Found 376 hits of ic50 data for polymerid = 50000420 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50111856
(CHEMBL21249 | {(R)-2-Amino-4-[benzo[1,3]dioxol-5-y...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@@H](C(=O)NO)C(=O)C(N)CNC(=O)OCC1c2ccccc2-c2ccccc12 Show InChI InChI=1S/C35H34N4O10S/c1-46-22-11-13-23(14-12-22)50(44,45)39(18-21-10-15-30-31(16-21)49-20-48-30)32(34(41)38-43)33(40)29(36)17-37-35(42)47-19-28-26-8-4-2-6-24(26)25-7-3-5-9-27(25)28/h2-16,28-29,32,43H,17-20,36H2,1H3,(H,37,42)(H,38,41)/t29?,32-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP) |
Bioorg Med Chem Lett 12: 1233-5 (2002)
BindingDB Entry DOI: 10.7270/Q29C6WR3 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50111848
((R)-2-[Benzo[1,3]dioxol-5-ylmethyl-(4-methoxy-benz...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](Cc1cccs1)C(=O)NO Show InChI InChI=1S/C22H22N2O7S2/c1-29-16-5-7-18(8-6-16)33(27,28)24(13-15-4-9-20-21(11-15)31-14-30-20)19(22(25)23-26)12-17-3-2-10-32-17/h2-11,19,26H,12-14H2,1H3,(H,23,25)/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP) |
Bioorg Med Chem Lett 12: 1233-5 (2002)
BindingDB Entry DOI: 10.7270/Q29C6WR3 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50111848
((R)-2-[Benzo[1,3]dioxol-5-ylmethyl-(4-methoxy-benz...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](Cc1cccs1)C(=O)NO Show InChI InChI=1S/C22H22N2O7S2/c1-29-16-5-7-18(8-6-16)33(27,28)24(13-15-4-9-20-21(11-15)31-14-30-20)19(22(25)23-26)12-17-3-2-10-32-17/h2-11,19,26H,12-14H2,1H3,(H,23,25)/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP) |
Bioorg Med Chem Lett 12: 1233-5 (2002)
BindingDB Entry DOI: 10.7270/Q29C6WR3 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50458764
(CHEMBL4209125)Show SMILES CCCCC[C@H]([C@@H](CC)N(O)C=O)C(=O)NCNC(=O)c1ccc(o1)-c1ccc(C(O)=O)c(OCC)c1 |r| Show InChI InChI=1S/C26H35N3O8/c1-4-7-8-9-18(20(5-2)29(35)16-30)24(31)27-15-28-25(32)22-13-12-21(37-22)17-10-11-19(26(33)34)23(14-17)36-6-3/h10-14,16,18,20,35H,4-9,15H2,1-3H3,(H,27,31)(H,28,32)(H,33,34)/t18-,20-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal 6His/flag-tagged BMP1 (121 to 721 residues) expressed in CHO cells using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5... |
ACS Med Chem Lett 9: 736-740 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00173
BindingDB Entry DOI: 10.7270/Q2X35127 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50458765
(CHEMBL4205697)Show SMILES CCCCC[C@H]([C@@H](CC)N(O)C=O)C(=O)NCNC(=O)c1ccc(o1)-c1ccc(c(OCC)c1)P(O)(O)=O |r| Show InChI InChI=1S/C25H36N3O9P/c1-4-7-8-9-18(19(5-2)28(32)16-29)24(30)26-15-27-25(31)21-12-11-20(37-21)17-10-13-23(38(33,34)35)22(14-17)36-6-3/h10-14,16,18-19,32H,4-9,15H2,1-3H3,(H,26,30)(H,27,31)(H2,33,34,35)/t18-,19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal 6His/flag-tagged BMP1 (121 to 721 residues) expressed in CHO cells using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5... |
ACS Med Chem Lett 9: 736-740 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00173
BindingDB Entry DOI: 10.7270/Q2X35127 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50458766
(CHEMBL4212386)Show SMILES CCCCC[C@H]([C@@H](CC)N(O)C=O)C(=O)NCNC(=O)c1ccc(o1)-c1ccc(C(=O)N[C@@H](CC(O)=O)C(O)=O)c(OCC)c1 |r| Show InChI InChI=1S/C30H40N4O11/c1-4-7-8-9-19(22(5-2)34(43)17-35)27(38)31-16-32-29(40)24-13-12-23(45-24)18-10-11-20(25(14-18)44-6-3)28(39)33-21(30(41)42)15-26(36)37/h10-14,17,19,21-22,43H,4-9,15-16H2,1-3H3,(H,31,38)(H,32,40)(H,33,39)(H,36,37)(H,41,42)/t19-,21+,22-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal 6His/flag-tagged BMP1 (121 to 721 residues) expressed in CHO cells using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5... |
ACS Med Chem Lett 9: 736-740 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00173
BindingDB Entry DOI: 10.7270/Q2X35127 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50458771
(CHEMBL4214046)Show SMILES CCCCC[C@H]([C@@H](CC)N(O)C=O)C(=O)NCNC(=O)c1ccc(o1)-c1cc(OCC)cc(c1)P(O)(O)=O |r| Show InChI InChI=1S/C25H36N3O9P/c1-4-7-8-9-20(21(5-2)28(32)16-29)24(30)26-15-27-25(31)23-11-10-22(37-23)17-12-18(36-6-3)14-19(13-17)38(33,34)35/h10-14,16,20-21,32H,4-9,15H2,1-3H3,(H,26,30)(H,27,31)(H2,33,34,35)/t20-,21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal 6His/flag-tagged BMP1 (121 to 721 residues) expressed in CHO cells using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5... |
ACS Med Chem Lett 9: 736-740 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00173
BindingDB Entry DOI: 10.7270/Q2X35127 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50458773
(CHEMBL4204567)Show SMILES CCCCC[C@H](CN(O)C=O)C(=O)NCNC(=O)c1ccc(o1)-c1cccc(OCC)c1 |r| Show InChI InChI=1S/C23H31N3O6/c1-3-5-6-8-18(14-26(30)16-27)22(28)24-15-25-23(29)21-12-11-20(32-21)17-9-7-10-19(13-17)31-4-2/h7,9-13,16,18,30H,3-6,8,14-15H2,1-2H3,(H,24,28)(H,25,29)/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal 6His/flag-tagged BMP1 (121 to 721 residues) expressed in CHO cells using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5... |
ACS Med Chem Lett 9: 736-740 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00173
BindingDB Entry DOI: 10.7270/Q2X35127 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50458774
(CHEMBL4202714)Show SMILES CCCCC[C@H](CN(O)C=O)C(=O)NCNC(=O)c1ccc(o1)-c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C22H27N3O7/c1-2-3-4-5-17(12-25(31)14-26)20(27)23-13-24-21(28)19-11-10-18(32-19)15-6-8-16(9-7-15)22(29)30/h6-11,14,17,31H,2-5,12-13H2,1H3,(H,23,27)(H,24,28)(H,29,30)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal 6His/flag-tagged BMP1 (121 to 721 residues) expressed in CHO cells using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5... |
ACS Med Chem Lett 9: 736-740 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00173
BindingDB Entry DOI: 10.7270/Q2X35127 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50458775
(CHEMBL4218415)Show SMILES CCCCC[C@H]([C@@H](CC)N(O)C=O)C(=O)NCNC(=O)c1ccc(o1)-c1cc(OCC)cc(c1)C(=O)N[C@@H](CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C30H40N4O11/c1-4-7-8-9-21(23(5-2)34(43)17-35)28(39)31-16-32-29(40)25-11-10-24(45-25)18-12-19(14-20(13-18)44-6-3)27(38)33-22(30(41)42)15-26(36)37/h10-14,17,21-23,43H,4-9,15-16H2,1-3H3,(H,31,39)(H,32,40)(H,33,38)(H,36,37)(H,41,42)/t21-,22+,23-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s... |
ACS Med Chem Lett 9: 736-740 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00173
BindingDB Entry DOI: 10.7270/Q2X35127 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50458763
(CHEMBL4202848)Show SMILES CCCCC[C@H]([C@@H](CC)N(O)C=O)C(=O)NCNC(=O)c1ccc(o1)-c1cc(OCC)cc(c1)C(O)=O |r| Show InChI InChI=1S/C26H35N3O8/c1-4-7-8-9-20(21(5-2)29(35)16-30)24(31)27-15-28-25(32)23-11-10-22(37-23)17-12-18(26(33)34)14-19(13-17)36-6-3/h10-14,16,20-21,35H,4-9,15H2,1-3H3,(H,27,31)(H,28,32)(H,33,34)/t20-,21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal 6His/flag-tagged BMP1 (121 to 721 residues) expressed in CHO cells using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5... |
ACS Med Chem Lett 9: 736-740 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00173
BindingDB Entry DOI: 10.7270/Q2X35127 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216807
((3R)-6-cyclohexyl-3-[3-({[(3,4-dimethoxyphenyl)sul...)Show SMILES COc1ccc(cc1OC)S(=O)(=O)NC(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO Show InChI InChI=1S/C23H32N4O8S/c1-33-18-12-11-17(14-19(18)34-2)36(31,32)27-22(29)21-24-23(35-26-21)16(13-20(28)25-30)10-6-9-15-7-4-3-5-8-15/h11-12,14-16,30H,3-10,13H2,1-2H3,(H,25,28)(H,27,29)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216831
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(4-pyridinyl)-1,2...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1ccncc1 Show InChI InChI=1S/C19H26N4O3/c24-17(22-25)13-16(8-4-7-14-5-2-1-3-6-14)19-21-18(23-26-19)15-9-11-20-12-10-15/h9-12,14,16,25H,1-8,13H2,(H,22,24)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216824
((3R)-6-cyclohexyl-N-hydroxy-3-(3-{4-[(methylsulfon...)Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO Show InChI InChI=1S/C21H30N4O5S/c1-31(28,29)25-18-12-10-16(11-13-18)20-22-21(30-24-20)17(14-19(26)23-27)9-5-8-15-6-3-2-4-7-15/h10-13,15,17,25,27H,2-9,14H2,1H3,(H,23,26)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216838
((3R)-6-cyclohexyl-N-hydroxy-3-{3-[1-(methylsulfony...)Show SMILES CS(=O)(=O)N1CCC(CC1)NCc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO Show InChI InChI=1S/C21H37N5O5S/c1-32(29,30)26-12-10-18(11-13-26)22-15-19-23-21(31-25-19)17(14-20(27)24-28)9-5-8-16-6-3-2-4-7-16/h16-18,22,28H,2-15H2,1H3,(H,24,27)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216796
((3R)-3-(3-{[acetyl(methyl)amino]methyl}-1,2,4-oxad...)Show SMILES CN(Cc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO)C(C)=O Show InChI InChI=1S/C18H30N4O4/c1-13(23)22(2)12-16-19-18(26-21-16)15(11-17(24)20-25)10-6-9-14-7-4-3-5-8-14/h14-15,25H,3-12H2,1-2H3,(H,20,24)/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50102948
(CHEMBL279023 | {(R)-4-[Benzo[1,3]dioxol-5-ylmethyl...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CCCNC(=O)OCc1ccccc1Cl)C(=O)NO Show InChI InChI=1S/C28H30ClN3O9S/c1-38-21-9-11-22(12-10-21)42(36,37)32(16-19-8-13-25-26(15-19)41-18-40-25)24(27(33)31-35)7-4-14-30-28(34)39-17-20-5-2-3-6-23(20)29/h2-3,5-6,8-13,15,24,35H,4,7,14,16-18H2,1H3,(H,30,34)(H,31,33)/t24-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP) |
Bioorg Med Chem Lett 12: 1233-5 (2002)
BindingDB Entry DOI: 10.7270/Q29C6WR3 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50102948
(CHEMBL279023 | {(R)-4-[Benzo[1,3]dioxol-5-ylmethyl...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CCCNC(=O)OCc1ccccc1Cl)C(=O)NO Show InChI InChI=1S/C28H30ClN3O9S/c1-38-21-9-11-22(12-10-21)42(36,37)32(16-19-8-13-25-26(15-19)41-18-40-25)24(27(33)31-35)7-4-14-30-28(34)39-17-20-5-2-3-6-23(20)29/h2-3,5-6,8-13,15,24,35H,4,7,14,16-18H2,1H3,(H,30,34)(H,31,33)/t24-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against procollagen C-Proteinase (PCP). |
Bioorg Med Chem Lett 11: 2085-8 (2001)
BindingDB Entry DOI: 10.7270/Q24X589D |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50111808
(CHEMBL282484 | {(R)-2-Amino-4-[benzo[1,3]dioxol-5-...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@@H](C(=O)NO)C(=O)C(N)CNC(=O)OCc1ccccc1Cl Show InChI InChI=1S/C28H29ClN4O10S/c1-40-19-7-9-20(10-8-19)44(38,39)33(14-17-6-11-23-24(12-17)43-16-42-23)25(27(35)32-37)26(34)22(30)13-31-28(36)41-15-18-4-2-3-5-21(18)29/h2-12,22,25,37H,13-16,30H2,1H3,(H,31,36)(H,32,35)/t22?,25-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP) |
Bioorg Med Chem Lett 12: 1233-5 (2002)
BindingDB Entry DOI: 10.7270/Q29C6WR3 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216841
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(4-morpholinylmet...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CN2CCOCC2)no1 Show InChI InChI=1S/C19H32N4O4/c24-18(21-25)13-16(8-4-7-15-5-2-1-3-6-15)19-20-17(22-27-19)14-23-9-11-26-12-10-23/h15-16,25H,1-14H2,(H,21,24)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216823
(2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C20H26N4O5/c25-17(23-28)12-14(8-4-7-13-5-2-1-3-6-13)19-22-18(24-29-19)16-11-15(20(26)27)9-10-21-16/h9-11,13-14,28H,1-8,12H2,(H,23,25)(H,26,27)/t14-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216833
((3R)-6-cyclohexyl-3-{3-[(cyclopropylamino)methyl]-...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CNC2CC2)no1 Show InChI InChI=1S/C18H30N4O3/c23-17(21-24)11-14(8-4-7-13-5-2-1-3-6-13)18-20-16(22-25-18)12-19-15-9-10-15/h13-15,19,24H,1-12H2,(H,21,23)/t14-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216830
((3R)-3-{3-[(cyclobutylamino)methyl]-1,2,4-oxadiazo...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CNC2CCC2)no1 Show InChI InChI=1S/C19H32N4O3/c24-18(22-25)12-15(9-4-8-14-6-2-1-3-7-14)19-21-17(23-26-19)13-20-16-10-5-11-16/h14-16,20,25H,1-13H2,(H,22,24)/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50111840
((R)-N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-(2-tr...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1C(F)(F)F)[C@H](C)C(=O)NO Show InChI InChI=1S/C18H19F3N2O5S/c1-12(17(24)22-25)23(11-13-5-3-4-6-16(13)18(19,20)21)29(26,27)15-9-7-14(28-2)8-10-15/h3-10,12,25H,11H2,1-2H3,(H,22,24)/t12-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP) |
Bioorg Med Chem Lett 12: 1233-5 (2002)
BindingDB Entry DOI: 10.7270/Q29C6WR3 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216843
(3-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cccc(c1)C(O)=O Show InChI InChI=1S/C21H27N3O5/c25-18(23-28)13-16(10-4-8-14-6-2-1-3-7-14)20-22-19(24-29-20)15-9-5-11-17(12-15)21(26)27/h5,9,11-12,14,16,28H,1-4,6-8,10,13H2,(H,23,25)(H,26,27)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216848
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(3-pyridinylmethy...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(Cc2cccnc2)no1 Show InChI InChI=1S/C20H28N4O3/c25-19(23-26)13-17(10-4-8-15-6-2-1-3-7-15)20-22-18(24-27-20)12-16-9-5-11-21-14-16/h5,9,11,14-15,17,26H,1-4,6-8,10,12-13H2,(H,23,25)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216842
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(2-pyridinylmethy...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(Cc2ccccn2)no1 Show InChI InChI=1S/C20H28N4O3/c25-19(23-26)13-16(10-6-9-15-7-2-1-3-8-15)20-22-18(24-27-20)14-17-11-4-5-12-21-17/h4-5,11-12,15-16,26H,1-3,6-10,13-14H2,(H,23,25)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216817
((3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(phenylsulfonyl...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)C(=O)NS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C21H28N4O6S/c26-18(23-28)14-16(11-7-10-15-8-3-1-4-9-15)21-22-19(24-31-21)20(27)25-32(29,30)17-12-5-2-6-13-17/h2,5-6,12-13,15-16,28H,1,3-4,7-11,14H2,(H,23,26)(H,25,27)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50458758
(CHEMBL4207907)Show SMILES CCCCC[C@H](CN(O)C=O)C(=O)NCNC(=O)c1ccc(o1)-c1cccc(c1)C(O)=O |r| Show InChI InChI=1S/C22H27N3O7/c1-2-3-4-6-17(12-25(31)14-26)20(27)23-13-24-21(28)19-10-9-18(32-19)15-7-5-8-16(11-15)22(29)30/h5,7-11,14,17,31H,2-4,6,12-13H2,1H3,(H,23,27)(H,24,28)(H,29,30)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal 6His/flag-tagged BMP1 (121 to 721 residues) expressed in CHO cells using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5... |
ACS Med Chem Lett 9: 736-740 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00173
BindingDB Entry DOI: 10.7270/Q2X35127 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216829
((3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(2-hydroxy-1,1-...)Show SMILES CC(C)(CO)NCc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO Show InChI InChI=1S/C19H34N4O4/c1-19(2,13-24)20-12-16-21-18(27-23-16)15(11-17(25)22-26)10-6-9-14-7-4-3-5-8-14/h14-15,20,24,26H,3-13H2,1-2H3,(H,22,25)/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216813
((3R)-6-cyclohexyl-N-hydroxy-3-{3-[6-(4-methyl-1-pi...)Show SMILES CN1CCNC(C1)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO Show InChI InChI=1S/C19H33N5O3/c1-24-11-10-20-16(13-24)18-21-19(27-23-18)15(12-17(25)22-26)9-5-8-14-6-3-2-4-7-14/h14-16,20,26H,2-13H2,1H3,(H,22,25)/t15-,16?/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50102988
(CHEMBL21486 | {(R)-4-[Benzo[1,3]dioxol-5-ylmethyl-...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CCCNC(=O)OCc1ccccc1)C(=O)NO Show InChI InChI=1S/C28H31N3O9S/c1-37-22-10-12-23(13-11-22)41(35,36)31(17-21-9-14-25-26(16-21)40-19-39-25)24(27(32)30-34)8-5-15-29-28(33)38-18-20-6-3-2-4-7-20/h2-4,6-7,9-14,16,24,34H,5,8,15,17-19H2,1H3,(H,29,33)(H,30,32)/t24-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against procollagen C-Proteinase (PCP). |
Bioorg Med Chem Lett 11: 2085-8 (2001)
BindingDB Entry DOI: 10.7270/Q24X589D |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50102988
(CHEMBL21486 | {(R)-4-[Benzo[1,3]dioxol-5-ylmethyl-...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CCCNC(=O)OCc1ccccc1)C(=O)NO Show InChI InChI=1S/C28H31N3O9S/c1-37-22-10-12-23(13-11-22)41(35,36)31(17-21-9-14-25-26(16-21)40-19-39-25)24(27(32)30-34)8-5-15-29-28(33)38-18-20-6-3-2-4-7-20/h2-4,6-7,9-14,16,24,34H,5,8,15,17-19H2,1H3,(H,29,33)(H,30,32)/t24-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP) |
Bioorg Med Chem Lett 12: 1233-5 (2002)
BindingDB Entry DOI: 10.7270/Q29C6WR3 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50241177
((R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-...)Show SMILES CN(C)C(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO |r| Show InChI InChI=1S/C17H28N4O4/c1-21(2)17(23)15-18-16(25-20-15)13(11-14(22)19-24)10-6-9-12-7-4-3-5-8-12/h12-13,24H,3-11H2,1-2H3,(H,19,22)/t13-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase assessed as [3H]procollagen turnover by scintillation counting |
Bioorg Med Chem Lett 18: 6562-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.036
BindingDB Entry DOI: 10.7270/Q2J1031M |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50402510
(CHEMBL2204087)Show SMILES COc1ccc(CCN(CCC(=O)NO)S(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1 Show InChI InChI=1S/C26H30N4O6S/c1-36-23-11-7-20(8-12-23)15-17-30(18-16-25(31)29-33)37(34,35)24-13-9-22(10-14-24)28-26(32)27-19-21-5-3-2-4-6-21/h2-14,33H,15-19H2,1H3,(H,29,31)(H2,27,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
FibroGen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PCP after 1 hr by fluorescence assay |
Bioorg Med Chem Lett 22: 7397-401 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.067
BindingDB Entry DOI: 10.7270/Q22808SM |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216790
((3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahyd...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1c[nH]c(=O)[nH]c1=O Show InChI InChI=1S/C18H25N5O5/c24-14(22-27)9-12(8-4-7-11-5-2-1-3-6-11)17-20-15(23-28-17)13-10-19-18(26)21-16(13)25/h10-12,27H,1-9H2,(H,22,24)(H2,19,21,25,26)/t12-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50111842
((R)-2-[Benzo[1,3]dioxol-5-ylmethyl-(4-methoxy-benz...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CC#C)C(O)=O Show InChI InChI=1S/C20H19NO7S/c1-3-4-17(20(22)23)21(12-14-5-10-18-19(11-14)28-13-27-18)29(24,25)16-8-6-15(26-2)7-9-16/h1,5-11,17H,4,12-13H2,2H3,(H,22,23)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against procollagen C-proteinase (PCP). |
Bioorg Med Chem Lett 12: 1233-5 (2002)
BindingDB Entry DOI: 10.7270/Q29C6WR3 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50241177
((R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-...)Show SMILES CN(C)C(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO |r| Show InChI InChI=1S/C17H28N4O4/c1-21(2)17(23)15-18-16(25-20-15)13(11-14(22)19-24)10-6-9-12-7-4-3-5-8-12/h12-13,24H,3-11H2,1-2H3,(H,19,22)/t13-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells by fluorescence assay |
Bioorg Med Chem Lett 18: 6562-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.036
BindingDB Entry DOI: 10.7270/Q2J1031M |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216855
((3R)-3-{3-[(tert-butylamino)methyl]-1,2,4-oxadiazo...)Show SMILES CC(C)(C)NCc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO Show InChI InChI=1S/C19H34N4O3/c1-19(2,3)20-13-16-21-18(26-23-16)15(12-17(24)22-25)11-7-10-14-8-5-4-6-9-14/h14-15,20,25H,4-13H2,1-3H3,(H,22,24)/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216802
((3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl...)Show SMILES CS(=O)(=O)NCc1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO |r| Show InChI InChI=1S/C16H28N4O5S/c1-26(23,24)17-11-14-18-16(25-20-14)13(10-15(21)19-22)9-5-8-12-6-3-2-4-7-12/h12-13,17,22H,2-11H2,1H3,(H,19,21)/t13-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216836
((3R)-6-cyclohexyl-N-hydroxy-3-{3-[(4-hydroxy-1-pip...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CN2CCC(O)CC2)no1 Show InChI InChI=1S/C20H34N4O4/c25-17-9-11-24(12-10-17)14-18-21-20(28-23-18)16(13-19(26)22-27)8-4-7-15-5-2-1-3-6-15/h15-17,25,27H,1-14H2,(H,22,26)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216801
((3R)-6-cyclohexyl-N-hydroxy-3-{3-[6-(methylamino)-...)Show SMILES CNc1ccc(cn1)-c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO Show InChI InChI=1S/C20H29N5O3/c1-21-17-11-10-16(13-22-17)19-23-20(28-25-19)15(12-18(26)24-27)9-5-8-14-6-3-2-4-7-14/h10-11,13-15,27H,2-9,12H2,1H3,(H,21,22)(H,24,26)/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216812
((3R)-6-cyclohexyl-N-hydroxy-3-[3-({[(4-methylpheny...)Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO Show InChI InChI=1S/C22H30N4O6S/c1-15-10-12-18(13-11-15)33(30,31)26-21(28)20-23-22(32-25-20)17(14-19(27)24-29)9-5-8-16-6-3-2-4-7-16/h10-13,16-17,29H,2-9,14H2,1H3,(H,24,27)(H,26,28)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50111854
(CHEMBL21237 | {(R)-2-Amino-4-[benzo[1,3]dioxol-5-y...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@@H](C(=O)NO)C(=O)C(N)CNC(=O)OCc1ccccc1 Show InChI InChI=1S/C28H30N4O10S/c1-39-20-8-10-21(11-9-20)43(37,38)32(15-19-7-12-23-24(13-19)42-17-41-23)25(27(34)31-36)26(33)22(29)14-30-28(35)40-16-18-5-3-2-4-6-18/h2-13,22,25,36H,14-17,29H2,1H3,(H,30,35)(H,31,34)/t22?,25-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP) |
Bioorg Med Chem Lett 12: 1233-5 (2002)
BindingDB Entry DOI: 10.7270/Q29C6WR3 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216809
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(5-pyrimidinyl)-1...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cncnc1 Show InChI InChI=1S/C18H25N5O3/c24-16(22-25)9-14(8-4-7-13-5-2-1-3-6-13)18-21-17(23-26-18)15-10-19-12-20-11-15/h10-14,25H,1-9H2,(H,22,24)/t14-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216808
((3R)-6-cyclohexyl-N-hydroxy-3-[3-(2-pyrazinyl)-1,2...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cnccn1 Show InChI InChI=1S/C18H25N5O3/c24-16(22-25)11-14(8-4-7-13-5-2-1-3-6-13)18-21-17(23-26-18)15-12-19-9-10-20-15/h9-10,12-14,25H,1-8,11H2,(H,22,24)/t14-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216805
((3R)-6-cyclohexyl-3-[3-(1,1-dioxido-2-isothiazolid...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(CN2CCCS2(=O)=O)no1 Show InChI InChI=1S/C18H30N4O5S/c23-17(20-24)12-15(9-4-8-14-6-2-1-3-7-14)18-19-16(21-27-18)13-22-10-5-11-28(22,25)26/h14-15,24H,1-13H2,(H,20,23)/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50111861
(CHEMBL281582 | {(R)-5-[Benzo[1,3]dioxol-5-ylmethyl...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CCCCNC(=O)OCc1ccccc1)C(=O)NO Show InChI InChI=1S/C29H33N3O9S/c1-38-23-11-13-24(14-12-23)42(36,37)32(18-22-10-15-26-27(17-22)41-20-40-26)25(28(33)31-35)9-5-6-16-30-29(34)39-19-21-7-3-2-4-8-21/h2-4,7-8,10-15,17,25,35H,5-6,9,16,18-20H2,1H3,(H,30,34)(H,31,33)/t25-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by ChEMBL
| Assay Description
Inhibitory activity against Procollagen C-Proteinase (PCP) |
Bioorg Med Chem Lett 12: 1233-5 (2002)
BindingDB Entry DOI: 10.7270/Q29C6WR3 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216811
((3R)-6-cyclohexyl-N-hydroxy-3-[3-({[(4-methoxyphen...)Show SMILES COc1ccc(cc1)S(=O)(=O)NC(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO Show InChI InChI=1S/C22H30N4O7S/c1-32-17-10-12-18(13-11-17)34(30,31)26-21(28)20-23-22(33-25-20)16(14-19(27)24-29)9-5-8-15-6-3-2-4-7-15/h10-13,15-16,29H,2-9,14H2,1H3,(H,24,27)(H,26,28)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216834
(2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...)Show SMILES NC(=O)c1ccnc(c1)-c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO Show InChI InChI=1S/C20H27N5O4/c21-18(27)14-9-10-22-16(11-14)19-23-20(29-25-19)15(12-17(26)24-28)8-4-7-13-5-2-1-3-6-13/h9-11,13,15,28H,1-8,12H2,(H2,21,27)(H,24,26)/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
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