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Compile Data Set for Download or QSAR

Found 767 hits of ic50 data for polymerid = 50001232,50003334   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50039246
PNG
((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1
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n/an/a 1.12E+3n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis

Bioorg Med Chem 21: 4938-50 (2013)


Article DOI: 10.1016/j.bmc.2013.06.063
BindingDB Entry DOI: 10.7270/Q2NZ891C
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50039246
PNG
((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1
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n/an/a 1.12E+3n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis

ACS Med Chem Lett 5: 889-93 (2014)


Article DOI: 10.1021/ml500134k
BindingDB Entry DOI: 10.7270/Q2WH2RS1
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50577088
PNG
(CHEMBL4860085)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(cc1)-c1ccc(C=O)cc1 |r|
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n/an/a 1.29E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113512
BindingDB Entry DOI: 10.7270/Q2R21568
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276009
PNG
(CHEMBL2403781)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+/t23-/m0/s1
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n/an/a 1.35E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 27: 822-831 (2019)


Article DOI: 10.1016/j.bmc.2019.01.024
BindingDB Entry DOI: 10.7270/Q28K7DJR
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276009
PNG
(CHEMBL2403781)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+/t23-/m0/s1
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n/an/a 1.35E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition mea...

Bioorg Med Chem 26: 3668-3687 (2018)


Article DOI: 10.1016/j.bmc.2018.05.049
BindingDB Entry DOI: 10.7270/Q20004MB
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276009
PNG
(CHEMBL2403781)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+/t23-/m0/s1
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n/an/a 1.35E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 27: 822-831 (2019)


Article DOI: 10.1016/j.bmc.2019.01.024
BindingDB Entry DOI: 10.7270/Q28K7DJR
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276009
PNG
(CHEMBL2403781)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+/t23-/m0/s1
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n/an/a 1.35E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cell line assessed as reduction in [3H]GABA uptake incubated for 10 mins

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113397
BindingDB Entry DOI: 10.7270/Q29S1VTT
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50039246
PNG
((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1
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n/an/a 1.55E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113512
BindingDB Entry DOI: 10.7270/Q2R21568
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50039246
PNG
((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1
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n/an/a 1.55E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.111920
BindingDB Entry DOI: 10.7270/Q2FJ2MJJ
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50276009
PNG
(CHEMBL2403781)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+/t23-/m0/s1
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n/an/a 1.59E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human GAT3 expressed in COS-7 cells assessed as reduction in [2H6]GABA uptake preincubated for 25 mins followed by [2H6]GABA addition a...

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113397
BindingDB Entry DOI: 10.7270/Q29S1VTT
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276022
PNG
(CHEMBL4126078)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1C |r|
Show InChI InChI=1S/C31H37NO6/c1-22-20-28(37-4)15-16-29(22)31(24-7-11-26(35-2)12-8-24,25-9-13-27(36-3)14-10-25)38-19-18-32-17-5-6-23(21-32)30(33)34/h7-16,20,23H,5-6,17-19,21H2,1-4H3,(H,33,34)/t23-/m0/s1
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n/an/a 1.66E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.111920
BindingDB Entry DOI: 10.7270/Q2FJ2MJJ
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50564011
PNG
(CHEMBL4779064)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1C |r|
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n/an/a 1.66E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mouse GTA4 receptor

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.111920
BindingDB Entry DOI: 10.7270/Q2FJ2MJJ
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276022
PNG
(CHEMBL4126078)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1C |r|
Show InChI InChI=1S/C31H37NO6/c1-22-20-28(37-4)15-16-29(22)31(24-7-11-26(35-2)12-8-24,25-9-13-27(36-3)14-10-25)38-19-18-32-17-5-6-23(21-32)30(33)34/h7-16,20,23H,5-6,17-19,21H2,1-4H3,(H,33,34)/t23-/m0/s1
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n/an/a 1.66E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cell line assessed as reduction in [3H]GABA uptake incubated for 10 mins

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113397
BindingDB Entry DOI: 10.7270/Q29S1VTT
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276022
PNG
(CHEMBL4126078)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1C |r|
Show InChI InChI=1S/C31H37NO6/c1-22-20-28(37-4)15-16-29(22)31(24-7-11-26(35-2)12-8-24,25-9-13-27(36-3)14-10-25)38-19-18-32-17-5-6-23(21-32)30(33)34/h7-16,20,23H,5-6,17-19,21H2,1-4H3,(H,33,34)/t23-/m0/s1
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n/an/a 1.66E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition mea...

Bioorg Med Chem 26: 3668-3687 (2018)


Article DOI: 10.1016/j.bmc.2018.05.049
BindingDB Entry DOI: 10.7270/Q20004MB
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50525189
PNG
(CHEMBL4458674)
Show SMILES OC(=O)CC1CNC=N1 |c:7|
Show InChI InChI=1S/C5H8N2O2/c8-5(9)1-4-2-6-3-7-4/h3-4H,1-2H2,(H,6,7)(H,8,9)
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n/an/a 1.90E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting...

J Med Chem 62: 5797-5809 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00026
BindingDB Entry DOI: 10.7270/Q2D2222H
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50039246
PNG
((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1
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n/an/a 1.95E+3n/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake

Eur J Med Chem 83: 256-73 (2014)


Article DOI: 10.1016/j.ejmech.2014.06.024
BindingDB Entry DOI: 10.7270/Q21N82P9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50039246
PNG
((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1
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n/an/a 1.95E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition mea...

Bioorg Med Chem 26: 3668-3687 (2018)


Article DOI: 10.1016/j.bmc.2018.05.049
BindingDB Entry DOI: 10.7270/Q20004MB
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50039246
PNG
((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1
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n/an/a 1.95E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 27: 822-831 (2019)


Article DOI: 10.1016/j.bmc.2019.01.024
BindingDB Entry DOI: 10.7270/Q28K7DJR
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50039246
PNG
((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1
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Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 27: 822-831 (2019)


Article DOI: 10.1016/j.bmc.2019.01.024
BindingDB Entry DOI: 10.7270/Q28K7DJR
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50039248
PNG
((R)-1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-...)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1
Show InChI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m1/s1
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n/an/a 1.95E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mouse GTA4 receptor

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.111920
BindingDB Entry DOI: 10.7270/Q2FJ2MJJ
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50525189
PNG
(CHEMBL4458674)
Show SMILES OC(=O)CC1CNC=N1 |c:7|
Show InChI InChI=1S/C5H8N2O2/c8-5(9)1-4-2-6-3-7-4/h3-4H,1-2H2,(H,6,7)(H,8,9)
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting...

J Med Chem 62: 5797-5809 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00026
BindingDB Entry DOI: 10.7270/Q2D2222H
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276020
PNG
(CHEMBL4127466)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCCC(C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+
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n/an/a 2.14E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition mea...

Bioorg Med Chem 26: 3668-3687 (2018)


Article DOI: 10.1016/j.bmc.2018.05.049
BindingDB Entry DOI: 10.7270/Q20004MB
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276020
PNG
(CHEMBL4127466)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCCC(C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+
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n/an/a 2.14E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 27: 822-831 (2019)


Article DOI: 10.1016/j.bmc.2019.01.024
BindingDB Entry DOI: 10.7270/Q28K7DJR
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276020
PNG
(CHEMBL4127466)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCCC(C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+
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n/an/a 2.14E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 27: 822-831 (2019)


Article DOI: 10.1016/j.bmc.2019.01.024
BindingDB Entry DOI: 10.7270/Q28K7DJR
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50039246
PNG
((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1
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n/an/a 2.24E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK cells assessed as reduction in [3H]GABA uptake by measuring remaining [3H]GABA uptake levels preincubated f...

Bioorg Med Chem 27: 144-152 (2019)


Article DOI: 10.1016/j.bmc.2018.11.028
BindingDB Entry DOI: 10.7270/Q24T6NR4
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50367949
PNG
(CHEMBL1788265)
Show SMILES OC(=O)C[C@H]1CCNC1 |r|
Show InChI InChI=1S/C6H11NO2/c8-6(9)3-5-1-2-7-4-5/h5,7H,1-4H2,(H,8,9)/t5-/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting...

