dichloro-1-methyl-5-[4-(2-methyl-imidazo[4,5-c...)
Show SMILES Cc1cnc2CC(=Nc3cc(Cl)c(Cl)cc3-n12)c1ccc(cc1)-n1c(C)nc2cnccc12 |c:6|
Show InChI InChI=1S/C25H18Cl2N6/c1-14-12-29-25-11-20(31-21-9-18(26)19(27)10-24(21)32(14)25)16-3-5-17(6-4-16)33-15(2)30-22-13-28-8-7-23(22)33/h3-10,12-13H,11H2,1-2H3
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552624
PNG
(WO2022101377, Example 23)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl
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TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50004615
PNG
(4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidaz...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)OC(C)(C)C)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7|
Show InChI InChI=1S/C33H33ClN4O4/c1-7-41-31(39)29-28(23-10-8-9-11-24(23)34)27(32(40)42-33(4,5)6)19(2)36-30(29)21-12-14-22(15-13-21)38-20(3)37-25-18-35-17-16-26(25)38/h8-18,27-28H,7H2,1-6H3
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.

J Med Chem 35: 3115-29 (1992)


BindingDB Entry DOI: 10.7270/Q28W3DX8
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033229
PNG
(8,9-Dimethyl-5-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2-n2ccnc2C1 |t:19|
Show InChI InChI=1S/C26H22N6/c1-16-12-22-25(13-17(16)2)31-11-10-28-26(31)14-21(30-22)19-4-6-20(7-5-19)32-18(3)29-23-15-27-9-8-24(23)32/h4-13,15H,14H2,1-3H3
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033249
PNG
(5,7,9-Trimethyl-2-[4-(2-methyl-imidazo[4,5-c]pyrid...)
Show SMILES CN1c2nc(C)cc(C)c2N=C(CC1=O)c1ccc(cc1)-n1c(C)nc2cnccc12 |c:11|
Show InChI InChI=1S/C24H22N6O/c1-14-11-15(2)26-24-23(14)28-19(12-22(31)29(24)4)17-5-7-18(8-6-17)30-16(3)27-20-13-25-10-9-21(20)30/h5-11,13H,12H2,1-4H3
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552611
PNG
(WO2022101377, Example 10)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NC1(CC1)c1ccc(Cl)cn1)c1ccccc1Cl
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TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033245
PNG
(8-Bromo-5-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyri...)
Show SMILES CN1c2ncc(Br)cc2N=C(CC1=O)c1ccc(cc1)-n1c(C)nc2cnccc12 |c:10|
Show InChI InChI=1S/C22H17BrN6O/c1-13-26-19-12-24-8-7-20(19)29(13)16-5-3-14(4-6-16)17-10-21(30)28(2)22-18(27-17)9-15(23)11-25-22/h3-9,11-12H,10H2,1-2H3
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552639
PNG
(WO2022101377, Example 38)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccc(cn1)C(F)(F)F)c1ccccc1Cl
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TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552617
PNG
(WO2022101377, Example 16)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)N[C@@H]1CCC(F)(F)C1)c1ccccc1Cl
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WIPO WO2022101377
n/an/a 1.40n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033255
PNG
(1,8-Dimethyl-5-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES CN1c2c(N=C(CC1=O)c1ccc(cc1)-n1c(C)nc3cnccc13)c(nn2C)-c1cccs1 |c:4|
Show InChI InChI=1S/C25H21N7OS/c1-15-27-19-14-26-11-10-20(19)32(15)17-8-6-16(7-9-17)18-13-22(33)30(2)25-24(28-18)23(29-31(25)3)21-5-4-12-34-21/h4-12,14H,13H2,1-3H3
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50004630
PNG
(4-(2-Chloro-phenyl)-2-methyl-6-[4-(2-methyl-imidaz...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)OC)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7|
Show InChI InChI=1S/C30H27ClN4O4/c1-5-39-30(37)27-26(21-8-6-7-9-22(21)31)25(29(36)38-4)17(2)33-28(27)19-10-12-20(13-11-19)35-18(3)34-23-16-32-15-14-24(23)35/h6-16,25-26H,5H2,1-4H3
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n/an/a 1.60n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.

J Med Chem 35: 3115-29 (1992)


BindingDB Entry DOI: 10.7270/Q28W3DX8
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033232
PNG
(8,9-Dichloro-5-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(Cl)c(Cl)cc2-n2ccnc2C1 |t:19|
Show InChI InChI=1S/C24H16Cl2N6/c1-14-29-21-13-27-7-6-22(21)32(14)16-4-2-15(3-5-16)19-12-24-28-8-9-31(24)23-11-18(26)17(25)10-20(23)30-19/h2-11,13H,12H2,1H3
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n/an/a 1.70n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets

J Med Chem 38: 3524-35 (1995)


BindingDB Entry DOI: 10.7270/Q2JS9R2X
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552616
PNG
(WO2022101377, Example 15)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCC1CC1)c1ccccc1Cl
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n/an/a 1.70n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552629
PNG
(WO2022101377, Example 28)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NC1CCC1)c1ccccc1Cl
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TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50004617
PNG
(4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-pyridi...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-c1cccnc1C |t:5,7|
Show InChI InChI=1S/C33H29ClN4O3/c1-4-41-33(40)30-29(25-10-5-6-12-26(25)34)28(32(39)38-27-13-7-8-18-36-27)21(3)37-31(30)23-16-14-22(15-17-23)24-11-9-19-35-20(24)2/h5-19,28-29H,4H2,1-3H3,(H,36,38,39)
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.

J Med Chem 35: 3115-29 (1992)


BindingDB Entry DOI: 10.7270/Q28W3DX8
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50033207
PNG
(7,8-Dimethyl-4-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2N=C(N)C1 |t:19,30|
Show InChI InChI=1S/C24H22N6/c1-14-10-20-21(11-15(14)2)29-24(25)12-19(28-20)17-4-6-18(7-5-17)30-16(3)27-22-13-26-9-8-23(22)30/h4-11,13H,12H2,1-3H3,(H2,25,29)
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n/an/a 1.90n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.

J Med Chem 38: 3514-23 (1995)


BindingDB Entry DOI: 10.7270/Q2PK0GSS
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552613
PNG
(WO2022101377, Example 12)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccc(OC(F)F)nc1)c1ccccc1Cl
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n/an/a 1.90n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552650
PNG
(WO2022101377, Example 49)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccc(Cl)cn1)c1ccccc1Cl
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TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
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