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Compile Data Set for Download or QSAR

Found 2 hits of ic50 for UniProtKB: P09810   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tryptophan 5-hydroxylase 1


(Rattus norvegicus)
BDBM50019143
PNG
(CHEMBL511275 | US10683309, Example LP533401)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccc(cc2)-c2cccc(F)c2)C(F)(F)F)nc(N)n1)C(O)=O |r|
Show InChI InChI=1S/C27H22F4N4O3/c28-20-3-1-2-19(13-20)16-8-10-18(11-9-16)24(27(29,30)31)38-23-14-22(34-26(33)35-23)17-6-4-15(5-7-17)12-21(32)25(36)37/h1-11,13-14,21,24H,12,32H2,(H,36,37)(H2,33,34,35)/t21-,24?/m0/s1
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CHEMBL
MCE
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysis


J Med Chem 57: 4692-709 (2014)


Article DOI: 10.1021/jm5002293
BindingDB Entry DOI: 10.7270/Q2CF9RP0
More data for this
Ligand-Target Pair
Tryptophan 5-hydroxylase 1


(Rattus norvegicus)
BDBM50019142
PNG
(CHEMBL3288777)
Show SMILES [H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(=O)NCC(=O)OCC)[C@@]1(C)Cc1nc3ccccc3nc1C2(C)C |r,t:9|
Show InChI InChI=1S/C40H55N3O3/c1-9-46-32(44)23-41-35(45)40-19-16-24(2)25(3)33(40)26-14-15-31-37(6)22-29-34(43-28-13-11-10-12-27(28)42-29)36(4,5)30(37)17-18-39(31,8)38(26,7)20-21-40/h10-14,24-25,30-31,33H,9,15-23H2,1-8H3,(H,41,45)/t24-,25+,30+,31-,33+,37+,38-,39-,40+/m1/s1
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 6.22E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysis


J Med Chem 57: 4692-709 (2014)


Article DOI: 10.1021/jm5002293
BindingDB Entry DOI: 10.7270/Q2CF9RP0
More data for this
Ligand-Target Pair