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Compile Data Set for Download or QSAR

Found 326 hits of ec50 data for polymerid = 50000337,6408   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-2


(Homo sapiens (Human))		BDBM50579802
PNG
(CHEMBL5081901)
Show SMILES Cc1n[nH]c(C)c1CCCOc1cc(OCCCc2cn(CCOCCOCCOCCOCCNC(=O)C3CCC(CN4C(=O)C=CC4=O)CC3)nn2)cc(c1)C(O)=O |c:47,(9.58,-37.95,;8.12,-38.43,;7.64,-39.9,;6.1,-39.89,;5.63,-38.43,;4.16,-37.96,;6.87,-37.52,;6.87,-35.98,;5.53,-35.21,;5.53,-33.67,;6.87,-32.9,;6.87,-31.36,;8.2,-30.59,;8.2,-29.04,;9.53,-28.27,;10.87,-29.03,;12.2,-28.26,;13.53,-29.02,;14.86,-28.25,;16.28,-28.86,;17.3,-27.71,;18.83,-27.87,;19.73,-26.62,;21.27,-26.77,;22.17,-25.52,;23.7,-25.68,;24.6,-24.43,;26.13,-24.59,;27.03,-23.34,;28.56,-23.49,;29.46,-22.24,;31,-22.4,;31.9,-21.15,;33.43,-21.3,;34.33,-20.05,;35.86,-20.21,;36.76,-18.96,;36.13,-17.56,;38.29,-19.12,;38.92,-20.52,;40.44,-20.68,;41.35,-19.43,;42.88,-19.59,;43.51,-21,;45.02,-21.32,;46.16,-20.28,;45.18,-22.85,;43.77,-23.47,;42.74,-22.33,;41.21,-22.49,;40.72,-18.03,;39.18,-17.86,;16.53,-26.38,;15.02,-26.71,;6.86,-28.28,;5.54,-29.05,;5.53,-30.59,;4.2,-28.28,;4.2,-26.74,;2.86,-29.05,)|
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n/an/an/an/a 0.609n/an/an/an/a


TBA

Assay Description
Induction of stability of human recombinant interleukin 2 assessed as increase in mouse CTLL-2 cell proliferation measured after 48 hrs by WST-1 assa...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01426
BindingDB Entry DOI: 10.7270/Q20005XS
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM50598492
PNG
(CHEMBL5205694)
Show SMILES C[C@H]1CC(=O)c2ccc(Nc3cc4c(cnc(OC5CC5)c4cn3)[C@](C)(N)C3CC3)cc2C11CC1 |r|
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n/an/an/an/a 9.40n/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00172
BindingDB Entry DOI: 10.7270/Q29G5RT0
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161762
PNG
(US9682976, 200 | US9682976, 220)
Show SMILES CC(O)COc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C25H33F2N9O3/c1-14(37)13-39-21-9-17(26)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-18(27)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14?,15-,16+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161764
PNG
(US9682976, 202)
Show SMILES COCCOc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1cnnn1 |r|
Show InChI InChI=1S/C24H32FN9O2/c1-24(2)13-17(11-18-5-4-8-33(18)24)28-22-19(25)14-26-23(30-22)29-16-6-7-21(36-10-9-35-3)20(12-16)34-15-27-31-32-34/h6-7,12,14-15,17-18H,4-5,8-11,13H2,1-3H3,(H2,26,28,29,30)/t17-,18+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161765
PNG
(US9682976, 203)
Show SMILES CC1(COc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2-n2cnnn2)COC1 |r|
Show InChI InChI=1S/C26H34FN9O2/c1-25(2)11-18(9-19-5-4-8-35(19)25)30-23-20(27)12-28-24(32-23)31-17-6-7-22(38-15-26(3)13-37-14-26)21(10-17)36-16-29-33-34-36/h6-7,10,12,16,18-19H,4-5,8-9,11,13-15H2,1-3H3,(H2,28,30,31,32)/t18-,19+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161767
PNG
(US9682976, 205)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)-n2cnnn2)ncc1F |r|
