Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate reductase (Escherichia coli) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 0.0230 | n/a | n/a | n/a | 6.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 6 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 0.0960 | n/a | n/a | n/a | 8.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Association constant(Kon) at Tyr-31 of dihydrofolate reductase (DHFR) | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a |
JST Curated by ChEMBL | Assay Description Inhibitory activity against dihydrofolate reductase | Bioorg Med Chem Lett 14: 2285-9 (2004) Article DOI: 10.1016/j.bmcl.2004.01.106 BindingDB Entry DOI: 10.7270/Q2ZK5G36 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18512 (5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Dissociation rate constant of compound for mutant T46N Escherichia coli dihydrofolate reductase | J Med Chem 35: 2912-5 (1992) BindingDB Entry DOI: 10.7270/Q20Z728B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18512 (5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic dissociation constant of compound for mutant T46S E. coli dihydrofolate reductase | J Med Chem 35: 2912-5 (1992) BindingDB Entry DOI: 10.7270/Q20Z728B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 2.30 | n/a | n/a | n/a | 6.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | 6.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50498878 (CHEMBL97567) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
Georgia Institute of Technology Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR at 10 uM using spyro orange reporter dye by differential scanning fluorimetry | Eur J Med Chem 103: 600-14 (2015) Article DOI: 10.1016/j.ejmech.2015.08.021 BindingDB Entry DOI: 10.7270/Q2DR2ZGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18512 (5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Inhibitor constant of compound for mutant T46A E. coli dihydrofolate reductase | J Med Chem 35: 2912-5 (1992) BindingDB Entry DOI: 10.7270/Q20Z728B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18049 (3-({[(4-{[(carbamimidamidomethanimidoyl)sulfanyl]m...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a |
York University Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR:NADPH complex expressed in Escherichia coli BL21 (DE3) rosetta cells | Bioorg Med Chem 18: 8485-92 (2010) Article DOI: 10.1016/j.bmc.2010.10.048 BindingDB Entry DOI: 10.7270/Q2V127PB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18512 (5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic dissociation constant of compound for mutant T46A E. coli dihydrofolate reductase | J Med Chem 35: 2912-5 (1992) BindingDB Entry DOI: 10.7270/Q20Z728B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 31 | n/a | n/a | n/a | 9.5 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50022833 ((S)-2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-pte...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | 60 | n/a | n/a | n/a | 7.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 84 | n/a | n/a | n/a | 8.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Dissociation constant(Koff) at Phe-31 of dihydrofolate reductase (DHFR) | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 140 | n/a | n/a | n/a | 8.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18044 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropter...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | 210 | n/a | n/a | n/a | 7.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18044 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropter...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Dissociation rate constant of compound for wild type Escherichia coli dihydrofolate reductase | J Med Chem 35: 2912-5 (1992) BindingDB Entry DOI: 10.7270/Q20Z728B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50422885 (CHEMBL2364573 | NADPH) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 220 | n/a | n/a | n/a | 7.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Association constant(Kon) at Tyr-31 of dihydrofolate reductase (DHFR) | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18044 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropter...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | 240 | n/a | n/a | n/a | 8.5 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Dissociation constant at Val-31(Kon)of dihydrofolate reductase (DHFR) | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18044 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropter...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | 243 | n/a | n/a | n/a | n/a | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Dissociation rate constant of compound for wild type Escherichia coli dihydrofolate reductase | J Med Chem 35: 2912-5 (1992) BindingDB Entry DOI: 10.7270/Q20Z728B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50022833 ((S)-2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-pte...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | 300 | n/a | n/a | n/a | 7.0 | 25 |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50022833 ((S)-2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-pte...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | 300 | n/a | n/a | n/a | 7.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 8.5 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50422885 (CHEMBL2364573 | NADPH) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 300 | n/a | n/a | n/a | 8.5 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50422885 (CHEMBL2364573 | NADPH) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 340 | n/a | n/a | n/a | 7.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50498873 (CHEMBL94742) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a |
Georgia Institute of Technology Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR at 10 uM using spyro orange reporter dye by differential scanning fluorimetry | Eur J Med Chem 103: 600-14 (2015) Article DOI: 10.1016/j.ejmech.2015.08.021 BindingDB Entry DOI: 10.7270/Q2DR2ZGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50422885 (CHEMBL2364573 | NADPH) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 380 | n/a | n/a | n/a | 7.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Association constant at Val-31(Kon) of dihydrofolate reductase (DHFR) | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50422885 (CHEMBL2364573 | NADPH) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 400 | n/a | n/a | n/a | 8.5 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 8.5 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50422885 (CHEMBL2364573 | NADPH) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 490 | n/a | n/a | n/a | 8.5 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Association constant (Kon) at Phe-31 of dihydrofolate reductase (DHFR) | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50498877 (CHEMBL316611) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a |
Georgia Institute of Technology Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR at 500 uM using spyro orange reporter dye by differential scanning fluorimetry | Eur J Med Chem 103: 600-14 (2015) Article DOI: 10.1016/j.ejmech.2015.08.021 BindingDB Entry DOI: 10.7270/Q2DR2ZGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50367343 ((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG MMDB PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 810 | n/a | n/a | n/a | 7.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | 9.5 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 6 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50022831 (6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | 6.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 8 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | 9.5 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18044 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropter...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic dissociation constant of compound for mutant T46N E. coli dihydrofolate reductase | J Med Chem 35: 2912-5 (1992) BindingDB Entry DOI: 10.7270/Q20Z728B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18044 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropter...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Dissociation rate constant of compound for mutant T46S Escherichia coli dihydrofolate reductase | J Med Chem 35: 2912-5 (1992) BindingDB Entry DOI: 10.7270/Q20Z728B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18044 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropter...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | 7.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 8.5 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18044 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropter...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | 8.5 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 6 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18061 (3-({[(4-nitrophenyl)methyl]sulfanyl}methanimidoyl)...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a |
York University Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR:NADPH complex expressed in Escherichia coli BL21 (DE3) rosetta cells | Bioorg Med Chem 18: 8485-92 (2010) Article DOI: 10.1016/j.bmc.2010.10.048 BindingDB Entry DOI: 10.7270/Q2V127PB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18049 (3-({[(4-{[(carbamimidamidomethanimidoyl)sulfanyl]m...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a |
York University Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR expressed in Escherichia coli BL21 (DE3) rosetta cells | Bioorg Med Chem 18: 8485-92 (2010) Article DOI: 10.1016/j.bmc.2010.10.048 BindingDB Entry DOI: 10.7270/Q2V127PB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50022831 (6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | 6.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 6 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50367343 ((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG MMDB PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | 7.0 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Dissociation constant at(Koff) Tyr-31 of dihydrofolate reductase (DHFR) | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50367343 ((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG MMDB PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | 7.0 | 25 |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18049 (3-({[(4-{[(carbamimidamidomethanimidoyl)sulfanyl]m...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a |
York University Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR:NADP+ complex expressed in Escherichia coli BL21 (DE3) rosetta cells | Bioorg Med Chem 18: 8485-92 (2010) Article DOI: 10.1016/j.bmc.2010.10.048 BindingDB Entry DOI: 10.7270/Q2V127PB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50498874 (CHEMBL1617293) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 6.16E+3 | n/a | n/a | n/a | n/a | n/a |
Georgia Institute of Technology Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR at 500 uM using spyro orange reporter dye by differential scanning fluorimetry | Eur J Med Chem 103: 600-14 (2015) Article DOI: 10.1016/j.ejmech.2015.08.021 BindingDB Entry DOI: 10.7270/Q2DR2ZGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18044 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropter...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | 8.5 | n/a |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18044 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropter...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | 6.60E+3 | n/a | n/a | n/a | 7.0 | 25 |
Pennsylvania State University Curated by ChEMBL | Assay Description Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | J Med Chem 31: 129-37 (1988) BindingDB Entry DOI: 10.7270/Q2MP53VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50498871 (CHEMBL97313) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 6.93E+3 | n/a | n/a | n/a | n/a | n/a |
Georgia Institute of Technology Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR at 500 uM using spyro orange reporter dye by differential scanning fluorimetry | Eur J Med Chem 103: 600-14 (2015) Article DOI: 10.1016/j.ejmech.2015.08.021 BindingDB Entry DOI: 10.7270/Q2DR2ZGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50291779 (3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 8.74E+3 | n/a | n/a | n/a | n/a | n/a |
Georgia Institute of Technology Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR at 500 uM using spyro orange reporter dye by differential scanning fluorimetry | Eur J Med Chem 103: 600-14 (2015) Article DOI: 10.1016/j.ejmech.2015.08.021 BindingDB Entry DOI: 10.7270/Q2DR2ZGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM50090051 (6,6-Dimethyl-1-p-tolyl-1,6-dihydro-[1,3,5]triazine...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 9.32E+3 | n/a | n/a | n/a | n/a | n/a |
Georgia Institute of Technology Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR at 500 uM using spyro orange reporter dye by differential scanning fluorimetry | Eur J Med Chem 103: 600-14 (2015) Article DOI: 10.1016/j.ejmech.2015.08.021 BindingDB Entry DOI: 10.7270/Q2DR2ZGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Escherichia coli) | BDBM18792 (1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | n/a |
Georgia Institute of Technology Curated by ChEMBL | Assay Description Binding affinity to Escherichia coli DHFR at 500 uM using spyro orange reporter dye by differential scanning fluorimetry | Eur J Med Chem 103: 600-14 (2015) Article DOI: 10.1016/j.ejmech.2015.08.021 BindingDB Entry DOI: 10.7270/Q2DR2ZGJ | |||||||||||
More data for this Ligand-Target Pair |
Displayed 1 to 50 (of 57 total ) | Next | Last >> |