Compile Data Set for Download or QSAR

Found 2104 hits of ic50 data for polymerid = 50000219   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM409275 (2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(C)c1 Show InChI InChI=1S/C18H18FN3O/c1-12-8-13(4-5-15(12)19)14-9-17-16(20-10-14)6-7-22(17)11-18(23)21(2)3/h4-10H,11H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...				US Patent US10377753 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GVK
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM436977 (1-[(4-Methyl-3-pyridyl)methyl]-6-(3,4,5-trifluorop...) Show SMILES Cc1ccncc1Cn1c2cc(cnc2[nH]c1=O)-c1cc(F)c(F)c(F)c1 Show InChI InChI=1S/C19H13F3N4O/c1-10-2-3-23-7-13(10)9-26-16-6-12(8-24-18(16)25-19(26)27)11-4-14(20)17(22)15(21)5-11/h2-8H,9H2,1H3,(H,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM436994 (6-(3,4-Difluorophenyl)-1-(2-oxobutyl)-3H-imidazo[4...) Show SMILES CCC(=O)Cn1c2cc(cnc2[nH]c1=O)-c1ccc(F)c(F)c1 Show InChI InChI=1S/C16H13F2N3O2/c1-2-11(22)8-21-14-6-10(7-19-15(14)20-16(21)23)9-3-4-12(17)13(18)5-9/h3-7H,2,8H2,1H3,(H,19,20,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50124908 (CHEMBL159560 | N-(2-Methoxy-benzyl)-4-trifluoromet...) Show SMILES COc1ccccc1CN=C(N)c1ccc(OC(F)(F)F)cc1 |w:9.9| Show InChI InChI=1S/C16H15F3N2O2/c1-22-14-5-3-2-4-12(14)10-21-15(20)11-6-8-13(9-7-11)23-16(17,18)19/h2-9H,10H2,1H3,(H2,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of the response to NMDA glutamate/glycine receptor NR2B subtype was determined using FLIPR assay				Bioorg Med Chem Lett 13: 697-700 (2003) BindingDB Entry DOI: 10.7270/Q2FX78TP
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50124909 (CHEMBL159744 | N-(3,5-Dimethyl-benzyl)-4-trifluoro...) Show SMILES Cc1cc(C)cc(CN=C(N)c2ccc(OC(F)(F)F)cc2)c1 |w:8.7| Show InChI InChI=1S/C17H17F3N2O/c1-11-7-12(2)9-13(8-11)10-22-16(21)14-3-5-15(6-4-14)23-17(18,19)20/h3-9H,10H2,1-2H3,(H2,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of the response to NMDA glutamate/glycine receptor NR2B subtype was determined using FLIPR assay				Bioorg Med Chem Lett 13: 697-700 (2003) BindingDB Entry DOI: 10.7270/Q2FX78TP
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM198665 (US9221796, 2b) Show SMILES Oc1ccc(cc1)C1CCN(CC1)[C@@H]1CCN(Cc2ccc(F)cc2)C1=O |r| Show InChI InChI=1S/C22H25FN2O2/c23-19-5-1-16(2-6-19)15-25-14-11-21(22(25)27)24-12-9-18(10-13-24)17-3-7-20(26)8-4-17/h1-8,18,21,26H,9-15H2/t21-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Binding affinity to GluN2B receptor in human cortex				ACS Med Chem Lett 9: 472-477 (2018) Article DOI: 10.1021/acsmedchemlett.8b00080 BindingDB Entry DOI: 10.7270/Q2PR7ZJT
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM436678 (2-[6-(5-Chloro-2-thienyl)-3-methyl-2-oxo-imidazo[4...) Show SMILES CN(C)C(=O)Cn1c2cc(cnc2n(C)c1=O)-c1ccc(Cl)s1 Show InChI InChI=1S/C15H15ClN4O2S/c1-18(2)13(21)8-20-10-6-9(11-4-5-12(16)23-11)7-17-14(10)19(3)15(20)22/h4-7H,8H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50212684 (2-(2-methoxy-benzyl)-5-trifluoromethoxy-2,3-dihydr...) Show SMILES COc1ccccc1CN1Cc2cc(OC(F)(F)F)ccc2C1=N Show InChI InChI=1S/C17H15F3N2O2/c1-23-15-5-3-2-4-11(15)9-22-10-12-8-13(24-17(18,19)20)6-7-14(12)16(22)21/h2-8,21H,9-10H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at NMDA NR2B receptor assessed as calcium flux				Bioorg Med Chem Lett 17: 3997-4000 (2007) Article DOI: 10.1016/j.bmcl.2007.04.084 BindingDB Entry DOI: 10.7270/Q21J99GV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM436762 (1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-[5-(difluorome...) Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CCC2)c1=O)-c1ccc(s1)C(F)F Show InChI InChI=1S/C17H16F2N4O2S/c1-21-16-11(23(17(21)25)9-14(24)22-5-2-6-22)7-10(8-20-16)12-3-4-13(26-12)15(18)19/h3-4,7-8,15H,2,5-6,9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM437086 (2-[6-(2,4-Difluoro-3-methyl-phenyl)-3-methyl-2-oxo...) Show SMILES CN(C)C(=O)Cn1c2cc(cnc2n(C)c1=O)-c1ccc(F)c(C)c1F Show InChI InChI=1S/C18H18F2N4O2/c1-10-13(19)6-5-12(16(10)20)11-7-14-17(21-8-11)23(4)18(26)24(14)9-15(25)22(2)3/h5-8H,9H2,1-4H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM409513 (2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(Cl)s1 Show InChI InChI=1S/C15H14ClN3OS/c1-18(2)15(20)9-19-6-5-11-12(19)7-10(8-17-11)13-3-4-14(16)21-13/h3-8H,9H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.31	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...				US Patent US10377753 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GVK
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM436860 (N-(3,3-Difluorocyclobutyl)-2-[2-oxo-6-[3-(trifluor...) Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2[nH]c(=O)n(CC(=O)NC3CC(F)(F)C3)c2c1 Show InChI InChI=1S/C19H15F5N4O2/c20-18(21)6-13(7-18)26-15(29)9-28-14-5-11(8-25-16(14)27-17(28)30)10-2-1-3-12(4-10)19(22,23)24/h1-5,8,13H,6-7,9H2,(H,26,29)(H,25,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM436768 (6-[5-(Difluoromethyl)-3-thienyl]-1-[2-(3-fluoroaze...) Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CC(F)C2)c1=O)-c1csc(c1)C(F)F Show InChI InChI=1S/C17H15F3N4O2S/c1-22-16-12(24(17(22)26)7-14(25)23-5-11(18)6-23)2-9(4-21-16)10-3-13(15(19)20)27-8-10/h2-4,8,11,15H,5-7H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50379671 (CHEMBL2013197) Show SMILES Oc1ccc2nc([nH]c2c1CN1CCCC1)-c1ccccc1 Show InChI InChI=1S/C18H19N3O/c22-16-9-8-15-17(14(16)12-21-10-4-5-11-21)20-18(19-15)13-6-2-1-3-7-13/h1-3,6-9,22H,4-5,10-12H2,(H,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.94	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Displacement of [3H]-Ro256981 from human NR2B receptor				Bioorg Med Chem Lett 22: 2620-3 (2012) Article DOI: 10.1016/j.bmcl.2012.01.108 BindingDB Entry DOI: 10.7270/Q2KD1ZX3
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50379688 (CHEMBL2013196) Show SMILES Oc1ccc2nc([nH]c2c1CN1CCCCCC1)-c1ccccc1 Show InChI InChI=1S/C20H23N3O/c24-18-11-10-17-19(16(18)14-23-12-6-1-2-7-13-23)22-20(21-17)15-8-4-3-5-9-15/h3-5,8-11,24H,1-2,6-7,12-14H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.94	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Displacement of [3H]-Ro256981 from human NR2B receptor				Bioorg Med Chem Lett 22: 2620-3 (2012) Article DOI: 10.1016/j.bmcl.2012.01.108 BindingDB Entry DOI: 10.7270/Q2KD1ZX3
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50379670 (CHEMBL2013195) Show SMILES Oc1ccc2nc([nH]c2c1CN1CCCCC1)-c1ccccc1 Show InChI InChI=1S/C19H21N3O/c23-17-10-9-16-18(15(17)13-22-11-5-2-6-12-22)21-19(20-16)14-7-3-1-4-8-14/h1,3-4,7-10,23H,2,5-6,11-13H2,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.94	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Displacement of [3H]-Ro256981 from human NR2B receptor				Bioorg Med Chem Lett 22: 2620-3 (2012) Article DOI: 10.1016/j.bmcl.2012.01.108 BindingDB Entry DOI: 10.7270/Q2KD1ZX3
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM437073 (1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-(2,4-difluoro-...) Show SMILES Cc1c(F)ccc(-c2cnc3n(C)c(=O)n(CC(=O)N4CCC4)c3c2)c1F Show InChI InChI=1S/C19H18F2N4O2/c1-11-14(20)5-4-13(17(11)21)12-8-15-18(22-9-12)23(2)19(27)25(15)10-16(26)24-6-3-7-24/h4-5,8-9H,3,6-7,10H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM437111 (2-[6-(3-Chloro-4-fluoro-phenyl)-2-oxo-3H-imidazo[4...) Show SMILES Fc1ccc(cc1Cl)-c1cnc2[nH]c(=O)n(CC(=O)NC3CC3)c2c1 Show InChI InChI=1S/C17H14ClFN4O2/c18-12-5-9(1-4-13(12)19)10-6-14-16(20-7-10)22-17(25)23(14)8-15(24)21-11-2-3-11/h1,4-7,11H,2-3,8H2,(H,21,24)(H,20,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50124923 (CHEMBL162080 | N-(3,5-Dimethyl-benzyl)-4-trifluoro...) Show SMILES Cc1cc(C)cc(CN=C(N)c2ccc(cc2)C(F)(F)F)c1 |w:8.7| Show InChI InChI=1S/C17H17F3N2/c1-11-7-12(2)9-13(8-11)10-22-16(21)14-3-5-15(6-4-14)17(18,19)20/h3-9H,10H2,1-2H3,(H2,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of the response to NMDA glutamate/glycine receptor NR2B subtype was determined using FLIPR assay				Bioorg Med Chem Lett 13: 697-700 (2003) BindingDB Entry DOI: 10.7270/Q2FX78TP
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM436719 (6-(4-Fluoro-3-methyl-phenyl)-3-methyl-1-(pyridazin...) Show SMILES Cc1cc(ccc1F)-c1cnc2n(C)c(=O)n(Cc3cccnn3)c2c1 Show InChI InChI=1S/C19H16FN5O/c1-12-8-13(5-6-16(12)20)14-9-17-18(21-10-14)24(2)19(26)25(17)11-15-4-3-7-22-23-15/h3-10H,11H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50301369 ((+)--5-Hydroxy-3-phenyl-5H-benzo[4,5]cyclohepta[1,...) Show SMILES OC1c2cccc(C#N)c2C=Cc2ncc(cc12)-c1ccccc1 |c:11| Show InChI InChI=1S/C21H14N2O/c22-12-15-7-4-8-18-17(15)9-10-20-19(21(18)24)11-16(13-23-20)14-5-2-1-3-6-14/h1-11,13,21,24H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity against NR2B receptor expressed in mouse Ltk cells assessed as inhibition of calcium influx by FLIPR assay				Bioorg Med Chem Lett 19: 5132-5 (2009) Article DOI: 10.1016/j.bmcl.2009.07.028 BindingDB Entry DOI: 10.7270/Q2X34XJW
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM436940 (6-(3,4-Difluorophenyl)-1-[(4-methyl-3-pyridyl)meth...) Show SMILES Cc1ccncc1Cn1c2cc(cnc2[nH]c1=O)-c1ccc(F)c(F)c1 Show InChI InChI=1S/C19H14F2N4O/c1-11-4-5-22-8-14(11)10-25-17-7-13(9-23-18(17)24-19(25)26)12-2-3-15(20)16(21)6-12/h2-9H,10H2,1H3,(H,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM437076 (1-(2-(3,3-Difluoroazetidin-1-yl)-2-oxoethyl)-6-(4-...) Show SMILES Cc1cc(ccc1F)-c1cnc2n(C)c(=O)n(CC(=O)N3CC(F)(F)C3)c2c1 Show InChI InChI=1S/C19H17F3N4O2/c1-11-5-12(3-4-14(11)20)13-6-15-17(23-7-13)24(2)18(28)26(15)8-16(27)25-9-19(21,22)10-25/h3-7H,8-10H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50080029 (4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...) Show SMILES C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 |r| Show InChI InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...				J Med Chem 62: 3-23 (2019) Article DOI: 10.1021/acs.jmedchem.7b01640 BindingDB Entry DOI: 10.7270/Q2N019RG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM436736 (6-(2,4-Difluoro-3-methyl-phenyl)-3-methyl-1-(pyrid...) Show SMILES Cc1c(F)ccc(c1F)-c1cnc2n(C)c(=O)n(Cc3cccnn3)c2c1 Show InChI InChI=1S/C19H15F2N5O/c1-11-15(20)6-5-14(17(11)21)12-8-16-18(22-9-12)25(2)19(27)26(16)10-13-4-3-7-23-24-13/h3-9H,10H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM617021 (US11752155, Compound E1-1.5B') Show SMILES CCc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26T0RS5
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM617021 (US11752155, Compound E1-1.5B') Show SMILES CCc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26T0RS5
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM617021 (US11752155, Compound E1-1.5B') Show SMILES CCc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26T0RS5
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50124917 (CHEMBL349727 | N-(3-Methoxy-benzyl)-4-trifluoromet...) Show SMILES COc1cccc(CN=C(N)c2ccc(OC(F)(F)F)cc2)c1 |w:8.7| Show InChI InChI=1S/C16H15F3N2O2/c1-22-14-4-2-3-11(9-14)10-21-15(20)12-5-7-13(8-6-12)23-16(17,18)19/h2-9H,10H2,1H3,(H2,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cells				Bioorg Med Chem Lett 13: 697-700 (2003) BindingDB Entry DOI: 10.7270/Q2FX78TP
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM437085 (1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-(3,4-difluorop...) Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CCC2)c1=O)-c1ccc(F)c(F)c1 Show InChI InChI=1S/C18H16F2N4O2/c1-22-17-15(24(18(22)26)10-16(25)23-5-2-6-23)8-12(9-21-17)11-3-4-13(19)14(20)7-11/h3-4,7-9H,2,5-6,10H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM437079 (1-[2-(3,3-Difluoroazetidin-1-yl)-2-oxo-ethyl]-6-(3...) Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CC(F)(F)C2)c1=O)-c1ccc(F)c(F)c1 Show InChI InChI=1S/C18H14F4N4O2/c1-24-16-14(5-11(6-23-16)10-2-3-12(19)13(20)4-10)26(17(24)28)7-15(27)25-8-18(21,22)9-25/h2-6H,7-9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM409515 (1-(Azetidin-1-yl)-2-[6-(5-methyl-2-thienyl)pyrrolo...) Show SMILES Cc1ccc(s1)-c1cnc2ccn(CC(=O)N3CCC3)c2c1 Show InChI InChI=1S/C17H17N3OS/c1-12-3-4-16(22-12)13-9-15-14(18-10-13)5-8-20(15)11-17(21)19-6-2-7-19/h3-5,8-10H,2,6-7,11H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...				US Patent US10377753 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GVK
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM409512 (2-[6-[3-(Difluoromethyl)phenyl]pyrrolo[3,2-b]pyrid...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cccc(c1)C(F)F Show InChI InChI=1S/C18H17F2N3O/c1-22(2)17(24)11-23-7-6-15-16(23)9-14(10-21-15)12-4-3-5-13(8-12)18(19)20/h3-10,18H,11H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...				US Patent US10377753 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GVK
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM409735 (2-[3-Chloro-6-(5-chloro-4-methyl-2-thienyl)pyrrolo...) Show SMILES CN(C)C(=O)Cn1cc(Cl)c2ncc(cc12)-c1cc(C)c(Cl)s1 Show InChI InChI=1S/C16H15Cl2N3OS/c1-9-4-13(23-16(9)18)10-5-12-15(19-6-10)11(17)7-21(12)8-14(22)20(2)3/h4-7H,8H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...				US Patent US10377753 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GVK
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM436679 (6-[5-(Difluoromethyl)-2-thienyl]-1-[2-(3-fluoroaze...) Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CC(F)C2)c1=O)-c1ccc(s1)C(F)F Show InChI InChI=1S/C17H15F3N4O2S/c1-22-16-11(24(17(22)26)8-14(25)23-6-10(18)7-23)4-9(5-21-16)12-2-3-13(27-12)15(19)20/h2-5,10,15H,6-8H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM436696 (1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(t...) Show SMILES Cn1c2ncc(cc2n(CC(=O)N2CCC2)c1=O)-c1ccc(s1)C(F)(F)F Show InChI InChI=1S/C17H15F3N4O2S/c1-22-15-11(24(16(22)26)9-14(25)23-5-2-6-23)7-10(8-21-15)12-3-4-13(27-12)17(18,19)20/h3-4,7-8H,2,5-6,9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10617676 (2020) BindingDB Entry DOI: 10.7270/Q2CJ8HHH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM409743 (2-[6-(3,5-Difluorophenyl)-3-(trifluoromethyl)pyrro...) Show SMILES CN(C)C(=O)Cn1cc(c2ncc(cc12)-c1cc(F)cc(F)c1)C(F)(F)F Show InChI InChI=1S/C18H14F5N3O/c1-25(2)16(27)9-26-8-14(18(21,22)23)17-15(26)5-11(7-24-17)10-3-12(19)6-13(20)4-10/h3-8H,9H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...				US Patent US10377753 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GVK
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM409623 (2-[6-(3-Chlorophenyl)-3-fluoro-pyrrolo[3,2-b]pyrid...) Show SMILES FC1CN(C1)C(=O)Cn1cc(F)c2ncc(cc12)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H14ClF2N3O/c19-13-3-1-2-11(4-13)12-5-16-18(22-6-12)15(21)9-23(16)10-17(25)24-7-14(20)8-24/h1-6,9,14H,7-8,10H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...				US Patent US10377753 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GVK
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM388296 (US10294230, Compound E1-2.2) Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2ZW1P6M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM388296 (US10294230, Compound E1-2.2) Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2ZW1P6M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM435144 (US10584127, Compound E1-2.2 | US11136328, Compound...) Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
Rugen Holdings (Cayman) Limited US Patent					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				US Patent US10584127 (2020) BindingDB Entry DOI: 10.7270/Q2Q242NP
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM435144 (US10584127, Compound E1-2.2 | US11136328, Compound...) Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H41VMF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM435144 (US10584127, Compound E1-2.2 | US11136328, Compound...) Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H41VMF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM435144 (US10584127, Compound E1-2.2 | US11136328, Compound...) Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H41VMF
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM617013 (US11752155, Compound E1-2.2B') Show SMILES Cc1ccc(COC(=O)C2CC[C@H](CNc3cccc4nncn34)C(F)(F)C2)cc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26T0RS5
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM388296 (US10294230, Compound E1-2.2) Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2ZW1P6M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM617013 (US11752155, Compound E1-2.2B') Show SMILES Cc1ccc(COC(=O)C2CC[C@H](CNc3cccc4nncn34)C(F)(F)C2)cc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26T0RS5
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM617013 (US11752155, Compound E1-2.2B') Show SMILES Cc1ccc(COC(=O)C2CC[C@H](CNc3cccc4nncn34)C(F)(F)C2)cc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26T0RS5
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM388301 (US10294230, Compound E1-22.2 | US10584127, Compoun...) Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3ncccn3)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C19H22F2N4O2/c1-14-3-5-15(6-4-14)12-27-18(26)25-10-7-16(19(20,21)13-25)11-24-17-22-8-2-9-23-17/h2-6,8-9,16H,7,10-13H2,1H3,(H,22,23,24)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26T0RS5
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM388301 (US10294230, Compound E1-22.2 | US10584127, Compoun...) Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3ncccn3)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C19H22F2N4O2/c1-14-3-5-15(6-4-14)12-27-18(26)25-10-7-16(19(20,21)13-25)11-24-17-22-8-2-9-23-17/h2-6,8-9,16H,7,10-13H2,1H3,(H,22,23,24)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26T0RS5
					More data for this Ligand-Target Pair

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