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Compile Data Set for Download or QSAR

Found 194 hits of ec50 data for polymerid = 4909   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332051
PNG
((E)-N'-(4-N,N-diethylamino- 2-hydroxybenzal)-2-{N-...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCCN(C)Cc2ccc(cc2)C(C)(C)C)c(O)c1
Show InChI InChI=1S/C29H45N5O2/c1-8-34(9-2)26-16-13-24(27(35)19-26)20-30-31-28(36)22-33(7)18-10-17-32(6)21-23-11-14-25(15-12-23)29(3,4)5/h11-16,19-20,35H,8-10,17-18,21-22H2,1-7H3,(H,31,36)/b30-20+
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n/an/an/an/a 130n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332034
PNG
((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(3- trif...)
Show SMILES CN(CCN(C)Cc1cccc(c1)C(F)(F)F)CC(=O)N\N=C\c1cccc(O)c1O
Show InChI InChI=1S/C21H25F3N4O3/c1-27(13-15-5-3-7-17(11-15)21(22,23)24)9-10-28(2)14-19(30)26-25-12-16-6-4-8-18(29)20(16)31/h3-8,11-12,29,31H,9-10,13-14H2,1-2H3,(H,26,30)/b25-12+
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n/an/an/an/a 170n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393295
PNG
(CHEMBL2135309)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 500n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332048
PNG
((E)-N'-(4-N,N-diethylamino- 2-hydroxybenzal)-2-{N-...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCN(C)Cc2ccc(cc2)C#N)c(O)c1
Show InChI InChI=1S/C25H34N6O2/c1-5-31(6-2)23-12-11-22(24(32)15-23)17-27-28-25(33)19-30(4)14-13-29(3)18-21-9-7-20(16-26)8-10-21/h7-12,15,17,32H,5-6,13-14,18-19H2,1-4H3,(H,28,33)/b27-17+
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n/an/an/an/a 530n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332038
PNG
((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(4-isopr...)
Show SMILES CC(C)c1ccc(CN(C)CCN(C)CC(=O)N\N=C\c2cccc(O)c2O)cc1
Show InChI InChI=1S/C23H32N4O3/c1-17(2)19-10-8-18(9-11-19)15-26(3)12-13-27(4)16-22(29)25-24-14-20-6-5-7-21(28)23(20)30/h5-11,14,17,28,30H,12-13,15-16H2,1-4H3,(H,25,29)/b24-14+
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n/an/an/an/a 560n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332033
PNG
((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCN(C)Cc2cccc(c2)C(F)(F)F)c(O)c1
Show InChI InChI=1S/C25H34F3N5O2/c1-5-33(6-2)22-11-10-20(23(34)15-22)16-29-30-24(35)18-32(4)13-12-31(3)17-19-8-7-9-21(14-19)25(26,27)28/h7-11,14-16,34H,5-6,12-13,17-18H2,1-4H3,(H,30,35)/b29-16+
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n/an/an/an/a 600n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393292
PNG
(CHEMBL2138065 | cid_46742345)
Show SMILES CC(C)(C)c1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H25N5/c1-25(2,3)20-14-12-18(13-15-20)17-27-24-22(19-9-5-4-6-10-19)29-30-23(28-24)21-11-7-8-16-26-21/h4-16H,17H2,1-3H3,(H,27,28,30)
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n/an/an/an/a 600n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332041
PNG
((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCN(C)Cc2cccc(OC)c2)c(O)c1
Show InChI InChI=1S/C25H37N5O3/c1-6-30(7-2)22-12-11-21(24(31)16-22)17-26-27-25(32)19-29(4)14-13-28(3)18-20-9-8-10-23(15-20)33-5/h8-12,15-17,31H,6-7,13-14,18-19H2,1-5H3,(H,27,32)/b26-17+
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n/an/an/an/a 760n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332031
PNG
((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)CN(C)CCN(C)Cc2cccc3ccccc23)c(O)c1
Show InChI InChI=1S/C28H37N5O2/c1-5-33(6-2)25-15-14-23(27(34)18-25)19-29-30-28(35)21-32(4)17-16-31(3)20-24-12-9-11-22-10-7-8-13-26(22)24/h7-15,18-19,34H,5-6,16-17,20-21H2,1-4H3,(H,30,35)/b29-19+
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n/an/an/an/a 780n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332035
PNG
((E)-N'-[(3-ethoxy-2- hydroxybenzal)methylene]- 2-{...)
Show SMILES CCOc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2ccc(cc2)C(C)C)c1O
Show InChI InChI=1S/C25H36N4O3/c1-6-32-23-9-7-8-22(25(23)31)16-26-27-24(30)18-29(5)15-14-28(4)17-20-10-12-21(13-11-20)19(2)3/h7-13,16,19,31H,6,14-15,17-18H2,1-5H3,(H,27,30)/b26-16+
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n/an/an/an/a 800n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332042
PNG
((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(3-metho...)
Show SMILES COc1cccc(CN(C)CCN(C)CC(=O)N\N=C\c2cccc(O)c2O)c1
Show InChI InChI=1S/C21H28N4O4/c1-24(14-16-6-4-8-18(12-16)29-3)10-11-25(2)15-20(27)23-22-13-17-7-5-9-19(26)21(17)28/h4-9,12-13,26,28H,10-11,14-15H2,1-3H3,(H,23,27)/b22-13+
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n/an/an/an/a 820n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332030
PNG
((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
Show SMILES CN(CCN(C)Cc1cccc2ccccc12)CC(=O)N\N=C\c1c(O)ccc2ccccc12
Show InChI InChI=1S/C28H30N4O2/c1-31(19-23-11-7-10-21-8-3-5-12-24(21)23)16-17-32(2)20-28(34)30-29-18-26-25-13-6-4-9-22(25)14-15-27(26)33/h3-15,18,33H,16-17,19-20H2,1-2H3,(H,30,34)/b29-18+
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n/an/an/an/a 830n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332044
PNG
((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
Show SMILES CN(CCN(C)Cc1ccc(cc1)C#N)CC(=O)N\N=C\c1c(O)ccc2ccccc12
Show InChI InChI=1S/C25H27N5O2/c1-29(17-20-9-7-19(15-26)8-10-20)13-14-30(2)18-25(32)28-27-16-23-22-6-4-3-5-21(22)11-12-24(23)31/h3-12,16,31H,13-14,17-18H2,1-2H3,(H,28,32)/b27-16+
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n/an/an/an/a 980n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332036
PNG
((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
Show SMILES CC(C)c1ccc(CN(C)CCN(C)CC(=O)N\N=C\c2c(O)ccc3ccccc23)cc1
Show InChI InChI=1S/C27H34N4O2/c1-20(2)22-11-9-21(10-12-22)18-30(3)15-16-31(4)19-27(33)29-28-17-25-24-8-6-5-7-23(24)13-14-26(25)32/h5-14,17,20,32H,15-16,18-19H2,1-4H3,(H,29,33)/b28-17+
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n/an/an/an/a 1.02E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 1.12E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393292
PNG
(CHEMBL2138065 | cid_46742345)
Show SMILES CC(C)(C)c1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H25N5/c1-25(2,3)20-14-12-18(13-15-20)17-27-24-22(19-9-5-4-6-10-19)29-30-23(28-24)21-11-7-8-16-26-21/h4-16H,17H2,1-3H3,(H,27,28,30)
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n/an/an/an/a 1.12E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393282
PNG
(CHEMBL2139663)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5/c1-16-10-12-17(13-11-16)15-24-22-20(18-7-3-2-4-8-18)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 1.19E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM482301
PNG
(US10919843, Compound X)
Show SMILES CCCCCC1=C(NCCC(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O |r,c:5,t:17,26|
Show InChI InChI=1S/C26H39NO3/c1-7-8-9-10-20-23(27-14-13-16(2)3)25(29)22(26(30)24(20)28)21-15-18(6)11-12-19(21)17(4)5/h15-16,19,21,27,30H,4,7-14H2,1-3,5-6H3/t19-,21+/m0/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...

US Patent US10919843 (2021)


BindingDB Entry DOI: 10.7270/Q2W66PVH
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393284
PNG
(CHEMBL2132069)
Show SMILES C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m1/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 1.40E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM482300
PNG
(US10919843, Compound IX)
Show SMILES CCCCCC1=C(NCC(C)(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O |r,c:5,t:17,26|
Show InChI InChI=1S/C26H39NO3/c1-8-9-10-11-19-22(27-15-26(5,6)7)24(29)21(25(30)23(19)28)20-14-17(4)12-13-18(20)16(2)3/h14,18,20,27,30H,2,8-13,15H2,1,3-7H3/t18-,20+/m0/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...

US Patent US10919843 (2021)


BindingDB Entry DOI: 10.7270/Q2W66PVH
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM482299
PNG
(US10919843, Compound VIII)
Show SMILES CCCCCC1=C(NCc2ccccc2)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O |r,c:5,t:20,29|
Show InChI InChI=1S/C28H35NO3/c1-5-6-8-13-22-25(29-17-20-11-9-7-10-12-20)27(31)24(28(32)26(22)30)23-16-19(4)14-15-21(23)18(2)3/h7,9-12,16,21,23,29,32H,2,5-6,8,13-15,17H2,1,3-4H3/t21-,23+/m0/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...

US Patent US10919843 (2021)


BindingDB Entry DOI: 10.7270/Q2W66PVH
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393289
PNG
(CHEMBL2137226)
Show SMILES Clc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C21H16ClN5/c22-17-10-6-7-15(13-17)14-24-21-19(16-8-2-1-3-9-16)26-27-20(25-21)18-11-4-5-12-23-18/h1-13H,14H2,(H,24,25,27)
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n/an/an/an/a 1.49E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM271481
PNG
(2-(7-(2-chloro-4-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3ccc(F)cc3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14ClFN2O6/c1-23-13-7-10(29-14-5-2-9(21)6-12(14)20)3-4-11(13)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 1.51E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...

US Patent US10065928 (2018)


BindingDB Entry DOI: 10.7270/Q2DB83WQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM482295
PNG
(US10919843, Compound IV)
Show SMILES CCCCCC1=C(NCC(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O |r,c:5,t:16,25|
Show InChI InChI=1S/C25H37NO3/c1-7-8-9-10-19-22(26-14-15(2)3)24(28)21(25(29)23(19)27)20-13-17(6)11-12-18(20)16(4)5/h13,15,18,20,26,29H,4,7-12,14H2,1-3,5-6H3/t18-,20+/m0/s1
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n/an/an/an/a 1.60E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...

US Patent US10919843 (2021)


BindingDB Entry DOI: 10.7270/Q2W66PVH
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 1.63E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM271462
PNG
(2-(4-hydroxy-1-methyl-7-(naphthalen-2-yloxy)-2-oxo...)
Show SMILES Cn1c2cc(Oc3ccc4ccccc4c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C23H18N2O6/c1-25-18-11-16(31-15-7-6-13-4-2-3-5-14(13)10-15)8-9-17(18)21(28)20(23(25)30)22(29)24-12-19(26)27/h2-11,28H,12H2,1H3,(H,24,29)(H,26,27)
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n/an/an/an/a 1.63E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...

US Patent US10065928 (2018)


BindingDB Entry DOI: 10.7270/Q2DB83WQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM482294
PNG
(US10919843, Compound III)
Show SMILES CCCCCNC1=C(CCCCC)C(=O)C(O)=C([C@@H]2C=C(C)CC[C@H]2C(C)=C)C1=O |r,c:6,t:16,19|
Show InChI InChI=1S/C26H39NO3/c1-6-8-10-12-20-23(27-15-11-9-7-2)25(29)22(26(30)24(20)28)21-16-18(5)13-14-19(21)17(3)4/h16,19,21,27,30H,3,6-15H2,1-2,4-5H3/t19-,21+/m0/s1
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n/an/an/an/a 1.70E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...

US Patent US10919843 (2021)


BindingDB Entry DOI: 10.7270/Q2W66PVH
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393292
PNG
(CHEMBL2138065 | cid_46742345)
Show SMILES CC(C)(C)c1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H25N5/c1-25(2,3)20-14-12-18(13-15-20)17-27-24-22(19-9-5-4-6-10-19)29-30-23(28-24)21-11-7-8-16-26-21/h4-16H,17H2,1-3H3,(H,27,28,30)
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n/an/an/an/a 1.71E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM482296
PNG
(US10919843, Compound V)
Show SMILES CCCCCC1=C(NCCCC)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O |r,c:5,t:16,25|
Show InChI InChI=1S/C25H37NO3/c1-6-8-10-11-19-22(26-14-9-7-2)24(28)21(25(29)23(19)27)20-15-17(5)12-13-18(20)16(3)4/h15,18,20,26,29H,3,6-14H2,1-2,4-5H3/t18-,20+/m0/s1
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n/an/an/an/a 1.80E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
NIH3T3-EPO-luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...

US Patent US10919843 (2021)


BindingDB Entry DOI: 10.7270/Q2W66PVH
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393288
PNG
(CHEMBL2142554)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1C
Show InChI InChI=1S/C23H21N5/c1-16-11-12-18(14-17(16)2)15-25-23-21(19-8-4-3-5-9-19)27-28-22(26-23)20-10-6-7-13-24-20/h3-14H,15H2,1-2H3,(H,25,26,28)
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n/an/an/an/a 1.85E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332050
PNG
((E)-N'-(3-ethoxy-2- hydroxybenzal)-2-{N-{2-[N- (4-...)
Show SMILES CCOc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2ccc(cc2)C(C)(C)C)c1O
Show InChI InChI=1S/C26H38N4O3/c1-7-33-23-10-8-9-21(25(23)32)17-27-28-24(31)19-30(6)16-15-29(5)18-20-11-13-22(14-12-20)26(2,3)4/h8-14,17,32H,7,15-16,18-19H2,1-6H3,(H,28,31)/b27-17+
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n/an/an/an/a 1.86E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393284
PNG
(CHEMBL2132069)
Show SMILES C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m1/s1
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n/an/an/an/a 1.88E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM482296
PNG
(US10919843, Compound V)
Show SMILES CCCCCC1=C(NCCCC)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O |r,c:5,t:16,25|
Show InChI InChI=1S/C25H37NO3/c1-6-8-10-11-19-22(26-14-9-7-2)24(28)21(25(29)23(19)27)20-15-17(5)12-13-18(20)16(3)4/h15,18,20,26,29H,3,6-14H2,1-2,4-5H3/t18-,20+/m0/s1
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n/an/an/an/a 1.90E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...

US Patent US10919843 (2021)


BindingDB Entry DOI: 10.7270/Q2W66PVH
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM271483
PNG
(2-(7-(2,3-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cccc(Cl)c3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14Cl2N2O6/c1-23-12-7-9(29-13-4-2-3-11(20)16(13)21)5-6-10(12)17(26)15(19(23)28)18(27)22-8-14(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 1.97E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...

US Patent US10065928 (2018)


BindingDB Entry DOI: 10.7270/Q2DB83WQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393283
PNG
(CHEMBL2144203)
Show SMILES C[C@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m0/s1
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n/an/an/an/a 2.06E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332029
PNG
((E)-N'-(3-ethoxy-2- hydroxybenzal)-2-{N-{2- [N-(na...)
Show SMILES CCOc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2cccc3ccccc23)c1O
Show InChI InChI=1S/C26H32N4O3/c1-4-33-24-14-8-11-21(26(24)32)17-27-28-25(31)19-30(3)16-15-29(2)18-22-12-7-10-20-9-5-6-13-23(20)22/h5-14,17,32H,4,15-16,18-19H2,1-3H3,(H,28,31)/b27-17+
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US Patent
n/an/an/an/a 2.11E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM271488
PNG
(2-(7-(2,5-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cc(Cl)ccc3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14Cl2N2O6/c1-23-13-7-10(29-14-6-9(20)2-5-12(14)21)3-4-11(13)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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US Patent
n/an/an/an/a 2.25E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...

US Patent US10065928 (2018)


BindingDB Entry DOI: 10.7270/Q2DB83WQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM271472
PNG
(2-(7-(2,5-difluorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cc(F)ccc3F)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14F2N2O6/c1-23-13-7-10(29-14-6-9(20)2-5-12(14)21)3-4-11(13)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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US Patent
n/an/an/an/a 2.26E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...

US Patent US10065928 (2018)


BindingDB Entry DOI: 10.7270/Q2DB83WQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332039
PNG
((E)-N'-(3-bromo-6- hydroxybenzal)-2-{N-{2- [N-(4-i...)
Show SMILES CC(C)c1ccc(CN(C)CCN(C)CC(=O)N\N=C\c2cc(Br)ccc2O)cc1
Show InChI InChI=1S/C23H31BrN4O2/c1-17(2)19-7-5-18(6-8-19)15-27(3)11-12-28(4)16-23(30)26-25-14-20-13-21(24)9-10-22(20)29/h5-10,13-14,17,29H,11-12,15-16H2,1-4H3,(H,26,30)/b25-14+
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US Patent
n/an/an/an/a 2.28E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM332027
PNG
((E)-N'-(3-methoxy-2- hydroxybenzal)-2-{N-{2-[N- (n...)
Show SMILES COc1cccc(\C=N\NC(=O)CN(C)CCN(C)Cc2cccc3ccccc23)c1O
Show InChI InChI=1S/C25H30N4O3/c1-28(17-21-11-6-9-19-8-4-5-12-22(19)21)14-15-29(2)18-24(30)27-26-16-20-10-7-13-23(32-3)25(20)31/h4-13,16,31H,14-15,17-18H2,1-3H3,(H,27,30)/b26-16+
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US Patent
n/an/an/an/a 2.29E+3n/an/an/an/a



Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent


Assay Description
The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...

US Patent US10196346 (2019)


BindingDB Entry DOI: 10.7270/Q2VQ34SQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393288
PNG
(CHEMBL2142554)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1C
Show InChI InChI=1S/C23H21N5/c1-16-11-12-18(14-17(16)2)15-25-23-21(19-8-4-3-5-9-19)27-28-22(26-23)20-10-6-7-13-24-20/h3-14H,15H2,1-2H3,(H,25,26,28)
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n/an/an/an/a 2.30E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393289
PNG
(CHEMBL2137226)
Show SMILES Clc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C21H16ClN5/c22-17-10-6-7-15(13-17)14-24-21-19(16-8-2-1-3-9-16)26-27-20(25-21)18-11-4-5-12-23-18/h1-13H,14H2,(H,24,25,27)
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n/an/an/an/a 2.33E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393281
PNG
(CHEMBL2139973)
Show SMILES Cc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C22H19N5/c1-16-8-7-9-17(14-16)15-24-22-20(18-10-3-2-4-11-18)26-27-21(25-22)19-12-5-6-13-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 2.39E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393300
PNG
(CHEMBL2130568)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C21H23N5/c1-3-9-16(10-4-1)15-23-21-19(17-11-5-2-6-12-17)25-26-20(24-21)18-13-7-8-14-22-18/h2,5-8,11-14,16H,1,3-4,9-10,15H2,(H,23,24,26)
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n/an/an/an/a 2.46E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393301
PNG
(CHEMBL2141722)
Show SMILES CC(C)(C)CCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H23N5/c1-20(2,3)12-14-22-19-17(15-9-5-4-6-10-15)24-25-18(23-19)16-11-7-8-13-21-16/h4-11,13H,12,14H2,1-3H3,(H,22,23,25)
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n/an/an/an/a 2.48E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393295
PNG
(CHEMBL2135309)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 2.49E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM482300
PNG
(US10919843, Compound IX)
Show SMILES CCCCCC1=C(NCC(C)(C)C)C(=O)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O |r,c:5,t:17,26|
Show InChI InChI=1S/C26H39NO3/c1-8-9-10-11-19-22(27-15-26(5,6)7)24(29)21(25(30)23(19)28)20-14-17(4)12-13-18(20)16(2)3/h14,18,20,27,30H,2,8-13,15H2,1,3-7H3/t18-,20+/m0/s1
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US Patent
n/an/an/an/a 2.50E+3n/an/an/an/a



Emerald Health Pharmaceuticals Inc.

US Patent


Assay Description
NIH3T3-EPO-luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...

US Patent US10919843 (2021)


BindingDB Entry DOI: 10.7270/Q2W66PVH
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM271463
PNG
(2-(4-hydroxy-1-methyl-6-(naphthalen-2-yloxy)-2-oxo...)
Show SMILES Cn1c2ccc(Oc3ccc4ccccc4c3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C23H18N2O6/c1-25-18-9-8-16(31-15-7-6-13-4-2-3-5-14(13)10-15)11-17(18)21(28)20(23(25)30)22(29)24-12-19(26)27/h2-11,28H,12H2,1H3,(H,24,29)(H,26,27)
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US Patent
n/an/an/an/a 2.52E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...

US Patent US10065928 (2018)


BindingDB Entry DOI: 10.7270/Q2DB83WQ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393283
PNG
(CHEMBL2144203)
Show SMILES C[C@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m0/s1
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n/an/an/an/a 2.55E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
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