Found 268 hits of ic50 for UniProtKB: O15554 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371391
(SENICAPOC)Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Kca 3.1 (unknown origin) |
J Med Chem 56: 593-624 (2013)
Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50547905
(CHEMBL4744833)Show SMILES COC(=O)N(C[C@H]1CCCN1C)C1(CC1)c1ccc(F)c(c1)C(F)(F)F |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Kca3.1 in human erythrocytes |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00569
BindingDB Entry DOI: 10.7270/Q2X63RJG |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50547897
(CHEMBL4749039)Show SMILES COC(=O)N(CC(C)(C)N)C1(CC1)c1ccc(F)c(c1)C(F)(F)F | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Kca3.1 in human erythrocytes |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00569
BindingDB Entry DOI: 10.7270/Q2X63RJG |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50547904
(CHEMBL4791725)Show SMILES COC(=O)N(C[C@@H]1CCCN1)C1(CC1)c1ccc(F)c(OC(F)(F)F)c1 |r| | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Kca3.1 in human erythrocytes |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00569
BindingDB Entry DOI: 10.7270/Q2X63RJG |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4/Potassium voltage-gated channel subfamily E member 1/Potassium voltage-gated channel subfamily KQT member 1
(Homo sapiens (Human)) | BDBM50099566
((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)Show InChI InChI=1S/C20H15F2NO/c21-16-12-10-15(11-13-16)20(19(23)24,14-6-2-1-3-7-14)17-8-4-5-9-18(17)22/h1-13H,(H2,23,24) | PDB
KEGG
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B.MOAD
DrugBank
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antibodypedia
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Selectivity for gardos channel; (Gardos channel vs 2000 nM for the cardiac IKs channel).) |
J Med Chem 44: 1627-53 (2001)
BindingDB Entry DOI: 10.7270/Q218376D |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50099566
((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)Show InChI InChI=1S/C20H15F2NO/c21-16-12-10-15(11-13-16)20(19(23)24,14-6-2-1-3-7-14)17-8-4-5-9-18(17)22/h1-13H,(H2,23,24) | PDB
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371390
(CHEMBL272039)Show InChI InChI=1S/C20H14F3NO/c21-15-9-5-13(6-10-15)20(19(24)25,14-7-11-16(22)12-8-14)17-3-1-2-4-18(17)23/h1-12H,(H2,24,25) | PDB
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371391
(SENICAPOC)Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24) | PDB
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MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371385
(CHEMBL260736)Show SMILES NC(=O)C(c1cccc(F)c1)(c1cccc(F)c1)c1cccc(F)c1 Show InChI InChI=1S/C20H14F3NO/c21-16-7-1-4-13(10-16)20(19(24)25,14-5-2-8-17(22)11-14)15-6-3-9-18(23)12-15/h1-12H,(H2,24,25) | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50547898
(CHEMBL4788143)Show SMILES CC(C)(N)CN(CC1CC1)C1(CC1)c1ccc(F)c(c1)C(F)(F)F | PDB
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| PC cid
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UniChem
| Article
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Kca3.1 in human erythrocytes |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00569
BindingDB Entry DOI: 10.7270/Q2X63RJG |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371388
(CHEMBL270704)Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1 Show InChI InChI=1S/C20H14F3NO/c21-16-7-1-13(2-8-16)20(19(24)25,14-3-9-17(22)10-4-14)15-5-11-18(23)12-6-15/h1-12H,(H2,24,25) | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371389
(CHEMBL272040)Show InChI InChI=1S/C20H15F2NO/c21-17-12-11-16(13-18(17)22)20(19(23)24,14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13H,(H2,23,24) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371384
(CHEMBL270071)Show InChI InChI=1S/C20H16FNO/c21-18-14-8-7-13-17(18)20(19(22)23,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,(H2,22,23) | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371382
(CHEMBL408700)Show SMILES NC(=O)C(c1ccc(F)cc1)(c1cccc(F)c1)c1cccc(F)c1 Show InChI InChI=1S/C20H14F3NO/c21-16-9-7-13(8-10-16)20(19(24)25,14-3-1-5-17(22)11-14)15-4-2-6-18(23)12-15/h1-12H,(H2,24,25) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM314248
(US9611232, Example 13)Show SMILES NC(=O)CN1[C@@H](c2ccccc2F)C(OC1=O)(c1ccccc1F)c1ccccc1F |r| Show InChI InChI=1S/C23H17F3N2O3/c24-17-10-4-1-7-14(17)21-23(15-8-2-5-11-18(15)25,16-9-3-6-12-19(16)26)31-22(30)28(21)13-20(27)29/h1-12,21H,13H2,(H2,27,29)/t21-/m0/s1 | PDB
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
Compounds were tested using a PatchXpress® (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corp... |
US Patent US9611232 (2017)
BindingDB Entry DOI: 10.7270/Q2P84DZM |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM314285
(US9611232, Example 17)Show SMILES NC(=O)CN1[C@@H](c2ccccc2F)C(OC1=O)(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C23H19FN2O3/c24-19-14-8-7-13-18(19)21-23(16-9-3-1-4-10-16,17-11-5-2-6-12-17)29-22(28)26(21)15-20(25)27/h1-14,21H,15H2,(H2,25,27)/t21-/m0/s1 | PDB
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| PC cid
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| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
Compounds were tested using a PatchXpress® (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corp... |
US Patent US9611232 (2017)
BindingDB Entry DOI: 10.7270/Q2P84DZM |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371395
(CHEMBL273092)Show InChI InChI=1S/C20H14F3NO/c21-14-11-9-13(10-12-14)20(19(24)25,15-5-1-3-7-17(15)22)16-6-2-4-8-18(16)23/h1-12H,(H2,24,25) | PDB
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM205030
(US9556132, 7 | process for preparing 2-(2-{2-[1-(2...)Show InChI InChI=1S/C21H14FN5O/c22-18-10-4-5-11-19(18)27-21(24-25-26-27)17-9-2-1-7-15(17)16-8-3-6-12-20(16)28-14-13-23/h1-12H,14H2 | PDB
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| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.3 | n/a |
Saniona A/S
US Patent
| Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas... |
US Patent US9556132 (2017)
BindingDB Entry DOI: 10.7270/Q2SF2Z5T |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM205069
(US9556132, 33 | process for preparing 5-{2-[2-(flu...)Show InChI InChI=1S/C20H14F2N4/c21-13-14-7-1-2-8-15(14)16-9-3-4-10-17(16)20-23-24-25-26(20)19-12-6-5-11-18(19)22/h1-12H,13H2 | PDB
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| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | 7.3 | n/a |
Saniona A/S
US Patent
| Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas... |
US Patent US9556132 (2017)
BindingDB Entry DOI: 10.7270/Q2SF2Z5T |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371386
(CHEMBL260953)Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1cccc(F)c1 Show InChI InChI=1S/C20H14F3NO/c21-16-8-4-13(5-9-16)20(19(24)25,14-6-10-17(22)11-7-14)15-2-1-3-18(23)12-15/h1-12H,(H2,24,25) | PDB
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50547900
(CHEMBL4756080)Show SMILES CC(C)(N)CN(C1CCC1)C1(CC1)c1cccc(c1)C(F)(F)F | PDB
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Kca3.1 in human erythrocytes |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00569
BindingDB Entry DOI: 10.7270/Q2X63RJG |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371377
(CHEMBL406683)Show InChI InChI=1S/C19H16ClN/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,21H2 | PDB
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| Article
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50279107
(1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | C...)Show InChI InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description
Inhibition of IK1 (unknown origin) |
Bioorg Med Chem Lett 19: 2299-304 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.077
BindingDB Entry DOI: 10.7270/Q29K4B38 |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50279107
(1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | C...)Show InChI InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H | PDB
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4SC AG
Curated by ChEMBL
| Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay |
Bioorg Med Chem Lett 19: 2299-304 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.077
BindingDB Entry DOI: 10.7270/Q29K4B38 |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM314217
(US9611232, Example 11)Show SMILES NC(=O)CN1[C@@H](c2ccccc2F)C(OC1=O)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C23H17F3N2O3/c24-16-9-5-14(6-10-16)23(15-7-11-17(25)12-8-15)21(18-3-1-2-4-19(18)26)28(13-20(27)29)22(30)31-23/h1-12,21H,13H2,(H2,27,29)/t21-/m0/s1 | PDB
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
Compounds were tested using a PatchXpress® (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corp... |
US Patent US9611232 (2017)
BindingDB Entry DOI: 10.7270/Q2P84DZM |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50547899
(CHEMBL4764429) | PDB
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TBA
| Assay Description
Inhibition of Kca3.1 in human erythrocytes |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00569
BindingDB Entry DOI: 10.7270/Q2X63RJG |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371383
(CHEMBL261828)Show InChI InChI=1S/C20H15F2NO/c21-17-10-4-8-15(12-17)20(19(23)24,14-6-2-1-3-7-14)16-9-5-11-18(22)13-16/h1-13H,(H2,23,24) | PDB
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Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM205019
(US9556132, 4 | process for preparing 1-(2-fluoroph...)Show InChI InChI=1S/C22H19FN4O2/c1-28-14-15-29-21-13-7-4-9-17(21)16-8-2-3-10-18(16)22-24-25-26-27(22)20-12-6-5-11-19(20)23/h2-13H,14-15H2,1H3 | PDB
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Saniona A/S
US Patent
| Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas... |
US Patent US9556132 (2017)
BindingDB Entry DOI: 10.7270/Q2SF2Z5T |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371387
(CHEMBL261606)Show InChI InChI=1S/C20H15F2NO/c21-17-12-6-4-10-15(17)20(19(23)24,14-8-2-1-3-9-14)16-11-5-7-13-18(16)22/h1-13H,(H2,23,24) | PDB
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Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371396
(CHEMBL270913)Show InChI InChI=1S/C20H15F2NO/c21-16-11-12-17(18(22)13-16)20(19(23)24,14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13H,(H2,23,24) | PDB
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| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM205016
(US9556132, 3 | process for preparing 5-[2-(2-ethox...)Show InChI InChI=1S/C21H17FN4O/c1-2-27-20-14-8-5-10-16(20)15-9-3-4-11-17(15)21-23-24-25-26(21)19-13-7-6-12-18(19)22/h3-14H,2H2,1H3 | PDB
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Saniona A/S
US Patent
| Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas... |
US Patent US9556132 (2017)
BindingDB Entry DOI: 10.7270/Q2SF2Z5T |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50019902
(CHEMBL3287207)Show SMILES CC(N1c2sccc2S(=O)(=O)CC1=O)c1ccc(F)c(OC(F)(F)F)c1 Show InChI InChI=1S/C15H11F4NO4S2/c1-8(9-2-3-10(16)11(6-9)24-15(17,18)19)20-13(21)7-26(22,23)12-4-5-25-14(12)20/h2-6,8H,7H2,1H3 | PDB
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Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition... |
ACS Med Chem Lett 5: 460-1 (2014)
Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM200905
(US9533999, i-39)Show SMILES Fc1ccc(CN2c3sccc3S(=O)(=O)CC2=O)cc1OC(F)(F)F Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-10(9)23-14(16,17)18)6-19-12(20)7-25(21,22)11-3-4-24-13(11)19/h1-5H,6-7H2 | PDB
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Boehringer Ingelheim International GmbH
