Compile Data Set for Download or QSAR

Found 2381 hits of ki for JAK2/TYK2
having polymerids = 4916 and
complexids = 50000451   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50526620 (CHEMBL4460368) Show SMILES CNc1cc(Nc2cccn(-c3cc(C)n(C)n3)c2=O)nn2c(cnc12)C(=O)N[C@@H]1C[C@@H]1F |r| Show InChI InChI=1S/C21H22FN9O2/c1-11-7-18(28-29(11)3)30-6-4-5-13(21(30)33)25-17-9-15(23-2)19-24-10-16(31(19)27-17)20(32)26-14-8-12(14)22/h4-7,9-10,12,14,23H,8H2,1-3H3,(H,25,27)(H,26,32)/t12-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...				ACS Med Chem Lett 10: 383-388 (2019) Article DOI: 10.1021/acsmedchemlett.9b00035 BindingDB Entry DOI: 10.7270/Q2TM7FKX
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50526622 (CHEMBL4442827) Show SMILES CNc1cc(Nc2cccn(-c3ccc(C)nn3)c2=O)nn2c(cnc12)C(=O)N[C@@H]1C[C@@H]1F |r| Show InChI InChI=1S/C21H20FN9O2/c1-11-5-6-18(28-27-11)30-7-3-4-13(21(30)33)25-17-9-15(23-2)19-24-10-16(31(19)29-17)20(32)26-14-8-12(14)22/h3-7,9-10,12,14,23H,8H2,1-2H3,(H,25,29)(H,26,32)/t12-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...				ACS Med Chem Lett 10: 383-388 (2019) Article DOI: 10.1021/acsmedchemlett.9b00035 BindingDB Entry DOI: 10.7270/Q2TM7FKX
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50565986 (CHEMBL4789639) Show SMILES [2H]C([2H])([2H])NC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncc(F)cn2)c1OC Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TYK2 JH2 domain (unknown origin) by HTRF assay based Morrison titration analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01698 BindingDB Entry DOI: 10.7270/Q2XW4PJX
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50507816 (Bms-986165 | Deucravacitinib) Show SMILES [2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4-5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23,24,25,29)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of TYK2 in human Jurkat cells assessed as reduction in IFN-alpha stimulated TYK2 phosphorylation by caspase3/7 reagent-based Western blot ...				Eur J Med Chem 163: 413-427 (2019) Article DOI: 10.1016/j.ejmech.2018.11.072 BindingDB Entry DOI: 10.7270/Q2736V7K
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50507816 (Bms-986165 | Deucravacitinib) Show SMILES [2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4-5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23,24,25,29)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Curated by ChEMBL					Assay Description Binding affinity to TYK2 pseudokinase domain (unknown origin)				Bioorg Med Chem Lett 29: 2034-2041 (2019) Article DOI: 10.1016/j.bmcl.2019.06.042 BindingDB Entry DOI: 10.7270/Q2H70KB6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50507816 (Bms-986165 | Deucravacitinib) Show SMILES [2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC Show InChI InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4-5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23,24,25,29)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of fluorescein labeled probe binding to His-tagged human TYK2 pseudokinase domain (575-869 residues) by Morrison titration based HTRF assa...				J Med Chem 62: 8973-8995 (2019) Article DOI: 10.1021/acs.jmedchem.9b00444 BindingDB Entry DOI: 10.7270/Q2930XJS