Show InChI InChI=1S/C23H30FN9O2/c1-23(2)12-16(10-17-4-3-7-32(17)23)27-21-18(24)13-25-22(29-21)28-15-5-6-20(35-9-8-34)19(11-15)33-14-26-30-31-33/h5-6,11,13-14,16-17,34H,3-4,7-10,12H2,1-2H3,(H2,25,27,28,29)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161768
PNG
(US9682976, 206)
Show SMILES CC(O)COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1cnnn1 |r|
Show InChI InChI=1S/C24H32FN9O2/c1-15(35)13-36-21-7-6-16(10-20(21)34-14-27-31-32-34)29-23-26-12-19(25)22(30-23)28-17-9-18-5-4-8-33(18)24(2,3)11-17/h6-7,10,12,14-15,17-18,35H,4-5,8-9,11,13H2,1-3H3,(H2,26,28,29,30)/t15?,17-,18+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161769
PNG
(US9682976, 207)
Show SMILES COCCOCCOc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1cnnn1 |r|
Show InChI InChI=1S/C26H36FN9O3/c1-26(2)15-19(13-20-5-4-8-35(20)26)30-24-21(27)16-28-25(32-24)31-18-6-7-23(39-12-11-38-10-9-37-3)22(14-18)36-17-29-33-34-36/h6-7,14,16-17,19-20H,4-5,8-13,15H2,1-3H3,(H2,28,30,31,32)/t19-,20+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161747
PNG
(BDBM161772 | US9682976, 189 | US9682976, 219)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)C#N)ncc1F |r|
Show InChI InChI=1S/C23H29FN6O2/c1-23(2)12-17(11-18-4-3-7-30(18)23)27-21-19(24)14-26-22(29-21)28-16-5-6-20(32-9-8-31)15(10-16)13-25/h5-6,10,14,17-18,31H,3-4,7-9,11-12H2,1-2H3,(H2,26,27,28,29)/t17-,18+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161777
PNG
(US9682976, 215 | US9682976, 218 | US9682976, 224)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCCO)c(c2)-n2cnnn2)ncc1F |r|
Show InChI InChI=1S/C24H32FN9O2/c1-24(2)13-17(11-18-5-3-8-33(18)24)28-22-19(25)14-26-23(30-22)29-16-6-7-21(36-10-4-9-35)20(12-16)34-15-27-31-32-34/h6-7,12,14-15,17-18,35H,3-5,8-11,13H2,1-2H3,(H2,26,28,29,30)/t17-,18+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161777
PNG
(US9682976, 215 | US9682976, 218 | US9682976, 224)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCCO)c(c2)-n2cnnn2)ncc1F |r|
Show InChI InChI=1S/C24H32FN9O2/c1-24(2)13-17(11-18-5-3-8-33(18)24)28-22-19(25)14-26-23(30-22)29-16-6-7-21(36-10-4-9-35)20(12-16)34-15-27-31-32-34/h6-7,12,14-15,17-18,35H,3-5,8-11,13H2,1-2H3,(H2,26,28,29,30)/t17-,18+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161762
PNG
(US9682976, 200 | US9682976, 220)
Show SMILES CC(O)COc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C25H33F2N9O3/c1-14(37)13-39-21-9-17(26)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-18(27)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14?,15-,16+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161400
PNG
(US9682976, 186 | US9682976, 221 | US9682976, 77)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCO)c1=O |r|
Show InChI InChI=1S/C24H31F2N9O3/c1-24(2)12-14(9-15-5-4-6-34(15)24)28-21-17(26)13-27-22(30-21)29-18-11-19(35-23(37)33(3)31-32-35)20(10-16(18)25)38-8-7-36/h10-11,13-15,36H,4-9,12H2,1-3H3,(H2,27,28,29,30)/t14-,15+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161785
PNG
(US9682976, 223)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)-n2cnnn2)ncc1Cl |r|
Show InChI InChI=1S/C23H30ClN9O2/c1-23(2)12-16(10-17-4-3-7-32(17)23)27-21-18(24)13-25-22(29-21)28-15-5-6-20(35-9-8-34)19(11-15)33-14-26-30-31-33/h5-6,11,13-14,16-17,34H,3-4,7-10,12H2,1-2H3,(H2,25,27,28,29)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161777
PNG
(US9682976, 215 | US9682976, 218 | US9682976, 224)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCCO)c(c2)-n2cnnn2)ncc1F |r|
Show InChI InChI=1S/C24H32FN9O2/c1-24(2)13-17(11-18-5-3-8-33(18)24)28-22-19(25)14-26-23(30-22)29-16-6-7-21(36-10-4-9-35)20(12-16)34-15-27-31-32-34/h6-7,12,14-15,17-18,35H,3-5,8-11,13H2,1-2H3,(H2,26,28,29,30)/t17-,18+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161797
PNG
(US9682976, 235)
Show SMILES C[C@H](O)COc1cc(F)c(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C25H33ClFN9O3/c1-14(37)13-39-21-9-18(27)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-17(26)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14-,15+,16-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161798
PNG
(US9682976, 236)
Show SMILES CC(O)COc1cc(F)c(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C25H33ClFN9O3/c1-14(37)13-39-21-9-18(27)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-17(26)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14?,15-,16+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161799
PNG
(US9682976, 237)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(Cl)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCO)c1=O |r|
Show InChI InChI=1S/C24H31ClFN9O3/c1-24(2)12-14(9-15-5-4-6-34(15)24)28-21-16(25)13-27-22(30-21)29-18-11-19(35-23(37)33(3)31-32-35)20(10-17(18)26)38-8-7-36/h10-11,13-15,36H,4-9,12H2,1-3H3,(H2,27,28,29,30)/t14-,15+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM168227
PNG
(US9682976, 240)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(Cl)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(C)(C)O)c1=O |r|
Show InChI InChI=1S/C26H35ClFN9O3/c1-25(2)12-15(9-16-7-6-8-36(16)25)30-22-17(27)13-29-23(32-22)31-19-11-20(37-24(38)35(5)33-34-37)21(10-18(19)28)40-14-26(3,4)39/h10-11,13,15-16,39H,6-9,12,14H2,1-5H3,(H2,29,30,31,32)/t15-,16+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161805
PNG
(US9682976, 242)
Show SMILES COc1cc(cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c1F)-n1nnnc1C |r|
Show InChI InChI=1S/C23H29F2N9O/c1-13-30-31-32-34(13)16-9-18(20(25)19(10-16)35-4)28-22-26-12-17(24)21(29-22)27-14-8-15-6-5-7-33(15)23(2,3)11-14/h9-10,12,14-15H,5-8,11H2,1-4H3,(H2,26,27,28,29)/t14-,15+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161808
PNG
(US9682976, 249)
Show SMILES Cc1nnnn1-c1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c(F)cc1OC1COC1 |r|
Show InChI InChI=1S/C25H31F2N9O2/c1-14-32-33-34-36(14)21-9-20(18(26)8-22(21)38-17-12-37-13-17)30-24-28-11-19(27)23(31-24)29-15-7-16-5-4-6-35(16)25(2,3)10-15/h8-9,11,15-17H,4-7,10,12-13H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161818
PNG
(US9682976, 255)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(c(OC3COC3)cc2F)-n2nnnc2C2CC2)ncc1F |r|
Show InChI InChI=1S/C27H33F2N9O2/c1-27(2)11-16(8-17-4-3-7-37(17)27)31-24-20(29)12-30-26(33-24)32-21-10-22(38-25(15-5-6-15)34-35-36-38)23(9-19(21)28)40-18-13-39-14-18/h9-10,12,15-18H,3-8,11,13-14H2,1-2H3,(H2,30,31,32,33)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161824
PNG
(US9682976, 261)
Show SMILES CSc1nnnn1-c1cccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c1 |r|
Show InChI InChI=1S/C22H28FN9S/c1-22(2)12-15(11-16-8-5-9-31(16)22)25-19-18(23)13-24-20(27-19)26-14-6-4-7-17(10-14)32-21(33-3)28-29-30-32/h4,6-7,10,13,15-16H,5,8-9,11-12H2,1-3H3,(H2,24,25,26,27)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161825
PNG
(US9682976, 262)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2SC2COC2)ncc1F |r|
Show InChI InChI=1S/C24H30FN9OS/c1-24(2)11-16(10-17-7-4-8-33(17)24)27-21-20(25)12-26-22(29-21)28-15-5-3-6-18(9-15)34-23(30-31-32-34)36-19-13-35-14-19/h3,5-6,9,12,16-17,19H,4,7-8,10-11,13-14H2,1-2H3,(H2,26,27,28,29)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161829
PNG
(US9682976, 266 | US9682976, 271)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2SCCO)ncc1F |r|
Show InChI InChI=1S/C23H30FN9OS/c1-23(2)13-16(12-17-7-4-8-32(17)23)26-20-19(24)14-25-21(28-20)27-15-5-3-6-18(11-15)33-22(29-30-31-33)35-10-9-34/h3,5-6,11,14,16-17,34H,4,7-10,12-13H2,1-2H3,(H2,25,26,27,28)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161829
PNG
(US9682976, 266 | US9682976, 271)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2SCCO)ncc1F |r|
Show InChI InChI=1S/C23H30FN9OS/c1-23(2)13-16(12-17-7-4-8-32(17)23)26-20-19(24)14-25-21(28-20)27-15-5-3-6-18(11-15)33-22(29-30-31-33)35-10-9-34/h3,5-6,11,14,16-17,34H,4,7-10,12-13H2,1-2H3,(H2,25,26,27,28)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161837
PNG
(US9682976, 273 | US9682976, 274)
Show SMILES Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C23H30FN9O/c1-14-7-8-15(11-19(14)33-22(34)31(4)29-30-33)27-21-25-13-18(24)20(28-21)26-16-10-17-6-5-9-32(17)23(2,3)12-16/h7-8,11,13,16-17H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161837
PNG
(US9682976, 273 | US9682976, 274)
Show SMILES Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C23H30FN9O/c1-14-7-8-15(11-19(14)33-22(34)31(4)29-30-33)27-21-25-13-18(24)20(28-21)26-16-10-17-6-5-9-32(17)23(2,3)12-16/h7-8,11,13,16-17H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161842
PNG
(US9682976, 276)
Show SMILES Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C2COC2)c1=O |r|
Show InChI InChI=1S/C25H32FN9O2/c1-15-6-7-16(10-21(15)35-24(36)34(31-32-35)19-13-37-14-19)29-23-27-12-20(26)22(30-23)28-17-9-18-5-4-8-33(18)25(2,3)11-17/h6-7,10,12,17-19H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)/t17-,18+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161844
PNG
(US9682976, 278 | US9682976, 279)
Show SMILES COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C23H30FN9O2/c1-23(2)12-15(10-16-6-5-9-32(16)23)26-20-17(24)13-25-21(28-20)27-14-7-8-19(35-4)18(11-14)33-22(34)31(3)29-30-33/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161844
PNG
(US9682976, 278 | US9682976, 279)
Show SMILES COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C23H30FN9O2/c1-23(2)12-15(10-16-6-5-9-32(16)23)26-20-17(24)13-25-21(28-20)27-14-7-8-19(35-4)18(11-14)33-22(34)31(3)29-30-33/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161848
PNG
(US9682976, 281)
Show SMILES CSc1nnnn1-c1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)ccc1C |r|
Show InChI InChI=1S/C23H30FN9S/c1-14-7-8-15(11-19(14)33-22(34-4)29-30-31-33)27-21-25-13-18(24)20(28-21)26-16-10-17-6-5-9-32(17)23(2,3)12-16/h7-8,11,13,16-17H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161850
PNG
(US9682976, 282)
Show SMILES Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnnc1SCCO |r|
Show InChI InChI=1S/C24H32FN9OS/c1-15-6-7-16(12-20(15)34-23(30-31-32-34)36-10-9-35)28-22-26-14-19(25)21(29-22)27-17-11-18-5-4-8-33(18)24(2,3)13-17/h6-7,12,14,17-18,35H,4-5,8-11,13H2,1-3H3,(H2,26,27,28,29)/t17-,18+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161852
PNG
(US9682976, 284)
Show SMILES COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnnc1OC1COC1 |r|
Show InChI InChI=1S/C25H32FN9O3/c1-25(2)11-16(9-17-5-4-8-34(17)25)28-22-19(26)12-27-23(30-22)29-15-6-7-21(36-3)20(10-15)35-24(31-32-33-35)38-18-13-37-14-18/h6-7,10,12,16-18H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161857
PNG
(US9682976, 289)
Show SMILES Cc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(CC(C)(C)O)c1=O |r|
Show InChI InChI=1S/C26H36FN9O2/c1-16-8-9-17(12-21(16)36-24(37)35(32-33-36)15-26(4,5)38)30-23-28-14-20(27)22(31-23)29-18-11-19-7-6-10-34(19)25(2,3)13-18/h8-9,12,14,18-19,38H,6-7,10-11,13,15H2,1-5H3,(H2,28,29,30,31)/t18-,19+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161873
PNG
(US9682976, 301)
Show SMILES CC1(C)CC[C@H]2C[C@H](CCN12)Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2nnnc2C2COC2)ncc1F |r|
Show InChI InChI=1S/C27H33F2N9O/c1-27(2)7-5-18-9-17(6-8-37(18)27)31-24-21(29)12-30-26(33-24)32-22-11-23(19(10-20(22)28)15-3-4-15)38-25(34-35-36-38)16-13-39-14-16/h10-12,15-18H,3-9,13-14H2,1-2H3,(H2,30,31,32,33)/t17-,18-/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161897
PNG
(US9682976, 316 | US9682976, 317)
Show SMILES COCC1(COC)Oc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2-n2nnnc12 |r|
Show InChI InChI=1S/C26H34FN9O3/c1-25(2)12-17(10-18-6-5-9-35(18)25)29-22-19(27)13-28-24(31-22)30-16-7-8-21-20(11-16)36-23(32-33-34-36)26(39-21,14-37-3)15-38-4/h7-8,11,13,17-18H,5-6,9-10,12,14-15H2,1-4H3,(H2,28,29,30,31)/t17-,18+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161897
PNG
(US9682976, 316 | US9682976, 317)
Show SMILES COCC1(COC)Oc2ccc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)cc2-n2nnnc12 |r|
Show InChI InChI=1S/C26H34FN9O3/c1-25(2)12-17(10-18-6-5-9-35(18)25)29-22-19(27)13-28-24(31-22)30-16-7-8-21-20(11-16)36-23(32-33-34-36)26(39-21,14-37-3)15-38-4/h7-8,11,13,17-18H,5-6,9-10,12,14-15H2,1-4H3,(H2,28,29,30,31)/t17-,18+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM160830
PNG
(US9682976, 2)
Show SMILES CC1(C)C[C@@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F |r|
Show InChI InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16-/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM160843
PNG
(US9682976, 13)
Show SMILES COc1cc(Nc2ncc(F)c(N[C@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C |r|
Show InChI InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17-/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM160845
PNG
(US9682976, 14)
Show SMILES COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C |r|
Show InChI InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM160848
PNG
(US9682976, 16)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161048
PNG
(US9682976, 17)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4C[C@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O |r|
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m0/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161069
PNG
(US9682976, 23)
Show SMILES CC(C)Oc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C25H33F2N9O2/c1-14(2)38-21-10-17(26)19(11-20(21)36-24(37)34(5)32-33-36)30-23-28-13-18(27)22(31-23)29-15-9-16-7-6-8-35(16)25(3,4)12-15/h10-11,13-16H,6-9,12H2,1-5H3,(H2,28,29,30,31)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161074
PNG
(US9682976, 28)
Show SMILES Cc1nnnn1-c1cc(Nc2ncc(F)c(NC3CCN4CCCC4C3)n2)c(F)cc1C1CC1
Show InChI InChI=1S/C23H27F2N9/c1-13-30-31-32-34(13)21-11-20(18(24)10-17(21)14-4-5-14)28-23-26-12-19(25)22(29-23)27-15-6-8-33-7-2-3-16(33)9-15/h10-12,14-16H,2-9H2,1H3,(H2,26,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161100
PNG
(US9682976, 40)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCCN5C(C)(C)C4)n3)ccc2OC2COC2)c1=O
Show InChI InChI=1S/C25H32FN9O3/c1-25(2)11-16(9-17-5-4-8-34(17)25)28-22-19(26)12-27-23(30-22)29-15-6-7-21(38-18-13-37-14-18)20(10-15)35-24(36)33(3)31-32-35/h6-7,10,12,16-18H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161161
PNG
(US9682976, 47 | US9682976, 50)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2O[C@H]2CCOC2)c1=O |r|
Show InChI InChI=1S/C26H34FN9O3/c1-26(2)13-17(11-18-5-4-9-35(18)26)29-23-20(27)14-28-24(31-23)30-16-6-7-22(39-19-8-10-38-15-19)21(12-16)36-25(37)34(3)32-33-36/h6-7,12,14,17-19H,4-5,8-11,13,15H2,1-3H3,(H2,28,29,30,31)/t17-,18+,19+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161162
PNG
(US9682976, 48)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2O[C@@H]2CCOC2)c1=O |r|
Show InChI InChI=1S/C26H34FN9O3/c1-26(2)13-17(11-18-5-4-9-35(18)26)29-23-20(27)14-28-24(31-23)30-16-6-7-22(39-19-8-10-38-15-19)21(12-16)36-25(37)34(3)32-33-36/h6-7,12,14,17-19H,4-5,8-11,13,15H2,1-3H3,(H2,28,29,30,31)/t17-,18+,19-/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161163
PNG
(US9682976, 49)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCCN5C(C)(C)C4)n3)ccc2O[C@@H]2CCOC2)c1=O |r|
Show InChI InChI=1S/C26H34FN9O3/c1-26(2)13-17(11-18-5-4-9-35(18)26)29-23-20(27)14-28-24(31-23)30-16-6-7-22(39-19-8-10-38-15-19)21(12-16)36-25(37)34(3)32-33-36/h6-7,12,14,17-19H,4-5,8-11,13,15H2,1-3H3,(H2,28,29,30,31)/t17?,18?,19-/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161161
PNG
(US9682976, 47 | US9682976, 50)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2O[C@H]2CCOC2)c1=O |r|
Show InChI InChI=1S/C26H34FN9O3/c1-26(2)13-17(11-18-5-4-9-35(18)26)29-23-20(27)14-28-24(31-23)30-16-6-7-22(39-19-8-10-38-15-19)21(12-16)36-25(37)34(3)32-33-36/h6-7,12,14,17-19H,4-5,8-11,13,15H2,1-3H3,(H2,28,29,30,31)/t17-,18+,19+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
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