US Patent
| Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ... |
US Patent US9533999 (2017)
BindingDB Entry DOI: 10.7270/Q21V5C4S |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50371394
(CHEMBL258604)Show InChI InChI=1S/C20H16FNO/c21-18-13-11-17(12-14-18)20(19(22)23,15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-14H,(H2,22,23) | PDB
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Icagen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux |
J Med Chem 51: 976-82 (2008)
Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50019905
(CHEMBL3287210 | US9533999, ii-4)Show InChI InChI=1S/C16H13F3N2OS/c1-10(11-4-2-5-12(8-11)16(17,18)19)21-14(22)9-23-13-6-3-7-20-15(13)21/h2-8,10H,9H2,1H3 | PDB
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition... |
ACS Med Chem Lett 5: 460-1 (2014)
Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50019905
(CHEMBL3287210 | US9533999, ii-4)Show InChI InChI=1S/C16H13F3N2OS/c1-10(11-4-2-5-12(8-11)16(17,18)19)21-14(22)9-23-13-6-3-7-20-15(13)21/h2-8,10H,9H2,1H3 | PDB
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Boehringer Ingelheim International GmbH
US Patent
| Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ... |
US Patent US9533999 (2017)
BindingDB Entry DOI: 10.7270/Q21V5C4S |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM314284
(US9611232, Example 15)Show SMILES NC(=O)CN1[C@@H](c2ccccc2F)C(OC1=O)(c1cccc(F)c1)c1cccc(F)c1 |r| Show InChI InChI=1S/C23H17F3N2O3/c24-16-7-3-5-14(11-16)23(15-6-4-8-17(25)12-15)21(18-9-1-2-10-19(18)26)28(13-20(27)29)22(30)31-23/h1-12,21H,13H2,(H2,27,29)/t21-/m0/s1 | PDB
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
Compounds were tested using a PatchXpress® (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corp... |
US Patent US9611232 (2017)
BindingDB Entry DOI: 10.7270/Q2P84DZM |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM314215
(US9611232, Example 7)Show SMILES NC(=O)CN1[C@@H](c2ccc(F)cc2)C(OC1=O)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C23H17F3N2O3/c24-17-7-1-14(2-8-17)21-23(15-3-9-18(25)10-4-15,16-5-11-19(26)12-6-16)31-22(30)28(21)13-20(27)29/h1-12,21H,13H2,(H2,27,29)/t21-/m0/s1 | PDB
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Hoffmann-La Roche Inc.
US Patent
| Assay Description
Compounds were tested using a PatchXpress® (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corp... |
US Patent US9611232 (2017)
BindingDB Entry DOI: 10.7270/Q2P84DZM |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM200937
(US9533999, ii-5)Show InChI InChI=1S/C15H10ClF3N2OS/c16-11-4-3-9(6-10(11)15(17,18)19)7-21-13(22)8-23-12-2-1-5-20-14(12)21/h1-6H,7-8H2 | PDB
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Boehringer Ingelheim International GmbH
US Patent
| Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ... |
US Patent US9533999 (2017)
BindingDB Entry DOI: 10.7270/Q21V5C4S |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50547901
(CHEMBL4745327)Show SMILES CCOC(=O)N(CC(C)(C)N)C1(CC1)c1ccc(F)c(c1)C(F)(F)F | PDB
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TBA
| Assay Description
Inhibition of Kca3.1 in human erythrocytes |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00569
BindingDB Entry DOI: 10.7270/Q2X63RJG |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM200946
(US9533999, ii-8)Show SMILES FC(F)(F)S(=O)(=O)c1cc(CN2C(=O)CSc3cccnc23)ccc1Cl Show InChI InChI=1S/C15H10ClF3N2O3S2/c16-10-4-3-9(6-12(10)26(23,24)15(17,18)19)7-21-13(22)8-25-11-2-1-5-20-14(11)21/h1-6H,7-8H2 | PDB
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Boehringer Ingelheim International GmbH
US Patent
| Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ... |
US Patent US9533999 (2017)
BindingDB Entry DOI: 10.7270/Q21V5C4S |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50019903
(CHEMBL3287208 | US9533999, i-40)Show SMILES Fc1ccc(CN2c3ccsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-11(9)23-14(16,17)18)6-19-10-3-4-24-13(10)25(21,22)7-12(19)20/h1-5H,6-7H2 | PDB
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| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition... |
ACS Med Chem Lett 5: 460-1 (2014)
Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50019903
(CHEMBL3287208 | US9533999, i-40)Show SMILES Fc1ccc(CN2c3ccsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-11(9)23-14(16,17)18)6-19-10-3-4-24-13(10)25(21,22)7-12(19)20/h1-5H,6-7H2 | PDB
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| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ... |
US Patent US9533999 (2017)
BindingDB Entry DOI: 10.7270/Q21V5C4S |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50019900
(CHEMBL3287205 | US9533999, i-5)Show SMILES Fc1ccc(CN2C(=O)CS(=O)(=O)c3cccnc23)cc1OC(F)(F)F Show InChI InChI=1S/C15H10F4N2O4S/c16-10-4-3-9(6-11(10)25-15(17,18)19)7-21-13(22)8-26(23,24)12-2-1-5-20-14(12)21/h1-6H,7-8H2 | PDB
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| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition... |
ACS Med Chem Lett 5: 460-1 (2014)
Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50019900
(CHEMBL3287205 | US9533999, i-5)Show SMILES Fc1ccc(CN2C(=O)CS(=O)(=O)c3cccnc23)cc1OC(F)(F)F Show InChI InChI=1S/C15H10F4N2O4S/c16-10-4-3-9(6-11(10)25-15(17,18)19)7-21-13(22)8-26(23,24)12-2-1-5-20-14(12)21/h1-6H,7-8H2 | PDB
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| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ... |
US Patent US9533999 (2017)
BindingDB Entry DOI: 10.7270/Q21V5C4S |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50547906
(CHEMBL4743839)Show SMILES CCOC(=O)N(C[C@@H]1CCCN1)C1(CC1)c1ccc(F)c(c1)C(F)(F)F |r| | PDB
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KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Kca3.1 in human erythrocytes |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00569
BindingDB Entry DOI: 10.7270/Q2X63RJG |
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Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50019904
(CHEMBL3287209 | US9533999, ii-1)Show InChI InChI=1S/C15H11F3N2O2S/c16-15(17,18)22-11-4-1-3-10(7-11)8-20-13(21)9-23-12-5-2-6-19-14(12)20/h1-7H,8-9H2 | PDB
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| US Patent
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ... |
US Patent US9533999 (2017)
BindingDB Entry DOI: 10.7270/Q21V5C4S |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM50019904
(CHEMBL3287209 | US9533999, ii-1)Show InChI InChI=1S/C15H11F3N2O2S/c16-15(17,18)22-11-4-1-3-10(7-11)8-20-13(21)9-23-12-5-2-6-19-14(12)20/h1-7H,8-9H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition... |
ACS Med Chem Lett 5: 460-1 (2014)
Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM200942
(US9533999, ii-7)Show InChI InChI=1S/C15H10ClF3N2OS2/c16-10-4-3-9(6-12(10)24-15(17,18)19)7-21-13(22)8-23-11-2-1-5-20-14(11)21/h1-6H,7-8H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ... |
US Patent US9533999 (2017)
BindingDB Entry DOI: 10.7270/Q21V5C4S |
More data for this
Ligand-Target Pair | |
Intermediate conductance calcium-activated potassium channel protein 4
(Homo sapiens (Human)) | BDBM205066
(US9556132, 30 | process for preparing (e)-n-[(2-{2...)Show InChI InChI=1S/C20H14FN5O/c21-18-11-5-6-12-19(18)26-20(23-24-25-26)17-10-4-3-9-16(17)15-8-2-1-7-14(15)13-22-27/h1-13,27H/b22-13- | PDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
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| KEGG
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | 7.3 | n/a |
Saniona A/S
US Patent
| Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas... |
US Patent US9556132 (2017)
BindingDB Entry DOI: 10.7270/Q2SF2Z5T |
More data for this
Ligand-Target Pair | |
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