Found 48 hits of ic50 data for polymerid = 50000129,50006943 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Amiloride-sensitive sodium channel subunit alpha
(Mus musculus) | BDBM50112167
(CHEMBL3608428)Show SMILES Cl.[Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCc3ccccn3)cc2)(CCCc2ccc(OCC(=O)NCCc3ccccn3)cc2)C1 |r| Show InChI InChI=1S/C46H55ClN10O5.2ClH/c47-43-45(49)56-44(48)42(55-43)46(60)54-37-12-7-29-57(30-37,27-5-8-33-13-17-38(18-14-33)61-31-40(58)52-25-21-35-10-1-3-23-50-35)28-6-9-34-15-19-39(20-16-34)62-32-41(59)53-26-22-36-11-2-4-24-51-36;;/h1-4,10-11,13-20,23-24,37H,5-9,12,21-22,25-32H2,(H6-,48,49,52,53,54,56,58,59,60);2*1H/t37-;;/m0../s1 | UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base... |
ACS Med Chem Lett 6: 729-31 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00186
BindingDB Entry DOI: 10.7270/Q2348N52 |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Mus musculus) | BDBM50112170
(CHEMBL3608425)Show SMILES [O-]C(=O)C(F)(F)F.COc1ccc(CCC[N+]2(CCCc3ccccc3)CCCC(C2)NC(=O)c2nc(Cl)c(N)nc2N)cc1 Show InChI InChI=1S/C29H37ClN6O2.C2HF3O2/c1-38-24-15-13-22(14-16-24)11-6-18-36(17-5-10-21-8-3-2-4-9-21)19-7-12-23(20-36)33-29(37)25-27(31)35-28(32)26(30)34-25;3-2(4,5)1(6)7/h2-4,8-9,13-16,23H,5-7,10-12,17-20H2,1H3,(H4-,31,32,33,35,37);(H,6,7) | UniProtKB/SwissProt
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PC sid
UniChem
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PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base... |
ACS Med Chem Lett 6: 729-31 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00186
BindingDB Entry DOI: 10.7270/Q2348N52 |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190466
(CHEMBL212431 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCCCO)cc1 |w:14.15| Show InChI InChI=1S/C19H26ClN7O3/c20-15-17(22)26-16(21)14(25-15)18(29)27-19(23)24-9-2-1-4-12-5-7-13(8-6-12)30-11-3-10-28/h5-8,28H,1-4,9-11H2,(H4,21,22,26)(H3,23,24,27,29) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190487
(CHEMBL212531 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC[C@@H](O)CO)cc1 |w:14.15| Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)/t12-/m0/s1 | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190462
(CHEMBL212432 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCC(O)CO)cc1 |w:14.15| Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Mus musculus) | BDBM50112171
(CHEMBL3608426)Show SMILES Cl.[Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCn3ccnc3)cc2)(CCCc2ccc(OCC(=O)NCCn3ccnc3)cc2)C1 |r| Show InChI InChI=1S/C42H53ClN12O5.2ClH/c43-39-41(45)52-40(44)38(51-39)42(58)50-33-6-3-25-55(26-33,23-1-4-31-7-11-34(12-8-31)59-27-36(56)48-17-21-53-19-15-46-29-53)24-2-5-32-9-13-35(14-10-32)60-28-37(57)49-18-22-54-20-16-47-30-54;;/h7-16,19-20,29-30,33H,1-6,17-18,21-28H2,(H6-,44,45,48,49,50,52,56,57,58);2*1H/t33-;;/m0../s1 | UniProtKB/SwissProt
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base... |
ACS Med Chem Lett 6: 729-31 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00186
BindingDB Entry DOI: 10.7270/Q2348N52 |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190486
(CHEMBL211161 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCCO)cc1 |w:14.15| Show InChI InChI=1S/C18H24ClN7O3/c19-14-16(21)25-15(20)13(24-14)17(28)26-18(22)23-8-2-1-3-11-4-6-12(7-5-11)29-10-9-27/h4-7,27H,1-3,8-10H2,(H4,20,21,25)(H3,22,23,26,28) | PDB
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190494
(CHEMBL209303 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC[C@H](O)CO)cc1 |w:14.15| Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)/t12-/m1/s1 | PDB
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Mus musculus) | BDBM50112172
(CHEMBL3608427)Show SMILES [Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCCO)cc2)(CCCc2ccc(OCC(=O)NCCCO)cc2)C1 |r| Show InChI InChI=1S/C38H53ClN8O7.ClH/c39-35-37(41)46-36(40)34(45-35)38(52)44-29-8-3-21-47(24-29,19-1-6-27-9-13-30(14-10-27)53-25-32(50)42-17-4-22-48)20-2-7-28-11-15-31(16-12-28)54-26-33(51)43-18-5-23-49;/h9-16,29,48-49H,1-8,17-26H2,(H6-,40,41,42,43,44,46,50,51,52);1H/t29-;/m0./s1 | UniProtKB/SwissProt
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base... |
ACS Med Chem Lett 6: 729-31 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00186
BindingDB Entry DOI: 10.7270/Q2348N52 |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190481
(CHEMBL214239 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(CO)cc1 |w:14.15| Show InChI InChI=1S/C17H22ClN7O2/c18-13-15(20)24-14(19)12(23-13)16(27)25-17(21)22-8-2-1-3-10-4-6-11(9-26)7-5-10/h4-7,26H,1-3,8-9H2,(H4,19,20,24)(H3,21,22,25,27) | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190459
(CHEMBL377986 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES COc1ccc(CCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:10.9| Show InChI InChI=1S/C17H22ClN7O2/c1-27-11-7-5-10(6-8-11)4-2-3-9-22-17(21)25-16(26)12-14(19)24-15(20)13(18)23-12/h5-8H,2-4,9H2,1H3,(H4,19,20,24)(H3,21,22,25,26) | PDB
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190484
(CHEMBL210876 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(O)cc1 |w:14.15| Show InChI InChI=1S/C16H20ClN7O2/c17-12-14(19)23-13(18)11(22-12)15(26)24-16(20)21-8-2-1-3-9-4-6-10(25)7-5-9/h4-7,25H,1-3,8H2,(H4,18,19,23)(H3,20,21,24,26) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190468
(CHEMBL211600 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1cccc(OCCO)c1 |w:14.15| Show InChI InChI=1S/C18H24ClN7O3/c19-14-16(21)25-15(20)13(24-14)17(28)26-18(22)23-7-2-1-4-11-5-3-6-12(10-11)29-9-8-27/h3,5-6,10,27H,1-2,4,7-9H2,(H4,20,21,25)(H3,22,23,26,28) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190475
(CHEMBL380011 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1cccc(O)c1 |w:14.15| Show InChI InChI=1S/C16H20ClN7O2/c17-12-14(19)23-13(18)11(22-12)15(26)24-16(20)21-7-2-1-4-9-5-3-6-10(25)8-9/h3,5-6,8,25H,1-2,4,7H2,(H4,18,19,23)(H3,20,21,24,26) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190489
((4-{4-[N-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCCC(O)=O)cc1 |w:14.15| Show InChI InChI=1S/C19H24ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-9-2-1-3-11-4-6-12(7-5-11)31-10-8-13(28)29/h4-7H,1-3,8-10H2,(H,28,29)(H4,21,22,26)(H3,23,24,27,30) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Mus musculus) | BDBM50112169
(CHEMBL3608424)Show SMILES [Cl-].COc1ccc(CCC[N+]2(CCCc3ccc(cc3)C(=O)NCCCN(C)C)CCCC(C2)NC(=O)c2nc(Cl)c(N)nc2N)cc1 Show InChI InChI=1S/C35H49ClN8O3.ClH/c1-43(2)20-7-19-39-34(45)27-15-11-25(12-16-27)8-4-21-44(22-5-9-26-13-17-29(47-3)18-14-26)23-6-10-28(24-44)40-35(46)30-32(37)42-33(38)31(36)41-30;/h11-18,28H,4-10,19-24H2,1-3H3,(H5-,37,38,39,40,42,45,46);1H | UniProtKB/SwissProt
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Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base... |
ACS Med Chem Lett 6: 729-31 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00186
BindingDB Entry DOI: 10.7270/Q2348N52 |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190458
(CHEMBL386222 | sulfuric acid mono-(4-{4-[N-(3,5-di...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(cc1)S(O)(=O)=O |w:14.15| Show InChI InChI=1S/C16H20ClN7O4S/c17-12-14(19)23-13(18)11(22-12)15(25)24-16(20)21-8-2-1-3-9-4-6-10(7-5-9)29(26,27)28/h4-7H,1-3,8H2,(H4,18,19,23)(H,26,27,28)(H3,20,21,24,25) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190465
(1-(4-(4-aminophenyl)butyl)-3-(3,5-diamino-2-chloro...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(N)cc1 |w:14.15| Show InChI InChI=1S/C16H21ClN8O/c17-12-14(20)24-13(19)11(23-12)15(26)25-16(21)22-8-2-1-3-9-4-6-10(18)7-5-9/h4-7H,1-3,8,18H2,(H4,19,20,24)(H3,21,22,25,26) | PDB
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190488
(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)Show SMILES COC(=O)c1ccc(CCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:12.11| Show InChI InChI=1S/C18H22ClN7O3/c1-29-17(28)11-7-5-10(6-8-11)4-2-3-9-23-18(22)26-16(27)12-14(20)25-15(21)13(19)24-12/h5-8H,2-4,9H2,1H3,(H4,20,21,25)(H3,22,23,26,27) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190480
(CHEMBL214220 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES COc1ccc(OCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:10.9| Show InChI InChI=1S/C16H20ClN7O3/c1-26-9-3-5-10(6-4-9)27-8-2-7-21-16(20)24-15(25)11-13(18)23-14(19)12(17)22-11/h3-6H,2,7-8H2,1H3,(H4,18,19,23)(H3,20,21,24,25) | PDB
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| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190490
(CHEMBL212534 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1cccc(OCC(O)CO)c1 |w:14.15| Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-7-2-1-4-11-5-3-6-13(8-11)31-10-12(29)9-28/h3,5-6,8,12,28-29H,1-2,4,7,9-10H2,(H4,21,22,26)(H3,23,24,27,30) | PDB
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| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190493
(CHEMBL211658 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1OCC(O)CO |w:14.15| Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-4-3-6-11-5-1-2-7-13(11)31-10-12(29)9-28/h1-2,5,7,12,28-29H,3-4,6,8-10H2,(H4,21,22,26)(H3,23,24,27,30) | PDB
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| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190456
(CHEMBL209659 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1 |w:14.15| Show InChI InChI=1S/C16H20ClN7O/c17-12-14(19)23-13(18)11(22-12)15(25)24-16(20)21-9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2,(H4,18,19,23)(H3,20,21,24,25) | PDB
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| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190471
(CHEMBL379066 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1O |w:14.15| Show InChI InChI=1S/C16H20ClN7O2/c17-12-14(19)23-13(18)11(22-12)15(26)24-16(20)21-8-4-3-6-9-5-1-2-7-10(9)25/h1-2,5,7,25H,3-4,6,8H2,(H4,18,19,23)(H3,20,21,24,26) | PDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190455
(CHEMBL208889 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1OCCO |w:14.15| Show InChI InChI=1S/C18H24ClN7O3/c19-14-16(21)25-15(20)13(24-14)17(28)26-18(22)23-8-4-3-6-11-5-1-2-7-12(11)29-10-9-27/h1-2,5,7,27H,3-4,6,8-10H2,(H4,20,21,25)(H3,22,23,26,28) | PDB
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| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190478
(CHEMBL211946 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCOc1ccc(O)cc1 |w:14.15| Show InChI InChI=1S/C15H18ClN7O3/c16-11-13(18)22-12(17)10(21-11)14(25)23-15(19)20-6-1-7-26-9-4-2-8(24)3-5-9/h2-5,24H,1,6-7H2,(H4,17,18,22)(H3,19,20,23,25) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190460
(CHEMBL211773 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES COc1ccc(COCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:10.9| Show InChI InChI=1S/C16H20ClN7O3/c1-26-10-4-2-9(3-5-10)8-27-7-6-21-16(20)24-15(25)11-13(18)23-14(19)12(17)22-11/h2-5H,6-8H2,1H3,(H4,18,19,23)(H3,20,21,24,25) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190457
(CHEMBL211072 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(O)c(O)c1 |w:14.15| Show InChI InChI=1S/C16H20ClN7O3/c17-12-14(19)23-13(18)11(22-12)15(27)24-16(20)21-6-2-1-3-8-4-5-9(25)10(26)7-8/h4-5,7,25-26H,1-3,6H2,(H4,18,19,23)(H3,20,21,24,27) | PDB
