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Compile Data Set for Download or QSAR

Found 340 hits of ec50 data for polymerid = 4918   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466496
PNG
(US10799507, Example 162 | [3-(Hydroxymethyl)-1,1-D...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CS(=O)(=O)C1 |r|
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n/an/an/an/a 0.600n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466494
PNG
(US10799507, Example 160 | [3,3-Difluoro-1-(Hydroxy...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC(F)(F)C1 |r|
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n/an/an/an/a 0.800n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466343
PNG
((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1 |r|
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Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466345
PNG
((8S)-N-[(1S,2S)-2- cyclohexyl-2- hydroxy-1- methyl...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)C1CCCCC1 |r|
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n/an/an/an/a 1.10n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466347
PNG
((8S)—N-[(1S,2S)-2-Cyclopentyl-2-Hydroxy-1-Methyl-E...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)C1CCCC1 |r|
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Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466346
PNG
((8S)-N-[(2S)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1 |r|
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n/an/an/an/a 1.20n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466344
PNG
((8S)-N-(2- cyclohexyl-2- hydroxy-ethyl)-5- (7H-pyr...)
Show SMILES OC(CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1 |r|
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n/an/an/an/a 1.30n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466493
PNG
(US10799507, Example 159 | [1-(Hydroxymethyl)Cyclop...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCC1 |r|
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n/an/an/an/a 1.30n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466348
PNG
((8S)-N-[(1S,2S)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)cc1 |r|
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n/an/an/an/a 1.40n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466351
PNG
((8S)-N-[(1S,2S)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)cc1 |r|
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n/an/an/an/a 1.60n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466489
PNG
((3,3-Difluorocyclobutyl)Methyl (8S)-5-(7H-Pyrrolo[...)
Show SMILES FC1(F)CC(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)C1 |r|
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n/an/an/an/a 1.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466349
PNG
((8S)-N-[(2S)-2-(4- fluorophenyl)-2- hydroxy-ethyl]...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cc1 |r|
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n/an/an/an/a 1.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466495
PNG
(US10799507, Example 161 | [1-(Hydroxymethyl)Cycloh...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCCC1 |r|
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n/an/an/an/a 1.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466357
PNG
((8S)-N-[(2R)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1 |r|
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n/an/an/an/a 1.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r|
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n/an/an/an/a 2n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)


BindingDB Entry DOI: 10.7270/Q24B34DG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466492
PNG
(US10799507, Example 157 | [1-(hydroxymethyl)cyclob...)
Show SMILES OCC1(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCC1 |r|
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Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466353
PNG
((8S)-N-[(2R)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCC1 |r|
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n/an/an/an/a 2.10n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466356
PNG
((8S)-N-[(1S)-1-(4- cyano-3-fluoro- phenyl)ethyl]-5...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(F)c1 |r|
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n/an/an/an/a 2.20n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466372
PNG
((8S)-N-[(1S,2S)-2- (5-fluoro-2- pyridyl)-2- hydrox...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@H](O)c1ccc(F)cn1 |r|
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n/an/an/an/a 2.40n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466363
PNG
(N-[(1S)-1-(4- cyanophenyl) ethyl]-5-(7H- pyrrolo[2...)
Show SMILES C[C@H](NC(=O)C1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N |r|
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n/an/an/an/a 2.5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466350
PNG
((8S)-N-[(2S)-2-(4- cyanophenyl)-2- hydroxy-ethyl]-...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N |r|
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Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466365
PNG
((8S)-N-[[3,3- difluoro-1- (hydroxymethyl) cyclobut...)
Show SMILES OCC1(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC(F)(F)C1 |r|
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Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466366
PNG
((8S)-N-[(1R)-1- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCCCC1 |r|
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Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466371
PNG
((8S)-N-[(2R)-2-(4- cyanophenyl)-2- hydroxy-ethyl]-...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N |r|
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n/an/an/an/a 2.90n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466352
PNG
((8S)-N-[(2R)-2- hydroxy-2- tetrahydropyran- 4-yl-e...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCOCC1 |r|
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n/an/an/an/a 2.90n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475695
PNG
((4aR*,8aS*)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin...)
Show SMILES CC[C@@]12CN(CC[C@@H]1CCN(C2)S(N)(=O)=O)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/an/an/a 3n/an/an/an/a



LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)


BindingDB Entry DOI: 10.7270/Q24B34DG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466359
PNG
((8S)-N-[(1R)-1-(4- fluorophenyl)-2- hydroxy-ethyl]...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cc1 |r|
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n/an/an/an/a 3n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466362
PNG
((8S)-N-[(1S)-1-(4- cyano-2-fluoro- phenyl)ethyl]-5...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C#N |r|
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n/an/an/an/a 3.10n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466364
PNG
((8S)-N-[(1S)-1-(4- cyanophenyl) ethyl]-5-(7H- pyrr...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N |r|
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n/an/an/an/a 3.20n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466369
PNG
((8S)-N-[(1S)-1-(4- cyanophenyl)-2- hydroxy-1- meth...)
Show SMILES C[C@](CO)(NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N |r|
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n/an/an/an/a 3.20n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466488
PNG
((3,3-Difluorocyclobutyl)Methyl 5-(7H-Pyrrolo[2,3-d...)
Show SMILES FC1(F)CC(COC(=O)C2CCN(CC22CC2)c2ncnc3[nH]ccc23)C1
PDB

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n/an/an/an/a 3.20n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50434787
PNG
(CHEMBL2386635 | US10487083, Example C | US10703751...)
Show SMILES C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:18.21,wD:15.17,1.1,(49.07,-5.95,;48.31,-7.29,;46.77,-7.3,;49.09,-8.62,;48.48,-10.02,;49.62,-11.04,;49.62,-12.58,;50.95,-13.35,;52.28,-12.58,;53.75,-13.05,;54.65,-11.81,;53.75,-10.56,;52.28,-11.04,;50.94,-10.26,;50.61,-8.77,;51.68,-7.66,;53.17,-8.05,;54.24,-6.95,;53.83,-5.47,;54.9,-4.37,;56.39,-4.75,;57.88,-5.12,;52.34,-5.09,;51.26,-6.19,)|
Show InChI InChI=1S/C18H21N5O/c1-11(24)18-22-15-10-21-17-14(7-9-20-17)16(15)23(18)13-4-2-12(3-5-13)6-8-19/h7,9-13,24H,2-6H2,1H3,(H,20,21)/t11-,12-,13-/m1/s1
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US Patent
n/an/an/an/a 3.34n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...


US Patent US10703751 (2020)


BindingDB Entry DOI: 10.7270/Q2DN4832
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466367
PNG
((8S)-N-[(2R)-2- cyclobutyl-2- hydroxy-ethyl]-5- (7...)
Show SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C1CCC1 |r|
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Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466360
PNG
((8S)-N-[(1R)-1-(4- cyanophenyl)-2- hydroxy-ethyl]-...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N |r|
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n/an/an/an/a 3.5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466358
PNG
((8S)-N-[(4-cyano- 3-fluoro- phenyl)methyl]-5- (7H-...)
Show SMILES Fc1cc(CNC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)ccc1C#N |r|
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n/an/an/an/a 3.60n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466376
PNG
((8S)-N-[(1R)-1- (2,4- difluorophenyl)-2- hydroxy-e...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cc1F |r|
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n/an/an/an/a 3.70n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466497
PNG
(US10799507, Example 163 | [1- (cyanomethyl) cyclop...)
Show SMILES O=C(OCC1(CC#N)CC1)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12 |r|
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n/an/an/an/a 3.80n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475679
PNG
((4aR,8aS)-8a-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES C[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r|
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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)


BindingDB Entry DOI: 10.7270/Q24B34DG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466354
PNG
((8S)-N-[(2R)-2-(5- fluoro-2-pyridyl)- 2-hydroxy-et...)
Show SMILES O[C@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(F)cn1 |r|
PDB

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Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475700
PNG
((4aR,8aS)-8a-ethyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES CC[C@]12CN(CC[C@H]1CCN(C2)c1ncnc2[nH]ccc12)C#N |r|
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)


BindingDB Entry DOI: 10.7270/Q24B34DG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466361
PNG
(N-[(1R)-1-(4- cyanophenyl)-2- hydroxy-ethyl]-5- (7...)
Show SMILES OC[C@H](NC(=O)C1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N |r|
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Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466387
PNG
((8S)-N-[(1S,2R)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@H](O)c1ccc(F)cc1 |r|
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n/an/an/an/a 4.60n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466381
PNG
(N-[2-(4- cyanophenyl)-2- hydroxy-ethyl]-5- (7H-pyr...)
Show SMILES OC(CNC(=O)C1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N
PDB

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n/an/an/an/a 4.80n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466377
PNG
(N-[[3,3-difluoro-1- (hydroxymethyl) cyclobutyl]met...)
Show SMILES OCC1(CNC(=O)C2CCN(CC22CC2)c2ncnc3[nH]ccc23)CC(F)(F)C1
PDB

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n/an/an/an/a 4.80n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466375
PNG
(5-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- N-[(4- sulfa...)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)C2CCN(CC22CC2)c2ncnc3[nH]ccc23)cc1
PDB

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n/an/an/an/a 5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466498
PNG
(US10799507, Example 164 | [1-(Cyanomethyl)Cyclopro...)
Show SMILES O=C(OCC1(CC#N)CC1)C1CCN(CC11CC1)c1ncnc2[nH]ccc12
PDB

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n/an/an/an/a 5n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466383
PNG
((8S)—N-[(1S,2R)-2-(5-Fluoro-2-Pyridyl)-2-Hydroxy-1...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)cn1 |r|
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Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM475711
PNG
(6-[(3aS,7aS)-3a-methyl-5-(7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@]12CN(C[C@H]1CCN(C2)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N |r|
PDB

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LEO Pharma A/S

US Patent


Assay Description
Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...


US Patent US10851116 (2020)


BindingDB Entry DOI: 10.7270/Q24B34DG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466385
PNG
((8S)-N-[(1S,2S)-2- (4-cyanophenyl)- 2-hydroxy-1- m...)
Show SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(cc1)C#N |r|
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n/an/an/an/a 5.20n/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM466407
PNG
((8S)-N-[(1R)-1-(3- cyanophenyl)-2- hydroxy-ethyl]-...)
Show SMILES OC[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1cccc(c1)C#N |r|
PDB

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Leo Pharma A/S

US Patent


Assay Description
Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...


US Patent US10799507 (2020)


BindingDB Entry DOI: 10.7270/Q2VM4GBC
More data for this
Ligand-Target Pair
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