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Compile Data Set for Download or QSAR

Found 193 hits for UniProtKB: O43526   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395464
PNG
(CHEMBL2164048)
Show SMILES CC[C@H](C(=O)Nc1ccccc1N1CCCC1)c1ccccc1 |r|
Show InChI InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)/t17-/m0/s1
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395501
PNG
(CHEMBL2163658)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1cccc(OC)c1
Show InChI InChI=1S/C21H26N2O2/c1-3-18(16-9-8-10-17(15-16)25-2)21(24)22-19-11-4-5-12-20(19)23-13-6-7-14-23/h4-5,8-12,15,18H,3,6-7,13-14H2,1-2H3,(H,22,24)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2/Kv7.3


(Homo sapiens (Human))
BDBM50395464
PNG
(CHEMBL2164048)
Show SMILES CC[C@H](C(=O)Nc1ccccc1N1CCCC1)c1ccccc1 |r|
Show InChI InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)/t17-/m0/s1
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2/Q3 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395505
PNG
(CHEMBL2164068)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(F)cc1
Show InChI InChI=1S/C20H23FN2O/c1-2-17(15-9-11-16(21)12-10-15)20(24)22-18-7-3-4-8-19(18)23-13-5-6-14-23/h3-4,7-12,17H,2,5-6,13-14H2,1H3,(H,22,24)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM84184
PNG
(2-phenyl-N-(2-pyrrolidin-1-ylphenyl)butanamide | 2...)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395508
PNG
(CHEMBL2164062)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C20H22F2N2O/c1-2-15(14-9-10-16(21)17(22)13-14)20(25)23-18-7-3-4-8-19(18)24-11-5-6-12-24/h3-4,7-10,13,15H,2,5-6,11-12H2,1H3,(H,23,25)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395481
PNG
(CHEMBL2163667)
Show SMILES CCC(C(=O)Nc1ccc(cc1)N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-2-19(16-8-4-3-5-9-16)20(23)21-17-10-12-18(13-11-17)22-14-6-7-15-22/h3-5,8-13,19H,2,6-7,14-15H2,1H3,(H,21,23)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395500
PNG
(CHEMBL2163659)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1cccc(Cl)c1
Show InChI InChI=1S/C20H23ClN2O/c1-2-17(15-8-7-9-16(21)14-15)20(24)22-18-10-3-4-11-19(18)23-12-5-6-13-23/h3-4,7-11,14,17H,2,5-6,12-13H2,1H3,(H,22,24)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395518
PNG
(CHEMBL2164049)
Show SMILES CC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C19H22N2O/c1-15(16-9-3-2-4-10-16)19(22)20-17-11-5-6-12-18(17)21-13-7-8-14-21/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,20,22)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395498
PNG
(CHEMBL2163662)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClN2O/c1-2-17(15-9-11-16(21)12-10-15)20(24)22-18-7-3-4-8-19(18)23-13-5-6-14-23/h3-4,7-12,17H,2,5-6,13-14H2,1H3,(H,22,24)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395515
PNG
(CHEMBL2164054)
Show SMILES CCCC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C21H26N2O/c1-2-10-18(17-11-4-3-5-12-17)21(24)22-19-13-6-7-14-20(19)23-15-8-9-16-23/h3-7,11-14,18H,2,8-10,15-16H2,1H3,(H,22,24)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395514
PNG
(CHEMBL2164055)
Show SMILES O=C(Nc1ccccc1N1CCCC1)C1CCc2ccccc12
Show InChI InChI=1S/C20H22N2O/c23-20(17-12-11-15-7-1-2-8-16(15)17)21-18-9-3-4-10-19(18)22-13-5-6-14-22/h1-4,7-10,17H,5-6,11-14H2,(H,21,23)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395506
PNG
(CHEMBL2164066)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1cccc(C)c1
Show InChI InChI=1S/C21H26N2O/c1-3-18(17-10-8-9-16(2)15-17)21(24)22-19-11-4-5-12-20(19)23-13-6-7-14-23/h4-5,8-12,15,18H,3,6-7,13-14H2,1-2H3,(H,22,24)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395507
PNG
(CHEMBL2164064)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1cccc(F)c1
Show InChI InChI=1S/C20H23FN2O/c1-2-17(15-8-7-9-16(21)14-15)20(24)22-18-10-3-4-11-19(18)23-12-5-6-13-23/h3-4,7-11,14,17H,2,5-6,12-13H2,1H3,(H,22,24)
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n/an/a 360n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395499
PNG
(CHEMBL2163661)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(OC)cc1
Show InChI InChI=1S/C21H26N2O2/c1-3-18(16-10-12-17(25-2)13-11-16)21(24)22-19-8-4-5-9-20(19)23-14-6-7-15-23/h4-5,8-13,18H,3,6-7,14-15H2,1-2H3,(H,22,24)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395502
PNG
(CHEMBL2163657)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H23F3N2O/c1-2-17(15-8-7-9-16(14-15)21(22,23)24)20(27)25-18-10-3-4-11-19(18)26-12-5-6-13-26/h3-4,7-11,14,17H,2,5-6,12-13H2,1H3,(H,25,27)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395497
PNG
(CHEMBL2163664)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1F
Show InChI InChI=1S/C20H23FN2O/c1-2-15(16-9-3-4-10-17(16)21)20(24)22-18-11-5-6-12-19(18)23-13-7-8-14-23/h3-6,9-12,15H,2,7-8,13-14H2,1H3,(H,22,24)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395504
PNG
(CHEMBL2164069)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H22Cl2N2O/c1-2-15(14-9-10-16(21)17(22)13-14)20(25)23-18-7-3-4-8-19(18)24-11-5-6-12-24/h3-4,7-10,13,15H,2,5-6,11-12H2,1H3,(H,23,25)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM84166
PNG
(2-phenyl-N-(2-phenylphenyl)butanamide | 2-phenyl-N...)
Show SMILES CCC(C(=O)Nc1ccccc1-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H21NO/c1-2-19(17-11-5-3-6-12-17)22(24)23-21-16-10-9-15-20(21)18-13-7-4-8-14-18/h3-16,19H,2H2,1H3,(H,23,24)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395333
PNG
(CHEMBL2164389)
Show SMILES FC(F)(F)Oc1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C24H20F3N3O3/c25-24(26,27)33-18-10-8-16(9-11-18)15-29-22(31)21-19-6-1-2-7-20(19)23(32)30(21)14-12-17-5-3-4-13-28-17/h1-11,13,21H,12,14-15H2,(H,29,31)
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n/an/a 1.60E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2


J Med Chem 55: 6866-80 (2012)


Article DOI: 10.1021/jm300623u
BindingDB Entry DOI: 10.7270/Q2M909SB
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395516
PNG
(CHEMBL2164053)
Show SMILES CC(C)CC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C22H28N2O/c1-17(2)16-19(18-10-4-3-5-11-18)22(25)23-20-12-6-7-13-21(20)24-14-8-9-15-24/h3-7,10-13,17,19H,8-9,14-16H2,1-2H3,(H,23,25)
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n/an/a 2.22E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395503
PNG
(CHEMBL2163655)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1Cl
Show InChI InChI=1S/C20H23ClN2O/c1-2-15(16-9-3-4-10-17(16)21)20(24)22-18-11-5-6-12-19(18)23-13-7-8-14-23/h3-6,9-12,15H,2,7-8,13-14H2,1H3,(H,22,24)
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n/an/a 3.31E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395517
PNG
(CHEMBL2164052)
Show SMILES O=C(Nc1ccccc1N1CCCC1)C(C1CC1)c1ccccc1
Show InChI InChI=1S/C21H24N2O/c24-21(20(17-12-13-17)16-8-2-1-3-9-16)22-18-10-4-5-11-19(18)23-14-6-7-15-23/h1-5,8-11,17,20H,6-7,12-15H2,(H,22,24)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395475
PNG
(CHEMBL2163350)
Show SMILES CCC(C(=O)Nc1ccccc1-n1cccc1)c1ccccc1
Show InChI InChI=1S/C20H20N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-15,17H,2H2,1H3,(H,21,23)
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n/an/a 5.27E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50212239
PNG
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1
Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 channel


Proc Natl Acad Sci USA 104: 8520-5 (2007)


Article DOI: 10.1073/pnas.0611364104
BindingDB Entry DOI: 10.7270/Q2J10411
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2/Kv7.3


(Homo sapiens (Human))
BDBM50329203
PNG
(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)
Show SMILES FC(F)(F)COc1ncccc1CNC(=O)c1cncc(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H15ClF3N3O2/c21-17-5-3-13(4-6-17)15-8-16(10-25-9-15)18(28)27-11-14-2-1-7-26-19(14)29-12-20(22,23)24/h1-10H,11-12H2,(H,27,28)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2/Q3


Bioorg Med Chem Lett 20: 6812-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2/Kv7.3


(Homo sapiens (Human))
BDBM50329202
PNG
(5-(4-cyanophenyl)-N-(3,5-dimethylphenyl)nicotinami...)
Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(c2)-c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C21H17N3O/c1-14-7-15(2)9-20(8-14)24-21(25)19-10-18(12-23-13-19)17-5-3-16(11-22)4-6-17/h3-10,12-13H,1-2H3,(H,24,25)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2/Q3


Bioorg Med Chem Lett 20: 6812-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.121
BindingDB Entry DOI: 10.7270/Q2F76CS6
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395479
PNG
(CHEMBL2163673)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCOCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O2/c1-2-17(16-8-4-3-5-9-16)20(23)21-18-10-6-7-11-19(18)22-12-14-24-15-13-22/h3-11,17H,2,12-15H2,1H3,(H,21,23)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395474
PNG
(CHEMBL2163686)
Show SMILES CCC(C(=O)Nc1ccccc1Cl)c1ccccc1
Show InChI InChI=1S/C16H16ClNO/c1-2-13(12-8-4-3-5-9-12)16(19)18-15-11-7-6-10-14(15)17/h3-11,13H,2H2,1H3,(H,18,19)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395509
PNG
(CHEMBL2164061)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C22H28N2O3/c1-4-17(16-11-12-20(26-2)21(15-16)27-3)22(25)23-18-9-5-6-10-19(18)24-13-7-8-14-24/h5-6,9-12,15,17H,4,7-8,13-14H2,1-3H3,(H,23,25)
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n/an/a 2.02E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50312125
PNG
(3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395510
PNG
(CHEMBL2164060)
Show SMILES CCC(C(=O)N(C)c1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C21H26N2O/c1-3-18(17-11-5-4-6-12-17)21(24)22(2)19-13-7-8-14-20(19)23-15-9-10-16-23/h4-8,11-14,18H,3,9-10,15-16H2,1-2H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395511
PNG
(CHEMBL2164058)
Show SMILES O=C(Nc1ccccc1N1CCCC1)C1CCOc2ccccc12
Show InChI InChI=1S/C20H22N2O2/c23-20(16-11-14-24-19-10-4-1-7-15(16)19)21-17-8-2-3-9-18(17)22-12-5-6-13-22/h1-4,7-10,16H,5-6,11-14H2,(H,21,23)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395512
PNG
(CHEMBL2164057)
Show SMILES CC(C)(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-20(2,16-10-4-3-5-11-16)19(23)21-17-12-6-7-13-18(17)22-14-8-9-15-22/h3-7,10-13H,8-9,14-15H2,1-2H3,(H,21,23)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395513
PNG
(CHEMBL2164056)
Show SMILES O=C(Nc1ccccc1N1CCCC1)C1(CC1)c1ccccc1
Show InChI InChI=1S/C20H22N2O/c23-19(20(12-13-20)16-8-2-1-3-9-16)21-17-10-4-5-11-18(17)22-14-6-7-15-22/h1-5,8-11H,6-7,12-15H2,(H,21,23)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50050157
PNG
(CHEMBL1310568)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-7-5-10-17(13-15)21(25)23-19-12-6-11-18(14-19)22-20(24)16-8-3-2-4-9-16/h2-14H,1H3,(H,22,24)(H,23,25)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395476
PNG
(CHEMBL2163680)
Show SMILES CCC(C(=O)Nc1ccccc1-n1ccnc1)c1ccccc1
Show InChI InChI=1S/C19H19N3O/c1-2-16(15-8-4-3-5-9-15)19(23)21-17-10-6-7-11-18(17)22-13-12-20-14-22/h3-14,16H,2H2,1H3,(H,21,23)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395477
PNG
(CHEMBL2163679)
Show SMILES CCC(C(=O)Nc1ccccc1-n1c(O)ccc1O)c1ccccc1 |(13.24,-55.63,;12.47,-54.3,;10.93,-54.3,;10.16,-52.96,;10.93,-51.64,;8.62,-52.96,;7.85,-51.64,;8.62,-50.3,;7.85,-48.97,;6.31,-48.97,;5.54,-50.3,;6.31,-51.64,;5.54,-52.96,;5.97,-54.44,;7.41,-54.97,;4.69,-55.31,;3.48,-54.36,;4.01,-52.92,;3.15,-51.63,;10.16,-55.63,;8.62,-55.63,;7.85,-56.96,;8.62,-58.3,;10.16,-58.3,;10.93,-56.96,)|
Show InChI InChI=1S/C20H20N2O3/c1-2-15(14-8-4-3-5-9-14)20(25)21-16-10-6-7-11-17(16)22-18(23)12-13-19(22)24/h3-13,15,23-24H,2H2,1H3,(H,21,25)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395478
PNG
(CHEMBL2163675)
Show SMILES CCC(C(=O)Nc1ccccc1N(C)CC)c1ccccc1
Show InChI InChI=1S/C19H24N2O/c1-4-16(15-11-7-6-8-12-15)19(22)20-17-13-9-10-14-18(17)21(3)5-2/h6-14,16H,4-5H2,1-3H3,(H,20,22)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395480
PNG
(CHEMBL2163671)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCCCC1)c1ccccc1
Show InChI InChI=1S/C22H28N2O/c1-2-19(18-12-6-5-7-13-18)22(25)23-20-14-8-9-15-21(20)24-16-10-3-4-11-17-24/h5-9,12-15,19H,2-4,10-11,16-17H2,1H3,(H,23,25)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395482
PNG
(CHEMBL2163665)
Show SMILES CCC(C(=O)Nc1cccc(c1)N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-2-19(16-9-4-3-5-10-16)20(23)21-17-11-8-12-18(15-17)22-13-6-7-14-22/h3-5,8-12,15,19H,2,6-7,13-14H2,1H3,(H,21,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50050530
PNG
(CHEMBL3188857)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50050539
PNG
(CHEMBL3187891)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C20H17N3O2/c1-14-4-2-5-16(12-14)20(25)23-18-7-3-6-17(13-18)22-19(24)15-8-10-21-11-9-15/h2-13H,1H3,(H,22,24)(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50050534
PNG
(CHEMBL3183773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2/Kv7.3


(Homo sapiens (Human))
BDBM50130610
PNG
((E)-N-[(S)-1-(3-Morpholin-4-yl-phenyl)-ethyl]-3-ph...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccccc1)c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C21H24N2O2/c1-17(22-21(24)11-10-18-6-3-2-4-7-18)19-8-5-9-20(16-19)23-12-14-25-15-13-23/h2-11,16-17H,12-15H2,1H3,(H,22,24)/b11-10+/t17-/m0/s1
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n/an/an/an/a 690n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effect on resting membrane potential in SH-SY5Y human neuroblastoma cells expressing native KCNQ channels


J Med Chem 46: 3197-200 (2003)


Article DOI: 10.1021/jm034073f
BindingDB Entry DOI: 10.7270/Q2D21X11
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2/Kv7.3


(Homo sapiens (Human))
BDBM50120991
PNG
(CHEMBL3621444)
Show SMILES COCCN(C)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1
Show InChI InChI=1S/C16H28N4O4/c1-16(2,3)10-11(21)17-12-13(23-6)18-15(19-14(12)24-7)20(4)8-9-22-5/h8-10H2,1-7H3,(H,17,21)
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n/an/an/an/a 206n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells


Bioorg Med Chem Lett 25: 4941-4 (2015)


BindingDB Entry DOI: 10.7270/Q28054FG
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2/Kv7.3


(Homo sapiens (Human))
BDBM50120992
PNG
(CHEMBL3621445)
Show SMILES COc1nc(nc(OC)c1NC(=O)CC(C)(C)C)N1CCC(CC1)OC(C)C
Show InChI InChI=1S/C20H34N4O4/c1-13(2)28-14-8-10-24(11-9-14)19-22-17(26-6)16(18(23-19)27-7)21-15(25)12-20(3,4)5/h13-14H,8-12H2,1-7H3,(H,21,25)
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n/an/an/an/a 358n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells


Bioorg Med Chem Lett 25: 4941-4 (2015)


BindingDB Entry DOI: 10.7270/Q28054FG
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2/Kv7.3


(Homo sapiens (Human))
BDBM50120993
PNG
(CHEMBL3621446)
Show SMILES COC1CN(C1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1
Show InChI InChI=1S/C16H26N4O4/c1-16(2,3)7-11(21)17-12-13(23-5)18-15(19-14(12)24-6)20-8-10(9-20)22-4/h10H,7-9H2,1-6H3,(H,17,21)
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n/an/an/an/a 961n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells


Bioorg Med Chem Lett 25: 4941-4 (2015)


BindingDB Entry DOI: 10.7270/Q28054FG
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2/Kv7.3


(Homo sapiens (Human))
BDBM50120994
PNG
(CHEMBL3621447)
Show SMILES [H][C@]12CN(c3nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n3)[C@]([H])(CO1)C2 |r|
Show InChI InChI=1/C17H26N4O4/c1-17(2,3)7-12(22)18-13-14(23-4)19-16(20-15(13)24-5)21-8-11-6-10(21)9-25-11/h10-11H,6-9H2,1-5H3,(H,18,22)/t10-,11-/s2
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n/an/an/an/a 1.89E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Activation of human Kv7.2/7.3 expressed in CHOK1 cells


Bioorg Med Chem Lett 25: 4941-4 (2015)


BindingDB Entry DOI: 10.7270/Q28054FG
More data for this
Ligand-Target Pair
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