Found 6 hits of ic50 data for polymerid = 50001263 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dihydropyrimidine dehydrogenase [NADP(+)]
(Homo sapiens (Human)) | BDBM50124202
(5-Ethynyl-1H-pyrimidine-2,4-dione | CHEMBL355200)Show InChI InChI=1S/C6H4N2O2/c1-2-4-3-7-6(10)8-5(4)9/h1,3H,(H2,7,8,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD) |
Bioorg Med Chem Lett 13: 867-72 (2003)
BindingDB Entry DOI: 10.7270/Q21V5DBW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dihydropyrimidine dehydrogenase [NADP(+)]
(Homo sapiens (Human)) | BDBM50124200
(5-((E)-Styryl)-1H-pyrimidine-2,4-dione | CHEMBL352...)Show InChI InChI=1S/C12H10N2O2/c15-11-10(8-13-12(16)14-11)7-6-9-4-2-1-3-5-9/h1-8H,(H2,13,14,15,16) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD) |
Bioorg Med Chem Lett 13: 867-72 (2003)
BindingDB Entry DOI: 10.7270/Q21V5DBW |
More data for this Ligand-Target Pair | |
Dihydropyrimidine dehydrogenase [NADP(+)]
(Homo sapiens (Human)) | BDBM50124204
(5-Vinyl-1H-pyrimidine-2,4-dione | CHEMBL170188)Show InChI InChI=1S/C6H6N2O2/c1-2-4-3-7-6(10)8-5(4)9/h2-3H,1H2,(H2,7,8,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD) |
Bioorg Med Chem Lett 13: 867-72 (2003)
BindingDB Entry DOI: 10.7270/Q21V5DBW |
More data for this Ligand-Target Pair | |
Dihydropyrimidine dehydrogenase [NADP(+)]
(Homo sapiens (Human)) | BDBM50124201
(5-(3-Benzyloxy-benzyl)-1H-pyrimidine-2,4-dione | C...)Show SMILES O=c1[nH]cc(Cc2cccc(OCc3ccccc3)c2)c(=O)[nH]1 Show InChI InChI=1S/C18H16N2O3/c21-17-15(11-19-18(22)20-17)9-14-7-4-8-16(10-14)23-12-13-5-2-1-3-6-13/h1-8,10-11H,9,12H2,(H2,19,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD) |
Bioorg Med Chem Lett 13: 867-72 (2003)
BindingDB Entry DOI: 10.7270/Q21V5DBW |
More data for this Ligand-Target Pair | |
Dihydropyrimidine dehydrogenase [NADP(+)]
(Homo sapiens (Human)) | BDBM50124205
(2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonit...)Show InChI InChI=1S/C5H3N3O2/c6-1-3-2-7-5(10)8-4(3)9/h2H,(H2,7,8,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD) |
Bioorg Med Chem Lett 13: 867-72 (2003)
BindingDB Entry DOI: 10.7270/Q21V5DBW |
More data for this Ligand-Target Pair | |
Dihydropyrimidine dehydrogenase [NADP(+)]
(Homo sapiens (Human)) | BDBM50124203
(5-IODOURACIL | 5-Iodo-1H-pyrimidine-2,4-dione | CH...)Show InChI InChI=1S/C4H3IN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD) |
Bioorg Med Chem Lett 13: 867-72 (2003)
BindingDB Entry DOI: 10.7270/Q21V5DBW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |