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Compile Data Set for Download or QSAR

Found 297 hits of ic50 data for polymerid = 50000240   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Homo sapiens (Human))
BDBM50075321
PNG
(2-(2,6-Diisopropyl-phenyl)-4-hydroxy-isoindole-1,3...)
Show SMILES CC(C)c1cccc(C(C)C)c1N1C(=O)c2cccc(O)c2C1=O
Show InChI InChI=1S/C20H21NO3/c1-11(2)13-7-5-8-14(12(3)4)18(13)21-19(23)15-9-6-10-16(22)17(15)20(21)24/h5-12,22H,1-4H3
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n/an/a 4.30n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50075333
PNG
(5-Amino-2-(2,6-diisopropyl-phenyl)-isoindole-1,3-d...)
Show SMILES CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccc(N)cc2C1=O
Show InChI InChI=1S/C20H22N2O2/c1-11(2)14-6-5-7-15(12(3)4)18(14)22-19(23)16-9-8-13(21)10-17(16)20(22)24/h5-12H,21H2,1-4H3
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n/an/a 5.40n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50075323
PNG
(2-(2,6-Diethyl-phenyl)-5-hydroxy-isoindole-1,3-dio...)
Show SMILES CCc1cccc(CC)c1N1C(=O)c2ccc(O)cc2C1=O
Show InChI InChI=1S/C18H17NO3/c1-3-11-6-5-7-12(4-2)16(11)19-17(21)14-9-8-13(20)10-15(14)18(19)22/h5-10,20H,3-4H2,1-2H3
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n/an/a 9.60n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50066436
PNG
(2-(2,6-Dimethyl-phenyl)-5-hydroxy-isoindole-1,3-di...)
Show SMILES Cc1cccc(C)c1N1C(=O)c2ccc(O)cc2C1=O
Show InChI InChI=1S/C16H13NO3/c1-9-4-3-5-10(2)14(9)17-15(19)12-7-6-11(18)8-13(12)16(17)20/h3-8,18H,1-2H3
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n/an/a 10n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50075324
PNG
(2-(2,6-Diethyl-phenyl)-4-hydroxy-isoindole-1,3-dio...)
Show SMILES CCc1cccc(CC)c1N1C(=O)c2cccc(O)c2C1=O
Show InChI InChI=1S/C18H17NO3/c1-3-11-7-5-8-12(4-2)16(11)19-17(21)13-9-6-10-14(20)15(13)18(19)22/h5-10,20H,3-4H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50075330
PNG
(2-(2,6-Diisopropyl-phenyl)-4,5,6,7-tetrafluoro-3-t...)
Show SMILES CC(C)c1cccc(C(C)C)c1N1C(=O)c2c(C1=S)c(F)c(F)c(F)c2F
Show InChI InChI=1S/C20H17F4NOS/c1-8(2)10-6-5-7-11(9(3)4)18(10)25-19(26)12-13(20(25)27)15(22)17(24)16(23)14(12)21/h5-9H,1-4H3
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n/an/a 11n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50075328
PNG
(2-(2,6-Diisopropyl-phenyl)-5-hydroxy-isoindole-1,3...)
Show SMILES CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccc(O)cc2C1=O
Show InChI InChI=1S/C20H21NO3/c1-11(2)14-6-5-7-15(12(3)4)18(14)21-19(23)16-9-8-13(22)10-17(16)20(21)24/h5-12,22H,1-4H3
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n/an/a 15n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50066438
PNG
(5-Amino-2-(2,6-dimethyl-phenyl)-isoindole-1,3-dion...)
Show SMILES Cc1cccc(C)c1N1C(=O)c2ccc(N)cc2C1=O
Show InChI InChI=1S/C16H14N2O2/c1-9-4-3-5-10(2)14(9)18-15(19)12-7-6-11(17)8-13(12)16(18)20/h3-8H,17H2,1-2H3
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n/an/a 15n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50131276
PNG
(CHEMBL328470 | N-(3-{4-[3-(7-Chloro-quinolin-4-yla...)
Show SMILES CC(C)CN(CCCN1CCN(CCCNc2ccnc3cc(Cl)ccc23)CC1)C(=O)CC(=O)NO
Show InChI InChI=1S/C26H39ClN6O3/c1-20(2)19-33(26(35)18-25(34)30-36)12-4-11-32-15-13-31(14-16-32)10-3-8-28-23-7-9-29-24-17-21(27)5-6-22(23)24/h5-7,9,17,20,36H,3-4,8,10-16,18-19H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 28n/an/an/an/an/an/a



Universit£ de Lille 2

Curated by ChEMBL


Assay Description
Inhibitory activity against mammalian Aminopeptidase N (APN)


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50075326
PNG
(4-Amino-2-(2,6-dimethyl-phenyl)-isoindole-1,3-dion...)
Show SMILES Cc1cccc(C)c1N1C(=O)c2cccc(N)c2C1=O
Show InChI InChI=1S/C16H14N2O2/c1-9-5-3-6-10(2)14(9)18-15(19)11-7-4-8-12(17)13(11)16(18)20/h3-8H,17H2,1-2H3
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n/an/a 29n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50036828
PNG
(1-Mercaptomethyl-2-phenyl-ethyl-ammonium | 2-Amino...)
Show SMILES NC(CS)Cc1ccccc1
Show InChI InChI=1S/C9H13NS/c10-9(7-11)6-8-4-2-1-3-5-8/h1-5,9,11H,6-7,10H2
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n/an/a 30n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory potency against aminopeptidase N (APN)


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50075334
PNG
(4-Hydroxy-2-(2-methylsulfanyl-phenyl)-isoindole-1,...)
Show SMILES CSc1ccccc1N1C(=O)c2cccc(O)c2C1=O
Show InChI InChI=1S/C15H11NO3S/c1-20-12-8-3-2-6-10(12)16-14(18)9-5-4-7-11(17)13(9)15(16)19/h2-8,17H,1H3
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n/an/a 38n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50075336
PNG
(2-(2,6-Diisopropyl-phenyl)-4,5,6,7-tetrafluoro-iso...)
Show SMILES CC(C)c1cccc(C(C)C)c1N1C(=S)c2c(C1=S)c(F)c(F)c(F)c2F
Show InChI InChI=1S/C20H17F4NS2/c1-8(2)10-6-5-7-11(9(3)4)18(10)25-19(26)12-13(20(25)27)15(22)17(24)16(23)14(12)21/h5-9H,1-4H3
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n/an/a 41n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50075322
PNG
(2-(2,6-Dimethyl-phenyl)-4-hydroxy-isoindole-1,3-di...)
Show SMILES Cc1cccc(C)c1N1C(=O)c2cccc(O)c2C1=O
Show InChI InChI=1S/C16H13NO3/c1-9-5-3-6-10(2)14(9)17-15(19)11-7-4-8-12(18)13(11)16(17)20/h3-8,18H,1-2H3
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n/an/a 71n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50075337
PNG
(2-(2,6-Dimethyl-phenyl)-4-nitro-isoindole-1,3-dion...)
Show SMILES Cc1cccc(C)c1N1C(=O)c2cccc(c2C1=O)[N+]([O-])=O
Show InChI InChI=1S/C16H12N2O4/c1-9-5-3-6-10(2)14(9)17-15(19)11-7-4-8-12(18(21)22)13(11)16(17)20/h3-8H,1-2H3
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n/an/a>100n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50075331
PNG
(2-(2,6-Diisopropyl-phenyl)-4-nitro-isoindole-1,3-d...)
Show SMILES CC(C)c1cccc(C(C)C)c1N1C(=O)c2cccc(c2C1=O)[N+]([O-])=O
Show InChI InChI=1S/C20H20N2O4/c1-11(2)13-7-5-8-14(12(3)4)18(13)21-19(23)15-9-6-10-16(22(25)26)17(15)20(21)24/h5-12H,1-4H3
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n/an/a>100n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50075329
PNG
(2-(2,6-Diisopropyl-phenyl)-isoindole-1,3-dione | 2...)
Show SMILES CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H21NO2/c1-12(2)14-10-7-11-15(13(3)4)18(14)21-19(22)16-8-5-6-9-17(16)20(21)23/h5-13H,1-4H3
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n/an/a>100n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50066444
PNG
(2-(2,6-Dimethyl-phenyl)-5-nitro-isoindole-1,3-dion...)
Show SMILES Cc1cccc(C)c1N1C(=O)c2ccc(cc2C1=O)[N+]([O-])=O
Show InChI InChI=1S/C16H12N2O4/c1-9-4-3-5-10(2)14(9)17-15(19)12-7-6-11(18(21)22)8-13(12)16(17)20/h3-8H,1-2H3
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n/an/a>100n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50075327
PNG
(CHEMBL151461 | Pro-boroPro (PBP))
Show SMILES OB(O)[C@@H]1CCCC1C(=O)[C@@H]1CCCN1
Show InChI InChI=1S/C10H18BNO3/c13-10(9-5-2-6-12-9)7-3-1-4-8(7)11(14)15/h7-9,12,14-15H,1-6H2/t7?,8-,9+/m1/s1
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n/an/a>100n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50075335
PNG
(2-(2,6-Diisopropyl-phenyl)-5-nitro-isoindole-1,3-d...)
Show SMILES CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccc(cc2C1=O)[N+]([O-])=O
Show InChI InChI=1S/C20H20N2O4/c1-11(2)14-6-5-7-15(12(3)4)18(14)21-19(23)16-9-8-13(22(25)26)10-17(16)20(21)24/h5-12H,1-4H3
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n/an/a>100n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM23842
PNG
(2-[2,6-bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3...)
Show SMILES CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccccc2C1=S
Show InChI InChI=1S/C20H21NOS/c1-12(2)14-10-7-11-15(13(3)4)18(14)21-19(22)16-8-5-6-9-17(16)20(21)23/h5-13H,1-4H3
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n/an/a>100n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a>100n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aminopeptidase


(Homo sapiens (Human))
BDBM50066441
PNG
(2-(2,6-Dimethyl-phenyl)-isoindole-1,3-dione | 2-(2...)
Show SMILES Cc1cccc(C)c1N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C16H13NO2/c1-10-6-5-7-11(2)14(10)17-15(18)12-8-3-4-9-13(12)16(17)19/h3-9H,1-2H3
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n/an/a>100n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50075332
PNG
(2-(2-Methylsulfanyl-phenyl)-4-nitro-isoindole-1,3-...)
Show SMILES CSc1ccccc1N1C(=O)c2cccc(c2C1=O)[N+]([O-])=O
Show InChI InChI=1S/C15H10N2O4S/c1-22-12-8-3-2-6-10(12)16-14(18)9-5-4-7-11(17(20)21)13(9)15(16)19/h2-8H,1H3
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n/an/a>100n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50144944
PNG
(CHEMBL3764919)
Show SMILES CC(C)C[C@H](NC(=O)Nc1c(C)cccc1C)C(=O)NO
Show InChI InChI=1/C15H23N3O3/c1-9(2)8-12(14(19)18-21)16-15(20)17-13-10(3)6-5-7-11(13)4/h5-7,9,12,21H,8H2,1-4H3,(H,18,19)(H2,16,17,20)/t12-/s2
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n/an/a 120n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cells preincubated for 5 mins before L-leu-p-nitroanilide substrate addition for 1 hr by photometry


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50204146
PNG
(1-amino-2-phenylethyl(1-hydroxy-3-phenylpropyl)pho...)
Show SMILES NC(Cc1ccccc1)P(O)(O)C(=O)CCc1ccccc1
Show InChI InChI=1S/C17H22NO3P/c18-16(13-15-9-5-2-6-10-15)22(20,21)17(19)12-11-14-7-3-1-4-8-14/h1-10,16,20-22H,11-13,18H2
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n/an/a 240n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of APN


Bioorg Med Chem Lett 17: 1516-9 (2007)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50144931
PNG
(CHEMBL3764432)
Show SMILES CCc1cccc(CC)c1NC(=O)N[C@@H](CC(C)C)C(=O)NO
Show InChI InChI=1/C17H27N3O3/c1-5-12-8-7-9-13(6-2)15(12)19-17(22)18-14(10-11(3)4)16(21)20-23/h7-9,11,14,23H,5-6,10H2,1-4H3,(H,20,21)(H2,18,19,22)/t14-/s2
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n/an/a 280n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cells preincubated for 5 mins before L-leu-p-nitroanilide substrate addition for 1 hr by photometry


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50400532
PNG
(CHEMBL2204959)
Show SMILES CC(C)C[C@H](NC(=O)NCc1cccc2ccccc12)C(=O)NO
Show InChI InChI=1S/C18H23N3O3/c1-12(2)10-16(17(22)21-24)20-18(23)19-11-14-8-5-7-13-6-3-4-9-15(13)14/h3-9,12,16,24H,10-11H2,1-2H3,(H,21,22)(H2,19,20,23)/t16-/m0/s1
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n/an/a 420n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate...


ACS Med Chem Lett 3: 959-964 (2012)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50400529
PNG
(CHEMBL2204943)
Show SMILES CC(C)C[C@H](NC(=O)Nc1cccc2ccccc12)C(=O)NO
Show InChI InChI=1S/C17H21N3O3/c1-11(2)10-15(16(21)20-23)19-17(22)18-14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11,15,23H,10H2,1-2H3,(H,20,21)(H2,18,19,22)/t15-/m0/s1
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n/an/a 480n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate...


ACS Med Chem Lett 3: 959-964 (2012)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50382512
PNG
(CHEMBL2022238)
Show SMILES N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C29H48N12O8/c30-17(10-11-22(31)43)23(44)38-18(8-4-12-36-28(32)33)24(45)40-20(14-16-6-2-1-3-7-16)25(46)41-21(15-42)26(47)39-19(27(48)49)9-5-13-37-29(34)35/h1-3,6-7,17-21,42H,4-5,8-15,30H2,(H2,31,43)(H,38,44)(H,39,47)(H,40,45)(H,41,46)(H,48,49)(H4,32,33,36)(H4,34,35,37)/t17-,18-,19-,20+,21-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Institute of Advanced Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AP-N ectopeptidase activity using alanine-MCA as substrate preincubated for 10 mins with substrate by fluorimetric an...


J Med Chem 55: 1181-8 (2012)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50204160
PNG
(1-amino-2-methylpropyl(1-hydroxy-3-phenylpropyl)ph...)
Show SMILES CC(C)C(N)P(O)(O)C(=O)CCc1ccccc1
Show InChI InChI=1S/C13H22NO3P/c1-10(2)13(14)18(16,17)12(15)9-8-11-6-4-3-5-7-11/h3-7,10,13,16-18H,8-9,14H2,1-2H3
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n/an/a 500n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of APN


Bioorg Med Chem Lett 17: 1516-9 (2007)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50382508
PNG
(CHEMBL2022234)
Show SMILES N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C29H47FN12O8/c30-16-7-5-15(6-8-16)13-20(25(47)42-21(14-43)26(48)40-19(27(49)50)4-2-12-38-29(35)36)41-24(46)18(3-1-11-37-28(33)34)39-23(45)17(31)9-10-22(32)44/h5-8,17-21,43H,1-4,9-14,31H2,(H2,32,44)(H,39,45)(H,40,48)(H,41,46)(H,42,47)(H,49,50)(H4,33,34,37)(H4,35,36,38)/t17-,18-,19-,20+,21-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Institute of Advanced Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AP-N ectopeptidase activity using alanine-MCA as substrate preincubated for 10 mins with substrate by fluorimetric an...


J Med Chem 55: 1181-8 (2012)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50430635
PNG
(CHEMBL2332525)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccccc1Br)C(=O)NO
Show InChI InChI=1S/C13H18BrN3O3/c1-8(2)7-11(12(18)17-20)16-13(19)15-10-6-4-3-5-9(10)14/h3-6,8,11,20H,7H2,1-2H3,(H,17,18)(H2,15,16,19)/t11-/m0/s1
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n/an/a 530n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured a...


Bioorg Med Chem 21: 1621-7 (2013)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50204163
PNG
(CHEMBL227345 | alpha1-(1-amino-3-methylbutane)-alp...)
Show SMILES CC(C)CC(N)=P(O)(O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C13H21N2O3P/c1-10(2)8-12(14)19(17,18)13(16)15-9-11-6-4-3-5-7-11/h3-7,10,17-18H,8-9,14H2,1-2H3,(H,15,16)
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n/an/a 530n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of APN


Bioorg Med Chem Lett 17: 1516-9 (2007)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50204159
PNG
(CHEMBL226863 | alpha1-(1-amino-1-phenylmethane)-al...)
Show SMILES NC(Cc1ccccc1)P(O)(O)C(=O)Cc1ccccc1
Show InChI InChI=1S/C16H20NO3P/c17-15(11-13-7-3-1-4-8-13)21(19,20)16(18)12-14-9-5-2-6-10-14/h1-10,15,19-21H,11-12,17H2
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n/an/a 550n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of APN


Bioorg Med Chem Lett 17: 1516-9 (2007)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50204161
PNG
(CHEMBL227290 | bis-alpha-(1-amino-1-phenylmethane)...)
Show SMILES NC(Cc1ccccc1)P(O)(O)C(=N)Cc1ccccc1
Show InChI InChI=1S/C16H21N2O2P/c17-15(11-13-7-3-1-4-8-13)21(19,20)16(18)12-14-9-5-2-6-10-14/h1-10,15,18-21H,11-12,17H2
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n/an/a 600n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of APN


Bioorg Med Chem Lett 17: 1516-9 (2007)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50430634
PNG
(CHEMBL2332526)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccccc1C)C(=O)NO
Show InChI InChI=1S/C14H21N3O3/c1-9(2)8-12(13(18)17-20)16-14(19)15-11-7-5-4-6-10(11)3/h4-7,9,12,20H,8H2,1-3H3,(H,17,18)(H2,15,16,19)/t12-/m0/s1
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n/an/a 610n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured a...


Bioorg Med Chem 21: 1621-7 (2013)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50430632
PNG
(CHEMBL2332518)
Show SMILES CC(C)C[C@H](NC(=O)NCc1ccccc1Cl)C(=O)NO
Show InChI InChI=1S/C14H20ClN3O3/c1-9(2)7-12(13(19)18-21)17-14(20)16-8-10-5-3-4-6-11(10)15/h3-6,9,12,21H,7-8H2,1-2H3,(H,18,19)(H2,16,17,20)/t12-/m0/s1
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n/an/a 650n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured a...


Bioorg Med Chem 21: 1621-7 (2013)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50430633
PNG
(CHEMBL2332527)
Show SMILES COc1ccccc1NC(=O)N[C@@H](CC(C)C)C(=O)NO
Show InChI InChI=1S/C14H21N3O4/c1-9(2)8-11(13(18)17-20)16-14(19)15-10-6-4-5-7-12(10)21-3/h4-7,9,11,20H,8H2,1-3H3,(H,17,18)(H2,15,16,19)/t11-/m0/s1
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n/an/a 700n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured a...


Bioorg Med Chem 21: 1621-7 (2013)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50204157
PNG
(CHEMBL227340 | alpha1-(1-amino-1-phenylmethane)-al...)
Show SMILES NC(Cc1ccccc1)P(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C17H23N2O2P/c18-16(12-11-14-7-3-1-4-8-14)22(20,21)17(19)13-15-9-5-2-6-10-15/h1-10,17-18,20-22H,11-13,19H2
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n/an/a 710n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of APN


Bioorg Med Chem Lett 17: 1516-9 (2007)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50430631
PNG
(CHEMBL2332519)
Show SMILES CC(C)C[C@H](NC(=O)NCc1ccccc1Br)C(=O)NO
Show InChI InChI=1S/C14H20BrN3O3/c1-9(2)7-12(13(19)18-21)17-14(20)16-8-10-5-3-4-6-11(10)15/h3-6,9,12,21H,7-8H2,1-2H3,(H,18,19)(H2,16,17,20)/t12-/m0/s1
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n/an/a 730n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured a...


Bioorg Med Chem 21: 1621-7 (2013)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50400541
PNG
(CHEMBL2204950)
Show SMILES COc1cccc(CNC(=O)N[C@@H](CC(C)C)C(=O)NO)c1
Show InChI InChI=1S/C15H23N3O4/c1-10(2)7-13(14(19)18-21)17-15(20)16-9-11-5-4-6-12(8-11)22-3/h4-6,8,10,13,21H,7,9H2,1-3H3,(H,18,19)(H2,16,17,20)/t13-/m0/s1
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n/an/a 790n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate...


ACS Med Chem Lett 3: 959-964 (2012)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50382929
PNG
(CHEMBL2029399)
Show SMILES N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C32H53N13O9S/c33-18(16-55)25(48)41-20(10-11-24(34)47)27(50)42-19(8-4-12-39-31(35)36)26(49)44-22(14-17-6-2-1-3-7-17)28(51)45-23(15-46)29(52)43-21(30(53)54)9-5-13-40-32(37)38/h1-3,6-7,18-23,46,55H,4-5,8-16,33H2,(H2,34,47)(H,41,48)(H,42,50)(H,43,52)(H,44,49)(H,45,51)(H,53,54)(H4,35,36,39)(H4,37,38,40)/t18-,19-,20-,21-,22-,23-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human aminopeptidase N


ACS Med Chem Lett 3: 20-24 (2012)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50204149
PNG
(CHEMBL390323 | bis-alpha-(1-amino-3-phenylpropane)...)
Show SMILES NC(CCc1ccccc1)P(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C18H25N2O2P/c19-17(13-11-15-7-3-1-4-8-15)23(21,22)18(20)14-12-16-9-5-2-6-10-16/h1-10,17,20-23H,11-14,19H2
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n/an/a 830n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of APN


Bioorg Med Chem Lett 17: 1516-9 (2007)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50400537
PNG
(CHEMBL2204954)
Show SMILES CC(C)C[C@H](NC(=O)NCc1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C14H20FN3O3/c1-9(2)7-12(13(19)18-21)17-14(20)16-8-10-3-5-11(15)6-4-10/h3-6,9,12,21H,7-8H2,1-2H3,(H,18,19)(H2,16,17,20)/t12-/m0/s1
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n/an/a 910n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate...


ACS Med Chem Lett 3: 959-964 (2012)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50204148
PNG
(CHEMBL227347 | alpha1-(1-amino-2-methylpropane)-al...)
Show SMILES CC(C)C(N)=P(O)(O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C12H19N2O3P/c1-9(2)11(13)18(16,17)12(15)14-8-10-6-4-3-5-7-10/h3-7,9,16-17H,8,13H2,1-2H3,(H,14,15)
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n/an/a 930n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of APN


Bioorg Med Chem Lett 17: 1516-9 (2007)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50400544
PNG
(CHEMBL2204947)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccc(C)cc1)C(=O)NO
Show InChI InChI=1S/C14H21N3O3/c1-9(2)8-12(13(18)17-20)16-14(19)15-11-6-4-10(3)5-7-11/h4-7,9,12,20H,8H2,1-3H3,(H,17,18)(H2,15,16,19)/t12-/m0/s1
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n/an/a 940n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate...


ACS Med Chem Lett 3: 959-964 (2012)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50204150
PNG
(1-amino-3-methylbutyl(1-hydroxy-3-phenylpropyl)pho...)
Show SMILES CC(C)CC(N)P(O)(O)C(=O)CCc1ccccc1
Show InChI InChI=1S/C14H24NO3P/c1-11(2)10-13(15)19(17,18)14(16)9-8-12-6-4-3-5-7-12/h3-7,11,13,17-19H,8-10,15H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of APN


Bioorg Med Chem Lett 17: 1516-9 (2007)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50400542
PNG
(CHEMBL2204949)
Show SMILES COc1ccccc1CNC(=O)N[C@@H](CC(C)C)C(=O)NO
Show InChI InChI=1S/C15H23N3O4/c1-10(2)8-12(14(19)18-21)17-15(20)16-9-11-6-4-5-7-13(11)22-3/h4-7,10,12,21H,8-9H2,1-3H3,(H,18,19)(H2,16,17,20)/t12-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate...


ACS Med Chem Lett 3: 959-964 (2012)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50430636
PNG
(CHEMBL2332524)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccccc1Cl)C(=O)NO
Show InChI InChI=1S/C13H18ClN3O3/c1-8(2)7-11(12(18)17-20)16-13(19)15-10-6-4-3-5-9(10)14/h3-6,8,11,20H,7H2,1-2H3,(H,17,18)(H2,15,16,19)/t11-/m0/s1
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n/an/a 1.31E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured a...


Bioorg Med Chem 21: 1621-7 (2013)

More data for this
Ligand-Target Pair
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