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50526613 (CHEMBL4571920) Show SMILES CNc1cc(Nc2cccn(-c3cccc(F)n3)c2=O)nn2c(cnc12)C(=O)N[C@@H]1C[C@@H]1F |r| Show InChI InChI=1S/C21H18F2N8O2/c1-24-14-9-17(29-31-15(10-25-19(14)31)20(32)27-13-8-11(13)22)26-12-4-3-7-30(21(12)33)18-6-2-5-16(23)28-18/h2-7,9-11,13,24H,8H2,1H3,(H,26,29)(H,27,32)/t11-,13+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...				ACS Med Chem Lett 10: 383-388 (2019) Article DOI: 10.1021/acsmedchemlett.9b00035 BindingDB Entry DOI: 10.7270/Q2TM7FKX
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50526619 (CHEMBL4439957) Show SMILES CNc1cc(Nc2cccn(-c3ccc(F)cn3)c2=O)nn2c(cnc12)C(=O)N[C@@H]1C[C@@H]1F |r| Show InChI InChI=1S/C21H18F2N8O2/c1-24-15-8-17(29-31-16(10-26-19(15)31)20(32)28-14-7-12(14)23)27-13-3-2-6-30(21(13)33)18-5-4-11(22)9-25-18/h2-6,8-10,12,14,24H,7H2,1H3,(H,27,29)(H,28,32)/t12-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...				ACS Med Chem Lett 10: 383-388 (2019) Article DOI: 10.1021/acsmedchemlett.9b00035 BindingDB Entry DOI: 10.7270/Q2TM7FKX
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463662 (US10781204, Compound I-141 | US11434240, Compound ...) Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCNC(=O)CC1 Show InChI InChI=1S/C22H18FN7O2/c23-14-3-1-2-13(11-24)20(14)15-10-17(21-16(27-15)12-26-22(21)32)30-8-4-18(28-30)29-7-5-19(31)25-6-9-29/h1-4,8,10H,5-7,9,12H2,(H,25,31)(H,26,32)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463736 (US10781204, Compound I-213 | US10781204, Compound ...) Show SMILES CO[C@@H]1CCN(C[C@]1(C)O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C24H23FN6O3/c1-24(33)13-30(8-6-19(24)34-2)20-7-9-31(29-20)18-10-16(28-17-12-27-23(32)22(17)18)21-14(11-26)4-3-5-15(21)25/h3-5,7,9-10,19,33H,6,8,12-13H2,1-2H3,(H,27,32)/t19-,24+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463600 (US10781204, Compound I-142 | US10781204, Compound ...) Show SMILES O[C@H]1CCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C21H17FN6O2/c22-14-3-1-2-12(9-23)19(14)15-8-17(20-16(25-15)10-24-21(20)30)28-7-5-18(26-28)27-6-4-13(29)11-27/h1-3,5,7-8,13,29H,4,6,10-11H2,(H,24,30)/t13-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463671 (US10781204, Compound I-149 | US11434240, Compound ...) Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCCC(C1)N1CCOCC1 Show InChI InChI=1S/C26H26FN7O2/c27-19-5-1-3-17(14-28)24(19)20-13-22(25-21(30-20)15-29-26(25)35)34-8-6-23(31-34)33-7-2-4-18(16-33)32-9-11-36-12-10-32/h1,3,5-6,8,13,18H,2,4,7,9-12,15-16H2,(H,29,35)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463672 (US10781204, Compound I-150 | US11434240, Compound ...) Show SMILES C[C@H]1[C@H](O)CCN1c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C22H19FN6O2/c1-12-18(30)5-7-28(12)19-6-8-29(27-19)17-9-15(26-16-11-25-22(31)21(16)17)20-13(10-24)3-2-4-14(20)23/h2-4,6,8-9,12,18,30H,5,7,11H2,1H3,(H,25,31)/t12-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463682 (US10781204, Compound I-160 | US11434240, Compound ...) Show SMILES OC1CN(CCC1F)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N Show InChI InChI=1S/C22H18F2N6O2/c23-13-4-6-29(11-18(13)31)19-5-7-30(28-19)17-8-15(27-16-10-26-22(32)21(16)17)20-12(9-25)2-1-3-14(20)24/h1-3,5,7-8,13,18,31H,4,6,10-11H2,(H,26,32)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463684 (US10781204, Compound I-162 | US11434240, Compound ...) Show SMILES C[C@]1(O)CN(CC[C@H]1O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C23H21FN6O3/c1-23(33)12-29(7-5-18(23)31)19-6-8-30(28-19)17-9-15(27-16-11-26-22(32)21(16)17)20-13(10-25)3-2-4-14(20)24/h2-4,6,8-9,18,31,33H,5,7,11-12H2,1H3,(H,26,32)/t18-,23+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463689 (US10781204, Compound I-166 | US11434240, Compound ...) Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CC[C@@]2(CCNC2=O)C1 |r| Show InChI InChI=1S/C24H20FN7O2/c25-15-3-1-2-14(11-26)20(15)16-10-18(21-17(29-16)12-28-22(21)33)32-8-4-19(30-32)31-9-6-24(13-31)5-7-27-23(24)34/h1-4,8,10H,5-7,9,12-13H2,(H,27,34)(H,28,33)/t24-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463696 (US10781204, Compound I-173 | US11434240, Compound ...) Show SMILES O[C@H]1CN(CC[C@H]1F)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C22H18F2N6O2/c23-13-4-6-29(11-18(13)31)19-5-7-30(28-19)17-8-15(27-16-10-26-22(32)21(16)17)20-12(9-25)2-1-3-14(20)24/h1-3,5,7-8,13,18,31H,4,6,10-11H2,(H,26,32)/t13-,18+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463710 (US10781204, Compound I-187 | US11434240, Compound ...) Show SMILES CC1(C)C(O)CCN1c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N Show InChI InChI=1S/C23H21FN6O2/c1-23(2)18(31)6-8-29(23)19-7-9-30(28-19)17-10-15(27-16-12-26-22(32)21(16)17)20-13(11-25)4-3-5-14(20)24/h3-5,7,9-10,18,31H,6,8,12H2,1-2H3,(H,26,32)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463711 (US10781204, Compound I-188 | US11434240, Compound ...) Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1C[C@@H]2CC[C@H](C1)O2 |r| Show InChI InChI=1S/C23H19FN6O2/c24-16-3-1-2-13(9-25)21(16)17-8-19(22-18(27-17)10-26-23(22)31)30-7-6-20(28-30)29-11-14-4-5-15(12-29)32-14/h1-3,6-8,14-15H,4-5,10-12H2,(H,26,31)/t14-,15+	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463736 (US10781204, Compound I-213 | US10781204, Compound ...) Show SMILES CO[C@@H]1CCN(C[C@]1(C)O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C24H23FN6O3/c1-24(33)13-30(8-6-19(24)34-2)20-7-9-31(29-20)18-10-16(28-17-12-27-23(32)22(17)18)21-14(11-26)4-3-5-15(21)25/h3-5,7,9-10,19,33H,6,8,12-13H2,1-2H3,(H,27,32)/t19-,24+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463752 (US10781204, Compound I-229 | US11434240, Compound ...) Show SMILES CO[C@H]1CCN(C[C@@]1(C)O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C24H23FN6O3/c1-24(33)13-30(8-6-19(24)34-2)20-7-9-31(29-20)18-10-16(28-17-12-27-23(32)22(17)18)21-14(11-26)4-3-5-15(21)25/h3-5,7,9-10,19,33H,6,8,12-13H2,1-2H3,(H,27,32)/t19-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM570426 (US11434240, Compound I-62) Show SMILES CC1(O)CCCN(C1)C1C=C[N](=N1)c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |c:10,12| Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463591 (US10781204, Compound I-111 | US10781204, Compound ...) Show SMILES C[C@@]1(O)CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C23H21FN6O2/c1-23(32)7-3-8-29(13-23)19-6-9-30(28-19)18-10-16(27-17-12-26-22(31)21(17)18)20-14(11-25)4-2-5-15(20)24/h2,4-6,9-10,32H,3,7-8,12-13H2,1H3,(H,26,31)/t23-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463596 (US10781204, Compound I-194 | US10781204, Compound ...) Show SMILES OC1CCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N Show InChI InChI=1S/C21H17FN6O2/c22-14-3-1-2-12(9-23)19(14)15-8-17(20-16(25-15)10-24-21(20)30)28-7-5-18(26-28)27-6-4-13(29)11-27/h1-3,5,7-8,13,29H,4,6,10-11H2,(H,24,30)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463605 (US10781204, Compound I-84 | US11434240, Compound I...) Show SMILES NC1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F Show InChI InChI=1S/C23H19F4N7O/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(31-15)11-30-21(20)35)34-8-5-18(32-34)33-7-2-6-22(29,12-33)23(25,26)27/h1,3-5,8-9H,2,6-7,11-12,29H2,(H,30,35)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463609 (US10781204, Compound I-88 | US11434240, Compound I...) Show SMILES O[C@@]1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F |r| Show InChI InChI=1S/C23H18F4N6O2/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(30-15)11-29-21(20)34)33-8-5-18(31-33)32-7-2-6-22(35,12-32)23(25,26)27/h1,3-5,8-9,35H,2,6-7,11-12H2,(H,29,34)/t22-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463621 (US10781204, Compound I-100 | US11434240, Compound ...) Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCC2(C1)OCCO2 Show InChI InChI=1S/C23H19FN6O3/c24-15-3-1-2-14(11-25)20(15)16-10-18(21-17(27-16)12-26-22(21)31)30-6-4-19(28-30)29-7-5-23(13-29)32-8-9-33-23/h1-4,6,10H,5,7-9,12-13H2,(H,26,31)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463639 (US10781204, Compound I-118 | US11434240, Compound ...) Show SMILES N[C@]1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F |r| Show InChI InChI=1S/C23H19F4N7O/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(31-15)11-30-21(20)35)34-8-5-18(32-34)33-7-2-6-22(29,12-33)23(25,26)27/h1,3-5,8-9H,2,6-7,11-12,29H2,(H,30,35)/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463640 (US10781204, Compound I-119 | US11434240, Compound ...) Show SMILES N[C@@]1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F |r| Show InChI InChI=1S/C23H19F4N7O/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(31-15)11-30-21(20)35)34-8-5-18(32-34)33-7-2-6-22(29,12-33)23(25,26)27/h1,3-5,8-9H,2,6-7,11-12,29H2,(H,30,35)/t22-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463657 (US10781204, Compound I-136 | US11434240, Compound ...) Show SMILES O[C@H]1CCN(C[C@H]1O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C22H19FN6O3/c23-13-3-1-2-12(9-24)20(13)14-8-16(21-15(26-14)10-25-22(21)32)29-7-5-19(27-29)28-6-4-17(30)18(31)11-28/h1-3,5,7-8,17-18,30-31H,4,6,10-11H2,(H,25,32)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463752 (US10781204, Compound I-229 | US11434240, Compound ...) Show SMILES CO[C@H]1CCN(C[C@@]1(C)O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C24H23FN6O3/c1-24(33)13-30(8-6-19(24)34-2)20-7-9-31(29-20)18-10-16(28-17-12-27-23(32)22(17)18)21-14(11-26)4-3-5-15(21)25/h3-5,7,9-10,19,33H,6,8,12-13H2,1-2H3,(H,27,32)/t19-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463582 (US10781204, Compound I-186 | US10781204, Compound ...) Show SMILES CC1(O)CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N Show InChI InChI=1S/C23H21FN6O2/c1-23(32)7-3-8-29(13-23)19-6-9-30(28-19)18-10-16(27-17-12-26-22(31)21(17)18)20-14(11-25)4-2-5-15(20)24/h2,4-6,9-10,32H,3,7-8,12-13H2,1H3,(H,26,31)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463591 (US10781204, Compound I-111 | US10781204, Compound ...) Show SMILES C[C@@]1(O)CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C23H21FN6O2/c1-23(32)7-3-8-29(13-23)19-6-9-30(28-19)18-10-16(27-17-12-26-22(31)21(17)18)20-14(11-25)4-2-5-15(20)24/h2,4-6,9-10,32H,3,7-8,12-13H2,1H3,(H,26,31)/t23-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463596 (US10781204, Compound I-194 | US10781204, Compound ...) Show SMILES OC1CCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N Show InChI InChI=1S/C21H17FN6O2/c22-14-3-1-2-12(9-23)19(14)15-8-17(20-16(25-15)10-24-21(20)30)28-7-5-18(26-28)27-6-4-13(29)11-27/h1-3,5,7-8,13,29H,4,6,10-11H2,(H,24,30)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463605 (US10781204, Compound I-84 | US11434240, Compound I...) Show SMILES NC1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F Show InChI InChI=1S/C23H19F4N7O/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(31-15)11-30-21(20)35)34-8-5-18(32-34)33-7-2-6-22(29,12-33)23(25,26)27/h1,3-5,8-9H,2,6-7,11-12,29H2,(H,30,35)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463609 (US10781204, Compound I-88 | US11434240, Compound I...) Show SMILES O[C@@]1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F |r| Show InChI InChI=1S/C23H18F4N6O2/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(30-15)11-29-21(20)34)33-8-5-18(31-33)32-7-2-6-22(35,12-32)23(25,26)27/h1,3-5,8-9,35H,2,6-7,11-12H2,(H,29,34)/t22-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463621 (US10781204, Compound I-100 | US11434240, Compound ...) Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCC2(C1)OCCO2 Show InChI InChI=1S/C23H19FN6O3/c24-15-3-1-2-14(11-25)20(15)16-10-18(21-17(27-16)12-26-22(21)31)30-6-4-19(28-30)29-7-5-23(13-29)32-8-9-33-23/h1-4,6,10H,5,7-9,12-13H2,(H,26,31)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463639 (US10781204, Compound I-118 | US11434240, Compound ...) Show SMILES N[C@]1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F |r| Show InChI InChI=1S/C23H19F4N7O/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(31-15)11-30-21(20)35)34-8-5-18(32-34)33-7-2-6-22(29,12-33)23(25,26)27/h1,3-5,8-9H,2,6-7,11-12,29H2,(H,30,35)/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463640 (US10781204, Compound I-119 | US11434240, Compound ...) Show SMILES N[C@@]1(CCCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N)C(F)(F)F |r| Show InChI InChI=1S/C23H19F4N7O/c24-14-4-1-3-13(10-28)19(14)15-9-17(20-16(31-15)11-30-21(20)35)34-8-5-18(32-34)33-7-2-6-22(29,12-33)23(25,26)27/h1,3-5,8-9H,2,6-7,11-12,29H2,(H,30,35)/t22-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463657 (US10781204, Compound I-136 | US11434240, Compound ...) Show SMILES O[C@H]1CCN(C[C@H]1O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C22H19FN6O3/c23-13-3-1-2-12(9-24)20(13)14-8-16(21-15(26-14)10-25-22(21)32)29-7-5-19(27-29)28-6-4-17(30)18(31)11-28/h1-3,5,7-8,17-18,30-31H,4,6,10-11H2,(H,25,32)/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463662 (US10781204, Compound I-141 | US11434240, Compound ...) Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCNC(=O)CC1 Show InChI InChI=1S/C22H18FN7O2/c23-14-3-1-2-13(11-24)20(14)15-10-17(21-16(27-15)12-26-22(21)32)30-8-4-18(28-30)29-7-5-19(31)25-6-9-29/h1-4,8,10H,5-7,9,12H2,(H,25,31)(H,26,32)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463600 (US10781204, Compound I-142 | US10781204, Compound ...) Show SMILES O[C@H]1CCN(C1)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C21H17FN6O2/c22-14-3-1-2-12(9-23)19(14)15-8-17(20-16(25-15)10-24-21(20)30)28-7-5-18(26-28)27-6-4-13(29)11-27/h1-3,5,7-8,13,29H,4,6,10-11H2,(H,24,30)/t13-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463671 (US10781204, Compound I-149 | US11434240, Compound ...) Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CCCC(C1)N1CCOCC1 Show InChI InChI=1S/C26H26FN7O2/c27-19-5-1-3-17(14-28)24(19)20-13-22(25-21(30-20)15-29-26(25)35)34-8-6-23(31-34)33-7-2-4-18(16-33)32-9-11-36-12-10-32/h1,3,5-6,8,13,18H,2,4,7,9-12,15-16H2,(H,29,35)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463672 (US10781204, Compound I-150 | US11434240, Compound ...) Show SMILES C[C@H]1[C@H](O)CCN1c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C22H19FN6O2/c1-12-18(30)5-7-28(12)19-6-8-29(27-19)17-9-15(26-16-11-25-22(31)21(16)17)20-13(10-24)3-2-4-14(20)23/h2-4,6,8-9,12,18,30H,5,7,11H2,1H3,(H,25,31)/t12-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463682 (US10781204, Compound I-160 | US11434240, Compound ...) Show SMILES OC1CN(CCC1F)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N Show InChI InChI=1S/C22H18F2N6O2/c23-13-4-6-29(11-18(13)31)19-5-7-30(28-19)17-8-15(27-16-10-26-22(32)21(16)17)20-12(9-25)2-1-3-14(20)24/h1-3,5,7-8,13,18,31H,4,6,10-11H2,(H,26,32)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463684 (US10781204, Compound I-162 | US11434240, Compound ...) Show SMILES C[C@]1(O)CN(CC[C@H]1O)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C23H21FN6O3/c1-23(33)12-29(7-5-18(23)31)19-6-8-30(28-19)17-9-15(27-16-11-26-22(32)21(16)17)20-13(10-25)3-2-4-14(20)24/h2-4,6,8-9,18,31,33H,5,7,11-12H2,1H3,(H,26,32)/t18-,23+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463689 (US10781204, Compound I-166 | US11434240, Compound ...) Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1CC[C@@]2(CCNC2=O)C1 |r| Show InChI InChI=1S/C24H20FN7O2/c25-15-3-1-2-14(11-26)20(15)16-10-18(21-17(29-16)12-28-22(21)33)32-8-4-19(30-32)31-9-6-24(13-31)5-7-27-23(24)34/h1-4,8,10H,5-7,9,12-13H2,(H,27,34)(H,28,33)/t24-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463696 (US10781204, Compound I-173 | US11434240, Compound ...) Show SMILES O[C@H]1CN(CC[C@H]1F)c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |r| Show InChI InChI=1S/C22H18F2N6O2/c23-13-4-6-29(11-18(13)31)19-5-7-30(28-19)17-8-15(27-16-10-26-22(32)21(16)17)20-12(9-25)2-1-3-14(20)24/h1-3,5,7-8,13,18,31H,4,6,10-11H2,(H,26,32)/t13-,18+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463710 (US10781204, Compound I-187 | US11434240, Compound ...) Show SMILES CC1(C)C(O)CCN1c1ccn(n1)-c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N Show InChI InChI=1S/C23H21FN6O2/c1-23(2)18(31)6-8-29(23)19-7-9-30(28-19)17-10-15(27-16-12-26-22(32)21(16)17)20-13(11-25)4-3-5-14(20)24/h3-5,7,9-10,18,31H,6,8,12H2,1-2H3,(H,26,32)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM463711 (US10781204, Compound I-188 | US11434240, Compound ...) Show SMILES Fc1cccc(C#N)c1-c1cc(c2C(=O)NCc2n1)-n1ccc(n1)N1C[C@@H]2CC[C@H](C1)O2 |r| Show InChI InChI=1S/C23H19FN6O2/c24-16-3-1-2-13(9-25)21(16)17-8-19(22-18(27-17)10-26-23(22)31)30-7-6-20(28-30)29-11-14-4-5-15(12-29)32-14/h1-3,6-8,14-15H,4-5,10-12H2,(H,26,31)/t14-,15+	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10781204 (2020) BindingDB Entry DOI: 10.7270/Q21G0Q9G
					More data for this Ligand-Target Pair

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