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Compile Data Set for Download or QSAR

Found 14 hits of ic50 for UniProtKB: Q29463   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Anionic trypsin


(Bos taurus)		BDBM50054482
PNG
((S)-4-[(S)-2-((S)-1-Formyl-4-guanidino-butylcarbam...)
Show SMILES CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C=O
Show InChI InChI=1S/C24H42N6O6/c1-4-8-16(9-5-2)21(33)29-18(14-20(32)36-3)23(35)30-13-7-11-19(30)22(34)28-17(15-31)10-6-12-27-24(25)26/h15-19H,4-14H2,1-3H3,(H,28,34)(H,29,33)(H4,25,26,27)/t17-,18-,19-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate trypsin

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054483
PNG
((S)-4-{(S)-2-[(S)-1-(1-Carbamimidoyl-piperidin-3-y...)
Show SMILES CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1CCCN(C1)C(N)=N)C=O
Show InChI InChI=1S/C27H46N6O6/c1-4-8-19(9-5-2)24(36)31-21(15-23(35)39-3)26(38)33-13-7-11-22(33)25(37)30-20(17-34)14-18-10-6-12-32(16-18)27(28)29/h17-22H,4-16H2,1-3H3,(H3,28,29)(H,30,37)(H,31,36)/t18?,20-,21-,22-/m0/s1
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n/an/a 113n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate trypsin

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054483
PNG
((S)-4-{(S)-2-[(S)-1-(1-Carbamimidoyl-piperidin-3-y...)
Show SMILES CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1CCCN(C1)C(N)=N)C=O
Show InChI InChI=1S/C27H46N6O6/c1-4-8-19(9-5-2)24(36)31-21(15-23(35)39-3)26(38)33-13-7-11-22(33)25(37)30-20(17-34)14-18-10-6-12-32(16-18)27(28)29/h17-22H,4-16H2,1-3H3,(H3,28,29)(H,30,37)(H,31,36)/t18?,20-,21-,22-/m0/s1
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n/an/a 113n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate trypsin

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054499
PNG
(CHEMBL334454 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Show SMILES CC(N1CCC[C@H](NS(=O)(=O)Cc2ccccc2)C1=O)C(=O)N[C@H]1CCCC(C1O)C(N)=N
Show InChI InChI=1S/C22H33N5O5S/c1-14(21(29)25-17-10-5-9-16(19(17)28)20(23)24)27-12-6-11-18(22(27)30)26-33(31,32)13-15-7-3-2-4-8-15/h2-4,7-8,14,16-19,26,28H,5-6,9-13H2,1H3,(H3,23,24)(H,25,29)/t14?,16?,17-,18-,19?/m0/s1
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n/an/a 293n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
compound was tested in vitro for inhibition of serine protease Trypsin.

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054484
PNG
(CHEMBL344204 | CVS-1778 | N-((S)-1-Formyl-4-guanid...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)CN1CCCC[C@H](NS(=O)(=O)Cc2ccccc2)C1=O)C=O
Show InChI InChI=1S/C21H32N6O5S/c22-21(23)24-11-6-9-17(14-28)25-19(29)13-27-12-5-4-10-18(20(27)30)26-33(31,32)15-16-7-2-1-3-8-16/h1-3,7-8,14,17-18,26H,4-6,9-13,15H2,(H,25,29)(H4,22,23,24)/t17-,18-/m0/s1
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n/an/a 329n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate trypsin

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054505
PNG
(CHEMBL421760 | N-(3-Carbamimidoyl-2-hydroxy-cycloh...)
Show SMILES NC(=N)C1CCCC(NC(=O)CN2CC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O
Show InChI InChI=1S/C20H29N5O5S/c21-19(22)14-7-4-8-15(18(14)27)23-17(26)11-25-10-9-16(20(25)28)24-31(29,30)12-13-5-2-1-3-6-13/h1-3,5-6,14-16,18,24,27H,4,7-12H2,(H3,21,22)(H,23,26)/t14?,15?,16-,18?/m0/s1
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n/an/a 538n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
compound was tested in vitro for inhibition of serine protease Trypsin.

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054503
PNG
(CHEMBL263924 | N-((1S,2R)-3-Carbamimidoyl-2-hydrox...)
Show SMILES NC(=N)C1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)c3cccc4ccccc34)C2=O)[C@@H]1O
Show InChI InChI=1S/C24H31N5O5S/c25-23(26)17-9-4-10-18(22(17)31)27-21(30)14-29-13-5-11-19(24(29)32)28-35(33,34)20-12-3-7-15-6-1-2-8-16(15)20/h1-3,6-8,12,17-19,22,28,31H,4-5,9-11,13-14H2,(H3,25,26)(H,27,30)/t17?,18-,19-,22+/m0/s1
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n/an/a 1.02E+3n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
compound was tested in vitro for inhibition of serine protease Trypsin.

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054488
PNG
(CHEMBL138441 | CVS-1178 | N-((S)-1-Formyl-4-guanid...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)CN1CCC[C@H](NS(=O)(=O)Cc2ccccc2)C1=O)C=O
Show InChI InChI=1S/C20H30N6O5S/c21-20(22)23-10-4-8-16(13-27)24-18(28)12-26-11-5-9-17(19(26)29)25-32(30,31)14-15-6-2-1-3-7-15/h1-3,6-7,13,16-17,25H,4-5,8-12,14H2,(H,24,28)(H4,21,22,23)/t16-,17-/m0/s1
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n/an/a 1.55E+3n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate trypsin

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054501
PNG
(2-[(S)-3-(Butane-1-sulfonylamino)-2-oxo-piperidin-...)
Show SMILES CCCCS(=O)(=O)N[C@H]1CCCN(CC(=O)N[C@H]2CCCC(C2O)C(N)=N)C1=O
Show InChI InChI=1S/C18H33N5O5S/c1-2-3-10-29(27,28)22-14-8-5-9-23(18(14)26)11-15(24)21-13-7-4-6-12(16(13)25)17(19)20/h12-14,16,22,25H,2-11H2,1H3,(H3,19,20)(H,21,24)/t12?,13-,14-,16?/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
compound was tested in vitro for inhibition of serine protease Trypsin.

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054497
PNG
(CHEMBL141043 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Show SMILES NC(=N)C1CCC[C@H](NC(=O)CN2CCC[C@H](NC(=O)Cc3ccccc3)C2=O)C1O
Show InChI InChI=1S/C22H31N5O4/c23-21(24)15-8-4-9-16(20(15)30)25-19(29)13-27-11-5-10-17(22(27)31)26-18(28)12-14-6-2-1-3-7-14/h1-3,6-7,15-17,20,30H,4-5,8-13H2,(H3,23,24)(H,25,29)(H,26,28)/t15?,16-,17-,20?/m0/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
compound was tested in vitro for inhibition of serine protease Trypsin.

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054487
PNG
(CHEMBL342914 | N-[(S)-1-(1-Carbamimidoyl-piperidin...)
Show SMILES NC(=N)N1CCCC(C[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C=O)C1
Show InChI InChI=1S/C24H36N6O5S/c25-24(26)30-12-6-9-19(14-30)13-20(16-31)27-22(32)15-29-11-5-4-10-21(23(29)33)28-36(34,35)17-18-7-2-1-3-8-18/h1-3,7-8,16,19-21,28H,4-6,9-15,17H2,(H3,25,26)(H,27,32)/t19?,20-,21-/m0/s1
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n/an/a 1.51E+4n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate trypsin

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054487
PNG
(CHEMBL342914 | N-[(S)-1-(1-Carbamimidoyl-piperidin...)
Show SMILES NC(=N)N1CCCC(C[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C=O)C1
Show InChI InChI=1S/C24H36N6O5S/c25-24(26)30-12-6-9-19(14-30)13-20(16-31)27-22(32)15-29-11-5-4-10-21(23(29)33)28-36(34,35)17-18-7-2-1-3-8-18/h1-3,7-8,16,19-21,28H,4-6,9-15,17H2,(H3,25,26)(H,27,32)/t19?,20-,21-/m0/s1
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n/an/a 1.51E+4n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate trypsin

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054485
PNG
(CHEMBL342604 | N-[(S)-1-((R)-1-Carbamimidoyl-piper...)
Show SMILES NC(=N)N1CCC[C@H](C[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C=O)C1
Show InChI InChI=1S/C23H34N6O5S/c24-23(25)29-11-4-8-18(13-29)12-19(15-30)26-21(31)14-28-10-5-9-20(22(28)32)27-35(33,34)16-17-6-2-1-3-7-17/h1-3,6-7,15,18-20,27H,4-5,8-14,16H2,(H3,24,25)(H,26,31)/t18-,19+,20+/m1/s1
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n/an/a 6.07E+4n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate trypsin

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054486
PNG
(CHEMBL141424 | N-[(S)-1-((S)-1-Carbamimidoyl-piper...)
Show SMILES NC(=N)N1CCC[C@@H](C[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C=O)C1
Show InChI InChI=1S/C23H34N6O5S/c24-23(25)29-11-4-8-18(13-29)12-19(15-30)26-21(31)14-28-10-5-9-20(22(28)32)27-35(33,34)16-17-6-2-1-3-7-17/h1-3,6-7,15,18-20,27H,4-5,8-14,16H2,(H3,24,25)(H,26,31)/t18-,19-,20-/m0/s1
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n/an/a 6.48E+4n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate trypsin

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair