Found 163 hits of ic50 for UniProtKB: Q9Y3R4 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465983
(CHEMBL4277689)Show SMILES [H][C@]1(OC(=C[C@H](NC(N)=N)[C@H]1NC(=O)CCC(C)C)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C16H28N4O7/c1-7(2)3-4-11(23)20-12-8(19-16(17)18)5-10(15(25)26)27-14(12)13(24)9(22)6-21/h5,7-9,12-14,21-22,24H,3-4,6H2,1-2H3,(H,20,23)(H,25,26)(H4,17,18,19)/t8-,9+,12+,13+,14+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465985
(CHEMBL4280792)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)Cn1cc(nn1)-c1ccc(C)cc1)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C20H24N4O8/c1-10-2-4-11(5-3-10)12-7-24(23-22-12)8-16(28)21-17-13(26)6-15(20(30)31)32-19(17)18(29)14(27)9-25/h2-7,13-14,17-19,25-27,29H,8-9H2,1H3,(H,21,28)(H,30,31)/t13-,14+,17+,18+,19+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50330326
((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)Show SMILES [#6]-[#6](=O)-[#7]-[#6@@H]-1-[#6@H](-[#6]=[#6](-[#8]-[#6@H]-1-[#6@H](-[#8])-[#6@H](-[#8])-[#6]-[#8])-[#6](-[#8])=O)\[#7]=[#6](\[#7])-[#7] |r,c:6| Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01612 BindingDB Entry DOI: 10.7270/Q21J9FT0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465984
(CHEMBL4278858)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)Cn1cc(nn1)-c1ccc(N)cc1)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C19H23N5O8/c20-10-3-1-9(2-4-10)11-6-24(23-22-11)7-15(28)21-16-12(26)5-14(19(30)31)32-18(16)17(29)13(27)8-25/h1-6,12-13,16-18,25-27,29H,7-8,20H2,(H,21,28)(H,30,31)/t12-,13+,16+,17+,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465958
(CHEMBL4277391)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)Cn1cc(nn1)-c1ccc(F)cc1)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C19H21FN4O8/c20-10-3-1-9(2-4-10)11-6-24(23-22-11)7-15(28)21-16-12(26)5-14(19(30)31)32-18(16)17(29)13(27)8-25/h1-6,12-13,16-18,25-27,29H,7-8H2,(H,21,28)(H,30,31)/t12-,13+,16+,17+,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50330326
((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)Show SMILES [#6]-[#6](=O)-[#7]-[#6@@H]-1-[#6@H](-[#6]=[#6](-[#8]-[#6@H]-1-[#6@H](-[#8])-[#6@H](-[#8])-[#6]-[#8])-[#6](-[#8])=O)\[#7]=[#6](\[#7])-[#7] |r,c:6| Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01612 BindingDB Entry DOI: 10.7270/Q21J9FT0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50270441
(CHEMBL4099818)Show SMILES [H][C@]1(OC(=C[C@H](NC(N)=N)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)Cn1cc(nn1)-c1ccc(cc1)-c1ccccc1 |r,c:3| Show InChI InChI=1S/C26H29N7O6/c1-14(34)29-22-18(30-26(27)28)11-21(25(37)38)39-24(22)23(36)20(35)13-33-12-19(31-32-33)17-9-7-16(8-10-17)15-5-3-2-4-6-15/h2-12,18,20,22-24,35-36H,13H2,1H3,(H,29,34)(H,37,38)(H4,27,28,30)/t18-,20+,22+,23+,24+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 1990-2008 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01574 BindingDB Entry DOI: 10.7270/Q2XS5XV6 |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465974
(CHEMBL4284515)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CCC(C)C)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C15H25NO8/c1-7(2)3-4-11(20)16-12-8(18)5-10(15(22)23)24-14(12)13(21)9(19)6-17/h5,7-9,12-14,17-19,21H,3-4,6H2,1-2H3,(H,16,20)(H,22,23)/t8-,9+,12+,13+,14+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50330326
((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)Show SMILES [#6]-[#6](=O)-[#7]-[#6@@H]-1-[#6@H](-[#6]=[#6](-[#8]-[#6@H]-1-[#6@H](-[#8])-[#6@H](-[#8])-[#6]-[#8])-[#6](-[#8])=O)\[#7]=[#6](\[#7])-[#7] |r,c:6| Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 1990-2008 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01574 BindingDB Entry DOI: 10.7270/Q2XS5XV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50330326
((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)Show SMILES [#6]-[#6](=O)-[#7]-[#6@@H]-1-[#6@H](-[#6]=[#6](-[#8]-[#6@H]-1-[#6@H](-[#8])-[#6@H](-[#8])-[#6]-[#8])-[#6](-[#8])=O)\[#7]=[#6](\[#7])-[#7] |r,c:6| Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of MBP-fused recombinant human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed... |
Bioorg Med Chem 26: 5349-5358 (2018)
Article DOI: 10.1016/j.bmc.2018.05.035 BindingDB Entry DOI: 10.7270/Q29W0J57 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50330326
((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)Show SMILES [#6]-[#6](=O)-[#7]-[#6@@H]-1-[#6@H](-[#6]=[#6](-[#8]-[#6@H]-1-[#6@H](-[#8])-[#6@H](-[#8])-[#6]-[#8])-[#6](-[#8])=O)\[#7]=[#6](\[#7])-[#7] |r,c:6| Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01612 BindingDB Entry DOI: 10.7270/Q21J9FT0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50331682
((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)Show SMILES OC[C@@H](O)[C@@H](O)[C@@H]1OC(=C[C@H](O)[C@H]1NC(=O)CN=[N+]=[N-])C(O)=O |r,c:8| Show InChI InChI=1S/C11H16N4O8/c12-15-13-2-7(19)14-8-4(17)1-6(11(21)22)23-10(8)9(20)5(18)3-16/h1,4-5,8-10,16-18,20H,2-3H2,(H,14,19)(H,21,22)/t4-,5+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01612 BindingDB Entry DOI: 10.7270/Q21J9FT0 |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50331683
((2R,3R,4S)-4-hydroxy-3-(2-(4-phenyl-1H-1,2,3-triaz...)Show SMILES OC[C@@H](O)[C@@H](O)[C@@H]1OC(=C[C@H](O)[C@H]1NC(=O)Cn1cc(nn1)-c1ccccc1)C(O)=O |r,c:8| Show InChI InChI=1S/C19H22N4O8/c24-9-13(26)17(28)18-16(12(25)6-14(31-18)19(29)30)20-15(27)8-23-7-11(21-22-23)10-4-2-1-3-5-10/h1-7,12-13,16-18,24-26,28H,8-9H2,(H,20,27)(H,29,30)/t12-,13+,16+,17+,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human NEU2 using 4-MU-NANA as substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence plate... |
ACS Med Chem Lett 4: 532-7 (2013)
Article DOI: 10.1021/ml400080t BindingDB Entry DOI: 10.7270/Q25H7HNQ |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465973
(CHEMBL4291435)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)Cn1cc(nn1)-c1ccc(OC)cc1)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C20H24N4O9/c1-32-11-4-2-10(3-5-11)12-7-24(23-22-12)8-16(28)21-17-13(26)6-15(20(30)31)33-19(17)18(29)14(27)9-25/h2-7,13-14,17-19,25-27,29H,8-9H2,1H3,(H,21,28)(H,30,31)/t13-,14+,17+,18+,19+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50599899
(CHEMBL3589567)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CN=[N+]=[N-])C(O)=O)[C@H](O)[C@H](O)CN=[N+]=[N-] |r,c:3| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01612 BindingDB Entry DOI: 10.7270/Q21J9FT0 |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50599899
(CHEMBL3589567)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CN=[N+]=[N-])C(O)=O)[C@H](O)[C@H](O)CN=[N+]=[N-] |r,c:3| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01612 BindingDB Entry DOI: 10.7270/Q21J9FT0 |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50331682
((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)Show SMILES OC[C@@H](O)[C@@H](O)[C@@H]1OC(=C[C@H](O)[C@H]1NC(=O)CN=[N+]=[N-])C(O)=O |r,c:8| Show InChI InChI=1S/C11H16N4O8/c12-15-13-2-7(19)14-8-4(17)1-6(11(21)22)23-10(8)9(20)5(18)3-16/h1,4-5,8-10,16-18,20H,2-3H2,(H,14,19)(H,21,22)/t4-,5+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01612 BindingDB Entry DOI: 10.7270/Q21J9FT0 |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465968
(CHEMBL4291908)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CCCCC)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C15H25NO8/c1-2-3-4-5-11(20)16-12-8(18)6-10(15(22)23)24-14(12)13(21)9(19)7-17/h6,8-9,12-14,17-19,21H,2-5,7H2,1H3,(H,16,20)(H,22,23)/t8-,9+,12+,13+,14+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50330326
((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)Show SMILES [#6]-[#6](=O)-[#7]-[#6@@H]-1-[#6@H](-[#6]=[#6](-[#8]-[#6@H]-1-[#6@H](-[#8])-[#6@H](-[#8])-[#6]-[#8])-[#6](-[#8])=O)\[#7]=[#6](\[#7])-[#7] |r,c:6| Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 1.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Thammasat University
Curated by ChEMBL
| Assay Description Inhibition of human Neu2 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis |
J Med Chem 59: 4563-77 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01863 BindingDB Entry DOI: 10.7270/Q2QN68QP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50330326
((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)Show SMILES [#6]-[#6](=O)-[#7]-[#6@@H]-1-[#6@H](-[#6]=[#6](-[#8]-[#6@H]-1-[#6@H](-[#8])-[#6@H](-[#8])-[#6]-[#8])-[#6](-[#8])=O)\[#7]=[#6](\[#7])-[#7] |r,c:6| Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human NEU2 using 4MU-NeuAc as substrate after 15 to 30 mins by fluorimetric analysis |
ACS Med Chem Lett 4: 532-7 (2013)
Article DOI: 10.1021/ml400080t BindingDB Entry DOI: 10.7270/Q25H7HNQ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50330326
((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)Show SMILES [#6]-[#6](=O)-[#7]-[#6@@H]-1-[#6@H](-[#6]=[#6](-[#8]-[#6@H]-1-[#6@H](-[#8])-[#6@H](-[#8])-[#6]-[#8])-[#6](-[#8])=O)\[#7]=[#6](\[#7])-[#7] |r,c:6| Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 1.64E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Miyagi Cancer Center Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human NEU2 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate |
Antimicrob Agents Chemother 52: 3484-91 (2008)
Article DOI: 10.1128/AAC.00344-08 BindingDB Entry DOI: 10.7270/Q2BR8T42 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465995
(CHEMBL4291991)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)Cn1cc(nn1)-c1ccc(NC(C)=O)cc1)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C21H25N5O9/c1-10(28)22-12-4-2-11(3-5-12)13-7-26(25-24-13)8-17(31)23-18-14(29)6-16(21(33)34)35-20(18)19(32)15(30)9-27/h2-7,14-15,18-20,27,29-30,32H,8-9H2,1H3,(H,22,28)(H,23,31)(H,33,34)/t14-,15+,18+,19+,20+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM4706
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California-Davis
Curated by ChEMBL
| Assay Description Inhibition of recombinant human cytosolic sialidase NEU2 using Neu5Acalpha2-3GalbetapNP as substrate after 30 mins by colorimetric assay |
Bioorg Med Chem 26: 5751-5757 (2018)
Article DOI: 10.1016/j.bmc.2018.10.028 BindingDB Entry DOI: 10.7270/Q2BK1G2N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM4706
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01612 BindingDB Entry DOI: 10.7270/Q21J9FT0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50331682
((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)Show SMILES OC[C@@H](O)[C@@H](O)[C@@H]1OC(=C[C@H](O)[C@H]1NC(=O)CN=[N+]=[N-])C(O)=O |r,c:8| Show InChI InChI=1S/C11H16N4O8/c12-15-13-2-7(19)14-8-4(17)1-6(11(21)22)23-10(8)9(20)5(18)3-16/h1,4-5,8-10,16-18,20H,2-3H2,(H,14,19)(H,21,22)/t4-,5+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465977
(CHEMBL4291325)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CCCCC)C(O)=O)[C@H](O)[C@H](O)CNC(=O)CCCCC |r,c:3| Show InChI InChI=1S/C21H36N2O8/c1-3-5-7-9-16(26)22-12-14(25)19(28)20-18(23-17(27)10-8-6-4-2)13(24)11-15(31-20)21(29)30/h11,13-14,18-20,24-25,28H,3-10,12H2,1-2H3,(H,22,26)(H,23,27)(H,29,30)/t13-,14+,18+,19+,20+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465986
(CHEMBL4286830)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CC)C(O)=O)[C@H](O)[C@H](O)CNC(=O)CCCCC |r,c:3| Show InChI InChI=1S/C18H30N2O8/c1-3-5-6-7-14(24)19-9-11(22)16(25)17-15(20-13(23)4-2)10(21)8-12(28-17)18(26)27/h8,10-11,15-17,21-22,25H,3-7,9H2,1-2H3,(H,19,24)(H,20,23)(H,26,27)/t10-,11+,15+,16+,17+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50270464
(CHEMBL4076203)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)Cn1cc(nn1)-c1ccc(cc1)-c1ccccc1 |r,c:3| Show InChI InChI=1S/C25H26N4O7/c1-14(30)26-22-19(31)11-21(25(34)35)36-24(22)23(33)20(32)13-29-12-18(27-28-29)17-9-7-16(8-10-17)15-5-3-2-4-6-15/h2-12,19-20,22-24,31-33H,13H2,1H3,(H,26,30)(H,34,35)/t19-,20+,22+,23+,24+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 1990-2008 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01574 BindingDB Entry DOI: 10.7270/Q2XS5XV6 |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM4706
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01612 BindingDB Entry DOI: 10.7270/Q21J9FT0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465978
(CHEMBL4293651)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CCCCC)C(O)=O)[C@H](O)[C@H](O)CNC(=O)CCC |r,c:3| Show InChI InChI=1S/C19H32N2O8/c1-3-5-6-8-15(25)21-16-11(22)9-13(19(27)28)29-18(16)17(26)12(23)10-20-14(24)7-4-2/h9,11-12,16-18,22-23,26H,3-8,10H2,1-2H3,(H,20,24)(H,21,25)(H,27,28)/t11-,12+,16+,17+,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465979
(CHEMBL4281290)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CCCC)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C14H23NO8/c1-2-3-4-10(19)15-11-7(17)5-9(14(21)22)23-13(11)12(20)8(18)6-16/h5,7-8,11-13,16-18,20H,2-4,6H2,1H3,(H,15,19)(H,21,22)/t7-,8+,11+,12+,13+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50331682
((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)Show SMILES OC[C@@H](O)[C@@H](O)[C@@H]1OC(=C[C@H](O)[C@H]1NC(=O)CN=[N+]=[N-])C(O)=O |r,c:8| Show InChI InChI=1S/C11H16N4O8/c12-15-13-2-7(19)14-8-4(17)1-6(11(21)22)23-10(8)9(20)5(18)3-16/h1,4-5,8-10,16-18,20H,2-3H2,(H,14,19)(H,21,22)/t4-,5+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human NEU2 using 4-MU-NANA as substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence plate... |
ACS Med Chem Lett 4: 532-7 (2013)
Article DOI: 10.1021/ml400080t BindingDB Entry DOI: 10.7270/Q25H7HNQ |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465957
(CHEMBL4289583)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CCCCCC)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C16H27NO8/c1-2-3-4-5-6-12(21)17-13-9(19)7-11(16(23)24)25-15(13)14(22)10(20)8-18/h7,9-10,13-15,18-20,22H,2-6,8H2,1H3,(H,17,21)(H,23,24)/t9-,10+,13+,14+,15+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM4706
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01612 BindingDB Entry DOI: 10.7270/Q21J9FT0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM4706
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 1990-2008 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01574 BindingDB Entry DOI: 10.7270/Q2XS5XV6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM4706
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM4706
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of MBP-fused recombinant human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed... |
Bioorg Med Chem 26: 5349-5358 (2018)
Article DOI: 10.1016/j.bmc.2018.05.035 BindingDB Entry DOI: 10.7270/Q29W0J57 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465997
(CHEMBL4295174)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CC(C)C)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C14H23NO8/c1-6(2)3-10(19)15-11-7(17)4-9(14(21)22)23-13(11)12(20)8(18)5-16/h4,6-8,11-13,16-18,20H,3,5H2,1-2H3,(H,15,19)(H,21,22)/t7-,8+,11+,12+,13+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50428069
(CHEMBL2325813)Show SMILES CC(=O)N[C@H]1[C@H](CNNc2ccccc2)OC(=C[C@@H]1N=[N+]=[N-])C(O)=O |r,c:17| Show InChI InChI=1S/C15H18N6O4/c1-9(22)18-14-11(20-21-16)7-12(15(23)24)25-13(14)8-17-19-10-5-3-2-4-6-10/h2-7,11,13-14,17,19H,8H2,1H3,(H,18,22)(H,23,24)/t11-,13-,14+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate measured for every 30 seconds for 60 mins by fluorescen... |
J Med Chem 56: 2948-58 (2013)
Article DOI: 10.1021/jm301892f BindingDB Entry DOI: 10.7270/Q25M672F |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM4706
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description Inhibition of human NEU2 transiently transfected in HEK293T cells by fluorimetric analysis |
Bioorg Med Chem 17: 4595-603 (2009)
Article DOI: 10.1016/j.bmc.2009.04.065 BindingDB Entry DOI: 10.7270/Q2TX3FD8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465994
(CHEMBL4288490)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CCC)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C13H21NO8/c1-2-3-9(18)14-10-6(16)4-8(13(20)21)22-12(10)11(19)7(17)5-15/h4,6-7,10-12,15-17,19H,2-3,5H2,1H3,(H,14,18)(H,20,21)/t6-,7+,10+,11+,12+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50487728
(CHEMBL116550)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(C)=O)C(O)=O)[C@@H](O)[C@@H](O)CO |r,c:3| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6-,8+,9-,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid UniChem
| Article
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Homo sapiens (human) NEU2 expressed in HEK293 cells using 4MU-NeuAc as substrate after 10 to 30 min by fluorometric analysis |
Citation and Details
Article DOI: 10.1007/s00044-009-9269-6 BindingDB Entry DOI: 10.7270/Q2VD72BG |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465969
(CHEMBL4290966)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)c1ccccc1)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C16H19NO8/c18-7-10(20)13(21)14-12(9(19)6-11(25-14)16(23)24)17-15(22)8-4-2-1-3-5-8/h1-6,9-10,12-14,18-21H,7H2,(H,17,22)(H,23,24)/t9-,10+,12+,13+,14+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM4706
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description Inhibition of human NEU2 expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 532-7 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.084 BindingDB Entry DOI: 10.7270/Q2HD7VCB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50063303
((2R,3R,4S)-3-acetamido-4-amino-2-((1R,2R)-1,2,3-tr...)Show SMILES CC(=O)N[C@@H]1[C@@H](N)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H18N2O7/c1-4(15)13-8-5(12)2-7(11(18)19)20-10(8)9(17)6(16)3-14/h2,5-6,8-10,14,16-17H,3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate measured for every 30 seconds for 60 mins by fluorescen... |
J Med Chem 56: 2948-58 (2013)
Article DOI: 10.1021/jm301892f BindingDB Entry DOI: 10.7270/Q25M672F |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50270442
(CHEMBL4064112)Show SMILES [H][C@]1(OC(=C[C@H](NC(N)=N)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)Cn1cc(nn1)-c1ccc(cc1)C(O)=O |r,c:3| Show InChI InChI=1S/C21H25N7O8/c1-9(29)24-16-12(25-21(22)23)6-15(20(34)35)36-18(16)17(31)14(30)8-28-7-13(26-27-28)10-2-4-11(5-3-10)19(32)33/h2-7,12,14,16-18,30-31H,8H2,1H3,(H,24,29)(H,32,33)(H,34,35)(H4,22,23,25)/t12-,14+,16+,17+,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 1990-2008 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01574 BindingDB Entry DOI: 10.7270/Q2XS5XV6 |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM4706
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 4.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Miyagi Cancer Center Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human NEU2 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate |
Antimicrob Agents Chemother 52: 3484-91 (2008)
Article DOI: 10.1128/AAC.00344-08 BindingDB Entry DOI: 10.7270/Q2BR8T42 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465993
(CHEMBL4290253)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)CCCCC)C(O)=O)[C@H](O)[C@H](O)CNC(C)=O |r,c:3| Show InChI InChI=1S/C17H28N2O8/c1-3-4-5-6-13(23)19-14-10(21)7-12(17(25)26)27-16(14)15(24)11(22)8-18-9(2)20/h7,10-11,14-16,21-22,24H,3-6,8H2,1-2H3,(H,18,20)(H,19,23)(H,25,26)/t10-,11+,14+,15+,16+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM50465990
(CHEMBL4288030)Show SMILES [H][C@]1(OC(=C[C@H](O)[C@H]1NC(=O)Cn1cc(nn1)-c1ccc(cc1)C(F)(F)F)C(O)=O)[C@H](O)[C@H](O)CO |r,c:3| Show InChI InChI=1S/C20H21F3N4O8/c21-20(22,23)10-3-1-9(2-4-10)11-6-27(26-25-11)7-15(31)24-16-12(29)5-14(19(33)34)35-18(16)17(32)13(30)8-28/h1-6,12-13,16-18,28-30,32H,7-8H2,(H,24,31)(H,33,34)/t12-,13+,16+,17+,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat... |
J Med Chem 61: 11261-11279 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01411 BindingDB Entry DOI: 10.7270/Q2GF0X5V |
More data for this Ligand-Target Pair | |
Sialidase-2
(Homo sapiens (Human)) | BDBM4706
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7| Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Thammasat University
Curated by ChEMBL
| Assay Description Inhibition of human Neu2 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis |
J Med Chem 59: 4563-77 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01863 BindingDB Entry DOI: 10.7270/Q2QN68QP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |