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Compile Data Set for Download or QSAR

Found 100 hits of ic50 data for polymerid = 50001436   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072685
PNG
((3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperid...)
Show SMILES CC1C(O)C(O)C(O)C(CO)N1CC=O
Show InChI InChI=1S/C9H17NO5/c1-5-7(13)9(15)8(14)6(4-12)10(5)2-3-11/h3,5-9,12-15H,2,4H2,1H3
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n/an/a 4n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442341
PNG
(CHEMBL2442786)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccccc2F)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H19FN2O4/c1-7-12(19)14(21)13(20)10(16-7)6-11(18)17-9-5-3-2-4-8(9)15/h2-5,7,10,12-14,16,19-21H,6H2,1H3,(H,17,18)/t7-,10+,12+,13+,14+/m0/s1
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n/an/a 7.90n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072685
PNG
((3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperid...)
Show SMILES CC1C(O)C(O)C(O)C(CO)N1CC=O
Show InChI InChI=1S/C9H17NO5/c1-5-7(13)9(15)8(14)6(4-12)10(5)2-3-11/h3,5-9,12-15H,2,4H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072685
PNG
((3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperid...)
Show SMILES CC1C(O)C(O)C(O)C(CO)N1CC=O
Show InChI InChI=1S/C9H17NO5/c1-5-7(13)9(15)8(14)6(4-12)10(5)2-3-11/h3,5-9,12-15H,2,4H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442339
PNG
(CHEMBL2442788)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(F)cc2)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H19FN2O4/c1-7-12(19)14(21)13(20)10(16-7)6-11(18)17-9-4-2-8(15)3-5-9/h2-5,7,10,12-14,16,19-21H,6H2,1H3,(H,17,18)/t7-,10+,12+,13+,14+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442344
PNG
(CHEMBL2442783)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(C)cc2)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C15H22N2O4/c1-8-3-5-10(6-4-8)17-12(18)7-11-14(20)15(21)13(19)9(2)16-11/h3-6,9,11,13-16,19-21H,7H2,1-2H3,(H,17,18)/t9-,11+,13+,14+,15+/m0/s1
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n/an/a 15n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM394396
PNG
(US10308607, Compound II)
Show SMILES O[C@@H]1[C@H](O)[C@H](CF)N[C@H](CNC(=O)c2cccc3-c4ccccc4C(=O)c23)[C@H]1O |r|
Show InChI InChI=1S/C21H21FN2O5/c22-8-14-18(26)20(28)19(27)15(24-14)9-23-21(29)13-7-3-6-11-10-4-1-2-5-12(10)17(25)16(11)13/h1-7,14-15,18-20,24,26-28H,8-9H2,(H,23,29)/t14-,15+,18+,19+,20+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Washington University



Assay Description
Fucosidase inhibition was assessed by preparing a reaction mixture of 50 mM phosphate-citrate pH 4.5, 5 mM MgCl2, 640 nM 4-methylumbelliferyl-alpha-L...

J Med Chem 52: 2188-91 (2009)


BindingDB Entry DOI: 10.7270/Q29P3403
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442343
PNG
(CHEMBL2442784)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(C)cc2C)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C16H24N2O4/c1-8-4-5-11(9(2)6-8)18-13(19)7-12-15(21)16(22)14(20)10(3)17-12/h4-6,10,12,14-17,20-22H,7H2,1-3H3,(H,18,19)/t10-,12+,14+,15+,16+/m0/s1
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n/an/a 19n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072687
PNG
((S)-2-Amino-3-hydroxy-N-(3,4,5-trihydroxy-2-hydrox...)
Show SMILES CC1NC(CO)(CNC(=O)[C@@H](N)CO)C(O)C(O)C1O
Show InChI InChI=1S/C11H23N3O6/c1-5-7(17)8(18)9(19)11(4-16,14-5)3-13-10(20)6(12)2-15/h5-9,14-19H,2-4,12H2,1H3,(H,13,20)/t5?,6-,7?,8?,9?,11?/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442348
PNG
(CHEMBL2442779)
Show SMILES COc1ccc(NC(=O)C[C@H]2N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)cc1 |r|
Show InChI InChI=1S/C15H22N2O5/c1-8-13(19)15(21)14(20)11(16-8)7-12(18)17-9-3-5-10(22-2)6-4-9/h3-6,8,11,13-16,19-21H,7H2,1-2H3,(H,17,18)/t8-,11+,13+,14+,15+/m0/s1
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n/an/a 26n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442350
PNG
(CHEMBL2442777)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccccc2)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H20N2O4/c1-8-12(18)14(20)13(19)10(15-8)7-11(17)16-9-5-3-2-4-6-9/h2-6,8,10,12-15,18-20H,7H2,1H3,(H,16,17)/t8-,10+,12+,13+,14+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442345
PNG
(CHEMBL2442782)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2cccc(C)c2)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C15H22N2O4/c1-8-4-3-5-10(6-8)17-12(18)7-11-14(20)15(21)13(19)9(2)16-11/h3-6,9,11,13-16,19-21H,7H2,1-2H3,(H,17,18)/t9-,11+,13+,14+,15+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442340
PNG
(CHEMBL2442787)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2cccc(F)c2)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H19FN2O4/c1-7-12(19)14(21)13(20)10(16-7)6-11(18)17-9-4-2-3-8(15)5-9/h2-5,7,10,12-14,16,19-21H,6H2,1H3,(H,17,18)/t7-,10+,12+,13+,14+/m0/s1
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n/an/a 31n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442338
PNG
(CHEMBL2442773)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccc(F)cc2F)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H18F2N2O4/c1-6-12(20)14(22)13(21)10(17-6)5-11(19)18-9-3-2-7(15)4-8(9)16/h2-4,6,10,12-14,17,20-22H,5H2,1H3,(H,18,19)/t6-,10+,12+,13+,14+/m0/s1
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n/an/a 35n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072682
PNG
(CHEMBL115930 | {[(3,4,5-Trihydroxy-2-hydroxymethyl...)
Show SMILES CC1NC(CO)(CNC(=O)CNC(=O)OCc2ccccc2)C(O)C(O)C1O
Show InChI InChI=1S/C18H27N3O7/c1-11-14(24)15(25)16(26)18(10-22,21-11)9-20-13(23)7-19-17(27)28-8-12-5-3-2-4-6-12/h2-6,11,14-16,21-22,24-26H,7-10H2,1H3,(H,19,27)(H,20,23)
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n/an/a 40n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072687
PNG
((S)-2-Amino-3-hydroxy-N-(3,4,5-trihydroxy-2-hydrox...)
Show SMILES CC1NC(CO)(CNC(=O)[C@@H](N)CO)C(O)C(O)C1O
Show InChI InChI=1S/C11H23N3O6/c1-5-7(17)8(18)9(19)11(4-16,14-5)3-13-10(20)6(12)2-15/h5-9,14-19H,2-4,12H2,1H3,(H,13,20)/t5?,6-,7?,8?,9?,11?/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072684
PNG
(2-Amino-N-(3,4,5-trihydroxy-2-hydroxymethyl-6-meth...)
Show SMILES CC1NC(CO)(CNC(=O)CN)C(O)C(O)C1O
Show InChI InChI=1S/C10H21N3O5/c1-5-7(16)8(17)9(18)10(4-14,13-5)3-12-6(15)2-11/h5,7-9,13-14,16-18H,2-4,11H2,1H3,(H,12,15)
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n/an/a 50n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072687
PNG
((S)-2-Amino-3-hydroxy-N-(3,4,5-trihydroxy-2-hydrox...)
Show SMILES CC1NC(CO)(CNC(=O)[C@@H](N)CO)C(O)C(O)C1O
Show InChI InChI=1S/C11H23N3O6/c1-5-7(17)8(18)9(19)11(4-16,14-5)3-13-10(20)6(12)2-15/h5-9,14-19H,2-4,12H2,1H3,(H,13,20)/t5?,6-,7?,8?,9?,11?/m0/s1
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n/an/a 56n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442346
PNG
(CHEMBL2442781)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2ccccc2C)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C15H22N2O4/c1-8-5-3-4-6-10(8)17-12(18)7-11-14(20)15(21)13(19)9(2)16-11/h3-6,9,11,13-16,19-21H,7H2,1-2H3,(H,17,18)/t9-,11+,13+,14+,15+/m0/s1
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n/an/a 58n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM394397
PNG
(US10308607, Compound III)
Show SMILES O[C@@H]1[C@H](O)[C@H](CF)N[C@@H](CNC(=O)c2cccc3-c4ccccc4C(=O)c23)[C@H]1O |r|
Show InChI InChI=1S/C21H21FN2O5/c22-8-14-18(26)20(28)19(27)15(24-14)9-23-21(29)13-7-3-6-11-10-4-1-2-5-12(10)17(25)16(11)13/h1-7,14-15,18-20,24,26-28H,8-9H2,(H,23,29)/t14-,15-,18+,19+,20+/m0/s1
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n/an/a 59n/an/an/an/an/an/a



Washington University



Assay Description
Fucosidase inhibition was assessed by preparing a reaction mixture of 50 mM phosphate-citrate pH 4.5, 5 mM MgCl2, 640 nM 4-methylumbelliferyl-alpha-L...

J Med Chem 52: 2188-91 (2009)


BindingDB Entry DOI: 10.7270/Q29P3403
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072683
PNG
(3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperidi...)
Show SMILES CC1NC(CO)(C#N)C(O)C(O)C1O
Show InChI InChI=1S/C8H14N2O4/c1-4-5(12)6(13)7(14)8(2-9,3-11)10-4/h4-7,10-14H,3H2,1H3
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072686
PNG
(2-Aminomethyl-2-hydroxymethyl-6-methyl-piperidine-...)
Show SMILES CC1NC(CN)(CO)C(O)C(O)C1O
Show InChI InChI=1S/C8H18N2O4/c1-4-5(12)6(13)7(14)8(2-9,3-11)10-4/h4-7,10-14H,2-3,9H2,1H3
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442351
PNG
(CHEMBL2442776)
Show SMILES C[C@@H]1N[C@H](CCCc2ccccc2)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C15H23NO3/c1-10-13(17)15(19)14(18)12(16-10)9-5-8-11-6-3-2-4-7-11/h2-4,6-7,10,12-19H,5,8-9H2,1H3/t10-,12+,13+,14+,15+/m0/s1
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University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50118923
PNG
((1S,2S,3R)-4-Methyl-6-octylamino-cyclohexane-1,2,3...)
Show SMILES CCCCCCCCNC1CC(C)C(O)C(O)C1O
Show InChI InChI=1S/C15H31NO3/c1-3-4-5-6-7-8-9-16-12-10-11(2)13(17)15(19)14(12)18/h11-19H,3-10H2,1-2H3
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Keio University

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase

Bioorg Med Chem Lett 12: 2811-4 (2002)


BindingDB Entry DOI: 10.7270/Q2C24WZJ
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072683
PNG
(3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperidi...)
Show SMILES CC1NC(CO)(C#N)C(O)C(O)C1O
Show InChI InChI=1S/C8H14N2O4/c1-4-5(12)6(13)7(14)8(2-9,3-11)10-4/h4-7,10-14H,3H2,1H3
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072684
PNG
(2-Amino-N-(3,4,5-trihydroxy-2-hydroxymethyl-6-meth...)
Show SMILES CC1NC(CO)(CNC(=O)CN)C(O)C(O)C1O
Show InChI InChI=1S/C10H21N3O5/c1-5-7(16)8(17)9(18)10(4-14,13-5)3-12-6(15)2-11/h5,7-9,13-14,16-18H,2-4,11H2,1H3,(H,12,15)
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072683
PNG
(3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperidi...)
Show SMILES CC1NC(CO)(C#N)C(O)C(O)C1O
Show InChI InChI=1S/C8H14N2O4/c1-4-5(12)6(13)7(14)8(2-9,3-11)10-4/h4-7,10-14H,3H2,1H3
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n/an/a 122n/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442347
PNG
(CHEMBL2442780)
Show SMILES CCCCNC(=O)C[C@H]1N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C12H24N2O4/c1-3-4-5-13-9(15)6-8-11(17)12(18)10(16)7(2)14-8/h7-8,10-12,14,16-18H,3-6H2,1-2H3,(H,13,15)/t7-,8+,10+,11+,12+/m0/s1
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University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50065258
PNG
((2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1
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n/an/a 140n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of placental alpha-L-fucosidase (unknown origin)

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01673
BindingDB Entry DOI: 10.7270/Q23J3HVM
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50065258
PNG
((2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1
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University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072686
PNG
(2-Aminomethyl-2-hydroxymethyl-6-methyl-piperidine-...)
Show SMILES CC1NC(CN)(CO)C(O)C(O)C1O
Show InChI InChI=1S/C8H18N2O4/c1-4-5(12)6(13)7(14)8(2-9,3-11)10-4/h4-7,10-14H,2-3,9H2,1H3
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072684
PNG
(2-Amino-N-(3,4,5-trihydroxy-2-hydroxymethyl-6-meth...)
Show SMILES CC1NC(CO)(CNC(=O)CN)C(O)C(O)C1O
Show InChI InChI=1S/C10H21N3O5/c1-5-7(16)8(17)9(18)10(4-14,13-5)3-12-6(15)2-11/h5,7-9,13-14,16-18H,2-4,11H2,1H3,(H,12,15)
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442337
PNG
(CHEMBL2442774)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2c(F)cc(F)cc2F)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C14H17F3N2O4/c1-5-12(21)14(23)13(22)9(18-5)4-10(20)19-11-7(16)2-6(15)3-8(11)17/h2-3,5,9,12-14,18,21-23H,4H2,1H3,(H,19,20)/t5-,9+,12+,13+,14+/m0/s1
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University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072682
PNG
(CHEMBL115930 | {[(3,4,5-Trihydroxy-2-hydroxymethyl...)
Show SMILES CC1NC(CO)(CNC(=O)CNC(=O)OCc2ccccc2)C(O)C(O)C1O
Show InChI InChI=1S/C18H27N3O7/c1-11-14(24)15(25)16(26)18(10-22,21-11)9-20-13(23)7-19-17(27)28-8-12-5-3-2-4-6-12/h2-6,11,14-16,21-22,24-26H,7-10H2,1H3,(H,19,27)(H,20,23)
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442349
PNG
(CHEMBL2442778)
Show SMILES C[C@@H]1N[C@H](CC(=O)NCc2ccccc2)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C15H22N2O4/c1-9-13(19)15(21)14(20)11(17-9)7-12(18)16-8-10-5-3-2-4-6-10/h2-6,9,11,13-15,17,19-21H,7-8H2,1H3,(H,16,18)/t9-,11+,13+,14+,15+/m0/s1
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University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072682
PNG
(CHEMBL115930 | {[(3,4,5-Trihydroxy-2-hydroxymethyl...)
Show SMILES CC1NC(CO)(CNC(=O)CNC(=O)OCc2ccccc2)C(O)C(O)C1O
Show InChI InChI=1S/C18H27N3O7/c1-11-14(24)15(25)16(26)18(10-22,21-11)9-20-13(23)7-19-17(27)28-8-12-5-3-2-4-6-12/h2-6,11,14-16,21-22,24-26H,7-10H2,1H3,(H,19,27)(H,20,23)
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442342
PNG
(CHEMBL2442785)
Show SMILES C[C@@H]1N[C@H](CC(=O)Nc2c(C)cc(C)cc2C)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C17H26N2O4/c1-8-5-9(2)14(10(3)6-8)19-13(20)7-12-16(22)17(23)15(21)11(4)18-12/h5-6,11-12,15-18,21-23H,7H2,1-4H3,(H,19,20)/t11-,12+,15+,16+,17+/m0/s1
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University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50072686
PNG
(2-Aminomethyl-2-hydroxymethyl-6-methyl-piperidine-...)
Show SMILES CC1NC(CN)(CO)C(O)C(O)C1O
Show InChI InChI=1S/C8H18N2O4/c1-4-5(12)6(13)7(14)8(2-9,3-11)10-4/h4-7,10-14H,2-3,9H2,1H3
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Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans

Bioorg Med Chem Lett 8: 3353-8 (1999)


BindingDB Entry DOI: 10.7270/Q2MK6C1B
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50118919
PNG
((1S,2S,3R)-4-Methyl-6-nonylamino-cyclohexane-1,2,3...)
Show SMILES CCCCCCCCCNC1CC(C)C(O)C(O)C1O
Show InChI InChI=1S/C16H33NO3/c1-3-4-5-6-7-8-9-10-17-13-11-12(2)14(18)16(20)15(13)19/h12-20H,3-11H2,1-2H3
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Keio University

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase

Bioorg Med Chem Lett 12: 2811-4 (2002)


BindingDB Entry DOI: 10.7270/Q2C24WZJ
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50118928
PNG
((1S,2S,3R)-4-Methyl-6-phenethylamino-cyclohexane-1...)
Show SMILES CC1CC(NCCc2ccccc2)C(O)C(O)C1O
Show InChI InChI=1S/C15H23NO3/c1-10-9-12(14(18)15(19)13(10)17)16-8-7-11-5-3-2-4-6-11/h2-6,10,12-19H,7-9H2,1H3
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Keio University

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase

Bioorg Med Chem Lett 12: 2811-4 (2002)


BindingDB Entry DOI: 10.7270/Q2C24WZJ
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50118921
PNG
((1R,2S,3S)-4-Heptylamino-6-methyl-cyclohexane-1,2,...)
Show SMILES CCCCCCCNC1CC(C)C(O)C(O)C1O
Show InChI InChI=1S/C14H29NO3/c1-3-4-5-6-7-8-15-11-9-10(2)12(16)14(18)13(11)17/h10-18H,3-9H2,1-2H3
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Keio University

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase

Bioorg Med Chem Lett 12: 2811-4 (2002)


BindingDB Entry DOI: 10.7270/Q2C24WZJ
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50065258
PNG
((2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1
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Keio University

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase

Bioorg Med Chem Lett 12: 2811-4 (2002)


BindingDB Entry DOI: 10.7270/Q2C24WZJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50133508
PNG
((1R,3R,4S)-4-Decylamino-6-methyl-cyclohexane-1,2,3...)
Show SMILES CCCCCCCCCCN[C@H]1CC(C)[C@@H](O)C(O)[C@@H]1O
Show InChI InChI=1S/C17H35NO3/c1-3-4-5-6-7-8-9-10-11-18-14-12-13(2)15(19)17(21)16(14)20/h13-21H,3-12H2,1-2H3/t13?,14-,15+,16+,17?/m0/s1
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n/an/a 700n/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against alpha-Fucosidase in bovine kidney

Bioorg Med Chem Lett 13: 3461-3 (2003)


BindingDB Entry DOI: 10.7270/Q2FF3RR7
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50442352
PNG
(CHEMBL2442775)
Show SMILES CCCCCC[C@H]1N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C12H25NO3/c1-3-4-5-6-7-9-11(15)12(16)10(14)8(2)13-9/h8-16H,3-7H2,1-2H3/t8-,9+,10+,11+,12+/m0/s1
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n/an/a 890n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry

Bioorg Med Chem 21: 6565-73 (2013)


Article DOI: 10.1016/j.bmc.2013.08.028
BindingDB Entry DOI: 10.7270/Q2G73G5J
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50118922
PNG
((1R,2S,3S)-4-Butylamino-6-methyl-cyclohexane-1,2,3...)
Show SMILES CCCCNC1CC(C)C(O)C(O)C1O
Show InChI InChI=1S/C11H23NO3/c1-3-4-5-12-8-6-7(2)9(13)11(15)10(8)14/h7-15H,3-6H2,1-2H3
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n/an/a 920n/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase

Bioorg Med Chem Lett 12: 2811-4 (2002)


BindingDB Entry DOI: 10.7270/Q2C24WZJ
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50118920
PNG
((1R,2S,3S)-4-Benzylamino-6-methyl-cyclohexane-1,2,...)
Show SMILES CC1CC(NCc2ccccc2)C(O)C(O)C1O
Show InChI InChI=1S/C14H21NO3/c1-9-7-11(13(17)14(18)12(9)16)15-8-10-5-3-2-4-6-10/h2-6,9,11-18H,7-8H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney alpha-L-fucosidase

Bioorg Med Chem Lett 12: 2811-4 (2002)


BindingDB Entry DOI: 10.7270/Q2C24WZJ
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50133506
PNG
((1R,3R,4S)-4-Dodecylamino-6-methyl-cyclohexane-1,2...)
Show SMILES CCCCCCCCCCCCN[C@H]1CC(C)[C@@H](O)C(O)[C@@H]1O
Show InChI InChI=1S/C19H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-20-16-14-15(2)17(21)19(23)18(16)22/h15-23H,3-14H2,1-2H3/t15?,16-,17+,18+,19?/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against alpha-Fucosidase in bovine kidney

Bioorg Med Chem Lett 13: 3461-3 (2003)


BindingDB Entry DOI: 10.7270/Q2FF3RR7
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50133503
PNG
((1R,3R,6S)-4-Methyl-6-(4-phenyl-butylamino)-cycloh...)
Show SMILES CC1C[C@H](NCCCCc2ccccc2)[C@@H](O)C(O)[C@@H]1O
Show InChI InChI=1S/C17H27NO3/c1-12-11-14(16(20)17(21)15(12)19)18-10-6-5-9-13-7-3-2-4-8-13/h2-4,7-8,12,14-21H,5-6,9-11H2,1H3/t12?,14-,15+,16+,17?/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against alpha-Fucosidase in bovine kidney

Bioorg Med Chem Lett 13: 3461-3 (2003)


BindingDB Entry DOI: 10.7270/Q2FF3RR7
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM394398
PNG
(US10308607, Compound IV)
Show SMILES C[C@@H]1N\C(=C/C(=O)Nc2cccc3-c4ccccc4C(=O)c23)[C@@H](O)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C21H20N2O5/c1-10-18(25)21(28)20(27)15(22-10)9-16(24)23-14-8-4-7-12-11-5-2-3-6-13(11)19(26)17(12)14/h2-10,18,20-22,25,27-28H,1H3,(H,23,24)/b15-9-/t10-,18+,20+,21+/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Washington University



Assay Description
Fucosidase inhibition was assessed by preparing a reaction mixture of 50 mM phosphate-citrate pH 4.5, 5 mM MgCl2, 640 nM 4-methylumbelliferyl-alpha-L...

J Med Chem 52: 2188-91 (2009)


BindingDB Entry DOI: 10.7270/Q29P3403
More data for this
Ligand-Target Pair
Tissue alpha-L-fucosidase


(Homo sapiens (Human))		BDBM50133505
PNG
((1R,3R,6S)-4-Methyl-6-octylamino-cyclohexane-1,2,3...)
Show SMILES CCCCCCCCN[C@H]1CC(C)[C@@H](O)C(O)[C@@H]1O
Show InChI InChI=1S/C15H31NO3/c1-3-4-5-6-7-8-9-16-12-10-11(2)13(17)15(19)14(12)18/h11-19H,3-10H2,1-2H3/t11?,12-,13+,14+,15?/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against alpha-Fucosidase in bovine kidney

Bioorg Med Chem Lett 13: 3461-3 (2003)


BindingDB Entry DOI: 10.7270/Q2FF3RR7
More data for this
Ligand-Target Pair
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