new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 551 hits of ic50 for UniProtKB: Q13224   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM237334
PNG
((3aR,5R,6aS)-5-benzyl-2- ((R)-2-(3-fluoro-4- hydro...)
Show SMILES O[C@@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)c(F)c1 |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50124908
PNG
(CHEMBL159560 | N-(2-Methoxy-benzyl)-4-trifluoromet...)
Show SMILES COc1ccccc1CN=C(N)c1ccc(OC(F)(F)F)cc1 |w:9.9|
Show InChI InChI=1S/C16H15F3N2O2/c1-22-14-5-3-2-4-12(14)10-21-15(20)11-6-8-13(9-7-11)23-16(17,18)19/h2-9H,10H2,1H3,(H2,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 4.10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the response to NMDA glutamate/glycine receptor NR2B subtype was determined using FLIPR assay


Bioorg Med Chem Lett 13: 697-700 (2003)


BindingDB Entry DOI: 10.7270/Q2FX78TP
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50124909
PNG
(CHEMBL159744 | N-(3,5-Dimethyl-benzyl)-4-trifluoro...)
Show SMILES Cc1cc(C)cc(CN=C(N)c2ccc(OC(F)(F)F)cc2)c1 |w:8.7|
Show InChI InChI=1S/C17H17F3N2O/c1-11-7-12(2)9-13(8-11)10-22-16(21)14-3-5-15(6-4-14)23-17(18,19)20/h3-9H,10H2,1-2H3,(H2,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 4.20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the response to NMDA glutamate/glycine receptor NR2B subtype was determined using FLIPR assay


Bioorg Med Chem Lett 13: 697-700 (2003)


BindingDB Entry DOI: 10.7270/Q2FX78TP
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50212684
PNG
(2-(2-methoxy-benzyl)-5-trifluoromethoxy-2,3-dihydr...)
Show SMILES COc1ccccc1CN1Cc2cc(OC(F)(F)F)ccc2C1=N
Show InChI InChI=1S/C17H15F3N2O2/c1-23-15-5-3-2-4-11(15)9-22-10-12-8-13(24-17(18,19)20)6-7-14(12)16(22)21/h2-8,21H,9-10H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 5.90n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at NMDA NR2B receptor assessed as calcium flux


Bioorg Med Chem Lett 17: 3997-4000 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.084
BindingDB Entry DOI: 10.7270/Q21J99GV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50379688
PNG
(CHEMBL2013196)
Show SMILES Oc1ccc2nc([nH]c2c1CN1CCCCCC1)-c1ccccc1
Show InChI InChI=1S/C20H23N3O/c24-18-11-10-17-19(16(18)14-23-12-6-1-2-7-13-23)22-20(21-17)15-8-4-3-5-9-15/h3-5,8-11,24H,1-2,6-7,12-14H2,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro256981 from human NR2B receptor


Bioorg Med Chem Lett 22: 2620-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.108
BindingDB Entry DOI: 10.7270/Q2KD1ZX3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50379671
PNG
(CHEMBL2013197)
Show SMILES Oc1ccc2nc([nH]c2c1CN1CCCC1)-c1ccccc1
Show InChI InChI=1S/C18H19N3O/c22-16-9-8-15-17(14(16)12-21-10-4-5-11-21)20-18(19-15)13-6-2-1-3-7-13/h1-3,6-9,22H,4-5,10-12H2,(H,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro256981 from human NR2B receptor


Bioorg Med Chem Lett 22: 2620-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.108
BindingDB Entry DOI: 10.7270/Q2KD1ZX3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50379670
PNG
(CHEMBL2013195)
Show SMILES Oc1ccc2nc([nH]c2c1CN1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C19H21N3O/c23-17-10-9-16-18(15(17)13-22-11-5-2-6-12-22)21-19(20-16)14-7-3-1-4-8-14/h1,3-4,7-10,23H,2,5-6,11-13H2,(H,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro256981 from human NR2B receptor


Bioorg Med Chem Lett 22: 2620-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.108
BindingDB Entry DOI: 10.7270/Q2KD1ZX3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50124923
PNG
(CHEMBL162080 | N-(3,5-Dimethyl-benzyl)-4-trifluoro...)
Show SMILES Cc1cc(C)cc(CN=C(N)c2ccc(cc2)C(F)(F)F)c1 |w:8.7|
Show InChI InChI=1S/C17H17F3N2/c1-11-7-12(2)9-13(8-11)10-22-16(21)14-3-5-15(6-4-14)17(18,19)20/h3-9H,10H2,1-2H3,(H2,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 8.70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the response to NMDA glutamate/glycine receptor NR2B subtype was determined using FLIPR assay


Bioorg Med Chem Lett 13: 697-700 (2003)


BindingDB Entry DOI: 10.7270/Q2FX78TP
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50301369
PNG
((+)--5-Hydroxy-3-phenyl-5H-benzo[4,5]cyclohepta[1,...)
Show SMILES OC1c2cccc(C#N)c2C=Cc2ncc(cc12)-c1ccccc1 |c:11|
Show InChI InChI=1S/C21H14N2O/c22-12-15-7-4-8-18-17(15)9-10-20-19(21(18)24)11-16(13-23-20)14-5-2-1-3-6-14/h1-11,13,21,24H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity against NR2B receptor expressed in mouse Ltk cells assessed as inhibition of calcium influx by FLIPR assay


Bioorg Med Chem Lett 19: 5132-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.028
BindingDB Entry DOI: 10.7270/Q2X34XJW
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50124917
PNG
(CHEMBL349727 | N-(3-Methoxy-benzyl)-4-trifluoromet...)
Show SMILES COc1cccc(CN=C(N)c2ccc(OC(F)(F)F)cc2)c1 |w:8.7|
Show InChI InChI=1S/C16H15F3N2O2/c1-22-14-4-2-3-11(9-14)10-21-15(20)12-5-7-13(8-6-12)23-16(17,18)19/h2-9H,10H2,1H3,(H2,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 9.70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cells


Bioorg Med Chem Lett 13: 697-700 (2003)


BindingDB Entry DOI: 10.7270/Q2FX78TP
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM237552
PNG
(US10052306, 223 | rac-(3aR,5r,6aS)-5-(4- chloroben...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccc(Cl)cc3)C[C@H]2C1)c1ccc(O)cn1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11.5n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM238867
PNG
(US10052306, 306 | rac-4-{2-[(3aR,5R,6aS)- 5-benzyl...)
Show SMILES OC(CN1C[C@@H]2C[C@@H](Cc3ccccc3)C[C@@H]2C1)c1ccc(O)cc1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11.7n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50212685
PNG
(2-benzofuran-7-ylmethyl-5-trifluoromethoxy-2,3-dih...)
Show SMILES FC(F)(F)Oc1ccc2C(=N)N(Cc3cccc4ccoc34)Cc2c1
Show InChI InChI=1S/C18H13F3N2O2/c19-18(20,21)25-14-4-5-15-13(8-14)10-23(17(15)22)9-12-3-1-2-11-6-7-24-16(11)12/h1-8,22H,9-10H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at NMDA NR2B receptor assessed as calcium flux


Bioorg Med Chem Lett 17: 3997-4000 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.084
BindingDB Entry DOI: 10.7270/Q21J99GV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM238862
PNG
(US10052306, 301 | rac-4-{2-[(3aR,5S,6aS)- 5-benzyl...)
Show SMILES OC(CN1C[C@@H]2C[C@H](Cc3ccccc3)C[C@@H]2C1)c1ccc(O)c(F)c1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12.2n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50379676
PNG
(CHEMBL2013204)
Show SMILES Oc1ccc2nc([nH]c2c1CN1CCCC1)-c1cccc(F)c1F
Show InChI InChI=1S/C18H17F2N3O/c19-13-5-3-4-11(16(13)20)18-21-14-6-7-15(24)12(17(14)22-18)10-23-8-1-2-9-23/h3-7,24H,1-2,8-10H2,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro256981 from human NR2B receptor


Bioorg Med Chem Lett 22: 2620-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.108
BindingDB Entry DOI: 10.7270/Q2KD1ZX3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM237388
PNG
(US10052306, 204 | rac-(3aR,5r,6aS)-2-(2- hydroxy-2...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3cccs3)C[C@H]2C1)c1ccc(O)cc1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12.6n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM238861
PNG
(US10052306, 300 | rac-4-(2-((3aR,6aS)-5- benzylhex...)
Show SMILES OC(CN1C[C@@H]2CC(Cc3ccccc3)C[C@@H]2C1)c1ccc(O)cc1 |r,w:1.0,7.7|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13.9n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM237683
PNG
(US10052306, 229 | rac-(3aR,5r,6aS)-5-(2- fluoroben...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccccc3F)C[C@H]2C1)c1ccc(O)cc1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15.5n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM238865
PNG
(US10052306, 304 | rac-4-{2-[(3aR,5S,6aS)- 5-benzyl...)
Show SMILES OC(CN1C[C@@H]2C[C@H](Cc3ccccc3)C[C@@H]2C1)c1ccc(O)cc1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16.8n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM235335
PNG
(US10052306, 131 | US10052306, 281 | rac-(3aR,5r,6a...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17.4n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM237322
PNG
(US10052306, 168 | rac-(3aR,5r,6aS)-5-(4- fluoroben...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3)C[C@H]2C1)c1ccc(O)cn1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17.8n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 18.5n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 18.5n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM237551
PNG
(US10052306, 222 | rac-2-(2-(3-fluoro-4- hydroxyphe...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3cccs3)C[C@H]2C1)c1ccc(O)c(F)c1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 19.3n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM238863
PNG
(US10052306, 302 | rac-4-{2-[(3aR,5R,6aS)- 5-benzyl...)
Show SMILES OC(CN1C[C@@H]2C[C@@H](Cc3ccccc3)C[C@@H]2C1)c1ccc(O)c(F)c1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20.1n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM235341
PNG
((3aR,5S,6aS)-5-benzyl-2- ((S)-2-hydroxy-2-(4- hydr...)
Show SMILES O[C@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1 |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20.4n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM235341
PNG
((3aR,5S,6aS)-5-benzyl-2- ((S)-2-hydroxy-2-(4- hydr...)
Show SMILES O[C@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1 |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20.4n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21.2n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21.2n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361999
PNG
(US10221182, Compound E1-1.6 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21.2n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21.9n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM361992
PNG
(US10221182, Compound E1-1.4 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21.9n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM237325
PNG
(US10052306, 171 | rac-(3aR,5r,6aS)-2-(2-(3- fluoro...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3)C[C@H]2C1)c1ccc(O)c(F)c1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 22.1n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362001
PNG
(US10221182, Compound E1-1.7 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 22.4n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362001
PNG
(US10221182, Compound E1-1.7 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 22.4n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM362001
PNG
(US10221182, Compound E1-1.7 | US10221182, Compound...)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 22.4n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM238859
PNG
(US10052306, 298 | rac-6-(2-{5-benzyl- octahydrocyc...)
Show SMILES OC(CN1C[C@@H]2CC(Cc3ccccc3)C[C@@H]2C1)c1ccc(O)cn1 |r,w:1.0,7.7|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 22.4n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM280730
PNG
(US10030026, Compound C-12)
Show SMILES FC(F)Oc1ccc(nc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/an/a25



Rugen Holdings (Cayman) Limited

US Patent




US Patent US10030026 (2018)


BindingDB Entry DOI: 10.7270/Q26D5W1Q
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM235340
PNG
((3aR,5R,6aS)-5-benzyl-2- ((R)-2-hydroxy-2-(4- hydr...)
Show SMILES O[C@@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1 |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23.7n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM235340
PNG
((3aR,5R,6aS)-5-benzyl-2- ((R)-2-hydroxy-2-(4- hydr...)
Show SMILES O[C@@H](CN1C[C@H]2C[C@](O)(Cc3ccccc3)C[C@H]2C1)c1ccc(O)cc1 |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23.7n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM237699
PNG
(US10052306, 245 | rac-5-(2,4- difluorobenzyl)-2-(2...)
Show SMILES OC(CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3F)C[C@H]2C1)c1ccc(O)cc1 |r,w:1.0|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23.8n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



RUGEN HOLDINGS (CAYMAN) LIMITED

US Patent




US Patent US10221182 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM237709
PNG
((3aR,5S,6aS)-5-(4- fluorobenzyl)-2-((S)-2- hydroxy...)
Show SMILES O[C@@H](CN1C[C@H]2C[C@](O)(Cc3ccc(F)cc3)C[C@H]2C1)c1ccc(O)cn1 |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



CADENT THERAPEUTICS, INC.

US Patent




US Patent US10052306 (2018)


BindingDB Entry DOI: 10.7270/Q20R9RD3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/a25



Rugen Holdings (Cayman) Limited

US Patent




US Patent US10030026 (2018)


BindingDB Entry DOI: 10.7270/Q26D5W1Q
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/a25



Rugen Holdings (Cayman) Limited

US Patent




US Patent US10030026 (2018)


BindingDB Entry DOI: 10.7270/Q26D5W1Q
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50124914
PNG
(CHEMBL161180 | N-(3,5-Dichloro-benzyl)-4-trifluoro...)
Show SMILES NC(=NCc1cc(Cl)cc(Cl)c1)c1ccc(OC(F)(F)F)cc1 |w:2.2|
Show InChI InChI=1S/C15H11Cl2F3N2O/c16-11-5-9(6-12(17)7-11)8-22-14(21)10-1-3-13(4-2-10)23-15(18,19)20/h1-7H,8H2,(H2,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 24n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the response to NMDA glutamate/glycine receptor NR2B subtype was determined using FLIPR assay


Bioorg Med Chem Lett 13: 697-700 (2003)


BindingDB Entry DOI: 10.7270/Q2FX78TP
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 551 total )  |  Next  |  Last  >>
Jump to: