Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92485 (CDE-066 | US9120744, CDE-066) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | 5.0 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92485 (CDE-066 | US9120744, CDE-066) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | 7.8 | 23 |
University of Michigan | Assay Description Enzyme activity assay using human and murine PAI-1. | J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92486 (CDE-082 | US9120744, CDE-082) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | 5.0 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92486 (CDE-082 | US9120744, CDE-082) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | 7.8 | 23 |
University of Michigan | Assay Description Enzyme activity assay using human and murine PAI-1. | J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92482 (CDE-008 | US9120744, CDE-008) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 23 | n/a | n/a | n/a | 7.8 | 23 |
University of Michigan | Assay Description Enzyme activity assay using human and murine PAI-1. | J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92482 (CDE-008 | US9120744, CDE-008) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 23 | n/a | n/a | n/a | 5.0 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92487 (CDE-031 | US9120744, CDE-031) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 31 | n/a | n/a | n/a | 7.8 | 23 |
University of Michigan | Assay Description Enzyme activity assay using human and murine PAI-1. | J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92487 (CDE-031 | US9120744, CDE-031) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 31 | n/a | n/a | n/a | 5.0 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92484 (CDE-056 | US9120744, CDE-056) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 51 | n/a | n/a | n/a | 5.0 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92484 (CDE-056 | US9120744, CDE-056) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 51 | n/a | n/a | n/a | 7.8 | 23 |
University of Michigan | Assay Description Enzyme activity assay using human and murine PAI-1. | J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92483 (CDE-034 | US9120744, CDE-034) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 67 | n/a | n/a | n/a | 5.0 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92483 (CDE-034 | US9120744, CDE-034) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 67 | n/a | n/a | n/a | 7.8 | 23 |
University of Michigan | Assay Description Enzyme activity assay using human and murine PAI-1. | J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Rattus norvegicus) | BDBM50149275 (2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Binding affinity of the compound to towards NBD-labeled S119C Plasminogen activator inhibitor-1 mutant in rat | J Med Chem 47: 3491-4 (2004) Article DOI: 10.1021/jm049766q BindingDB Entry DOI: 10.7270/Q2D21X3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Rattus norvegicus) | BDBM50149275 (2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Binding affinity of compound towards latent Plasminogen activator inhibitor-1 expressed as apparent Kd | J Med Chem 47: 3491-4 (2004) Article DOI: 10.1021/jm049766q BindingDB Entry DOI: 10.7270/Q2D21X3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50149275 (2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical School Curated by ChEMBL | Assay Description Binding affinity to human immobilized PAI1 by surface plasmon resonance | J Biol Chem 282: 9288-96 (2007) Article DOI: 10.1074/jbc.M611642200 BindingDB Entry DOI: 10.7270/Q2FF3S51 | |||||||||||
More data for this Ligand-Target Pair |