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Compile Data Set for Download or QSAR

Found 176 hits of ec50 data for polymerid = 4909   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332051
PNG
((E)-N'-(4-N,N-diethylamino- 2-hydroxybenzal)-2-{N-...)
PDB

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n/an/an/an/a 130n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332034
PNG
((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(3- trif...)
PDB

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n/an/an/an/a 170n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393295
PNG
(CHEMBL2135309)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)
PDB

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n/an/an/an/a 500n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332048
PNG
((E)-N'-(4-N,N-diethylamino- 2-hydroxybenzal)-2-{N-...)
PDB

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n/an/an/an/a 530n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332038
PNG
((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(4-isopr...)
PDB

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n/an/an/an/a 560n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393292
PNG
(CHEMBL2138065 | cid_46742345)
Show SMILES CC(C)(C)c1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H25N5/c1-25(2,3)20-14-12-18(13-15-20)17-27-24-22(19-9-5-4-6-10-19)29-30-23(28-24)21-11-7-8-16-26-21/h4-16H,17H2,1-3H3,(H,27,28,30)
PDB

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n/an/an/an/a 600n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332033
PNG
((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
PDB

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n/an/an/an/a 600n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332041
PNG
((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
PDB

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n/an/an/an/a 760n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332031
PNG
((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
PDB

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n/an/an/an/a 780n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332035
PNG
((E)-N'-[(3-ethoxy-2- hydroxybenzal)methylene]- 2-{...)
PDB

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n/an/an/an/a 800n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332042
PNG
((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(3-metho...)
PDB

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n/an/an/an/a 820n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332030
PNG
((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
PDB

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n/an/an/an/a 830n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332044
PNG
((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
PDB

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n/an/an/an/a 980n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332036
PNG
((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
PDB

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n/an/an/an/a 1.02E+3n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393292
PNG
(CHEMBL2138065 | cid_46742345)
Show SMILES CC(C)(C)c1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H25N5/c1-25(2,3)20-14-12-18(13-15-20)17-27-24-22(19-9-5-4-6-10-19)29-30-23(28-24)21-11-7-8-16-26-21/h4-16H,17H2,1-3H3,(H,27,28,30)
PDB

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n/an/an/an/a 1.12E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
PDB

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n/an/an/an/a 1.12E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393282
PNG
(CHEMBL2139663)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5/c1-16-10-12-17(13-11-16)15-24-22-20(18-7-3-2-4-8-18)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
PDB

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n/an/an/an/a 1.19E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393284
PNG
(CHEMBL2132069)
Show SMILES C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m1/s1
PDB

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n/an/an/an/a 1.20E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
PDB

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n/an/an/an/a 1.40E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393289
PNG
(CHEMBL2137226)
Show SMILES Clc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C21H16ClN5/c22-17-10-6-7-15(13-17)14-24-21-19(16-8-2-1-3-9-16)26-27-20(25-21)18-11-4-5-12-23-18/h1-13H,14H2,(H,24,25,27)
PDB

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n/an/an/an/a 1.49E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271481
PNG
(2-(7-(2-chloro-4-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3ccc(F)cc3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
PDB

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n/an/an/an/a 1.51E+3n/an/an/an/a



Novartis Pharmaceuticals





J Med Chem 40: 3601-16 (1997)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271462
PNG
(2-(4-hydroxy-1-methyl-7-(naphthalen-2-yloxy)-2-oxo...)
Show SMILES Cn1c2cc(Oc3ccc4ccccc4c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
PDB

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n/an/an/an/a 1.63E+3n/an/an/an/a



Novartis Pharmaceuticals





J Med Chem 40: 3601-16 (1997)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
PDB

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n/an/an/an/a 1.63E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393292
PNG
(CHEMBL2138065 | cid_46742345)
Show SMILES CC(C)(C)c1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H25N5/c1-25(2,3)20-14-12-18(13-15-20)17-27-24-22(19-9-5-4-6-10-19)29-30-23(28-24)21-11-7-8-16-26-21/h4-16H,17H2,1-3H3,(H,27,28,30)
PDB

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n/an/an/an/a 1.71E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393288
PNG
(CHEMBL2142554)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1C
Show InChI InChI=1S/C23H21N5/c1-16-11-12-18(14-17(16)2)15-25-23-21(19-8-4-3-5-9-19)27-28-22(26-23)20-10-6-7-13-24-20/h3-14H,15H2,1-2H3,(H,25,26,28)
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n/an/an/an/a 1.85E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332050
PNG
((E)-N'-(3-ethoxy-2- hydroxybenzal)-2-{N-{2-[N- (4-...)
PDB

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n/an/an/an/a 1.86E+3n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393284
PNG
(CHEMBL2132069)
Show SMILES C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m1/s1
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n/an/an/an/a 1.88E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271483
PNG
(2-(7-(2,3-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cccc(Cl)c3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
PDB

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n/an/an/an/a 1.97E+3n/an/an/an/a



Novartis Pharmaceuticals





J Med Chem 40: 3601-16 (1997)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393283
PNG
(CHEMBL2144203)
Show SMILES C[C@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m0/s1
PDB

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n/an/an/an/a 2.06E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332029
PNG
((E)-N'-(3-ethoxy-2- hydroxybenzal)-2-{N-{2- [N-(na...)
PDB

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n/an/an/an/a 2.11E+3n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271488
PNG
(2-(7-(2,5-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cc(Cl)ccc3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
PDB

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n/an/an/an/a 2.25E+3n/an/an/an/a



Novartis Pharmaceuticals





J Med Chem 40: 3601-16 (1997)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271472
PNG
(2-(7-(2,5-difluorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cc(F)ccc3F)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
PDB

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n/an/an/an/a 2.26E+3n/an/an/an/a



Novartis Pharmaceuticals





J Med Chem 40: 3601-16 (1997)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332039
PNG
((E)-N'-(3-bromo-6- hydroxybenzal)-2-{N-{2- [N-(4-i...)
PDB

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n/an/an/an/a 2.28E+3n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332027
PNG
((E)-N'-(3-methoxy-2- hydroxybenzal)-2-{N-{2-[N- (n...)
PDB

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n/an/an/an/a 2.29E+3n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393288
PNG
(CHEMBL2142554)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1C
Show InChI InChI=1S/C23H21N5/c1-16-11-12-18(14-17(16)2)15-25-23-21(19-8-4-3-5-9-19)27-28-22(26-23)20-10-6-7-13-24-20/h3-14H,15H2,1-2H3,(H,25,26,28)
PDB

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n/an/an/an/a 2.30E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393289
PNG
(CHEMBL2137226)
Show SMILES Clc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C21H16ClN5/c22-17-10-6-7-15(13-17)14-24-21-19(16-8-2-1-3-9-16)26-27-20(25-21)18-11-4-5-12-23-18/h1-13H,14H2,(H,24,25,27)
PDB

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n/an/an/an/a 2.33E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393281
PNG
(CHEMBL2139973)
Show SMILES Cc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C22H19N5/c1-16-8-7-9-17(14-16)15-24-22-20(18-10-3-2-4-11-18)26-27-21(25-22)19-12-5-6-13-23-19/h2-14H,15H2,1H3,(H,24,25,27)
PDB

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n/an/an/an/a 2.39E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393300
PNG
(CHEMBL2130568)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C21H23N5/c1-3-9-16(10-4-1)15-23-21-19(17-11-5-2-6-12-17)25-26-20(24-21)18-13-7-8-14-22-18/h2,5-8,11-14,16H,1,3-4,9-10,15H2,(H,23,24,26)
PDB

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n/an/an/an/a 2.46E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393301
PNG
(CHEMBL2141722)
Show SMILES CC(C)(C)CCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H23N5/c1-20(2,3)12-14-22-19-17(15-9-5-4-6-10-15)24-25-18(23-19)16-11-7-8-13-21-16/h4-11,13H,12,14H2,1-3H3,(H,22,23,25)
PDB

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n/an/an/an/a 2.48E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393295
PNG
(CHEMBL2135309)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)
PDB

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n/an/an/an/a 2.49E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271463
PNG
(2-(4-hydroxy-1-methyl-6-(naphthalen-2-yloxy)-2-oxo...)
Show SMILES Cn1c2ccc(Oc3ccc4ccccc4c3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
PDB

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n/an/an/an/a 2.52E+3n/an/an/an/a



Novartis Pharmaceuticals





J Med Chem 40: 3601-16 (1997)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393283
PNG
(CHEMBL2144203)
Show SMILES C[C@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m0/s1
PDB

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n/an/an/an/a 2.55E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271486
PNG
(2-(7-(3,4-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3ccc(Cl)c(Cl)c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
PDB

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n/an/an/an/a 2.56E+3n/an/an/an/a



Novartis Pharmaceuticals





J Med Chem 40: 3601-16 (1997)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393295
PNG
(CHEMBL2135309)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)
PDB

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n/an/an/an/a 2.57E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393282
PNG
(CHEMBL2139663)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5/c1-16-10-12-17(13-11-16)15-24-22-20(18-7-3-2-4-8-18)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
PDB

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n/an/an/an/a 2.60E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332049
PNG
((E)-N'-(3-methoxy-2- hydroxybenzal)-2-{N-{2-[N- (4...)
PDB

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n/an/an/an/a 2.76E+3n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393289
PNG
(CHEMBL2137226)
Show SMILES Clc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C21H16ClN5/c22-17-10-6-7-15(13-17)14-24-21-19(16-8-2-1-3-9-16)26-27-20(25-21)18-11-4-5-12-23-18/h1-13H,14H2,(H,24,25,27)
PDB

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n/an/an/an/a 2.77E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332040
PNG
((E)-N'-(3,5-di-tert-butyl-2- hydroxybenzal)-2-{N-{...)
PDB

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n/an/an/an/a 2.77E+3n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM332047
PNG
((E)-N'-(3-ethoxy-2- hydroxybenzal)-2-{N-{2- [N-(4-...)
PDB

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n/an/an/an/a 2.77E+3n/an/an/an/a



University of Antwerp





J Med Chem 48: 1768-80 (2005)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50393281
PNG
(CHEMBL2139973)
Show SMILES Cc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C22H19N5/c1-16-8-7-9-17(14-16)15-24-22-20(18-10-3-2-4-11-18)26-27-21(25-22)19-12-5-6-13-23-19/h2-14H,15H2,1H3,(H,24,25,27)
PDB

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n/an/an/an/a 2.91E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis


Bioorg Med Chem Lett 22: 76-81 (2011)

More data for this
Ligand-Target Pair
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