J Med Chem 62: 5797-5809 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00026
BindingDB Entry DOI: 10.7270/Q2D2222H
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50563998
PNG
(CHEMBL4781266)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6](\c1sccc1-[#6])-c1sccc1-[#6])-[#6](-[#6]-[#6]-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-[#6]-c1ccccc1Cl
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n/an/a 2.46E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mouse GAT3 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.111920
BindingDB Entry DOI: 10.7270/Q2FJ2MJJ
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50563998
PNG
(CHEMBL4781266)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6](\c1sccc1-[#6])-c1sccc1-[#6])-[#6](-[#6]-[#6]-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-[#6]-c1ccccc1Cl
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n/an/a 2.46E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mouse GAT3 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113512
BindingDB Entry DOI: 10.7270/Q2R21568
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50367949
PNG
(CHEMBL1788265)
Show SMILES OC(=O)C[C@H]1CCNC1 |r|
Show InChI InChI=1S/C6H11NO2/c8-6(9)3-5-1-2-7-4-5/h5,7H,1-4H2,(H,8,9)/t5-/m1/s1
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n/an/a 2.51E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting...

J Med Chem 62: 5797-5809 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00026
BindingDB Entry DOI: 10.7270/Q2D2222H
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50013223
PNG
(CHEMBL349005 | Pyrrolidin-3-yl-acetic acid ((S)-(+...)
Show SMILES OC(=O)C[C@@H]1CCNC1
Show InChI InChI=1S/C6H11NO2/c8-6(9)3-5-1-2-7-4-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1
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n/an/a 2.51E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting...

J Med Chem 62: 5797-5809 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00026
BindingDB Entry DOI: 10.7270/Q2D2222H
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50013223
PNG
(CHEMBL349005 | Pyrrolidin-3-yl-acetic acid ((S)-(+...)
Show SMILES OC(=O)C[C@@H]1CCNC1
Show InChI InChI=1S/C6H11NO2/c8-6(9)3-5-1-2-7-4-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting...

J Med Chem 62: 5797-5809 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00026
BindingDB Entry DOI: 10.7270/Q2D2222H
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50518211
PNG
(CHEMBL4447559)
Show SMILES OC(=O)[C@H]1CNC[C@H](C1)N\N=C\c1cc(F)ccc1-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C19H19ClFN3O2/c20-15-3-1-12(2-4-15)18-6-5-16(21)7-13(18)10-23-24-17-8-14(19(25)26)9-22-11-17/h1-7,10,14,17,22,24H,8-9,11H2,(H,25,26)/b23-10+/t14-,17+/m1/s1
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n/an/a 2.75E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 expressed in COS7 cells assessed as reduction in [2H6]GABA uptake preincubated for 25 mins followed by [2H6]GABA addition an...

Bioorg Med Chem 27: 144-152 (2019)


Article DOI: 10.1016/j.bmc.2018.11.028
BindingDB Entry DOI: 10.7270/Q24T6NR4
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50466783
PNG
(CHEMBL4289242)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc2sccc2c1 |r|
Show InChI InChI=1S/C32H33NO4S/c1-36-28-11-6-25(7-12-28)32(26-8-13-29(37-2)14-9-26,27-10-15-30-23(21-27)16-20-38-30)17-4-19-33-18-3-5-24(22-33)31(34)35/h4,6-17,20-21,24H,3,5,18-19,22H2,1-2H3,(H,34,35)/b17-4+/t24-/m0/s1
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n/an/a 2.82E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT3 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 26: 5944-5961 (2018)


Article DOI: 10.1016/j.bmc.2018.11.002
BindingDB Entry DOI: 10.7270/Q28K7CSG
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50466783
PNG
(CHEMBL4289242)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc2sccc2c1 |r|
Show InChI InChI=1S/C32H33NO4S/c1-36-28-11-6-25(7-12-28)32(26-8-13-29(37-2)14-9-26,27-10-15-30-23(21-27)16-20-38-30)17-4-19-33-18-3-5-24(22-33)31(34)35/h4,6-17,20-21,24H,3,5,18-19,22H2,1-2H3,(H,34,35)/b17-4+/t24-/m0/s1
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n/an/a 2.88E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 26: 5944-5961 (2018)


Article DOI: 10.1016/j.bmc.2018.11.002
BindingDB Entry DOI: 10.7270/Q28K7CSG
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50570588
PNG
(CHEMBL4845832)
Show SMILES O[C@@H](CNCc1ccccc1)[C@H](Cc1ccccc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
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n/an/a 2.95E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human GAT3 expressed in COS-7 cells assessed as reduction in [2H6]GABA uptake preincubated for 25 mins followed by [2H6]GABA addition a...

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113397
BindingDB Entry DOI: 10.7270/Q29S1VTT
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50276022
PNG
(CHEMBL4126078)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1C |r|
Show InChI InChI=1S/C31H37NO6/c1-22-20-28(37-4)15-16-29(22)31(24-7-11-26(35-2)12-8-24,25-9-13-27(36-3)14-10-25)38-19-18-32-17-5-6-23(21-32)30(33)34/h7-16,20,23H,5-6,17-19,21H2,1-4H3,(H,33,34)/t23-/m0/s1
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n/an/a 3.16E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human GAT3 expressed in COS-7 cells assessed as reduction in [2H6]GABA uptake preincubated for 25 mins followed by [2H6]GABA addition a...

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113397
BindingDB Entry DOI: 10.7270/Q29S1VTT
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50466779
PNG
(CHEMBL4278924)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCCC(C1)C(O)=O)(c1ccc(OC)cc1)c1ccc2OCOc2c1
Show InChI InChI=1S/C31H33NO6/c1-35-26-11-6-23(7-12-26)31(24-8-13-27(36-2)14-9-24,25-10-15-28-29(19-25)38-21-37-28)16-4-18-32-17-3-5-22(20-32)30(33)34/h4,6-16,19,22H,3,5,17-18,20-21H2,1-2H3,(H,33,34)/b16-4+
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n/an/a 3.16E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 26: 5944-5961 (2018)


Article DOI: 10.1016/j.bmc.2018.11.002
BindingDB Entry DOI: 10.7270/Q28K7CSG
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Homo sapiens (Human))		BDBM50039246
PNG
((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Show SMILES COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1
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n/an/a 3.31E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of human GAT3 expressed in COS7 cells assessed as reduction in [2H6]GABA uptake preincubated for 25 mins followed by [2H6]GABA addition an...

Bioorg Med Chem 27: 144-152 (2019)


Article DOI: 10.1016/j.bmc.2018.11.028
BindingDB Entry DOI: 10.7270/Q24T6NR4
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276009
PNG
(CHEMBL2403781)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+/t23-/m0/s1
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n/an/a 3.39E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT3 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition mea...

Bioorg Med Chem 26: 3668-3687 (2018)


Article DOI: 10.1016/j.bmc.2018.05.049
BindingDB Entry DOI: 10.7270/Q20004MB
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276009
PNG
(CHEMBL2403781)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+/t23-/m0/s1
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n/an/a 3.39E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT3 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 27: 822-831 (2019)


Article DOI: 10.1016/j.bmc.2019.01.024
BindingDB Entry DOI: 10.7270/Q28K7DJR
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276009
PNG
(CHEMBL2403781)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+/t23-/m0/s1
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n/an/a 3.39E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT3 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 27: 822-831 (2019)


Article DOI: 10.1016/j.bmc.2019.01.024
BindingDB Entry DOI: 10.7270/Q28K7DJR
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50276009
PNG
(CHEMBL2403781)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C31H35NO5/c1-35-27-13-7-24(8-14-27)31(25-9-15-28(36-2)16-10-25,26-11-17-29(37-3)18-12-26)19-5-21-32-20-4-6-23(22-32)30(33)34/h5,7-19,23H,4,6,20-22H2,1-3H3,(H,33,34)/b19-5+/t23-/m0/s1
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n/an/a 3.39E+3n/an/an/an/an/an/a


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Assay Description
Inhibition of mouse GAT3 expressed in HEK293 cell line assessed as reduction in [3H]GABA uptake incubated for 10 mins

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113397
BindingDB Entry DOI: 10.7270/Q29S1VTT
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50466782
PNG
(CHEMBL4288852)
Show SMILES COc1ccc(cc1)C(\C=C\CN1CCCC(C1)C(O)=O)(c1ccc(OC)cc1)c1ccc2sccc2c1
Show InChI InChI=1S/C32H33NO4S/c1-36-28-11-6-25(7-12-28)32(26-8-13-29(37-2)14-9-26,27-10-15-30-23(21-27)16-20-38-30)17-4-19-33-18-3-5-24(22-33)31(34)35/h4,6-17,20-21,24H,3,5,18-19,22H2,1-2H3,(H,34,35)/b17-4+
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n/an/a 3.55E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...

Bioorg Med Chem 26: 5944-5961 (2018)


Article DOI: 10.1016/j.bmc.2018.11.002
BindingDB Entry DOI: 10.7270/Q28K7CSG
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50563989
PNG
(CHEMBL4778208)
Show SMILES [#6]-[#6](-[#8])-[#6]-[#6](-[#7](-[#6])-[#6]-[#6]\[#6]=[#6](\c1sccc1-[#6])-c1sccc1-[#6])-[#6](=O)-[#7]-[#6]-c1ccccc1Cl
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n/an/a 3.63E+3n/an/an/an/an/an/a


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Inhibition of mouse GAT3 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.111920
BindingDB Entry DOI: 10.7270/Q2FJ2MJJ
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50563994
PNG
(CHEMBL4780692)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6](\c1sccc1-[#6])-c1sccc1-[#6])-[#6](-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-c1ccccc1Cl
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n/an/a 3.63E+3n/an/an/an/an/an/a


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Inhibition of mouse GAT3 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.111920
BindingDB Entry DOI: 10.7270/Q2FJ2MJJ
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50563989
PNG
(CHEMBL4778208)
Show SMILES [#6]-[#6](-[#8])-[#6]-[#6](-[#7](-[#6])-[#6]-[#6]\[#6]=[#6](\c1sccc1-[#6])-c1sccc1-[#6])-[#6](=O)-[#7]-[#6]-c1ccccc1Cl
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Inhibition of mouse GAT3 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.111920
BindingDB Entry DOI: 10.7270/Q2FJ2MJJ
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50563988
PNG
(CHEMBL4793917)
Show SMILES [#6]-[#6](-[#8])-[#6]-[#6](-[#7](-[#6])-[#6]-[#6]\[#6]=[#6](\c1sccc1-[#6])-c1sccc1-[#6])-[#6](=O)-[#7]-[#6]-c1ccccc1
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n/an/a 3.89E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mouse GAT4 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.111920
BindingDB Entry DOI: 10.7270/Q2FJ2MJJ
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50563988
PNG
(CHEMBL4793917)
Show SMILES [#6]-[#6](-[#8])-[#6]-[#6](-[#7](-[#6])-[#6]-[#6]\[#6]=[#6](\c1sccc1-[#6])-c1sccc1-[#6])-[#6](=O)-[#7]-[#6]-c1ccccc1
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Inhibition of mouse GAT4 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.111920
BindingDB Entry DOI: 10.7270/Q2FJ2MJJ
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50563978
PNG
(CHEMBL4798809)
Show SMILES NCC(O)C(O)=O
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n/an/a 3.98E+3n/an/an/an/an/an/a


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Assay Description
Inhibition of mouse GAT3 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho...

Citation and Details

Article DOI: 10.1016/j.ejmech.2019.111920
BindingDB Entry DOI: 10.7270/Q2FJ2MJJ
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent GABA transporter 3


(Mus musculus)		BDBM50577081
PNG
(CHEMBL4852705)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-c1ccc(F)cc1
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n/an/a 4.37E+3n/an/an/an/an/an/a


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Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113512
BindingDB Entry DOI: 10.7270/Q2R21568
More data for this
Ligand-Target Pair
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