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| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190483
((4-{4-[N-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCC(O)=O)cc1 |w:14.15| Show InChI InChI=1S/C18H22ClN7O4/c19-14-16(21)25-15(20)13(24-14)17(29)26-18(22)23-8-2-1-3-10-4-6-11(7-5-10)30-9-12(27)28/h4-7H,1-3,8-9H2,(H,27,28)(H4,20,21,25)(H3,22,23,26,29) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190479
(CHEMBL211664 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCc1ccccc1 |w:14.15| Show InChI InChI=1S/C15H18ClN7O/c16-11-13(18)22-12(17)10(21-11)14(24)23-15(19)20-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H4,17,18,22)(H3,19,20,23,24) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190477
(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(cc1)C(O)=O |w:14.15| Show InChI InChI=1S/C17H20ClN7O3/c18-12-14(20)24-13(19)11(23-12)15(26)25-17(21)22-8-2-1-3-9-4-6-10(7-5-9)16(27)28/h4-7H,1-3,8H2,(H,27,28)(H4,19,20,24)(H3,21,22,25,26) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190461
(CHEMBL208620 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCCCc1ccccc1 |w:14.15| Show InChI InChI=1S/C18H24ClN7O/c19-14-16(21)25-15(20)13(24-14)17(27)26-18(22)23-11-7-2-1-4-8-12-9-5-3-6-10-12/h3,5-6,9-10H,1-2,4,7-8,11H2,(H4,20,21,25)(H3,22,23,26,27) | PDB
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| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190463
(CHEMBL209977 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCc1ccc(O)cc1 |w:14.15| Show InChI InChI=1S/C14H16ClN7O2/c15-10-12(17)21-11(16)9(20-10)13(24)22-14(18)19-6-5-7-1-3-8(23)4-2-7/h1-4,23H,5-6H2,(H4,16,17,21)(H3,18,19,22,24) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190464
(1-(3,5-diamino-2-chloropyrazine-6-carbonyl)-3-(5-(...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCCc1ccc(O)cc1 |w:14.15| Show InChI InChI=1S/C17H22ClN7O2/c18-13-15(20)24-14(19)12(23-13)16(27)25-17(21)22-9-3-1-2-4-10-5-7-11(26)8-6-10/h5-8,26H,1-4,9H2,(H4,19,20,24)(H3,21,22,25,27) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190485
(CHEMBL211611 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCc1ccccc1 |w:14.15| Show InChI InChI=1S/C14H16ClN7O/c15-10-12(17)21-11(16)9(20-10)13(23)22-14(18)19-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H4,16,17,21)(H3,18,19,22,23) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM81819
(Benzamil | CAS_1937-37-7 | CHEMBL212579 | NSC_1081...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCc1ccccc1 |w:14.15| Show InChI InChI=1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22) | PDB
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| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190470
(CHEMBL377239 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCCc1ccccc1 |w:14.15| Show InChI InChI=1S/C17H22ClN7O/c18-13-15(20)24-14(19)12(23-13)16(26)25-17(21)22-10-6-2-5-9-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10H2,(H4,19,20,24)(H3,21,22,25,26) | PDB
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| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Mus musculus) | BDBM50112168
(CHEMBL3608423)Show SMILES [Cl-].COc1ccc(CCC[N@@+]2(C)CCC[C@@H](C2)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |r| Show InChI InChI=1S/C21H29ClN6O2.ClH/c1-28(11-3-5-14-7-9-16(30-2)10-8-14)12-4-6-15(13-28)25-21(29)17-19(23)27-20(24)18(22)26-17;/h7-10,15H,3-6,11-13H2,1-2H3,(H4-,23,24,25,27,29);1H/t15-,28-;/m0./s1 | UniProtKB/SwissProt
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base... |
ACS Med Chem Lett 6: 729-31 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00186
BindingDB Entry DOI: 10.7270/Q2348N52 |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190474
(6-(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbon...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)cc1 |w:14.15| Show InChI InChI=1S/C22H28ClN7O8/c23-16-18(25)29-17(24)11(28-16)19(34)30-22(26)27-8-2-1-3-9-4-6-10(7-5-9)37-21-14(33)12(31)13(32)15(38-21)20(35)36/h4-7,12-15,21,31-33H,1-3,8H2,(H,35,36)(H4,24,25,29)(H3,26,27,30,34)/t12-,13-,14+,15-,21?/m0/s1 | PDB
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| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190495
(CHEMBL209104 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES COc1ccc(CCCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:11.10| Show InChI InChI=1S/C18H24ClN7O2/c1-28-12-8-6-11(7-9-12)5-3-2-4-10-23-18(22)26-17(27)13-15(20)25-16(21)14(19)24-13/h6-9H,2-5,10H2,1H3,(H4,20,21,25)(H3,22,23,26,27) | PDB
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| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190491
(CHEMBL210966 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show InChI InChI=1S/C12H20ClN7O/c1-2-3-4-5-6-17-12(16)20-11(21)7-9(14)19-10(15)8(13)18-7/h2-6H2,1H3,(H4,14,15,19)(H3,16,17,20,21) | PDB
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| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190472
(CHEMBL211793 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCc1ccc(O)cc1 |w:14.15| Show InChI InChI=1S/C15H18ClN7O2/c16-11-13(18)22-12(17)10(21-11)14(25)23-15(19)20-7-1-2-8-3-5-9(24)6-4-8/h3-6,24H,1-2,7H2,(H4,17,18,22)(H3,19,20,23,25) | PDB
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| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190473
(CHEMBL377688 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show InChI InChI=1S/C8H12ClN7O2/c9-4-6(11)15-5(10)3(14-4)7(18)16-8(12)13-1-2-17/h17H,1-2H2,(H4,10,11,15)(H3,12,13,16,18) | PDB
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| n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190492
(CHEMBL210981 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES CCCCCCCCN=C(N)NC(=O)c1nc(Cl)c(N)nc1N |w:8.7| Show InChI InChI=1S/C14H24ClN7O/c1-2-3-4-5-6-7-8-19-14(18)22-13(23)9-11(16)21-12(17)10(15)20-9/h2-8H2,1H3,(H4,16,17,21)(H3,18,19,22,23) | PDB
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| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190482
(CHEMBL210967 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES COc1ccc(CCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:9.8| Show InChI InChI=1S/C16H20ClN7O2/c1-26-10-6-4-9(5-7-10)3-2-8-21-16(20)24-15(25)11-13(18)23-14(19)12(17)22-11/h4-7H,2-3,8H2,1H3,(H4,18,19,23)(H3,20,21,24,25) | PDB
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| n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM115076
(3,5-bis(azanyl)-N-[azanyl(phenylazanyl)methylidene...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=Nc1ccccc1 |w:14.15| Show InChI InChI=1S/C12H12ClN7O/c13-8-10(15)19-9(14)7(18-8)11(21)20-12(16)17-6-4-2-1-3-5-6/h1-5H,(H4,14,15,19)(H3,16,17,20,21) | PDB
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| n/a | n/a | 401 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190469
(CHEMBL210866 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCCCCCc1ccccc1 |w:14.15| Show InChI InChI=1S/C20H28ClN7O/c21-16-18(23)27-17(22)15(26-16)19(29)28-20(24)25-13-9-4-2-1-3-6-10-14-11-7-5-8-12-14/h5,7-8,11-12H,1-4,6,9-10,13H2,(H4,22,23,27)(H3,24,25,28,29) | PDB
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| n/a | n/a | 477 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM16173
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) | PDB
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Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
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