BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 34 hits of ic50 for UniProtKB: P09038   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM142256
PNG
(US8933099, 22 | US9951047, Compound (I))
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM142255
PNG
(US8933099, 21)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C31H35N5O5/c1-32-31(38)36-15-11-24-18-28(27(20-26(24)36)40-17-16-39-3)41-25-8-12-33-29(19-25)34-30(37)23-6-4-21(5-7-23)22-9-13-35(2)14-10-22/h4-8,11-12,15,18-20,22H,9-10,13-14,16-17H2,1-3H3,(H,32,38)(H,33,34,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM142236
PNG
(US8933099, 2)
Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1
Show InChI InChI=1S/C30H33N5O4/c1-4-34-14-10-21(11-15-34)20-5-7-22(8-6-20)29(36)33-28-18-24(9-13-32-28)39-27-17-23-12-16-35(30(37)31-2)25(23)19-26(27)38-3/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50000130
PNG
(CHEMBL320550)
Show SMILES OC1C(O)C(NC(=O)COc2ccc(Cl)cc2Cl)OC(C1O)C(O)=O
Show InChI InChI=1S/C14H15Cl2NO8/c15-5-1-2-7(6(16)3-5)24-4-8(18)17-13-11(21)9(19)10(20)12(25-13)14(22)23/h1-3,9-13,19-21H,4H2,(H,17,18)(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 10n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
24% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50000128
PNG
(CHEMBL113091)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)NC1OC(C(O)C(O)C1O)C(O)=O
Show InChI InChI=1S/C16H21NO10/c1-24-7-4-6(5-8(25-2)12(7)26-3)14(21)17-15-11(20)9(18)10(19)13(27-15)16(22)23/h4-5,9-11,13,15,18-20H,1-3H3,(H,17,21)(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 58n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
23% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50421574
PNG
(CHEMBL2303729)
Show SMILES O[C@@H]1[C@H](O)[C@H](OCCN2C(=O)CCC2=O)O[C@H]([C@H]1O)C(O)=O |r|
Show InChI InChI=1S/C12H17NO9/c14-5-1-2-6(15)13(5)3-4-21-12-9(18)7(16)8(17)10(22-12)11(19)20/h7-10,12,16-18H,1-4H2,(H,19,20)/t7-,8-,9-,10+,12+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a<100n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
25% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167952
PNG
(1-(4-(3-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1cccc(c1)N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C22H26N4O3/c1-28-19-6-4-5-17(13-19)26-11-9-25(10-12-26)14-18(27)15-29-22-20-7-2-3-8-21(20)23-16-24-22/h2-8,13,16,18,27H,9-12,14-15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 103n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50331095
PNG
(CHEMBL1289494 | Tivozanib)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 114n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167953
PNG
(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1ccc(cc1)N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C22H26N4O3/c1-28-19-8-6-17(7-9-19)26-12-10-25(11-13-26)14-18(27)15-29-22-20-4-2-3-5-21(20)23-16-24-22/h2-9,16,18,27H,10-15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 122n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167954
PNG
(1-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)-3-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1/C22H23F3N4O2/c23-22(24,25)16-4-3-5-17(12-16)29-10-8-28(9-11-29)13-18(30)14-31-21-19-6-1-2-7-20(19)26-15-27-21/h1-7,12,15,18,30H,8-11,13-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 145n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167956
PNG
(1-(4-(3,4-Dichlorophenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C21H22Cl2N4O2/c22-18-6-5-15(11-19(18)23)27-9-7-26(8-10-27)12-16(28)13-29-21-17-3-1-2-4-20(17)24-14-25-21/h1-6,11,14,16,28H,7-10,12-13H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 178n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167951
PNG
(1-(4-(2-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C22H26N4O3/c1-28-21-9-5-4-8-20(21)26-12-10-25(11-13-26)14-17(27)15-29-22-18-6-2-3-7-19(18)23-16-24-22/h2-9,16-17,27H,10-15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 209n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167957
PNG
(1-(4-(2,4-Dimethylphenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES Cc1ccc(N2CCN(CC(O)COc3ncnc4ccccc34)CC2)c(C)c1
Show InChI InChI=1/C23H28N4O2/c1-17-7-8-22(18(2)13-17)27-11-9-26(10-12-27)14-19(28)15-29-23-20-5-3-4-6-21(20)24-16-25-23/h3-8,13,16,19,28H,9-12,14-15H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 222n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167950
PNG
(1-(4-(4-Nitrophenyl)piperazin-1-yl)-3-(quinazolin-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1/C21H23N5O4/c27-18(14-30-21-19-3-1-2-4-20(19)22-15-23-21)13-24-9-11-25(12-10-24)16-5-7-17(8-6-16)26(28)29/h1-8,15,18,27H,9-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 248n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167945
PNG
(1-(4-Phenylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1/C21H24N4O2/c26-18(15-27-21-19-8-4-5-9-20(19)22-16-23-21)14-24-10-12-25(13-11-24)17-6-2-1-3-7-17/h1-9,16,18,26H,10-15H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 293n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167949
PNG
(1-(4-(4-Fluorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1/C21H23FN4O2/c22-16-5-7-17(8-6-16)26-11-9-25(10-12-26)13-18(27)14-28-21-19-3-1-2-4-20(19)23-15-24-21/h1-8,15,18,27H,9-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50421574
PNG
(CHEMBL2303729)
Show SMILES O[C@@H]1[C@H](O)[C@H](OCCN2C(=O)CCC2=O)O[C@H]([C@H]1O)C(O)=O |r|
Show InChI InChI=1S/C12H17NO9/c14-5-1-2-6(15)13(5)3-4-21-12-9(18)7(16)8(17)10(22-12)11(19)20/h7-10,12,16-18H,1-4H2,(H,19,20)/t7-,8-,9-,10+,12+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 340n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
25% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167948
PNG
(1-(4-(2-Fluorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1F
Show InChI InChI=1/C21H23FN4O2/c22-18-6-2-4-8-20(18)26-11-9-25(10-12-26)13-16(27)14-28-21-17-5-1-3-7-19(17)23-15-24-21/h1-8,15-16,27H,9-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 372n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167955
PNG
(1-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1/C21H22Cl2N4O2/c22-17-5-3-7-19(20(17)23)27-10-8-26(9-11-27)12-15(28)13-29-21-16-4-1-2-6-18(16)24-14-25-21/h1-7,14-15,28H,8-13H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 398n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167947
PNG
(1-(4-(3-Chlorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1/C21H23ClN4O2/c22-16-4-3-5-17(12-16)26-10-8-25(9-11-26)13-18(27)14-28-21-19-6-1-2-7-20(19)23-15-24-21/h1-7,12,15,18,27H,8-11,13-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 402n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167959
PNG
(1-(4-Methylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES CN1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C16H22N4O2/c1-19-6-8-20(9-7-19)10-13(21)11-22-16-14-4-2-3-5-15(14)17-12-18-16/h2-5,12-13,21H,6-11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 419n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167958
PNG
(1-(4-Benzylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1/C22H26N4O2/c27-19(16-28-22-20-8-4-5-9-21(20)23-17-24-22)15-26-12-10-25(11-13-26)14-18-6-2-1-3-7-18/h1-9,17,19,27H,10-16H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 444n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167946
PNG
(1-(4-(2-Chlorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1Cl
Show InChI InChI=1/C21H23ClN4O2/c22-18-6-2-4-8-20(18)26-11-9-25(10-12-26)13-16(27)14-28-21-17-5-1-3-7-19(17)23-15-24-21/h1-8,15-16,27H,9-14H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 506n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167960
PNG
(1-(4-Ethylpiperazin-1-yl)-3-(quinazolin-4-yloxy)pr...)
Show SMILES CCN1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C17H24N4O2/c1-2-20-7-9-21(10-8-20)11-14(22)12-23-17-15-5-3-4-6-16(15)18-13-19-17/h3-6,13-14,22H,2,7-12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 519n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167961
PNG
(1-(Dimethylamino)-3-(quinazolin-4-yloxy)propan-2-o...)
Show SMILES CN(C)CC(O)COc1ncnc2ccccc12
Show InChI InChI=1/C13H17N3O2/c1-16(2)7-10(17)8-18-13-11-5-3-4-6-12(11)14-9-15-13/h3-6,9-10,17H,7-8H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 582n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167965
PNG
(1-(2-Methyl-1H-imidazol-1-yl)-3-(quinazolin-4-ylox...)
Show SMILES Cc1nccn1CC(O)COc1ncnc2ccccc12
Show InChI InChI=1/C15H16N4O2/c1-11-16-6-7-19(11)8-12(20)9-21-15-13-4-2-3-5-14(13)17-10-18-15/h2-7,10,12,20H,8-9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 586n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167966
PNG
(1-(4-Methyl-1H-imidazol-1-yl)-3-(quinazolin-4-ylox...)
Show SMILES Cc1cn(CC(O)COc2ncnc3ccccc23)cn1
Show InChI InChI=1/C15H16N4O2/c1-11-6-19(10-18-11)7-12(20)8-21-15-13-4-2-3-5-14(13)16-9-17-15/h2-6,9-10,12,20H,7-8H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 592n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167963
PNG
(1-(Piperidin-1-yl)-3-(quinazolin-4-yloxy)propan-2-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCCCC1
Show InChI InChI=1/C16H21N3O2/c20-13(10-19-8-4-1-5-9-19)11-21-16-14-6-2-3-7-15(14)17-12-18-16/h2-3,6-7,12-13,20H,1,4-5,8-11H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 593n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167962
PNG
(1-Morpholino-3-(quinazolin-4-yloxy)propan-2-ol (3r...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCOCC1
Show InChI InChI=1/C15H19N3O3/c19-12(9-18-5-7-20-8-6-18)10-21-15-13-3-1-2-4-14(13)16-11-17-15/h1-4,11-12,19H,5-10H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 602n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167964
PNG
(1-(1H-Imidazol-1-yl)-3-(quinazolin-4-yloxy)propan-...)
Show SMILES OC(COc1ncnc2ccccc12)Cn1ccnc1
Show InChI InChI=1/C14H14N4O2/c19-11(7-18-6-5-15-10-18)8-20-14-12-3-1-2-4-13(12)16-9-17-14/h1-6,9-11,19H,7-8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 609n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50182285
PNG
(CHEMBL3819473)
Show SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@@H](O)CC(O)(C(F)(F)F)C(F)(F)F |r,t:9|
Show InChI InChI=1/C24H34F6O3/c1-20-9-7-14(31)11-13(20)3-4-15-16-5-6-18(21(16,2)10-8-17(15)20)19(32)12-22(33,23(25,26)27)24(28,29)30/h3,14-19,31-33H,4-12H2,1-2H3/t14-,15-,16-,17-,18+,19-,20-,21-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FGF2 assessed as reduction in HSPG/FGF2/FGDR interaction by measuring FGF2 mediated A475-CHO-flg-1A-luc cell to CHO-K...


J Med Chem 59: 4651-63 (2016)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50182286
PNG
(CHEMBL3819333)
Show SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(O)CC(O)(C(F)(F)F)C(F)(F)F |r,t:9|
Show InChI InChI=1/C24H34F6O3/c1-20-9-7-14(31)11-13(20)3-4-15-16-5-6-18(21(16,2)10-8-17(15)20)19(32)12-22(33,23(25,26)27)24(28,29)30/h3,14-19,31-33H,4-12H2,1-2H3/t14-,15-,16-,17-,18+,19?,20-,21-/s2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FGF2 assessed as reduction in HSPG/FGF2/FGDR interaction by measuring FGF2 mediated A475-CHO-flg-1A-luc cell to CHO-K...


J Med Chem 59: 4651-63 (2016)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50000129
PNG
(CHEMBL112763)
Show SMILES OC1C(O)C(NC(=O)c2ccc(F)c(F)c2)OC(C1O)C(O)=O
Show InChI InChI=1S/C13H13F2NO7/c14-5-2-1-4(3-6(5)15)11(20)16-12-9(19)7(17)8(18)10(23-12)13(21)22/h1-3,7-10,12,17-19H,(H,16,20)(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.10E+4n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
25% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50260260
PNG
(Biotin-Ala-(Arg)9 | CID44576236 | [amino({[(1R,2S,...)
Show SMILES [#7]-[#6](=[#7+])-[#7]-[#6]-[#6]-1-[#8]-[#6](-[#8]-[#6]-2-[#6](-[#6]-[#8])-[#8]-[#6](-[#8]-[#6]-3-[#6](-[#8])-[#6](-[#6]-[#6](\[#7+]=[#6](/[#7])-[#7])-[#6]-3-[#8]-[#6]-3-[#8]-[#6](-[#6]-[#7]-[#6](-[#7])=[#7+])-[#6](-[#8])-[#6](-[#8])-[#6]-3\[#7+]=[#6](\[#7])-[#7])\[#7+]=[#6](\[#7])-[#7])-[#6]-2-[#8])-[#6](-[#7]-[#6](-[#7])=[#7+])-[#6](-[#8])-[#6]-1-[#8]
Show InChI InChI=1S/C29H58N18O13/c30-24(31)42-2-7-13(50)15(52)10(46-28(38)39)21(55-7)58-18-6(45-27(36)37)1-5(44-26(34)35)12(49)20(18)60-23-17(54)19(9(4-48)57-23)59-22-11(47-29(40)41)16(53)14(51)8(56-22)3-43-25(32)33/h5-23,48-54H,1-4H2,(H4,30,31,42)(H4,32,33,43)(H4,34,35,44)(H4,36,37,45)(H4,38,39,46)(H4,40,41,47)/p+6
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Binding affinity to biotinylated FGF2 in CHO cells by flow cytometry


J Biol Chem 282: 13585-91 (2007)


Article DOI: 10.1074/jbc.M700463200
More data for this
Ligand-Target Pair